Melatonin in mitochondrial dysfunction and related disorders

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works

Sequence and organization of the human mitochondrial genome

Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,640 · see citing works

Hydroperoxide metabolism in mammalian organs.

Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827 · see citing works

Oxyl radicals, redox-sensitive signalling cascades and antioxidants

Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930 · see citing works

Mild cognitive impairment

Gauthier, S. G., Reisberg, ‌., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 3,920 · see citing works

Mitochondrial diseases in man and mouse

Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060 · see citing works

Regulation of antioxidant enzymes: a significant role for melatonin

Rodrı́guez, C., Mayo, J. C., Sainz, R. M., Antolı́n, I., Herrera, F., Martı́n, V., & Reiter, R. J. (2003) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00092.x · Cited by 1,990 · see citing works

Free radical-mediated oxidation of free amino acids and amino acid residues in proteins

Stadtman, E. R., & Levine, R. L. (2003) · Amino Acids · doi:10.1007/s00726-003-0011-2 · Cited by 1,968 · see citing works

ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES 1

Lerner, A. B., Case, J. D., TAKAHASHI, Y., Lee, T. H., & Mori, W. (1958) · Journal of the American Chemical Society · doi:10.1021/ja01543a060 · Cited by 1,759 · see citing works

Mitochondrial Respiratory-Chain Diseases

DiMauro, S., & Schon, E. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022567 · Cited by 1,650 · see citing works

Association between mitochondrial dysfunction and severity and outcome of septic shock

Brealey, D. A., Brand, M. P., Hargreaves, I. P., Heales, S., Land, J. M., Smolenski, R. T., Davies, N. A., Cooper, C. E., & Singer, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09459-x · Cited by 1,505 · see citing works

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

Rubbo, H., Radí, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., KIRK, M. C., & Freeman, B. Α. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47160-8 · Cited by 1,350 · see citing works

The Pineal and Its Hormones in the Control of Reproduction in Mammals*

Reiter, R. J. (1980) · Endocrine Reviews · doi:10.1210/edrv-1-2-109 · Cited by 1,254 · see citing works

Mitochondria and neuronal survival

Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243 · see citing works

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

Linnane, A. W., Ozawa, T., Marzuki, S., & Tanaka, M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92145-4 · Cited by 1,192 · see citing works

Actions of Melatonin in the Reduction of Oxidative Stress

Reiter, R. J., Tan, D. X., Osuna, C., & Gitto, E. (2000) · Journal of Biomedical Science · doi:10.1007/bf02253360 · Cited by 1,182 · see citing works

Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

Reppert, S. M., Weaver, D. R., & Ebisawa, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90055-8 · Cited by 1,096 · see citing works

Mitochondria, oxygen free radicals, disease and ageing

Raha, S., & Robinson, B. H. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01674-1 · Cited by 1,066 · cited 1× · see citing works

Mitochondrial role in cell aging

Miquel, J., Economos, A. C., Fleming, J., & Johnson, J. E. (1980) · Experimental Gerontology · doi:10.1016/0531-5565(80)90010-8 · Cited by 937 · see citing works

The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it

Fahn, S., & Cohen, G. (1992) · Annals of Neurology · doi:10.1002/ana.410320616 · Cited by 927 · see citing works

Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.

Reppert, S. M., Godson, C., Mahle, C. D., Weaver, D. R., Slaugenhaupt, S. A., & Gusella, J. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8734 · Cited by 882 · see citing works

Mitochondrial Dysfunction in Neurodegenerative Diseases

Johri, A., & Beal, M. F. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192138 · Cited by 806 · see citing works

Classic toxin-induced animal models of Parkinson?s disease: 6-OHDA and MPTP

Schober, A. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0938-y · Cited by 803 · see citing works

Effect of Bright Light and Melatonin on Cognitive and Noncognitive Function in Elderly Residents of Group Care Facilities: A Randomized Controlled Trial

Riemersma-van der Lek, R. F. (2008) · JAMA · doi:10.1001/jama.299.22.2642 · Cited by 803 · see citing works

Mitochondrial permeability transition: a common pathway to necrosis and apoptosis

Js, K., He, L., & Lemasters, J. J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00618-1 · Cited by 756 · see citing works

Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance

Hardeland, R. (2005) · Endocrine · doi:10.1385/endo:27:2:119 · Cited by 670 · see citing works

Mitochondrial calcium and the permeability transition in cell death

Lemasters, J. J., Theruvath, T. P., Zhong, Z., & Nieminen, A. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.06.009 · Cited by 656 · see citing works

REVIEW: Gastrointestinal Melatonin: Localization, Function, and Clinical Relevance

Bubenik, G. A. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1020107915919 · Cited by 655 · see citing works

The mitochondrial energy transduction system and the aging process

Navarro, A., & Boveris, A. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00213.2006 · Cited by 646 · see citing works

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

Dubocovich, M. L., Delagrange, P., Krause, D. N., Sugden, D., Cardinali, D. P., & Olcese, J. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002832 · Cited by 636 · see citing works

Melatonin as a chronobiotic

Arendt, J., & Skene, D. J. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.05.002 · Cited by 629 · see citing works

Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.

Reiter, R. J., Tan, D., Mayo, J. C., Sainz, R. M., León, J., & Czarnocki, Z. (2003) · Acta Biochimica Polonica · doi:10.18388/abp.2003_3637 · Cited by 623 · see citing works

Mitochondrial dysfunction in neurodegenerative diseases

Beal, M. F. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00114-5 · Cited by 608 · see citing works

Identification of the Melatonin-binding SiteMT 3 as the Quinone Reductase 2

Nosjean, O., Ferro, M., Cogé, F., Beauverger, P., Henlin, J., Lefoulon, F., Fauchère, J., Delagrange, P., Canet, E., & Boutin, J. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005141200 · Cited by 604 · see citing works

Nitric oxide synthase activity in mitochondria

Ghafourifar, P., & Richter, C. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01397-5 · Cited by 567 · see citing works

Mitochondrial Disorders in the Nervous System

DiMauro, S., & Schon, E. A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094302 · Cited by 536 · see citing works

A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes

Tomás‐Zapico, C., & Coto‐Montes, A. M. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00248.x · Cited by 504 · see citing works

Apoptosis driven by IP3‐linked mitochondrial calcium signals

Szalai, G., Krishnamurthy, R., & Hajnóczky, G. (1999) · The EMBO Journal · doi:10.1093/emboj/18.22.6349 · Cited by 495 · see citing works

Melatonin-Immune System Relationships

Guerrero, J. M., & Reiter, R. J. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394335 · Cited by 476 · see citing works

Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines

Hardeland, R., Tan, D., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00701.x · Cited by 474 · see citing works

Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes

Antolı́n, I., Rodrı́guez, C., Sainz, R. M., Mayo, J. C., Urı́a, H., Kotler, M. L., Rodríguez‐Colunga, M. J., Tolivia, D., & Menéndez-Peláez, A. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.8.8666165 · Cited by 469 · see citing works

Mitochondria-targeted antioxidants protect against amyloid-β toxicity in Alzheimer's disease neurons

Manczak, M., Mao, P., Calkins, M. J., Cornea, A., Reddy, A. P., Murphy, M. P., Szeto, H. H., Park, B., & Reddy, P. H. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100564 · Cited by 469 · see citing works

Oxidative modification of proteins during aging

Levine, R. L., & Stadtman, E. R. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00135-8 · Cited by 466 · see citing works

Untitled work

Aurora (2010) · doi:10.5664/jcsm.27717 · Cited by 463 · see citing works

Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure

Brealey, D. A., Karyampudi, S., Jacques, T. S., Novelli, M. R., Stidwill, R. P., Taylor, V., Smolenski, R. T., & Singer, M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00432.2003 · Cited by 461 · see citing works

Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance

Carrillo‐Vico, A., Calvo, J. R., Abreu, P. M., Lardone, P. J., García‐Mauriño, S., Reiter, R. J., & Guerrero, J. M. (2004) · The FASEB Journal · doi:10.1096/fj.03-0694fje · Cited by 457 · see citing works

Mitochondrial Dysfunction and Psychiatric Disorders

Rezin, G. T., Amboni, G., Zugno, A. I., Quevedo, J., & STRECK, E. L. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9865-8 · Cited by 443 · see citing works

The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances

Hardeland, R., Reiter, R. J., Pöeggeler, B., & Tan, D. X. (1993) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80016-8 · Cited by 424 · see citing works

Antiinflammatory Activity of Melatonin in Central Nervous System

Esposito, E., & Cuzzocrea, S. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246155 · Cited by 408 · see citing works

An introduction to the free radical hypothesis in Parkinson's disease

Olanow, C. W. (1992) · Annals of Neurology · doi:10.1002/ana.410320703 · Cited by 382 · see citing works

Evidence for melatonin synthesis in mouse and human bone marrow cells

Conti, A., Conconi, S., Hertens, E., Skwarło‐Sońta, K., Markowska, M., & Maestroni, G. J. M. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.280401.x · Cited by 381 · see citing works

Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

Paradies, G., Petrosillo, G., Paradies, V., Reiter, R. J., & Ruggiero, F. M. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00759.x · Cited by 378 · see citing works

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau

Melov, S., Adlard, P. A., Morten, K., Johnson, F., Golden, T. R., Hinerfeld, D., Schilling, B., Mavros, C., Masters, C. L., Volitakis, I., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000536 · Cited by 363 · see citing works

Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients

Boeve, B. F. (2003) · Sleep Medicine · doi:10.1016/s1389-9457(03)00072-8 · Cited by 363 · see citing works

The role of the mitochondrial permeability transition pore in heart disease

Halestrap, A. P., & Pasdois, P. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.017 · Cited by 362 · see citing works

Circadian Rhythms, Oxidative Stress, and Antioxidative Defense Mechanisms

Hardeland, R., Coto‐Montes, A. M., & Pöeggeler, B. (2003) · Chronobiology International · doi:10.1081/cbi-120025245 · Cited by 358 · see citing works

The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

Pérez‐Campo, R., Lopez‐Torres, M., Cadenas, S., Rojas, C., & Barja, G. (1998) · Journal of Comparative Physiology B · doi:10.1007/s003600050131 · Cited by 356 · see citing works

Melatonin but not vitamins C and E maintains glutathione homeostasis in t‐butyl hydroperoxide‐induced mitochondrial oxidative stress

Martı́n, M., Macías, M. J., Escames, G., León, J., & Acuña-Castroviejo, D. (2000) · The FASEB Journal · doi:10.1096/fj.99-0865fje · Cited by 347 · see citing works

Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols

Brown, G. C., & Borutaite, V. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.03.016 · Cited by 344 · see citing works

Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing

Cooper, J. A. D., Mann, V. M., & Schapira, A. H. V. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90270-u · Cited by 335 · see citing works

Melatonin induces γ-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells

Urata, Y., Honma, S., Goto, S., Todoroki, S., Iida, T., Cho, S., Honma, K., & Kondo, T. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00131-8 · Cited by 333 · see citing works

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

Matsubara, E., Bryant‐Thomas, T., Pacheco Quinto, J., Henry, T. L., Poeggeler, B., Herbert, D., Cruz‐Sanchez, F., Chyan, Y., Smith, M. A., Perry, G., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01654.x · Cited by 332 · see citing works

Melatonin and mitochondrial function

León, J., Acuña-Castroviejo, D., Sainz, R. M., Mayo, J. C., Tan, D., & Reiter, R. J. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.03.003 · Cited by 331 · see citing works

Nuclear localization of melatonin in different mammalian tissues: Immunocytochemical and radioimmunoassay evidence

Menéndez-Peláez, A., Pöeggeler, B., Reiter, R. J., Barlow‐Walden, L., Pablos, M. I., & Tan, D.-X. (1993) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240530415 · Cited by 325 · see citing works

Liver mitochondrial respiratory functions decline with age

Yen, T., Chen, Y.-S., King, K.-L., Yeh, S.-H., & Wei, Y. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92701-0 · Cited by 323 · see citing works

A Novel Melatonin Metabolite, Cyclic 3-Hydroxymelatonin: A Biomarker ofin VivoHydroxyl Radical Generation

Tan, D., Manchester, L. C., Reiter, R. J., Plummer, B. F., Hardies, L. J., Weintraub, S. T., Vijayalaxmi, V., & Shepherd, A. M. M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9826 · Cited by 319 · see citing works

Oxidative Damage to Mitochondrial Complex I Due to Peroxynitrite

Murray, J. M., Taylor, S. W., Zhang, B., Ghosh, S. S., & Capaldi, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305694200 · Cited by 318 · see citing works

Senescence-accelerated mouse (SAM): a biogerontological resource in aging research

Takeda, T. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00008-1 · Cited by 311 · see citing works

Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti‐apoptotic effects of melatonin

Andrabi, S. A., Sayeed, I., Siemen, D., Wolf, G. L., & Horn, T. F. W. (2004) · The FASEB Journal · doi:10.1096/fj.03-1031fje · Cited by 311 · see citing works

The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

Tan, D., Pöeggeler, B., Reiter, R. J., et al. (1993) · Cancer Letters · doi:10.1016/0304-3835(93)90076-l · Cited by 308 · see citing works

In vitro and in vivo formation of two new metabolites of melatonin.

Hirata, F., Hayaishi, O., Tokuyama, T., & Senoh, S. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42976-1 · Cited by 302 · see citing works

The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron–sulfur cluster N2

Genova, M. L., Ventura, B., Giuliano, G., Bovina, C., Formiggini, G., Castelli, G. P., & Lenaz, G. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02850-2 · Cited by 297 · see citing works

Hydrogen peroxide release by mitochondria increases during aging

Sohal, R. S., & Sohal, B. H. (1991) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(91)90034-w · Cited by 296 · see citing works

Melatonin‐induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo

Martı́n, M., Macías, M., Escames, G., Reiter, R. J., Agapito, M. T., Ortíz, G. G., & Acuña-Castroviejo, D. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.280407.x · Cited by 295 · see citing works

MPTP as a Mitochondrial Neurotoxic Model of Parkinson's Disease

Przedborski, S., Tieu, K., Perier, C., & Vila, M. (2004) · Journal of Bioenergetics and Biomembranes · doi:10.1023/b:jobb.0000041771.66775.d5 · Cited by 289 · see citing works

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

López, A., García, J. A., Escames, G., Venegas, C., Ortiz, F., López, L. C., & Acuña-Castroviejo, D. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00647.x · Cited by 277 · see citing works

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice

Li, F., Calingasan, N. Y., Yu, F., Mauck, W. M., Toidze, M., Almeida, C. G., Takahashi, R. H., Carlson, G. A., Beal, M. F., Lin, M. T. S., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02455.x · Cited by 276 · see citing works

Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in parkinson's disease

Hattori, N., Tanaka, M., Ozawa, T., & Mizuno, Y. (1991) · Annals of Neurology · doi:10.1002/ana.410300409 · Cited by 275 · see citing works

Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease

Medeiros, C. A. M., de Bruin, P. F. C., Lopes, L. A., Magalhães, M. C., Seabra, M. D. L. V., & de Bruin, V. M. S. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0390-x · Cited by 269 · see citing works

On the Role of Melatonin in Skin Physiology and Pathology

Slominski, A. T., Fischer, T. W., Zmijewski, M. A., Wortsman, J., Semak, I. V., Zbytek, B., Slominski, R. M., & Tobin, D. J. (2005) · Endocrine · doi:10.1385/endo:27:2:137 · Cited by 265 · see citing works

Melatonin for sleep disturbances in Parkinson's disease

Dowling, G. A., Mastick, J., Colling, E., Carter, J. H., Singer, C. M., & Aminoff, M. J. (2005) · Sleep Medicine · doi:10.1016/j.sleep.2005.04.004 · Cited by 264 · see citing works

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy

Heiser, V., Scherzinger, E., Boeddrich, A., Nordhoff, E., Lurz, R., Schugardt, N., Lehrach, H. R., & Wanker, E. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110138997 · Cited by 262 · see citing works

Structure and Organization of Mitochondrial Respiratory Complexes: A New Understanding of an Old Subject

Lenaz, G., & Genova, M. L. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2704 · Cited by 261 · see citing works

Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria

Martı́n, M., Macías, M. J., León, J., Escames, G., Khaldy, H., & Acuña-Castroviejo, D. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00138-8 · Cited by 261 · see citing works

Protection against cognitive deficits and markers of neurodegeneration by long‐term oral administration of melatonin in a transgenic model of Alzheimer disease

Olcese, J., Cao, C., Mori, T., Mamcarz, M. B., Maxwell, A. K., Runfeldt, M. J., Wang, L., Zhang, C., Lin, X., Zhang, G., et al. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00692.x · Cited by 260 · see citing works

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases

Gibson, G. E., Starkov, A. A., Blass, J. P., Ratan, R. R., & Beal, M. F. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.08.010 · Cited by 256 · see citing works

N 1 ‐acetyl‐ N 2 ‐formyl‐5‐methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant

Tan, D. X., Manchester, L. C., Burkhardt, S., Sainz, R. M., Mayo, J. C., Kohen, R., Shohami, E., Huo, Y., Hardeland, R., & Reiter, R. J. (2001) · The FASEB Journal · doi:10.1096/fj.01-0309fje · Cited by 253 · see citing works

Transcriptional activation of the nuclear receptor RZRα by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand

Wiesenberg, I., Missbach, M., Kahlen, J.-P., Schräder, M., & Carlberg, C. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.3.327 · Cited by 250 · see citing works

Melatonin-mitochondria Interplay in Health and Disease

Acuña-Castroviejo, D., López, L. C., Escames, G., López, A., García, J. A., & Reiter, R. J. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611794863517 · Cited by 245 · see citing works

Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole

Tan, D., Reiter, R. J., Chen, L., Pöeggeler, B., Manchester, L. C., & Barlow‐Walden, L. (1994) · Carcinogenesis · doi:10.1093/carcin/15.2.215 · Cited by 243 · see citing works

Mitochondrial Dysfunction: Common Final Pathway in Brain Aging and Alzheimer’s Disease—Therapeutic Aspects

Müller, W. E., Eckert, A., Kurz, C., Eckert, G. P., & Leuner, K. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8141-5 · Cited by 243 · see citing works

Amyloid-β and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline

Reddy, P. H., Mańczak, M., Mao, P., Calkins, M. J., Reddy, A. P., & Shirendeb, U. P. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100504 · Cited by 240 · see citing works

Melatonin, immune function and aging

Srinivasan, V. J., Gj, M., Cardinali, D. P., Esquifino, A. I., Pandi-Perumal, S. R., & Miller, S. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-17 · Cited by 239 · see citing works

Putting Cancer to Sleep at Night: The Neuroendocrine/Circadian Melatonin Signal

Blask, D. E., Dauchy, R. T., & Sauer, L. A. (2005) · Endocrine · doi:10.1385/endo:27:2:179 · Cited by 238 · see citing works

Melatonin and circadian control in mammals

Armstrong, S. M. (1989) · Cellular and Molecular Life Sciences · doi:10.1007/bf01953050 · Cited by 235 · see citing works

The Mitochondrial Production of Reactive Oxygen Species in Relation to Aging and Pathology

Genova, M. L., Pich, M. M., Bernacchia, A., Bianchi, C., Biondi, A., Bovina, C., Falasca, A. I., Formiggini, G., Castelli, G. P., & Lenaz, G. (2004) · Springer eBooks · doi:10.1007/978-3-662-41088-2_10 · Cited by 233 · see citing works

The Antiapoptotic Activity of Melatonin in Neurodegenerative Diseases

Wang, X. (2009) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00105.x · Cited by 232 · see citing works

Melatonin: Signaling mechanisms of a pleiotropic agent

Hardeland, R. (2009) · BioFactors · doi:10.1002/biof.23 · Cited by 227 · see citing works

Mitochondrial Variants in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

Rollins, B. L., Martin, M. V., Sequeira, A., Moon, E. A., Morgan, L. Z., Watson, S. J., Schatzberg, A. F., Akil, H., Myers, R., Jones, E. G., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004913 · Cited by 212 · see citing works

Rhythms of glutathione peroxidase and glutathione reductase in brain of chick and their inhibition by light

Pablos, M. I., Reiter, R. J., Ortíz, G. G., Guerrero, J. M., Agapito, M. T., Chuang, J.-I., & Sewerynek, E. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(97)00043-0 · Cited by 210 · see citing works

ACQUIRED IMMUNE DEFICIENCY SYNDROME IN BLACK AFRICANS

Clumeck, N., Mascart-Lemone, F., Maubeuge, J. D., Brenez, D., & Marcelis, L. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91808-1 · Cited by 209 · see citing works

Involvement of NOX2 in the Development of Behavioral and Pathologic Alterations in Isolated Rats

Schiavone, S., Sorce, S., Dubois-Dauphin, M., Jaquet, V., Colaianna, M., Zotti, M., Cuomo, V., Trabace, L., & Krause, K.-H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.033 · Cited by 208 · see citing works

Therapeutic Actions of Melatonin in Cancer: Possible Mechanisms

Srinivasan, V., Spence, D. W., Pandi-Perumal, S. R., Trakht, I., & Cardinali, D. P. (2008) · Integrative Cancer Therapies · doi:10.1177/1534735408322846 · Cited by 208 · see citing works

Clinical Aspects of Melatonin Intervention in Alzheimers Disease Progression

Cardinali, D. P., Furio, A. M., & Brusco, L. I. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246209 · Cited by 204 · see citing works

Melatonin-induced temperature suppression and its acute phase-shifting effects correlate in a dose-dependent manner in humans

Deacon, S., & Arendt, J. (1995) · Brain Research · doi:10.1016/0006-8993(95)96872-i · Cited by 203 · see citing works

The pathophysiology of mitochondrial disease as modeled in the mousePreprint

Wallace, D. C., & Fan, W. (2009) · Genes & Development · doi:10.1101/gad.1784909 · Cited by 201 · see citing works

The Mitochondrial Production of Reactive Oxygen Species in Relation to Aging and Pathology

Genova, M. L., Pich, M. M., Bernacchia, A., BIANCHI, C., Biondi, A., Bovina, C., Falasca, A. I., Formiggini, G., Castelli, G. P., & Lenaz, G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1293.010 · Cited by 198 · see citing works

Melatonin's unique radical scavenging properties – roles of its functional substituents as revealed by a comparison with its structural analogs

Pöeggeler, B., Thuermann, S., Dose, A., Schoenke, M., Burkhardt, S., & Hardeland, R. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.01873.x · Cited by 196 · see citing works

Melatonin counteracts lipopolysaccharide‐induced expression and activity of mitochondrial nitric oxide synthase in rats

Escames, G., León, J., Macías, M. J., Khaldy, H., & Acuña-Castroviejo, D. (2003) · The FASEB Journal · doi:10.1096/fj.02-0692fje · Cited by 191 · see citing works

Reperfusion injury on cardiac myocytes after simulated ischemia

Hoek, T. L. V., Shao, Z., Li, C., Zak, R., Schumacker, P. T., & Becker, L. B. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.4.h1334 · Cited by 188 · see citing works

Mitochondrial medicine--molecular pathology of defective oxidative phosphorylation.

Fosslien, E. (2001) · PubMed · Cited by 186 · see citing works

Ischemia/reperfusion‐induced arrhythmias in the isolated rat heart: Prevention by melatonin

Tan, D. X., Manchester, L. C., Reiter, R. J., Qi, W., Kim, S. J., & El‐Sokkary, G. H. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00558.x · Cited by 183 · see citing works

Role of Mitochondrial Amyloid-β in Alzheimer's Disease

Chen, J. X., & Yan, S. S. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100357 · Cited by 181 · see citing works

Interactions of melatonin and its metabolites with the ABTS cation radical: extension of the radical scavenger cascade and formation of a novel class of oxidation products, C2‐substituted 3‐indolinones

Rosen, J., Than, N. N., Koch, D., Pöeggeler, B., Laatsch, H., & Hardeland, R. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00379.x · Cited by 178 · see citing works

Melatonin therapy for REM sleep behavior disorder

Takeuchi, N., Uchimura, N., Hashizume, Y., Mukai, M., Etoh, Y., YAMAMOTO, K., Kotorii, T., Ohshima, H., Ohshima, M., & Maeda, H. (2001) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.2001.00854.x · Cited by 175 · see citing works

Parkinson’s disease: genetic versus toxin‐induced rodent models

Terzioglu, M., & Galter, D. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06302.x · Cited by 173 · see citing works

Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease

Zheng, F., Chang, Y. S., Cheng, Y., Zhang, B. W., Qu, Z., Qin, C., & Zhang, J. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00144.x · Cited by 169 · see citing works

Possible therapeutic value of melatonin in mild cognitive impairment: A retrospective study

Furio, A. M., Brusco, L. I., & Cardinali, D. P. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00491.x · Cited by 167 · see citing works

Age-related mitochondrial genotypic and phenotypic alterations in human skeletal muscle

Pesce, V., Cormio, A., Fracasso, F., Vecchiet, J., Felzani, G., Lezza, A. M. S., Cantatore, P., & Gadaleta, M. N. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00517-2 · Cited by 165 · see citing works

Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases

Gu, M., Owen, A., Toffa, S., Cooper, J. A. D., Dexter, D. T., Jenner, P. G., MARSDEN, C. D., & Schapira, A. H. V. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00095-1 · Cited by 164 · see citing works

Nature and cause of mitochondrial dysfunction in Huntington’s disease: focusing on huntingtin and the striatum

Oliveira, J. M. A. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06741.x · Cited by 163 · see citing works

Melatonin advances the circadian timing of EEG sleep and directly facilitates sleep without altering its duration in extended sleep opportunities in humans

Rajaratnam, S. M. W., Middleton, B., Stone, B. M., Arendt, J., & Dijk, D. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.073742 · Cited by 160 · see citing works

Melatonin counteracts inducible mitochondrial nitric oxide synthase‐dependent mitochondrial dysfunction in skeletal muscle of septic mice

Escames, G., López, L. C., Tapias, V., Utrilla, P., Reiter, R., Hitos, A. B., León, J., Rodríguez, M. I., & Acuña-Castroviejo, D. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00281.x · Cited by 158 · see citing works

Brain mitochondrial dysfunction in aging, neurodegeneration and Parkinson's disease

Navarro, A. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00034 · Cited by 158 · see citing works

Chronobiotics—drugs that shift rhythms

Dawson, D. E., & Armstrong, S. M. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)02020-9 · Cited by 150 · see citing works

Binding of Melatonin to Human and Rat Plasma Proteins

Cardinali, D. P., Lynch, H. J., & Wurtman, R. J. (1972) · Endocrinology · doi:10.1210/endo-91-5-1213 · Cited by 148 · see citing works

Improvement of sleep quality by melatonin

Wurtman, R. J., & Zhdanova, I. V. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92509-0 · Cited by 146 · see citing works

The chronobiotic properties of melatonin

Pévet, P., Bothorel, B., Slotten, H. A., & Saboureau, M. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0584-1 · Cited by 146 · see citing works

Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment

Jean‐Louis, G., von Gizycki, H., & Zizi, F. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00557.x · Cited by 143 · see citing works

Protective effect of melatonin on 3‐nitropropionic acid‐induced oxidative stress in synaptosomes in an animal model of Huntington's disease

Túnez, I., Montilla, P., Muñoz, M. D. C., Feijóo, M., & Salcedo, M. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00163.x · Cited by 141 · see citing works

Drug Treatment of REM Sleep Behavior Disorder: the Use of Drug Therapies Other Than Clonazepam

Anderson, K. N., & Shneerson, J. M. (2009) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27492 · Cited by 139 · see citing works

Long‐term melatonin administration protects brain mitochondria from aging

Carretero, M., Escames, G., López, L. C., Venegas, C., Dayoub, J. C., García‐Corzo, L., & Acuña-Castroviejo, D. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00700.x · Cited by 137 · see citing works

N‐acetyltransferase is not the rate‐limiting enzyme of melatonin synthesis at night

Liu, T., & Borjigin, J. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00223.x · Cited by 135 · see citing works

The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion,

Ambrosio, G. (1991) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(91)90183-m · Cited by 134 · see citing works

Gene Regulation by Melatonin

Carlberg, C. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05403.x · Cited by 134 · see citing works

Aging Enhances the Activation of the Permeability Transition Pore in Mitochondria

Mather, M. W., & Rottenberg, H. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2994 · Cited by 134 · see citing works

Why Mitochondrial Genes are Most Often Found in Nuclei

Berg, O. G., & Kurland, C. G. (2000) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a026376 · Cited by 133 · see citing works

Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid‐β1–42

Zhou, J., Zhang, S., Zhao, X., & Wei, T. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00570.x · Cited by 123 · see citing works

Alzheimer's disease: diverse aspects of mitochondrial malfunctioning.

Santos, R. X., Correia, S. C., Wang, X., Perry, G. L., Smith, M. A., Moreira, P. I., & Zhu, X. (2010) · Europe PMC (PubMed Central) · Cited by 120 · see citing works

A higher oxidative status accelerates senescence and aggravates age-dependent disorders in SAMP strains of mice

Hosokawa, M. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00091-x · Cited by 120 · see citing works

Clinical Implications of Mitochondrial Dysfunction

Muravchick, S., Levy, R. J., & Warltier, D. C. (2006) · Anesthesiology · doi:10.1097/00000542-200610000-00029 · Cited by 120 · see citing works

Protective effects of melatonin on myocardial ischemia-reperfusion induced infarct size and oxidative changes.

Şahna, E., Parlakpınar, H., Türköz, Y., et al. (2005) · Physiological Research · doi:10.33549/physiolres.930664 · Cited by 120 · see citing works

Therapeutic prospects for mitochondrial disease

Schon, E. A., DiMauro, S., Hirano, M., & Gilkerson, R. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.04.007 · Cited by 118 · see citing works

Origin of cerebrospinal fluid melatonin and possible function in the integration of photoperiod

Tricoire-Leignel, H., Møller, M., Chemineau, P., & Malpaux, B. (2019) · Bioscientifica Proceedings · doi:10.1530/biosciprocs.5.023 · Cited by 118 · see citing works

Melatonin inhibits cardiolipin peroxidation in mitochondria and prevents the mitochondrial permeability transition and cytochrome c release

Petrosillo, G., Moro, N., Ruggiero, F. M., & Paradies, G. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.06.032 · Cited by 117 · see citing works

Potential use of melatonergic drugs in analgesia: Mechanisms of action

Srinivasan, V., Pandi-Perumal, S. R., Spence, D. W., Moscovitch, A., Trakht, I., Brown, G. M., & Cardinali, D. P. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.12.001 · Cited by 114 · see citing works

Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials

Quinn, J. F., Kulhanek, D. J., Nowlin, J., Jones, R. E., Praticò, D., Rokach, J., & Stackman, R. W. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.023 · Cited by 114 · see citing works

Melatonin and human reproduction: Shedding light on the darkness hormone

Srinivasan, V., Spence, W., Pandi-Perumal, S. R., Zakharia, R., Bhatnagar, K. P., & Brzezinski, A. (2009) · Gynecological Endocrinology · doi:10.3109/09513590903159649 · Cited by 114 · see citing works

Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging.

Wei, Y., Wu, S., Ma, Y., & Lee, H. (2009) · PubMed · Cited by 113 · see citing works

Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin‐induced nephrotoxicity in rats

Hara, M., Yoshida, M., Nishijima, H., Yokosuka, M., Iigo, M., Ohtani‐Kaneko, R., Shimada, A., Hasegawa, T., Akama, Y., & Hirata, K. (2001) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.300301.x · Cited by 113 · see citing works

Melatonin Reduces Oxidative Damage of Neural Lipids and Proteins in Senescence-Accelerated Mouse

Okatani, Y., Wakatsuki, A., Reiter, R. J., & Miyahara, Y. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00005-2 · Cited by 112 · see citing works

Melatonin and its brain metabolite N1‐acetyl‐5‐methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice

Tapias, V., Escames, G., López, L. C., López, A., Camacho, E., Carriòn, M. D., Entrena, A., Gallo, M. Á., Espinosa, A., & Acuña-Castroviejo, D. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22123 · Cited by 108 · see citing works

Significance of High Levels of Endogenous Melatonin in Mammalian Cerebrospinal Fluid and in the Central Nervous System

Tan, D., Manchester, L. C., Sánchez‐Barceló, E. J., Mediavilla, M. D., & Reiter, R. J. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246182 · Cited by 107 · see citing works

Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice

López, L. C., Escames, G., Tapias, V., Utrilla, P., León, J., & Acuña-Castroviejo, D. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.09.008 · Cited by 107 · see citing works

New Control of Mitochondrial Membrane Potential and ROS Formation A Hypothesis

Lee, I., Bender, E., Arnold, S., & Kadenbach, B. (2001) · Biological Chemistry · doi:10.1515/bc.2001.198 · Cited by 105 · see citing works

Melatonin protects against isoproterenol‐induced myocardial injury in the rat: antioxidative mechanisms

Mukherjee, D., Roy, S. G., Bandyopadhyay, A., Chattopadhyay, A., Basu, A., Mitra, E., Ghosh, A. K., Reiter, R. J., & Bandyopadhyay, D. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00749.x · Cited by 104 · see citing works

Melatonin scavenges hydroxyl radical and protects isolated rat hearts from ischemic reperfusion injury

Kaneko, S., Okumura, K., Numaguchi, Y., et al. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00607-x · Cited by 103 · see citing works

Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease

Beal, M. F. (2009) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(09)70812-0 · Cited by 103 · see citing works

Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice

Rodríguez, M. I., Escames, G., López, L. C., López, A., García, J. A. G., Ortiz, F., Sánchez, V., Romeu, M., & Acuña-Castroviejo, D. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.003 · Cited by 102 · see citing works

Mechanism of the peroxidase activity of Cu, Zn superoxide dismutase

Liochev, S. I., & Fridovich, I. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.02.036 · Cited by 97 · see citing works

Melatonin attenuates amyloid beta25–35-induced apoptosis in mouse microglial BV2 cells

Jang, M.-H., Jung, S.-B., Lee, M., Kim, C., Oh, Y.-T., Kang, I., Kim, J., & Kim, E. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.01.003 · Cited by 93 · see citing works

Melatonin in septic shock: Some recent concepts

Srinivasan, V., Pandi-Perumal, S. R., Spence, D. W., Kato, H., & Cardinali, D. P. (2010) · Journal of Critical Care · doi:10.1016/j.jcrc.2010.03.006 · Cited by 92 · see citing works

NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells

Collins-Underwood, J. R., Zhao, W., Sharpe, J. G., & Robbins, M. E. C. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.06.024 · Cited by 91 · see citing works

Mitochondria: beyond oxidative phosphorylation

Schatz, G. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00018-y · Cited by 90 · see citing works

The Use of Chronobiotics in the Resynchronization of the Sleep–wake Cycle

Cardinali, D. P., Furio, A. M., Reyes, M. P., & Brusco, L. I. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9009-2 · Cited by 86 · see citing works

Oxidation of melatonin by carbonate radicals and chemiluminescence emitted during pyrrole ring cleavage

Hardeland, R., Pöeggeler, B., Niebergall, R., & Zelosko, V. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02941.x · Cited by 85 · see citing works

Protective effect of melatonin against the 1‐methyl‐4‐phenylpyridinium‐induced inhibition of Complex I of the mitochondrial respiratory chain

Absi, E., Ayala, A., Machado, A., & Parrado, J. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.290106.x · Cited by 83 · see citing works

Effect of Antioxidant-Enriched Diets on Glutathione Redox Status in Tissue Homogenates and Mitochondria of the Senescence-Accelerated Mouse

Rebrin, I., Zicker, S., Wedekind, K. J., Paetau-Robinson, I., Packer, L., & Sohal, R. S. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.008 · Cited by 82 · see citing works

Melatonin Effects in a Patient with Severe REM Sleep Behavior Disorder: Case Report and Theoretical Considerations

Kunz, D., & Bes, F. (2008) · Neuropsychobiology · doi:10.1159/000119383 · Cited by 81 · see citing works

Mitochondrial biology in Alzheimer’s disease pathogenesis

Galindo, M. F., Ikuta, I., Zhu, X., Casadesús, G., & Jordán, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06814.x · Cited by 78 · see citing works

Melatonin protects hepatic mitochondrial respiratory chain activity in senescence‐accelerated mice

Okatani, Y., Wakatsuki, A., & Reiter, R. J. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.1o106.x · Cited by 77 · see citing works

Early increase of Nox4 NADPH oxidase and superoxide generation following endothelin‐1‐induced stroke in conscious rats

McCann, S., Dusting, G. J., & Roulston, C. L. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21700 · Cited by 72 · see citing works

Melatonin administration prevents cardiac and diaphragmatic mitochondrial oxidative damage in senescence-accelerated mice

Rodríguez, M. I., Escames, G., López, L. C., García, J. A. G., Ortiz, F., López, A., & Acuña-Castroviejo, D. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0260 · Cited by 70 · see citing works

Clinical Features and Pathogenesis of Alzheimer’s Disease: Involvement of Mitochondria and Mitochondrial DNA

Mancuso, M., Orsucci, D., LoGerfo, A., Calsolaro, V., & Siciliano, G. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6448-9_4 · Cited by 69 · see citing works

Low and high melatonin excretors among healthy individuals

Bergiannaki, J., Soldatos, C. R., Paparrigopoulos, T. J., et al. (1995) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1995.tb00155.x · Cited by 68 · see citing works

Acutely administered melatonin restores hepatic mitochondrial physiology in old mice

Okatani, Y., Wakatsuki, A., Reiter, R. J., & Miyahara, Y. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00260-1 · Cited by 65 · see citing works

Protein Tyrosine Nitration of the Flavin Subunit Is Associated with Oxidative Modification of Mitochondrial Complex II in the Post-ischemic Myocardium

Chen, C., Chen, J., Rawale, S. V., Varadharaj, S., Kaumaya, P. T. P., Zweier, J. L., & Chen, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802691200 · Cited by 65 · see citing works

Hepatic mitochondrial dysfunction in senescence‐accelerated mice: correction by long‐term, orally administered physiological levels of melatonin

Okatani, Y., Wakatsuki, A., Reiter, R. J., & Miyahara, Y. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.02109.x · Cited by 64 · see citing works

Single‐nucleotide polymorphisms and mRNA expression for melatonin synthesis rate‐limiting enzyme in recurrent depressive disorder

Gałecki, P., Szemraj, J., Bartosz, G., Bieńkiewicz, M., Gałecka, E., Florkowski, A., Lewiñski, A., & Karbownik‐Lewińska, M. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00754.x · Cited by 64 · see citing works

Cognitive Effects of Exogenous Melatonin Administration in Elderly Persons: A Pilot Study

Peck, J. S. (2004) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.12.4.432 · Cited by 63 · see citing works

Melatonin Synthesis in the Human Pineal Gland: Advantages, Implications, and Difficulties

Ackermann, K., & Stehle, J. H. (2006) · Chronobiology International · doi:10.1080/07420520500464379 · Cited by 63 · see citing works

Melatonin Prevents Age-Related Mitochondrial Dysfunction in Rat Brain Via Cardiolipin Protection

Petrosillo, G., Fattoretti, P., Matera, M., Ruggiero, F. M., Bertoni–Freddari, C., & Paradies, G. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0772 · Cited by 62 · see citing works

The Role of Mitochondria in Brain Aging and the Effects of Melatonin

Escames, G., López, A., Garcia, J. A. D., Garcia, L., Acuña-Castroviejo, D., Garcia, J. J., & López, L. C. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246245 · Cited by 61 · see citing works

Melatonin prevents oxidative stress‐mediated mitochondrial permeability transition and death in skeletal muscle cells

Hibaoui, Y., Roulet, E., & Rüegg, U. T. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00707.x · Cited by 61 · see citing works

Mitochondrial superoxide: a key player in Alzheimer's disease

Massaad, C. A., Pautler, R. G., & Klann, E. (2009) · Aging · doi:10.18632/aging.100088 · Cited by 60 · see citing works

Melatonin Protects Against Ischaemic-reperfusion Myocardial Damage

Salie, R., Harper, I. S., Cillie, C., et al. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1306 · Cited by 58 · see citing works

Melatonin Beyond Its Classical Functions

Hardeland, R., & Pöeggeler, B. (2008) · The Open Physiology Journal · doi:10.2174/1874360900801010001 · Cited by 55 · see citing works

Melatonin synthesis and melatonin‐membrane receptor (MT1) expression during rat thymus development: role of the pineal gland

Jiménez‐Jorge, S., Jiménez‐Caliani, A. J., Guerrero, J. M., Naranjo, M. C., Lardone, P. J., Carrillo‐Vico, A., Osuna, C., & Molinero, P. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00220.x · Cited by 55 · see citing works

Melatonin as a therapeutic tool in ophthalmology: implications for glaucoma and uveitis

Rosenstein, R. E., Pandi-Perumal, S. R., Srinivasan, V., Spence, D. W., Brown, G. M., & Cardinali, D. P. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00764.x · Cited by 53 · see citing works

Genetic regulation of melatonin excretion in urine

Wetterberg, L., Iselius, L., & Lindsten, J. (1983) · Clinical Genetics · doi:10.1111/j.1399-0004.1983.tb00093.x · Cited by 51 · see citing works

Modulation of mitochondrial calcium as a pharmacological target for Alzheimer's disease

Hung, C. H.-L., Ho, J. Y. S., & Chang, R. C. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.05.003 · Cited by 46 · see citing works

Melatonin Beyond Its Classical Functions

Hardeland, R., & Pöeggeler, B. (2008) · The Open Physiology Journal · doi:10.2174/1874360900901010001 · Cited by 43 · see citing works

Differential effects of melatonin on amyloid-β peptide 25-35-induced mitochondrial dysfunction in hippocampal neurons at different stages of culture

Dong, W., Huang, F. P., Fan, W., Cheng, S., Chen, Y., Zhang, W., Shi, H., & He, H. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00734.x · Cited by 41 · see citing works

Melatonin is released in the third ventricle in humans. A study in movement disorders

Leston, J., Harthé, C., Brun, J., Mottolèse, C., Mertens, P., Sindou, M., & Claustrat, B. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.12.008 · Cited by 40 · see citing works

Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line

Luchetti, F., Canonico, B., Mannello, F., Masoni, C., D'Emilio, A., Battistelli, M., Papa, S., & Falcieri, E. (2006) · Toxicology in Vitro · doi:10.1016/j.tiv.2006.08.003 · Cited by 40 · see citing works

Investigations of melatonin secretion in man

Grof, E., Grof, P., Brown, G. M., Arató, M., & Lane, J. D. (1985) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(85)90026-0 · Cited by 40 · see citing works

24-Hour variation in gene expression of redox pathway enzymes in rat hypothalamus: effect of melatonin treatment

Jiménez‐Ortega, V., Cano, P., Cardinali, D. P., & Esquifino, A. I. (2009) · Redox Report · doi:10.1179/135100009x392548 · Cited by 38 · see citing works

Day-time naps and melatonin in blind people

Lockley, S. W., Tabandeh, H., Skene, D. J., Buttery, R., Bird, A. C., Defrance, R., & Arendt, J. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92508-2 · Cited by 35 · see citing works

Nitric oxide, hypoxia and brain inflammation

Mander, P. K., & Brown, G. C. (2004) · Biochemical Society Transactions · doi:10.1042/bst0321068 · Cited by 35 · see citing works

Alzheimer's Proteins, Oxidative Stress, and Mitochondrial Dysfunction Interplay in a Neuronal Model of Alzheimer's Disease

Bobba, A., Petragallo, V. A., Marra, E., & Atlante, A. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/621870 · Cited by 34 · see citing works

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Minich, D. M., Henning, M., Darley, C., Fahoum, M., Schuler, C. B., & Frame, J. (2022) · Nutrients · doi:10.3390/nu14193934 · Cited by 176 · see citing works

A model of the mitochondrial basis of bipolar disorder

Morris, G., Walder, K., McGee, S. L., Dean, O. M., Tye, S. J., Maes, M., & Berk, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.014 · Cited by 162 · see citing works

Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration

Jha, S. K., Jha, N. K., Kumar, D., Ambasta, R. K., & Kumar, P. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.06.015 · Cited by 122 · see citing works

Loss of response to melatonin treatment is associated with slow melatonin metabolism

Braam, W., Van Geijlswijk, I., Keijzer, H., Smits, M. G., Didden, R., & Curfs, L. M. G. (2010) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2010.01283.x · Cited by 94 · see citing works

Serum melatonin levels in melanoma patients after repeated oral administration

Kane, M. A., Johnson, A., Nash, A., Boose, D., Mathai, G., Balmer, C. M., Yohn, J. J., & Robinson, W. A. (1994) · Melanoma Research · doi:10.1097/00008390-199402000-00009 · Cited by 9 · see citing works

The Effects of Melatonin Treatment on Oxidative Stress Induced by Ovariohysterectomy in DogsPreprint

Salavati, S., Mogheiseh, A., Nazıfı, S., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-123019/v1 · Cited by 3 · see citing works

Are the proposed benefits of melatonin-rich foods too hard to swallow?

Kennaway, D. J. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.962686 · Cited by 33 · see citing works

Effects of long-term light, darkness and oral administration of melatonin on serum levels of melatonin

Farhadi, N., Ghareghani, M., & Farhadi, Z. (2016) · Biomedical Journal · doi:10.1016/j.bj.2015.09.003 · Cited by 33 · see citing works