The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Microtubule Organization and Function in Epithelial Cells
Open accessAbstract
Microtubules are essential for many aspects of polarity in multicellular organisms, ranging from the asymmetric distribution of cell‐fate determinants in the one‐cell embryo to the transient polarity generated in migrating fibroblasts. Epithelial cells exhibit permanent cell polarity characterized by apical and basolateral surface domains of distinct protein and lipid composition that are segregated by tight junctions. They are also endowed with a microtubule network that reflects the asymmetry of their cell surface: microtubule minus‐ends face the apical‐ and microtubule plus‐ends the basal domain. Strikingly, the formation of distinct surface domains during epithelial differentiation is accompanied by the re‐organization of microtubules from a uniform array focused at the centrosome to the noncentrosomal network that aligns along the apico‐basolateral polarity axis. The significance of this coincidence for epithelial morphogenesis and the signaling mechanisms that drive microtubule repolymerization in developing epithelia remain major unresolved questions that we are only beginning to address. Studies in cultured polarized epithelial cells have established that microtubules serve as tracks that facilitate targeted vesicular transport. Novel findings suggest, moreover, that microtubule‐based transport promotes protein sorting, and even the generation of transport carriers in the endo‐ and exocytic pathways.
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Cites
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Morphogenesis of the Polarized Epithelial Cell Phenotype
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Building epithelial architecture: insights from three-dimensional culture models
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A Novel Clathrin Adaptor Complex Mediates Basolateral Targeting in Polarized Epithelial Cells
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Endocytic Traffic in Polarized Epithelial Cells: Role of the Actin and Microtubule Cytoskeleton
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Cited by
RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
Organization of vesicular trafficking in epithelia
Rodriguez-Boulan, E., Kreitzer, G., & Müsch, A. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1593 · Cited by 574
Self-citationFass, E., Shvets, E., Degani, I., Hirschberg, K., & Elazar, Z. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607031200 · Cited by 286
Systematic gene tagging using CRISPR/Cas9 in human stem cells to illuminate cell organization
Roberts, B., Haupt, A., Tucker, A., Grancharova, T., Arakaki, J., Fuqua, M. A., Nelson, A., Hookway, C., Ludmann, S. A., Mueller, I. A., et al. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-03-0209 · Cited by 262
Treyer, A., & Müsch, A. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c120009 · Cited by 252
Self-citation
Metadata
- Authors
- Müsch, A.
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2003-12-11
- Volume
- 5
- Issue
- 1
- Pages
- 1-9
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W1861708461
- Cited by
- 270
- References
- 84
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
