The DOI matches its Crossref record; 276 of the 276 references it cites were found in a registry or an index.
The mitochondrial permeability transition from in vitro artifact to disease target
Abstract
The mitochondrial permeability transition pore is a high conductance channel whose opening leads to an increase of mitochondrial inner membrane permeability to solutes with molecular masses up to approximately 1500 Da. In this review we trace the rise of the permeability transition pore from the status of in vitro artifact to that of effector mechanism of cell death. We then cover recent results based on genetic inactivation of putative permeability transition pore components, and discuss their meaning for our understanding of pore structure. Finally, we discuss evidence indicating that the permeability transition pore plays a role in pathophysiology, with specific emphasis on in vivo models of disease.
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“Since these dysfunctions are known to activate mPTP [2], it can be expected that mPTP activity will be enhanced in dysfunctional mitochondria in aging.”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [2]
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Metadata
- Authors
- Bernardi, P., Krauskopf, A., Basso, E., Petronilli, V., Blalchy‐Dyson, E., Di Lisa, F., & Forte, M. A.
- Affiliations
- University of Padua (IT)
- Oregon Health & Science University (US)
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2006-04-10
- Volume
- 273
- Issue
- 10
- Pages
- 2077-2099
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2060605524
- Cited by
- 627
- References
- 276
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 11 · 2023: 20 · 2022: 19 · 2021: 23 · 2020: 23 · 2019: 26 · 2018: 28 · 2017: 20 · 2016: 23 · 2015: 24 · 2014: 38 · 2013: 39 · 2012: 37
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Journal (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM069883, GM 69883)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- mitochondrial permeability transition pore, inner mitochondrial membrane permeability, cell death, gene inactivation, pore structure, mitochondrial disease, in vivo disease models
- MeSH terms
- Mitochondrial Permeability Transition Pore, Animals, Humans, Liver Diseases, Muscular Diseases, Nervous System Diseases, Artifacts, Drug Delivery Systems, Myocardial Ischemia, Mitochondrial Membrane Transport Proteins
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