It Takes Two to Tango": The relational domain in a cohort of subjects with erectile dysfunction (ED)
Abstract
INTRODUCTION: The relational domain of erectile dysfunction (ED) is difficult to investigate in a clinical setting. We developed and validated SIEDY, a 13-item structured interview, that evaluates, besides the organic (Scale 1) and intra-psychic (Scale 3) domains, also the relational one (Scale 2). We previously established a pathological threshold for SIEDY Scale 1 and 3. AIM: The aim of this study is to identify a pathological threshold of SIEDY Scale 2. METHOD: A nonselected, consecutive series of 2,992 subjects with ED was retrospectively evaluated. In a first consecutive series of 844 patients (Sample A, studied without systematically applying a psychometric test: Middlesex Hospital Questionnaire), a pathological threshold of SIEDY Scale 2 score was identified through receiver operating characteristic, using, as surrogate marker of impaired couple relationship, at least a positive answer to two standard questions on conflict within the couple and on the presence of extramarital affairs. MAIN OUTCOME MEASURE: Sensitivity and specificity, along with possible associations with biological and psychological correlates were verified in a further sample of 2,148 patients (Sample B). RESULTS: In Sample A, a threshold of Scale 2 score ≥2 predicts couple impairment with a sensitivity of 53% and specificity of 66% and an overall accuracy of 62.0 ± 2.2% (P < 0.0001). When this threshold was verified in sample B, Scale 2 score ≥2 was associated with a higher risk of anxiety and depressive symptoms, higher prevalence of psychopathology, and higher Scale 3 scoring, even after adjusting for confounders. In the same sample, a Scale 2 score ≥2 was associated with a reduced intimacy during sexual intercourse and overall worse sexual functioning. CONCLUSIONS: Until now, no instrument is available to quantify the marital domain of ED. The validation of a threshold of SIEDY Scale 2 score (≥2) represents an easy tool for the identification of ED patients with a relevant marital impairment.
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A disruption of the sexual response causes considerable distress in men and their partners.
“Furthermore, a disruption of the sexual response causes considerable distress in men and their partners.6, 7, 8”
From A Psychosocial Approach to Erectile Dysfunction: Position Statements from the European Society of Sexual Medicine (ESSM) (2021) · cites this paper as [8]
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Boddi, V., Fisher, A. D., Maseroli, E., Rastrelli, G., Corona, G., Jannini, E. A., Ricca, V., Mannucci, E., & Maggi, M. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12382 · Cited by 14 · see citing works
Neuroimaging biomarkers of psychogenic erectile dysfunction: protocol for a systematic review
Yin, T., Li, Z., Xiong, J., Lan, L., Sun, R., Ren, F., & Zhang, P. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-030061 · Cited by 13 · see citing works
Damage of Infill Masonry Walls due to Vertical Loads in Buildings with Reinforced Concrete Structure
Dias, J. M. (2023) · WSEAS TRANSACTIONS ON APPLIED AND THEORETICAL MECHANICS · doi:10.37394/232011.2023.18.4 · Cited by 9 · see citing works
Ma, Z., Ren, F., Huang, X., Yang, X., Li, H., Li, G., Chang, D., Yin, T., & Zhang, P. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.12.006 · Cited by 8 · see citing works
Rastrelli, G., & Forti, G. (2017) · Endocrinology · doi:10.1007/978-3-319-29456-8_31-1 · Cited by 8 · see citing works
Age disparity in couples and the sexual and general health of the male partner
Sparano, C., Rastrelli, G., Corona, G., Vignozzi, L., Vignoli, D., & Maggi, M. (2024) · Andrology · doi:10.1111/andr.13738 · Cited by 7 · see citing works
Is marijuana a foe of male sexuality? Data from a large cohort of men with sexual dysfunction
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Rastrelli, G., & Forti, G. (2017) · Endocrinology · doi:10.1007/978-3-319-44441-3_31 · Cited by 5 · see citing works
Patients with testosterone deficiency syndrome and type 2 diabetes.
Corona, G., & Maggi, M. (2013) · PubMed · Cited by 4 · see citing works
Acquired hypoprolactinemia in men, possible phenotype
Corona, G., Rastrelli, G., Sparano, C., Vignozzi, L., & Maggi, M. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-024-09895-9 · Cited by 4 · see citing works
Infertility and Sexual Dysfunction (SD) in the Couple
Grill, E. A., Khavari, R., Zurawin, J. L., Gonzalez, J. R. F., & Pastuszak, A. W. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3100-2_32 · Cited by 4 · see citing works
Male Sex Hormones in Andrology Today
Bianchi, N., Prontera, O., Dicuio, M., Concetti, S., Sforza, A., & Corona, G. (2022) · Springer eBooks · doi:10.1007/978-3-031-11701-5_19 · Cited by 3 · see citing works
Avanafil: The Second-Generation Treatment of Erectile Dysfunction
Corona, G., Maggi, M., & Jannini, E. A. (2016) · European Medical Journal · doi:10.33590/emj/10314434 · Cited by 3 · see citing works
Lafortune, D., Bonneau, J., Lapointe, V. A., Dubé, S., Calazana, F., Labrie, C., Canivet, C., & Godbout, N. (2025) · The Journal of Sex Research · doi:10.1080/00224499.2025.2478574 · Cited by 2 · see citing works
Sparano, C., Corona, G., Rastrelli, G., Vignozzi, L., Vignoli, D., & Maggi, M. (2025) · Andrology · doi:10.1111/andr.70023 · Cited by 2 · see citing works
Testosterone and Sexual Function
Corona, G., Rastrelli, G., Ferri, S., Sforza, A., & Maggi, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-46086-4_14 · Cited by 2 · see citing works
SIEDY Diagnostic Accuracy in Assessing Erectile Dysfunction in Young Men Living With HIV
Tiecco, G., Cesanelli, F., Colangelo, C., Gregorio, M. D., Delbarba, A., Facondo, P., Riva, M., Cappelli, C., Focà, E., Castelli, F., et al. (2026) · Andrology · doi:10.1111/andr.70215 · Cited by 1 · see citing works
Rokach, A., & Patel, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819174-3.00009-7 · Cited by 1 · see citing works
Testosterone and Sexual Function
Corona, G., Rastrelli, G., Ferri, S., Sforza, A., & Maggi, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-31501-5_17 · Cited by 1 · see citing works
Fertility and Testosterone Improvement in Male Patients After Bariatric Surgery
Luconi, M., Corona, G., Facchiano, E., Lucchese, M., & Maggi, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800872-0.00010-x
Lotti, F., Rochira, V., Pivonello, R., Santi, D., Galdiero, M., Maseroli, E., Antonio, B., Fustini, M., Peri, A., Sforza, A., et al. (2016) · IRIS UNIMORE (University of Modena and Reggio Emilia)
Rastrelli, G., Corona, G., & Maggi, M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64967-x
Sexuality Across Lifespan IV: Focus on Men’s Vulnerabilities
Corona, G., Maggi, M., & Graziottin, A. (2024) · Trends in andrology and sexual medicine · doi:10.1007/978-3-031-55080-5_4
Rastrelli, G., Corona, G., & Maggi, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00107-2
Testosteron und sexuelle Funktion
Corona, G., Rastrelli, G., Ferri, S., Sforza, A., & Maggi, M. (2024) · Springer eBooks · doi:10.1007/978-3-031-65245-5_17
- Authors
- Boddi, V., Corona, G., Fisher, A. D., Mannucci, E., Ricca, V., Sforza, A., Forti, G., & Maggi, M.
- Affiliations
- University of Florence (IT)
- Ospedale Bellaria (IT)
- Corresponding author
- Maggi, Mario
- Venue
- The Journal of Sexual Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-12-01
- Volume
- 9
- Issue
- 12
- Pages
- 3126-3136
- ISSN
- 1743-6095 (ISSN-L)
- 1743-6109
- OpenAlex
- W2134035598
- Cited by
- 61
- References
- 55
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 8
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Journal of Sexual Medicine (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
- Keywords
- erectile dysfunction, relational domains, couple relationships, sexual dysfunction assessment, sexual intimacy, anxiety and depressive symptoms, psychopathology, adultery, couple conflict
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Antisocial Personality Disorder, Anxiety, Depression, Humans, Erectile Dysfunction, Interview, Psychological, Male, Marriage, Middle Aged, Retrospective Studies, ROC Curve, Sensitivity and Specificity, Cohort Studies, Young Adult
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