Modulation of Taste Sensitivity by GLP‐1 Signaling in Taste Buds
Open accessAbstract
Modulation of sensory function can help animals adjust to a changing external and internal environment. Even so, mechanisms for modulating taste sensitivity are poorly understood. Using immunohistochemical, biochemical, and behavioral approaches, we found that the peptide hormone glucagon‐like peptide‐1 (GLP‐1) and its receptor (GLP‐1R) are expressed in mammalian taste buds. Furthermore, we found that GLP‐1 signaling plays an important role in the modulation of taste sensitivity: GLP‐1R knockout mice exhibit a dramatic reduction in sweet taste sensitivity as well as an enhanced sensitivity to umami‐tasting stimuli. Together, these findings suggest a novel paracrine mechanism for the hormonal modulation of taste function in mammals.
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Semaglutide's effects in suppressing consummatory behaviors are not specific to alcohol and might be driven by its ability to reduce appetite and thirst, palatability for sweet, and/or metabolic energy needs and calorie intake.
“From a mechanistic standpoint, these results suggest that semaglutide’s effects in suppressing consummatory behaviors are not specific to alcohol and might be driven by its ability to reduce appetite and thirst, such as the need for general fluid intake (55–60), palatability for sweet (taste) (61–64), and/or metabolic energy needs and calorie intake (24, 65–68).”
From The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission (2023) · cites this paper as [62]
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- Authors
- Martin, B., Dotson, C. D., Shin, Y., Ji, S., Drucker, D. J., Maudsley, S., & Munger, S. D.
- Affiliations
- National Institutes of Health (US)
- University of Maryland, Baltimore (US)
- Mount Sinai Hospital (CA)
- Corresponding author
- Munger, Steven D.
- ORCID
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2009-07
- Volume
- 1170
- Issue
- 1
- Pages
- 98-101
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC3731136
- OpenAlex
- W1991945414
- Cited by
- 137
- References
- 14
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 2 · 2022: 9 · 2021: 15 · 2020: 9 · 2019: 10 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 9 · 2014: 7 · 2013: 14 · 2012: 4
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (ZIAAG000318)
- National Institute on Deafness and Other Communication Disorders (R01DC008301, DC008301, DC005786, R01DC005786)
- National Institute of Dental and Craniofacial Research (DE007309, T32DE007309)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- glucagon-like peptide-1, GLP-1 receptor, taste buds, taste sensitivity, sweet taste, umami taste, paracrine signaling, taste receptor neurons
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Animals, Taste, Taste Buds, Signal Transduction, Receptors, Glucagon, Mice, Knockout, Mice, Glucagon-Like Peptide 1
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