Cited by 280Primate Behavior and EcologyNeural and Behavioral Psychology StudiesFace Recognition and Perception

The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.

The von Economo neurons in the frontoinsular and anterior cingulate cortex

Open access

Allman, John M., Tetreault, Nicole A., Hakeem, Atiya Y., Manaye, Kebreten F., Semendeferi, Katerina, Erwin, Joseph M., Park, Soyoung, Goubert, Virginie, Hof, Patrick R.·2011·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.2011.06011.xPMC PMC3140770

Open this paper in CoChat — free account

Abstract

The von Economo neurons (VENs) are large bipolar neurons located in the frontoinsular cortex (FI) and limbic anterior (LA) area in great apes and humans but not in other primates. Our stereological counts of VENs in FI and LA show them to be more numerous in humans than in apes. In humans, small numbers of VENs appear the 36th week postconception, with numbers increasing during the first 8 months after birth. There are significantly more VENs in the right hemisphere in postnatal brains; this may be related to asymmetries in the autonomic nervous system. VENs are also present in elephants and whales and may be a specialization related to very large brain size. The large size and simple dendritic structure of these projection neurons suggest that they rapidly send basic information from FI and LA to other parts of the brain, while slower neighboring pyramids send more detailed information. Selective destruction of VENs in early stages of frontotemporal dementia (FTD) implies that they are involved in empathy, social awareness, and self‐control, consistent with evidence from functional imaging.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1749-6632.2011.06011.x

Cites

79 of 79 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657
Empathy for Pain Involves the Affective but not Sensory Components of Pain
Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., & Frith, C. D. (2004) · Science · doi:10.1126/science.1093535 · Cited by 3,929
The neural basis of economic decision-making in the Ultimatum Game.
Sanfey, A. G., Rilling, J. K., Aronson, J. A., Nystrom, L. E., & Cohen, J. D. (2003) · Science · doi:10.1126/science.1082976 · Cited by 3,375
A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks
Sridharan, D., Levitin, D. J., & Menon, V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800005105 · Cited by 2,892
A neural system for error detection and compensation
Gehring, W. J., Goss, B., Coles, M. G. H., Meyer, D. E., & Donchin, E. (1993) · Psychological Science · doi:10.1111/j.1467-9280.1993.tb00586.x · Cited by 2,862
Distinct brain networks for adaptive and stable task control in humans
Dosenbach, N. U. F., Fair, D. A., Miezin, F. M., Cohen, A. L., Wenger, K. K., Dosenbach, R. A. T., Fox, M. D., Snyder, A. Z., Vincent, J. L., Raichle, M. E., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704320104 · Cited by 2,632
Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain
Lamm, C., Decety, J., & Singer, T. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.014 · Cited by 2,016
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,497
Social intelligence in the normal and autistic brain: An fMRI study
Baron‐Cohen, S., Ring, H. A., Wheelwright, S., Bullmore, E. T., Brammer, M. J., Simmons, A., & Williams, S. C. R. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00621.x · Cited by 1,320
Cardiovascular effects of human insular cortex stimulation
Oppenheimer, S. M., Gelb, A., Girvin, J. P., & Hachinski, V. C. (1992) · Neurology · doi:10.1212/wnl.42.9.1727 · Cited by 1,272

Show all 79 references

Research works printed but not linked: 7

Seeley W., 2011, Distinctive neurons in anterior cingulated and frontoinsular cortex: a historical perspective, Cereb. Cortex
Betz W., 1881, Ueber die feinere Structur der Gehirnrinde des Menschen, Zentralbl. Med. Wiss., 19, 193
Ramón y Cajal S., 1899, Textura del Sistema Nervioso del Hombre y de los Vertebrados, Tomo II
Williamson P.C., 2010, The Human Illnesses: Neuropsyciatric Disorders and the Nature of the Human Brain
van Kooten .2008.Autism counts. Dissertation Maastricht University.
Wittling W., 1995, Brain Asymmetry, 305
Rose M., 1928, Die Inselrinde des Menschen und der Tiere, J. Psychol. Neurol., 37, 467

Sorted by citations

Salience processing and insular cortical function and dysfunction
Uddin, L. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3857 · Cited by 2,083
Interoceptive inference, emotion, and the embodied self
Seth, A. K. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.09.007 · Cited by 1,816
The Neural Basis of Empathy
Bernhardt, B. C., & Singer, T. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150536 · Cited by 952
Why primate models matter
Phillips, K. A., Bales, K. L., Capitanio, J. P., Conley, A. J., Czoty, P. W., Hart, B. A. ‘., Hopkins, W. D., Hu, S., Miller, L. A., Nader, M. A., et al. (2014) · American Journal of Primatology · doi:10.1002/ajp.22281 · Cited by 649
The insular cortex
Nieuwenhuys, R. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-53860-4.00007-6 · Cited by 580
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393
Finding the self by losing the self: neural correlates of ego-dissolution under psilocybin
Lebedev, A. V., Lövdén, M., Rosenthal, G., Feilding, A., Nutt, D. J., & Carhart-Harris, R. L. (2015) · Human Brain Mapping · doi:10.1002/hbm.22833 · Cited by 339
Anterior insula as a gatekeeper of executive control
Molnar-Szakacs, I., & Uddin, L. Q. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104736 · Cited by 333
Dissociable large-scale networks anchored in the right anterior insula subserve affective experience and attention
Touroutoglou, A., Hollenbeck, M., Dickerson, B. C., & Feldman Barrett, L. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.02.012 · Cited by 276
Insular Cortex is Critical for the Perception, Modulation, and Chronification of Pain
Lu, C., Yang, T., Zhao, H., Zhang, M., Meng, F., Fu, H., Xie, Y., & Xu, H. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-016-0016-y · Cited by 270
Evolution of prefrontal cortex
Preuss, T. M., & Wise, S. P. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01076-5 · Cited by 257
In the body's eye: the computational anatomy of interoceptive inference
Allen, M., Levy, A., Parr, T., & Friston, K. J. (2022) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1010490 · Cited by 185
In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities
Schmidt, B. Z., Lehmann, M., Gutbier, S., Nembo, E. N., Noël, S., Smirnova, L., Forsby, A., Hescheler, J., Avci, H. X., Härtung, T., et al. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1805-9 · Cited by 191
Interoceptive inference: From computational neuroscience to clinic
Owens, A. P., Allen, M., Ondobaka, S., & Friston, K. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.017 · Cited by 187
Von Economo neurons in the anterior insula of the macaque monkey.
Evrard, H., Forro, T., & Logothetis, N. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.003 · Cited by 159
Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD
Pineda, S. S., Lee, H., Fitzwalter, B. E., Mohammadi, S., Pregent, L., Gardashli, M., Mantero, J. C., Engelberg-Cook, E., DeJesus‐Hernandez, M., van Blitterswijk, M., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.031 · Cited by 158
Stress and central autonomic network
Lamotte, G. J., Shouman, K., & Benarroch, E. E. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102870 · Cited by 162
Empathy and contextual social cognition
Melloni, M., López, V., & Ibáñez, A. M. (2013) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-013-0205-3 · Cited by 147
The complex genetics and biology of human temperament: a review of traditional concepts in relation to new molecular findings
Cloninger, C. R., Cloninger, K. M., Zwir, I. J. S., & Keltikangas‐Järvinen, L. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0621-4 · Cited by 149
Resting state functional connectivity of five neural networks in bipolar disorder and schizophrenia
Mamah, D. T., Barch, D. M., & Repovš, G. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.01.051 · Cited by 148
Von Economo neurons: Clinical and evolutionary perspectives
Butti, C., Santos, M., Uppal, N., & Hof, P. R. (2011) · Cortex · doi:10.1016/j.cortex.2011.10.004 · Cited by 140
Self-citation
Anterior insula regulates brain network transitions that gate conscious access
Huang, Z., Tarnal, V., Vlisides, P. E., Janke, E., McKinney, A., Picton, P., Mashour, G. A., & Hudetz, A. G. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109081 · Cited by 122
The human insula: Architectonic organization and postmortem MRI registration
Morel, A., Gallay, M. N., Baechler, A., Wyss, M., & Gallay, D. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.076 · Cited by 121
From conflict management to reward-based decision making: Actors and critics in primate medial frontal cortex
Silvetti, M., Alexander, W., Verguts, T., & Brown, J. W. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.003 · Cited by 118
Neuropil distribution in the cerebral cortex differs between humans and chimpanzees
Spocter, M. A., Hopkins, W. D., Barks, S. K., Bianchi, S., Hehmeyer, A. E., Anderson, S. M., Stimpson, C. D., Fobbs, A. J., Hof, P. R., & Sherwood, C. C. (2012) · Journal of Comparative Neurology · doi:10.1002/cne.23074 · Cited by 113
Self-citation
Human brain evolution writ large and small
Sherwood, C. C., Bauernfeind, A. L., Bianchi, S., Raghanti, M. A., & Hof, P. R. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-53860-4.00011-8 · Cited by 113
Self-citation
Modular architectonic organization of the insula in the macaque monkey
Evrard, H., Logothetis, N., & Craig, A. (2014) · The Journal of comparative neurology · doi:10.1002/cne.23436 · Cited by 113
Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations
Zhou, F., Li, J., Zhao, W., Xu, L., Zheng, X., Fu, M., Yao, S., Kendrick, K. M., Wager, T. D., & Becker, B. (2020) · eLife · doi:10.7554/elife.56929 · Cited by 105
Three genetic–environmental networks for human personality
Zwir, I. J. S., del Val, C., Arnedo, J., Pulkki-Råbäck, L., Konte, B., Yang, S. S., Romero‐Zaliz, R., Hintsanen, M., Cloninger, K. M., Garcia, D., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0579-x · Cited by 108
The Neuropsychology of Anxiety
McNaughton, N., & Gray, J. A. (2024) · doi:10.1093/oso/9780198843313.001.0001 · Cited by 99
Transcriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons
Hodge, R. D., Miller, J. A., Novotny, M. A., Kalmbach, B. E., Ting, J. T., Bakken, T. E., Aevermann, B. D., Barkan, E. R., Berkowitz-Cerasano, M. L., Cobbs, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14952-3 · Cited by 95
Human Brain Evolution
Kaas, J. H., & Preuss, T. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385870-2.00042-1 · Cited by 91
Consistent Anterior–Posterior Segregation of the Insula During the First 2 Years of Life
Alcauter, S., Lin, W., Smith, J. K., Gilmore, J. H., & Gao, W. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht312 · Cited by 94
Progranulin: at the interface of neurodegenerative and metabolic diseases
Nguyen, A. D., Nguyen, T. A., Martens, L. H., Mitic, L. L., & Farese, R. V. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.08.003 · Cited by 90
Social Cognition and Emotional Assessment (SEA) is a Marker of Medial and Orbital Frontal Functions: A Voxel-Based Morphometry Study in Behavioral Variant of Frontotemporal Degeneration
Bertoux, M., Volle, E., Funkiewiez, A., de Souza, L. C., Leclercq, D., & Dubois, B. (2012) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617712001300 · Cited by 99
The prefrontal cortex: from monkey to man
Lévy, R. (2023) · Brain · doi:10.1093/brain/awad389 · Cited by 88
Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP
Kutch, J. J., Yani, M. S., Asavasopon, S., Kirages, D. J., Rana, M., Cosand, L., Labus, J. S., Kilpatrick, L. A., Ashe-McNalley, C., Farmer, M. A., et al. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.05.013 · Cited by 81
Towards a classification of alexithymia: Primary, secondary and organic
Messina, A., Beadle, J. N., & Paradiso, S. (2014) · Giornale italiano di psicopatologia/Journal of psychopathology/Italian journal of psychopathology · Cited by 76
Processing own-age vs. other-age faces: Neuro-behavioral correlates and effects of emotion
Ebner, N. C., Johnson, M. R., Rieckmann, A., Durbin, K. A., Johnson, M. K., & Fischer, H. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.029 · Cited by 81
Updating and characterizing neuroanatomical markers in high-risk subjects, recently diagnosed and chronic patients with schizophrenia: A revised coordinate-based meta-analysis
Liloia, D., Brasso, C., Cauda, F., Mancuso, L., Nani, A., Manuello, J., Costa, T., Duca, S., & Rocca, P. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.010 · Cited by 71
Human von Economo Neurons Express Transcription Factors Associated with Layer V Subcerebral Projection Neurons
Cobos, I., & Seeley, W. W. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht219 · Cited by 71
Emotion regulation across the life span
Helion, C., Krueger, S. M., & Ochsner, K. N. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804281-6.00014-8 · Cited by 78
Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia
Tan, R. H., Wong, S., Kril, J. J., Piguet, O., Hornberger, M., Hodges, J. R., & Halliday, G. M. (2014) · Brain · doi:10.1093/brain/awu118 · Cited by 68
Generating Human Neurons In Vitro and Using Them to Understand Neuropsychiatric Disease
Pașca, S. P., Panagiotakos, G., & Dolmetsch, R. E. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170328 · Cited by 68
Echo time‐dependent quantitative susceptibility mapping contains information on tissue properties
Sood, S., Urriola, J., Reutens, D. C., O’Brien, K., Bollmann, S., Barth, M., & Vegh, V. (2016) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26281 · Cited by 64
Intersections and Divergences Between Empathizing and Mentalizing: Development, Recent Advancements by Neuroimaging and the Future of Animal Modeling
Cerniglia, L., Bartolomeo, L. D., Capobianco, M., Russo, S. L. M. L., Festucci, F., Tambelli, R., Adriani, W., & Cimino, S. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00212 · Cited by 72
The Role of Alpha-Synuclein and Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders
Torres, C. A. M., Wassouf, Z., Zafar, F., Sastre, D., Outeiro, T. F., & Schüle, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165724 · Cited by 64
Mindfulness meditation and consciousness: An integrative neuroscientific perspective
Manuello, J., Vercelli, U., Nani, A., Costa, T., & Cauda, F. (2016) · Consciousness and Cognition · doi:10.1016/j.concog.2015.12.005 · Cited by 66
Insular subdivisions functional connectivity dysfunction within major depressive disorder
Peng, X., Lin, P., Wu, X., Gong, R., Yang, R., & Wang, J. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.018 · Cited by 60
The neurobiology of human crying
Bylsma, L. M., Gračanin, A., & Vingerhoets, A. J. J. M. (2018) · Clinical Autonomic Research · doi:10.1007/s10286-018-0526-y · Cited by 57
Anatomical and functional connectivity support the existence of a salience network node within the caudal ventrolateral prefrontal cortex
Trambaiolli, L. R., Peng, X., Lehman, J. F., Linn, G., Russ, B. E., Schroeder, C. E., Liu, H., & Haber, S. N. (2022) · eLife · doi:10.7554/elife.76334 · Cited by 56
Autonomic Dysfunction in Autism Spectrum Disorder
Owens, A. P., Mathias, C. J., & Iodice, V. (2021) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2021.787037 · Cited by 55
Concordance of white matter and gray matter abnormalities in autism spectrum disorders: A voxel‐based meta‐analysis study
Cauda, F., Costa, T., Palermo, S., D’Agata, F., Diano, M., Bianco, F., Duca, S., & Keller, R. (2013) · Human Brain Mapping · doi:10.1002/hbm.22313 · Cited by 56
Empathetic Factors and Influences on Physical Performance: A Topical Review
Behm, D. G., & Carter, T. B. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.686262 · Cited by 54
Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study
Mutsaerts, H. J. M. M., Mirza, S. S., Petr, J., Thomas, D. L., Cash, D. M., Bocchetta, M., Vita, E. D., Metcalfe, A. W. S., Shirzadi, Z., Robertson, A. D., et al. (2019) · Brain · doi:10.1093/brain/awz039 · Cited by 60
The Neurobiology of Imagination: Possible Role of Interaction-Dominant Dynamics and Default Mode Network
Agnati, L. F., Guidolin, D., Battistin, L., Pagnoni, G., & Fuxé, K. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00296 · Cited by 58
Electrical stimulation of the insular cortex as a novel target for the relief of refractory pain: An experimental approach in rodents
Dimov, L. F., Toniolo, E. F., Matielo, H. A., de Andrade, D. C., Garcı́a-Larrea, L., Ballester, G., Teixeira, M. J., & Dale, C. S. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.11.036 · Cited by 51
Neural markers of familial risk for depression: An investigation of cortical thickness abnormalities in healthy adolescent daughters of mothers with recurrent depression.
Foland‐Ross, L. C., Gilbert, B. L., Joormann, J., & Gotlib, I. H. (2015) · Journal of Abnormal Psychology · doi:10.1037/abn0000050 · Cited by 53
Neural Mechanisms Behind Identification of Leptokurtic Noise and Adaptive Behavioral Response
d’Acremont, M., & Bossaerts, P. L. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw013 · Cited by 50
Oxytocin‐ and arginine vasopressin‐containing fibers in the cortex of humans, chimpanzees, and rhesus macaques
Flattery, C. N. R., Ross, A. P., Sahu, S. P., Siegel, E. R., Dooyema, J. M., Cree, M. A., Stopa, E. G., Young, L. J., Rilling, J. K., Albers, H. E., et al. (2018) · American Journal of Primatology · doi:10.1002/ajp.22875 · Cited by 53
The neocortex of cetaceans: cytoarchitecture and comparison with other aquatic and terrestrial species
Butti, C., Raghanti, M. A., Sherwood, C. C., & Hof, P. R. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.05980.x · Cited by 48
Self-citation
An Active-Inference Approach to Second-Person Neuroscience
Lehmann, K., Bolis, D., Friston, K. J., Schilbach, L., Ramstead, M. J. D., & Kanske, P. (2023) · Perspectives on Psychological Science · doi:10.1177/17456916231188000 · Cited by 53
Transcriptomic insights into human brain evolution: acceleration, neutrality, heterochrony
Somel, M., Rohlfs, R. V., & Liu, X. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.09.001 · Cited by 49
Evolutionary appearance of von Economo’s neurons in the mammalian cerebral cortex
Cauda, F., Geminiani, G. C., & Vercelli, A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00104 · Cited by 53
Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants
Lin, L., Nana, A. L., Hepker, M., Hwang, J., Gaus, S. E., Spina, S., Cosme, C. G., Gan, L., Grinberg, L. T., Geschwind, D. H., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0809-0 · Cited by 48
Cortical Activation Patterns of Bodily Attention triggered by Acupuncture Stimulation
Jung, W.-M., Lee, I., Wallraven, C., Ryu, Y.-H., Park, H., & Chae, Y. (2015) · Scientific Reports · doi:10.1038/srep12455 · Cited by 48
Salience Network Atrophy Links Neuron Type-Specific Pathobiology to Loss of Empathy in Frontotemporal Dementia
Pasquini, L., Nana, A. L., Toller, G., Brown, J. A., Deng, J., Staffaroni, A. M., Kim, E. J., Hwang, J., Li, L., Park, Y., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa119 · Cited by 51
Voxel-based morphometry study of the insular cortex in female patients with current and remitted depression
Liu, C.-H., Jing, B., Ma, X., Xu, P., Zhang, Y., Li, F., Wang, Y., Tang, L., Wang, Y.-J., Li, H.-Y., et al. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.058 · Cited by 46
Von Economo Neurons – Primate-Specific or Commonplace in the Mammalian Brain?
Banovac, I., Sedmak, D., Judáš, M., & Petanjek, Z. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.714611 · Cited by 46
Cognitive enhancement with Salience Network electrical stimulation is influenced by network structural connectivity
Li, L. M., Violante, I. R., Leech, R., Hampshire, A., Opitz, A., McArthur, D. A., Carmichael, D. W., & Sharp, D. J. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.10.069 · Cited by 45
Dopamine D3 receptor antagonists: a patent review (2007 – 2012)
Micheli, F., & Heidbreder, C. (2013) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2013.757593 · Cited by 39
Connecting Circuits with Networks in Addiction Neuroscience: A Salience Network Perspective
Cushnie, A. K., Tang, W., & Heilbronner, S. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24109083 · Cited by 47
Exploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine Learning
Koutsouleris, N., Pantelis, C., Velakoulis, D., McGuire, P. K., Dwyer, D., Urquijo-Castro, M. F., Paul, R., Dong, S., Popovic, D., Oeztuerk, O. F., et al. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.2075 · Cited by 42
Inter-individual variability in metacognitive ability for visuomotor performance and underlying brain structures
Sinanaj, I., Cojan, Y., & Vuilleumier, P. O. (2015) · Consciousness and Cognition · doi:10.1016/j.concog.2015.07.012 · Cited by 44
The insula: Leveraging cellular and systems-level research to better understand its roles in health and schizophrenia
Kittleson, A. R., Woodward, N. D., Heckers, S., & Sheffield, J. M. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105643 · Cited by 39
Impact of repeated blast exposure on active-duty United States Special Operations Forces
Gilmore, N., Tseng, C.-E. J., Maffei, C., Tromly, S. L., Deary, K. B., McKinney, I. R., Kelemen, J. N., Healy, B. C., Hu, C. G., Ramos‐Llordén, G., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2313568121 · Cited by 37
Calcitonin Gene-Related Peptide Modulates Heat Nociception in the Human Brain - An fMRI Study in Healthy Volunteers
Asghar, M. S., Becerra, L. R., Larsson, H. B. W., Borsook, D., & Ashina, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150334 · Cited by 37
Organization and hierarchy of the human functional brain network lead to a chain-like core
Mastrandrea, R., Gabrielli, A., Piras, F., Spalletta, G., Caldarelli, G., & Gili, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-04716-3 · Cited by 36
Long-range functional interactions of anterior insula and medial frontal cortex are differently modulated by visuospatial and inductive reasoning tasks
Ebisch, S. J. H., Mantini, D., Romanelli, R., Tommasi, M., Perrucci, M. G., Romani, G. L., Colom, R., & Saggino, A. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.058 · Cited by 37
An Update on Apathy in Alzheimer’s Disease
Dolphin, H., Dyer, A. H., McHale, C., O’Dowd, S., & Kennelly, S. (2023) · Geriatrics · doi:10.3390/geriatrics8040075 · Cited by 40
Abnormal Brain Areas Common to the Focal Epilepsies: Multivariate Pattern Analysis of fMRI
Pedersen, M., Curwood, E. K., Vaughan, D. N., Omidvarnia, A., & Jackson, G. D. (2015) · Brain Connectivity · doi:10.1089/brain.2015.0367 · Cited by 35
Disrupted development and imbalanced function in the global neuronal workspace: a positive-feedback mechanism for the emergence of ASD in early infancy
Fields, C., & Glazebrook, J. F. (2016) · Cognitive Neurodynamics · doi:10.1007/s11571-016-9419-8 · Cited by 33
Von Economo Neurons in the Human Medial Frontopolar Cortex
González-Acosta, C. A., Escobar, M. I., Casanova, M. F., Pimienta, H. J., & Buriticá, E. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00064 · Cited by 33
Functional parcellation of the operculo-insular cortex in perceptual decision making: An fMRI study
Rebola, J., Castelhano, J., Ferreira, C., & Castelo-Branco, M. S. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.06.020 · Cited by 33
Altered white matter integrity in adults with autism spectrum disorder and an IQ >100: a diffusion tensor imaging study
Nickel, K., van Elst, L. T., Perlov, E., Endres, D., Müller, G. T., Riedel, A., Fangmeier, T., & Maier, S. J. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12731 · Cited by 32
Bridging psychiatry and neurology through social neuroscience
Ibáñez, A. M., Kuljiš, R. O., Matallana, D., & Manes, F. (2014) · World Psychiatry · doi:10.1002/wps.20125 · Cited by 31
von Economo Neuron Density and Thalamus Volumes in Behavioral Deficits in Frontotemporal Dementia Cases with and without a C9ORF72 Repeat Expansion
Yang, Y., Halliday, G. M., Hodges, J. R., & Tan, R. H. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170002 · Cited by 32
Evolutionary divergence of neuroanatomical organization and related genes in chimpanzees and bonobos
Staes, N., Smaers, J. B., Kunkle, A. E., Hopkins, W. D., Bradley, B. J., & Sherwood, C. C. (2018) · Cortex · doi:10.1016/j.cortex.2018.09.016 · Cited by 31
Neural representation of the parent–child attachment from infancy to adulthood
Ulmer-Yaniv, A., Waidergoren, S., Shaked, A., Salomon, R., & Feldman, R. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab132 · Cited by 35
Monetary reward suppresses anterior insula activity during social pain
Cristofori, I., Harquel, S., Isnard, J., Mauguı̀ere, F., & Sirigu, A. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv054 · Cited by 31
Situating Empathy in HCI/CSCW: A Scoping Review
Genç, H. U., & Verma, H. (2024) · Proceedings of the ACM on Human-Computer Interaction · doi:10.1145/3687052 · Cited by 30
A role for the anterior insular cortex in the global neuronal workspace model of consciousness
Michel, M. (2017) · Consciousness and Cognition · doi:10.1016/j.concog.2017.02.004 · Cited by 30
Circles of engagement: Childhood pain and parent brain
Simons, L. E., Goubert, L., Vervoort, T., & Borsook, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.020 · Cited by 31
Self-Transcendence in Mountaineering and BASE Jumping
Monasterio, E., & Cloninger, C. R. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02686 · Cited by 28
The Psychobiology of the Path to a Joyful Life:Implications for Future Research and Practice
Cloninger, K. M., & Cloninger, C. R. (2019) · The Journal of Positive Psychology · doi:10.1080/17439760.2019.1685579 · Cited by 28
Nature versus Nurture in Frontotemporal Lobar Degeneration: the Interaction of Genetic Background and Education on Brain Damage
Premi, E., Garibotto, V., Alberici, A., Paghera, B., Giubbini, R., Padovani, A., & Borroni, B. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000339366 · Cited by 27
Von Economo neurons are part of a larger neuronal population that are selectively vulnerable in C9orf72 frontotemporal dementia
Gami‐Patel, P., van Dijken, I., Swieten, J. C. V., Pijnenburg, Y. A. L., Bank, N. B., Rozemüller, A. J. M., Hoozemans, J. J. M., & Dijkstra, A. A. (2019) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12558 · Cited by 27
Distinct effects of ASD and ADHD symptoms on reward anticipation in participants with ADHD, their unaffected siblings and healthy controls: a cross-sectional study
van Dongen, E. V., von Rhein, D. T., O’Dwyer, L., Franke, B., Hartman, C. A., Heslenfeld, D. J., Hoekstra, P. J., Oosterlaan, J., Rommelse, N. N. J., & Buitelaar, J. K. (2015) · Molecular Autism · doi:10.1186/s13229-015-0043-y · Cited by 28
Ultrasocial
Gowdy, J. M. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108974264 · Cited by 25
Single subject analyses reveal consistent recruitment of frontal operculum in performance monitoring
Amiez, C., Wutte, M., Faillenot, I., Petrides, M., Burle, B., & Procyk, E. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.03.003 · Cited by 24

Authors: Allman, J. M., Tetreault, N. A., Hakeem, A. Y., Manaye, K. F., Semendeferi, K., Erwin, J. M., Park, S., Goubert, V., & Hof, P. R.
Affiliations: California Institute of Technology (US)
Corresponding author: Allman, John M.
ORCID: Semendeferi, Katerina
Hof, Patrick R.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2011-04
Volume: 1225
Issue: 1
Pages: 59-71
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.2011.06011.x
PMC: PMC3140770
OpenAlex: W2164876229
Cited by: 280
References: 79
Citations by year: 2026: 18 · 2025: 11 · 2024: 42 · 2023: 16 · 2022: 9 · 2021: 42 · 2020: 18 · 2019: 21 · 2018: 14 · 2017: 13 · 2016: 18 · 2015: 13 · 2014: 13 · 2013: 15 · 2012: 12
FWCI: 1.72
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 27 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: National Institute on Aging (R44AG014308)
National Institute of Mental Health (R01MH089406)
Topics: Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Primate Behavior and Ecology
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
Keywords: von Economo neurons, frontoinsular cortex, anterior cingulate cortex, human evolution, great apes, postnatal development, hemispheric lateralization, autonomic nervous system, brain size, elephants, whales, frontotemporal dementia, empathy, social awareness, self-control
MeSH terms: Animals, Cell Count, Biological Evolution, Gyrus Cinguli, Humans, Models, Biological, Neurons, Primates, Growth and Development

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The von Economo neurons in the frontoinsular and anterior cingulate cortex

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks