Cited by 169Neural and Behavioral Psychology StudiesDecision-Making and Behavioral EconomicsNeurotransmitter Receptor Influence on Behavior

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Orbitofrontal contributions to value-based decision making: evidence from humans with frontal lobe damage

Fellows, Lesley K.·2011·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.2011.06229.x

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Abstract

The work described here aims to isolate the component processes of decision making that rely critically on particular subregions of the human prefrontal cortex, with a particular focus on the orbitofrontal cortex. Here, experiments isolating specific aspects of decision making, using very simple preference judgment and reinforcement learning paradigms, were carried out in patients with focal frontal damage. The orbitofrontal cortex and the adjacent ventromedial prefrontal cortex play a critical role in decisions based on subjective value, across many categories of stimuli, and in learning to choose between stimuli based on value feedback. However, these regions are not required for learning to choose between actions based on feedback, which instead seems to rely critically on the dorsomedial prefrontal cortex. These results point to a potentially common role for the orbitofrontal cortex in representing the context-sensitive, subjective value of stimuli to allow consistent choices between them. They also argue for multiple, parallel, value-based processes that influence behavior through dissociable mechanisms.

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Authors: Fellows, L. K.
Affiliations: McGill University (CA)
Corresponding author: Fellows, Lesley K.
ORCID: Fellows, Lesley K.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2011-12
Volume: 1239
Issue: 1
Pages: 51-58
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.2011.06229.x
OpenAlex: W1950138029
Cited by: 169
References: 37
Citations by year: 2026: 1 · 2025: 11 · 2024: 5 · 2023: 11 · 2022: 7 · 2021: 6 · 2020: 43 · 2019: 4 · 2018: 10 · 2017: 15 · 2016: 17 · 2015: 16 · 2014: 11 · 2013: 6 · 2012: 5
FWCI: 0.62
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: University of Pennsylvania
Canadian Institutes of Health Research (MOP-77583)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: orbitofrontal cortex, value-based decision making, frontal lobe damage, ventromedial prefrontal cortex, dorsomedial prefrontal cortex, subjective value, reinforcement learning, preference judgments
MeSH terms: Animals, Brain Damage, Chronic, Brain Injuries, Brain Mapping, Decision Making, Frontal Lobe, Humans, Models, Psychological, Neurons, Reinforcement, Psychology, Reversal Learning, Social Values

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Orbitofrontal contributions to value-based decision making: evidence from humans with frontal lobe damage

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