The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Orbitofrontal contributions to value-based decision making: evidence from humans with frontal lobe damage
Abstract
The work described here aims to isolate the component processes of decision making that rely critically on particular subregions of the human prefrontal cortex, with a particular focus on the orbitofrontal cortex. Here, experiments isolating specific aspects of decision making, using very simple preference judgment and reinforcement learning paradigms, were carried out in patients with focal frontal damage. The orbitofrontal cortex and the adjacent ventromedial prefrontal cortex play a critical role in decisions based on subjective value, across many categories of stimuli, and in learning to choose between stimuli based on value feedback. However, these regions are not required for learning to choose between actions based on feedback, which instead seems to rely critically on the dorsomedial prefrontal cortex. These results point to a potentially common role for the orbitofrontal cortex in representing the context-sensitive, subjective value of stimuli to allow consistent choices between them. They also argue for multiple, parallel, value-based processes that influence behavior through dissociable mechanisms.
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“Consistent with this neurophysiological and neuroimaging evidence, lesions of the OFC can impair behavioural changes to non-reward. For example, reward reversal learning is impaired during decision-making in humans, who continue responding to the previously rewarded, now non-rewarded, stimulus (Rolls et al., 1994; Hornak et al., 2004; Fellows, 2011).”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Fellows, 2011
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Metadata
- Authors
- Fellows, L. K.
- Affiliations
- McGill University (CA)
- Corresponding author
- Fellows, Lesley K.
- ORCID
- Fellows, Lesley K.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2011-12
- Volume
- 1239
- Issue
- 1
- Pages
- 51-58
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1950138029
- Cited by
- 169
- References
- 37
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 5 · 2023: 11 · 2022: 7 · 2021: 6 · 2020: 43 · 2019: 4 · 2018: 10 · 2017: 15 · 2016: 17 · 2015: 16 · 2014: 11 · 2013: 6 · 2012: 5
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pennsylvania
- Canadian Institutes of Health Research (MOP-77583)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- orbitofrontal cortex, value-based decision making, frontal lobe damage, ventromedial prefrontal cortex, dorsomedial prefrontal cortex, subjective value, reinforcement learning, preference judgments
- MeSH terms
- Animals, Brain Damage, Chronic, Brain Injuries, Brain Mapping, Decision Making, Frontal Lobe, Humans, Models, Psychological, Neurons, Reinforcement, Psychology, Reversal Learning, Social Values
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