Altered Mitochondrial DNA Methylation Pattern in Alzheimer Disease–Related Pathology and in Parkinson Disease
Open accessAbstract
Mitochondrial dysfunction is linked with the etiopathogenesis of Alzheimer disease and Parkinson disease. Mitochondria are intracellular organelles essential for cell viability and are characterized by the presence of the mitochondrial (mt)DNA. DNA methylation is a well-known epigenetic mechanism that regulates nuclear gene transcription. However, mtDNA methylation is not the subject of the same research attention. The present study shows the presence of mitochondrial 5-methylcytosine in CpG and non-CpG sites in the entorhinal cortex and substantia nigra of control human postmortem brains, using the 454 GS FLX Titanium pyrosequencer. Moreover, increased mitochondrial 5-methylcytosine levels are found in the D-loop region of mtDNA in the entorhinal cortex in brain samples with Alzheimer disease-related pathology (stages I to II and stages III to IV of Braak and Braak; n = 8) with respect to control cases. Interestingly, this region shows a dynamic pattern in the content of mitochondrial 5-methylcytosine in amyloid precursor protein/presenilin 1 mice along with Alzheimer disease pathology progression (3, 6, and 12 months of age). Finally, a loss of mitochondrial 5-methylcytosine levels in the D-loop region is found in the substantia nigra in Parkinson disease (n = 10) with respect to control cases. In summary, the present findings suggest mtDNA epigenetic modulation in human brain is vulnerable to neurodegenerative disease states.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Alzheimer disease-related pathology is associated with lower mt-ND1 methylation.
“and patients with Alzheimer disease-related pathology have reduced levels of mt-ND1 methylation116.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [116]
Parkinson disease patients have reduced D-loop methylation.
“Patients with Parkinson disease have decreased methylation of the D-loop116”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [116]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works
Sequence and organization of the human mitochondrial genome
Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,640 · see citing works
Functions of DNA methylation: islands, start sites, gene bodies and beyond
Jones, P. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3230 · Cited by 6,061 · see citing works
Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172 · see citing works
DNA methylation landscapes: Provocative insights from epigenomics
Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039 · see citing works
Mitochondrial Complex I Deficiency in Parkinson's Disease
Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02325.x · Cited by 2,283 · see citing works
Du, P., Zhang, X., Huang, C.-C., Jafari, N., Kibbe, W. A., Hou, L., & Lin, S. M. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-587 · Cited by 2,136 · see citing works
MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE
Schapira, A. H. V., Cooper, J. A. D., Dexter, D. T., Jenner, P. G., Clark, J. B., & MARSDEN, C. D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92366-0 · Cited by 1,757 · see citing works
Bender, A., Krishnan, K. J., Morris, C. M., Taylor, G. A., Reeve, A. K., Perry, R. H., Jaros, E., Hersheson, J. S., Betts, J., Klopstock, T., et al. (2006) · Nature Genetics · doi:10.1038/ng1769 · Cited by 1,570 · see citing works
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
Feng, J., Zhou, Y., Campbell, S. L., Le, T., Li, E., Sweatt, J. D., Silva, A. J., & Fan, G. (2010) · Nature Neuroscience · doi:10.1038/nn.2514 · Cited by 1,019 · see citing works
Neuropathological assessment of Parkinson’s disease: refining the diagnostic criteria
Dickson, D. W., Braak, H., Duda, J. E., Duyckaerts, C., Gasser, T., Halliday, G. M., Hardy, J., Leverenz, J. B., Del Tredici, K., Wszolek, Z. K., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70238-8 · Cited by 972 · see citing works
The Human Mitochondrial Transcriptome
Mercer, T. R., Neph, S., Dinger, M. E., Crawford, J., Smith, M. A., Shearwood, A.-M. J., Haugen, E., Bracken, C. P., Rackham, O., Stamatoyannopoulos, J. A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.051 · Cited by 905 · see citing works
Keeney, P., Xie, J., Capaldi, R., & Bennett, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0984-06.2006 · Cited by 757 · see citing works
CENTRAL CERVICAL CORD SYNDROME AFTER HEADING A FOOTBALL
Scoppetta, C., & Vaccario, M. L. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92517-5 · Cited by 755 · see citing works
Dynamic DNA methylation across diverse human cell lines and tissuesPreprint
Varley, K. E., Gertz, J., Bowling, K. M., Parker, S. L., Reddy, T. E., Pauli, F., Cross, M. K., Williams, B. A., Stamatoyannopoulos, J. A., Crawford, G. E., et al. (2013) · Genome Research · doi:10.1101/gr.147942.112 · Cited by 693 · see citing works
Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA
Falkenberg, M., Gaspari, M., Rantanen, A., Trifunovic, A., Larsson, N.-G., & Gustafsson, C. M. (2002) · Nature Genetics · doi:10.1038/ng909 · Cited by 598 · cited 2× · see citing works
“Moreover, mtDNA is devoid of intronic regions, and the only noncoding sequence is known as the control region or D-loop, which regulates mitochondrial transcription and replication.11 Interestingly, reduced content and activity of complex I and IV subunits of the respiratory chain, such as ND4 in AD brains12e15 and ND…”
BackgroundCoskun, P. E., Beal, M. F., & Wallace, D. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403649101 · Cited by 556 · see citing works
Shock, L. S., Thakkar, P. V., Peterson, E. J., Moran, R. G., & Taylor, S. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012311108 · Cited by 555 · see citing works
Brain cytochrome oxidase in Alzheimer's disease
Kish, S. J., Bergeron, C., Rajput, A., Dozic, S., Mastrogiacomo, F., Chang, L., Wilson, J. M., DiStefano, L. M., & Nobrega, J. N. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09439.x · Cited by 537 · see citing works
Genomic Distribution and Inter-Sample Variation of Non-CpG Methylation across Human Cell Types
Ziller, M. J., Müller, F., Liao, J., Zhang, Y., Gu, H., Bock, C., Boyle, P. J., Epstein, C. B., Bernstein, B., Lengauer, T., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002389 · Cited by 398 · see citing works
Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation
Chestnut, B. A., Qing, C., Price, A. C., Lesuisse, C., Wong, M., & Martin, L. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1639-11.2011 · Cited by 365 · see citing works
Bosetti, F. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00314-1 · Cited by 348 · see citing works
Marked changes in mitochondrial DNA deletion levels in Alzheimer brains
Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., McKee, A. C., Beal, M. F., Graham, B. H., & Wallace, D. C. (1994) · Genomics · doi:10.1006/geno.1994.1525 · Cited by 309 · see citing works
A mitochondrial etiology of Alzheimer and Parkinson disease
Coskun, P. E., Wyrembak, J., Schriner, S. E., Chen, H.-W., Marciniack, C., LaFerla, F. M., & Wallace, D. C. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.08.008 · Cited by 297 · see citing works
The Control Region of Mitochondrial DNA Shows an Unusual CpG and Non-CpG Methylation Pattern
Bellizzi, D., D’Aquila, P., Scafone, T., Giordano, M., Riso, V., Riccio, A., & Passarino, G. (2013) · DNA Research · doi:10.1093/dnares/dst029 · Cited by 267 · see citing works
Hattingen, E., Magerkurth, J., Pilatus, U., Mozer, A., Seifried, C., Steinmetz, H., Zanella, F. E., & Hilker, R. (2009) · Brain · doi:10.1093/brain/awp293 · Cited by 224 · see citing works
Mitochondrial transcription and its regulation in mammalian cells
Asin-Cayuela, J., & Gustafsson, C. M. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.01.003 · Cited by 223 · see citing works
Ohm, T. G., Müller, H., Braak, H., & Böhl, J. (1995) · Neuroscience · doi:10.1016/0306-4522(95)90397-p · Cited by 222 · see citing works
A novel role for mitochondria in regulating epigenetic modifications in the nucleus
Smiraglia, D. J., Kulawiec, M., Bistulfi, G. L., Ghoshal, S., & Singh, K. K. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.8.6215 · Cited by 215 · see citing works
Mitochondrial DNA in mortal and immortal human cells. Genome number, integrity, and methylation.
Reis, R. J. S., & Goldstein, S. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44633-3 · Cited by 203 · see citing works
Effect of aging on 5-hydroxymethylcytosine in brain mitochondria
Dzitoyeva, S., Chen, H., & Manev, H. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.02.006 · Cited by 202 · see citing works
Mammalian transcription factor A is a core component of the mitochondrial transcription machinery
Shi, Y.-H., Dierckx, A., Wanrooij, P. H., Wanrooij, S., Larsson, N., Wilhelmsson, L., Falkenberg, M., & Gustafsson, C. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1119738109 · Cited by 189 · see citing works
Hong, E. E., Okitsu, C. Y., Smith, A. D., & Hsieh, C.-L. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00220-13 · Cited by 175 · see citing works
Ferrer, I. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.03.005 · Cited by 174 · see citing works
Self-citationFerrer, I. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9243-5 · Cited by 172 · see citing works
Self-citationEpigenetics, epidemiology and mitochondrial DNA diseases
Chinnery, P. F., Elliott, H. R., Hudson, G., Samuels, D. C., & Relton, C. L. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyr232 · Cited by 168 · see citing works
Methylation pattern of mouse mitochondrial DNA
Pollack, Y., Kasir, J., Shemer, R., Metzger, S., & Moshe Szyf, A. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.12.4811 · Cited by 161 · see citing works
Terni, B., Boada, J., Portero‐Otin, M., Pamplona, R., & Ferrer, I. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00266.x · Cited by 159 · see citing works
Self-citationCoskun, P. E., Wyrembak, J., Derbereva, O., Melkonian, G., Doran, E. W., Lott, I. T., Head, E., Cotman, C. W., & Wallace, D. C. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100351 · Cited by 158 · see citing works
She, H., Yang, Q., Shepherd, K. R., Smith, Y., Miller, G. W., Testa, C. M., & Mao, Z. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43871 · Cited by 156 · see citing works
Nass, M. M. K. (1973) · Journal of Molecular Biology · doi:10.1016/0022-2836(73)90239-8 · Cited by 141 · see citing works
Infantino, V., Castegna, A., Iacobazzi, F., Spera, I., Scala, I., Andria, G., & Iacobazzi, V. (2010) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2010.11.166 · Cited by 132 · see citing works
BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing
Lutsik, P., Feuerbach, L., Arand, J., Lengauer, T., Walter, J., & Bock, C. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr312 · Cited by 131 · see citing works
Somatic mitochondrial DNA mutations in early parkinson and incidental lewy body disease
Lin, M. T. S., Cantuti‐Castelvetri, I., Zheng, K., Jackson, K. E., Tan, Y. B., Arzberger, T., Lees, A. J., Betensky, R. A., Beal, M. F., & Simon, D. K. (2012) · Annals of Neurology · doi:10.1002/ana.23568 · Cited by 125 · see citing works
Aso, E., Lomoio, S., López‐González, I., Joda, L., Carmona, M., Fernández‐Yagüe, N., Moreno, J., Juvés, S., Pujol, A., Pamplona, R., et al. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00560.x · Cited by 118 · see citing works
Self-citationAksenov, M. Y., Tucker, H. M., Nair, P., Aksenova, M. V., Butterfield, D. A., Estus, S., & Markesbery, W. R. (1999) · Neurochemical Research · doi:10.1023/a:1020783614031 · Cited by 102 · see citing works
Temporal Sequence of Alzheimer’s Disease-Related Pathology
Braak, H., & Braak, E. (1999) · Cerebral cortex · doi:10.1007/978-1-4615-4885-0_14 · Cited by 94 · see citing works
Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders
Dickson, D. W. (2011) · Wiley eBooks · doi:10.1002/9781444341256 · Cited by 92 · see citing works
5-Methylcytidylic Acid: Absence from Mitochondrial DNA of Frogs and HeLa Cells
Dawid, I. B. (1974) · Science · doi:10.1126/science.184.4132.80 · Cited by 87 · see citing works
Ghosh, S., Sengupta, S., & Scaria, V. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.07.007 · Cited by 84 · see citing works
Mitochondrial Dysfunction in Neurodegenerative Diseases
Schapira, A. H. V. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9855-x · Cited by 84 · see citing works
Groot, G. S. P., & Kroon, A. M. (1979) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(79)90233-8 · Cited by 72 · see citing works
Mitochondria in health, aging and diseases: the epigenetic perspective
D'Aquila, P., Bellizzi, D., & Passarino, G. (2015) · Biogerontology (Dordrecht) · doi:10.1007/s10522-015-9562-3 · Cited by 62 · see citing works
Methylation of Mitochondrial DNA Is Not a Useful Marker for Cancer Detection
Maekawa, M., Taniguchi, T., Higashi, H., Sugimura, H., Sugano, K., & Kanno, T. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2004.035139 · Cited by 59 · see citing works
Hamblet, N. S., Ragland, B. D., Ali, M. A., Conyers, B., & Castora, F. J. (2005) · Electrophoresis · doi:10.1002/elps.200500420 · Cited by 53 · see citing works
Günther, C., Hadeln, K. V., Müller-Thomsen, T., Alberici, A., Binetti, G., Hock, C., Nitsch, R. M., Stoppe, G., Reiss, J., Gal, A., et al. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.07.070 · Cited by 53 · see citing works
Fukuyama, R., Hatanpaa, K. J., Rapoport, S. I., & Chandrasekaran, K. (1996) · Brain Research · doi:10.1016/0006-8993(95)01517-5 · Cited by 53 · see citing works
Mitochondrial transcription factor A variants and the risk of Parkinson's disease
Gawęda-Walerych, K., Safranow, K., Maruszak, A., Białecka, M. A., Kłodowska-Duda, G. A., Czyźewski, K., Sławek, J. W., Rudzińska, M., Styczyńska, M., Opala, G., et al. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.037 · Cited by 50 · see citing works
Belin, A. C., Björk, B. F., Westerlund, M., Galter, D., Sydow, O., Lind, C., Pernold, K., Rosvall, L., Håkansson, A., Winblad, B., et al. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.05.010 · Cited by 48 · see citing works
Lewy body pathology is associated with mitochondrial DNA damage in Parkinson's disease
Müller, S. K., Bender, A., Laub, C., Högen, T., Schlaudraff, F., Liss, B., Klopstock, T., & Elstner, M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.016 · Cited by 47 · see citing works
The interface of transcription and DNA replication in the mitochondria
Kasiviswanathan, R., Collins, T., & Copeland, W. C. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.12.005 · Cited by 46 · see citing works
The Mitochondrial Epigenome: a Role in Alzheimer’s Disease?
Devall, M. A. M., Mill, J. S., & Lunnon, K. (2014) · Epigenomics · doi:10.2217/epi.14.50 · Cited by 44 · see citing works
Mitochondrial DNA: a blind spot in neuroepigenetics
Manev, H., Dzitoyeva, S., & Chen, H. (2012) · BioMolecular Concepts · doi:10.1515/bmc-2011-0058 · Cited by 43 · see citing works
Mitochondrial transcription factor A (TFAM) gene variation in Parkinson's disease
Álvarez, V., Corao, A. I., Sánchez-Ferrero, E., de Mena, L., Alonso‐Montes, C., Huerta, C., Estrada, M. B., Ribacoba, R., Guisasola, L. M., Salvador, C., et al. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.010 · Cited by 32 · see citing works
Role of mt DNA ‐related mitoepigenetic phenomena in cancer
Ferreira, A., Serafim, T. L., Sardão, V. A., & Cunha‐Oliveira, T. (2014) · European Journal of Clinical Investigation · doi:10.1111/eci.12359 · Cited by 25 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Jellinger K, Mizuno Y: Parkinson's disease. Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders. Edited by Dickson DW. Basel, ISN Neuropath Press, 2003, pp 159e187
Cited by
Sorted by citations
Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: Recent advances.
Wang, W., Zhao, F., Ma, X., Perry, G., & Zhu, X. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00376-6 · Cited by 1,274 · see citing works
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works
Picca, A., Calvani, R., Coelho‐Júnior, H. J., Landi, F., Bernabei, R., & Marzetti, E. (2020) · Antioxidants · doi:10.3390/antiox9080647 · Cited by 456 · see citing works
CpG and non-CpG methylation in epigenetic gene regulation and brain function
Jang, H., Shin, W., Lee, J., & Do, J. (2017) · Genes · doi:10.3390/genes8060148 · Cited by 427 · see citing works
Monoaminergic neuropathology in Alzheimer’s disease
Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Milošević, N. J., Bažadona, D., Buée, L., de Silva, R., Giovanni, G. D., et al. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.001 · Cited by 289 · see citing works
Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer’s disease
Li, Y., Xia, X., Wang, Y., & Zheng, J. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02613-9 · Cited by 219 · see citing works
Piper, J. D., & Piper, P. W. (2017) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12284 · Cited by 202 · see citing works
Chen, K., Lu, P., Beeraka, N. M., Sukocheva, O. A., Madhunapantula, S. V., Liu, J., Sinelnikov, M. Y., Nikolenko, V. N., Bulygin, K. V., Михалева, Л. М., et al. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.09.012 · Cited by 196 · see citing works
Mitochondrial DNA Methylation and Human Diseases
Stoccoro, A., & Coppedè, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094594 · Cited by 186 · see citing works
Epigenetics of Alzheimer’s Disease
Perković, M. N., Paska, A. V., Konjevod, M., Kouter, K., Štrac, D. Š., Erjavec, G. N., & Pivac, N. (2021) · Biomolecules · doi:10.3390/biom11020195 · Cited by 181 · see citing works
Mitochondrial DNA: Epigenetics and Environment
Sharma, N., Pasala, M., & Prakash, A. (2019) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22319 · Cited by 151 · see citing works
Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas
Área-Gómez, E., Guardia‐Laguarta, C., Schon, E. A., & Przedborski, S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci120848 · Cited by 169 · see citing works
Epigenetics in Alzheimer’s Disease: Perspective of DNA Methylation
Qazi, T. J., Quan, Z., Mir, A., & Qing, H. (2018) · Molecular Neurobiology · doi:10.1007/s12035-016-0357-6 · Cited by 153 · see citing works
Bhatti, G. K., Reddy, A. P., Reddy, P. H., & Bhatti, J. S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00369 · Cited by 145 · see citing works
Research Progress in the Pathogenesis of Alzheimer's Disease
Chen, Y. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.235112 · Cited by 139 · see citing works
Kleszczyński, K., Zillikens, D., & Fischer, T. W. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12338 · Cited by 138 · see citing works
Miller, S., & Muqit, M. M. K. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.04.029 · Cited by 129 · see citing works
Targeting mitophagy in Parkinson's disease
Clark, E. H., de la Torre, A. V., Hoshikawa, T., & Briston, T. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.014294 · Cited by 128 · see citing works
Epigenetic regulation in Parkinson’s disease
Labbé, C., Lorenzo‐Betancor, O., & Ross, O. A. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1590-9 · Cited by 115 · see citing works
One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration
Lionaki, E., Ploumi, C., & Tavernarakis, N. (2022) · Cells · doi:10.3390/cells11020214 · Cited by 110 · see citing works
Decreased Methylation of the Mitochondrial D-Loop Region in Late-Onset Alzheimer’s Disease
Stoccoro, A., Siciliano, G., Migliore, L., & Coppedè, F. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170139 · Cited by 110 · see citing works
Peng, Y., Gao, P., Shi, L., Chen, L., Liu, J., & Long, J. (2020) · Antioxidants & Redox Signaling · doi:10.1089/ars.2019.7763 · Cited by 110 · see citing works
<scp>DNA</scp> methylation in Parkinson's disease
Wüllner, U., Kaut, O., deBoni, L., Piston, D., & Schmitt, I. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13646 · Cited by 107 · see citing works
Quan, S., Fu, X., Cai, H., Ren, Z., Xu, Y., & Jia, L. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00815-2 · Cited by 107 · see citing works
Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease
Picca, A., Guerra, F., Calvani, R., Coelho‐Júnior, H. J., Bossola, M., Landi, F., Bernabei, R., Bucci, C., & Marzetti, E. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051440 · Cited by 98 · see citing works
van der Wijst, M. G. P., van Tilburg, A. Y., Ruiters, M. H. J., & Rots, M. G. (2017) · Scientific Reports · doi:10.1038/s41598-017-00263-z · Cited by 92 · see citing works
Role of Epigenetics in Alzheimer’s Disease Pathogenesis
Stoccoro, A., & Coppedè, F. (2018) · Neurodegenerative Disease Management · doi:10.2217/nmt-2018-0004 · Cited by 90 · see citing works
Epigenetic Changes in Alzheimer’s Disease: DNA Methylation and Histone Modification
Plano, L. M. D., Saitta, A., Oddo, S., & Caccamo, A. (2024) · Cells · doi:10.3390/cells13080719 · Cited by 91 · see citing works
Stoccoro, A., Mosca, L., Carnicelli, V., Cavallari, U., Lunetta, C., Marocchi, A., Migliore, L., & Coppedè, F. (2018) · Epigenomics · doi:10.2217/epi-2018-0072 · Cited by 80 · see citing works
Kaur, G., Rathod, S. S. S., Ghoneim, M. M., Alshehri, S., Ahmad, J., Mishra, A., & Alhakamy, N. A. (2022) · Biology · doi:10.3390/biology11010090 · Cited by 79 · see citing works
Opening up the DNA methylome of dementia
Delgado‐Morales, R., & Esteller, M. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.242 · Cited by 74 · see citing works
Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice
Zhang, H., Su, Y., Sun, Z., Chen, M., Han, Y., Li, Y., Dong, X., Ding, S., Fang, Z., Li, W., et al. (2021) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.03.003 · Cited by 76 · see citing works
Mitoepigenetics and Neurodegenerative Diseases
Coppedè, F., & Stoccoro, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00086 · Cited by 73 · see citing works
Sanyal, T., Bhattacharjee, P., Bhattacharjee, S., & Bhattacharjee, P. (2018) · Toxicology · doi:10.1016/j.tox.2018.06.012 · Cited by 67 · see citing works
Epigenetic modification in Parkinson’s disease
Song, H., Chen, J., Huang, J., Sun, P., Liu, Y., Xu, L., Wei, C., Mu, X., Lu, X., Wang, W., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1123621 · Cited by 68 · see citing works
Monti, N., Cavallaro, R. A., Stoccoro, A., Nicolia, V., Scarpa, S., Kovács, G. G., Fiorenza, M. T., Lucarelli, M., Aronica, E., Ferrer, I., et al. (2020) · Epigenetics · doi:10.1080/15592294.2020.1722917 · Cited by 66 · see citing works
Self-citationThe potential role of mitochondria in the microbiota-gut-brain axis: Implications for brain health
Qiao, L., Yang, G., Wang, P., & Xu, C. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107434 · Cited by 70 · see citing works
Novielli, C., Mandò, C., Tabano, S. M., Anelli, G. M., Fontana, L., Antonazzo, P. G. M., Miozzo, M. R., & Cetin, I. (2017) · Placenta · doi:10.1016/j.placenta.2017.05.008 · Cited by 63 · see citing works
Xu, Y., Xu, L., Han, M., Liu, X., Li, F., Zhou, X., Wang, Y., & Bi, J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.09.094 · Cited by 63 · see citing works
Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease
Atlante, A., Amadoro, G., Bobba, A., & Latina, V. (2020) · Cells · doi:10.3390/cells9112347 · Cited by 64 · see citing works
Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility
Liu, Y.-F., Zhu, J., Tian, X. Y., Liu, H., Zhang, T., Zhang, Y., Xie, S.-A., Zheng, M., Kong, W., Yao, W., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2240-7 · Cited by 62 · see citing works
Dysregulation of energy metabolism in Alzheimer's disease
Yuan, Y., Zhao, G., & Zhao, Y. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12800-8 · Cited by 60 · see citing works
Mitochondrial genetics and therapeutic overview of Leber's hereditary optic neuropathy
Ramasamy, S., Manickam, A., & Michael, M. (2017) · Indian Journal of Ophthalmology · doi:10.4103/ijo.ijo_358_17 · Cited by 59 · see citing works
Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis
Stoccoro, A., Smith, A. R., Mosca, L., Marocchi, A., Gerardi, F., Lunetta, C., Cereda, C., Gagliardi, S., Lunnon, K., Migliore, L., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00933-2 · Cited by 57 · see citing works
Mitochondrial dysfunction in Alzheimer’s disease: a key frontier for future targeted therapies
Wang, S., Liao, Z., Zhang, Q., Han, X., Liu, C., & Wang, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1484373 · Cited by 57 · see citing works
Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing
Billard, P., & Poncet, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194959 · Cited by 57 · see citing works
The Role of Epigenetics in Neuroinflammatory-Driven Diseases
Giallongo, S., Longhitano, L., Denaro, S., D’Aprile, S., Torrisi, F., Spina, E. L., Giallongo, C., Mannino, G., Furno, D. L., Zappalà, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315218 · Cited by 60 · see citing works
Dysfunctional Mitochondrial Bioenergetics and Synaptic Degeneration in Alzheimer Disease
Tang, J. J., Oliveros, A., & Jang, M. (2019) · International Neurourology Journal · doi:10.5213/inj.1938036.018 · Cited by 56 · see citing works
Yue, Y., Ren, L., Zhang, C., Miao, K., Tan, K., Yang, Q., Hu, Y., Xi, G., Luo, G., Yang, M., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201168119 · Cited by 54 · see citing works
Epigenetic Biomarkers for Parkinson’s Disease: From Diagnostics to Therapeutics
Jakubowski, J. L., & Labrie, V. (2016) · Journal of Parkinson s Disease · doi:10.3233/jpd-160914 · Cited by 53 · see citing works
Hajjo, R., Sabbah, D. A., Abusara, O. H., & Bawab, A. Q. A. (2022) · Diagnostics · doi:10.3390/diagnostics12122975 · Cited by 55 · see citing works
Epigenetics: Recent Advances and Its Role in the Treatment of Alzheimer's Disease
Xiao, X., Liu, X., & Jiao, B. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.538301 · Cited by 49 · see citing works
Investigation of mitochondrial DNA copy number in patients with major depressive disorder
Chung, J. K., Lee, S. Y., Park, M., Joo, E.-J., & Kim, S. A. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.112616 · Cited by 48 · see citing works
Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective
Xu, S., Zhang, X., Liu, C., Liu, Q., Chai, H., Luo, Y., & Li, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.688789 · Cited by 49 · see citing works
Dostal, V., & Churchill, M. E. A. (2019) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.01.006 · Cited by 47 · see citing works
One-carbon epigenetics and redox biology of neurodegeneration
Coppedè, F. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.002 · Cited by 47 · see citing works
Bicci, I., Calabrese, C., Golder, Z. J., Gómez-Durán, A., & Chinnery, P. F. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab1179 · Cited by 46 · see citing works
Li, Y., Xie, L., Huang, T., Zhang, Y., Zhou, J., Qi, B., Wang, X., Chen, Z., & Li, P. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00778 · Cited by 46 · see citing works
Amyloid precursor protein‐mediated mitochondrial regulation and Alzheimer's disease
Lopez Sanchez, M. I. G., van Wijngaarden, P., & Trounce, I. A. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14554 · Cited by 45 · see citing works
Bilyard, M. K., Becker, S. M., & Balasubramanian, S. (2020) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2020.01.014 · Cited by 45 · see citing works
Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue
Devall, M. A. M., Smith, R. G., Jeffries, A. R., Hannon, E. J., Davies, M. N., Schalkwyk, L. C., Mill, J. S., Weedon, M. N., & Lunnon, K. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0337-3 · Cited by 44 · see citing works
Abnormal Homocysteine Metabolism: An Insight of Alzheimer’s Disease from DNA Methylation
Pi, T., Liu, B., & Jing-shan, S. (2020) · Behavioural Neurology · doi:10.1155/2020/8438602 · Cited by 42 · see citing works
Xu, Y., Cheng, L. J., Sun, J., Li, F., Liu, X., Wei, Y., Han, M., Zhu, Z., Bi, J., Lai, C., et al. (2021) · Neurochemical Research · doi:10.1007/s11064-020-03192-y · Cited by 42 · see citing works
Schaffner, S. L., & Kobor, M. S. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.971298 · Cited by 41 · see citing works
Mitochondrial DNA Methylation and Related Disease
Gao, D., Zhu, B., Sun, H., & Wang, X. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6674-0_9 · Cited by 39 · see citing works
Go, R. C. P., Corley, M. J., Ross, G. W., Petrovitch, H., Masaki, K., Maunakea, A. K., He, Q., & Tiirikainen, M. (2020) · BMC Neuroscience · doi:10.1186/s12868-020-00582-4 · Cited by 39 · see citing works
Stoccoro, A., Smith, A. R., Baldacci, F., Gamba, C. D., Gerfo, A. L., Ceravolo, R., Lunnon, K., Migliore, L., & Coppedè, F. (2021) · Genes · doi:10.3390/genes12050720 · Cited by 39 · see citing works
Neurodegenerative movement disorders: An epigenetics perspective and promise for the future
Murthy, M. N., Cheng, Y., Holton, J., & Bettencourt, C. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12757 · Cited by 25 · see citing works
mtDNA Maintenance and Alterations in the Pathogenesis of Neurodegenerative Diseases
Shang, D., Huang, M., Wang, B., Yan, X., Wu, Z., & Zhang, X. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220810114644 · Cited by 41 · see citing works
Li, X., Wu, Z., Si, X., Li, J., Wu, G., & Wang, M. (2025) · European journal of medical research · doi:10.1186/s40001-025-02699-w · Cited by 42 · see citing works
The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity
Bacalini, M. G., D’Aquila, P., Marasco, E., Nardini, C., Montesanto, A., Franceschi, C., Passarino, G., Garagnani, P., & Bellizzi, D. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.01.006 · Cited by 37 · see citing works
New Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders
Wilkins, H., & Morris, J. K. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612822666161230144517 · Cited by 34 · see citing works
Moawad, M. H. E. D., Serag, I., Alkhawaldeh, I. M., Abbas, A., Sharaf, A., Alsalah, S., Sadeq, M. A., Shalaby, M. M. M., Hefnawy, M. T., Abouzid, M., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04468-y · Cited by 34 · see citing works
Mitochondrial epigenetics regulating inflammation in cancer and aging
Chatterjee, D., Das, P., & Chakrabarti, O. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.929708 · Cited by 33 · see citing works
Role of mtDNA disturbances in the pathogenesis of Alzheimer’s and Parkinson’s disease
Antonyová, V., Kejík, Z., Brogyányi, T., Kaplánek, R., Pajková, M., Talianová, V., Hromádka, R., Masařík, M., Sýkora, D., Mikšátková, L., et al. (2020) · DNA Repair · doi:10.1016/j.dnarep.2020.102871 · Cited by 45 · see citing works
Jové, M., Mota‐Martorell, N., Torres, P., Ayala, V., Portero‐Otín, M., Ferrer, I., & Pamplona, R. (2021) · Life · doi:10.3390/life11050388 · Cited by 30 · see citing works
Self-citationCholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson’s Disease
Iarkov, A., Mendoza, C., & Echeverrı́a, V. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.665820 · Cited by 34 · see citing works
Mitochondrial DNA and Neurodegeneration: Any Role for Dietary Antioxidants?
Bordoni, L., & Gabbianelli, R. (2020) · Antioxidants · doi:10.3390/antiox9080764 · Cited by 32 · see citing works
HIV-1 Tat and cocaine impact mitochondrial epigenetics: effects on DNA methylation
Doke, M., Jeganathan, V., McLaughlin, J. P., & Samikkannu, T. (2020) · Epigenetics · doi:10.1080/15592294.2020.1834919 · Cited by 30 · see citing works
Characterization of Mitochondrial DNA Methylation of Alzheimer’s Disease in Plasma Cell-Free DNA
Ding, B.-R., Zhang, X., Wan, Z.-Q., Tian, F., Ling, J., Tan, J.-Q., & Peng, X.-Q. (2023) · Diagnostics · doi:10.3390/diagnostics13142351 · Cited by 31 · see citing works
Stoccoro, A., & Coppedè, F. (2024) · Biomolecules · doi:10.3390/biom14111366 · Cited by 32 · see citing works
Increase in Mitochondrial D-Loop Region Methylation Levels in Mild Cognitive Impairment Individuals
Stoccoro, A., Baldacci, F., Ceravolo, R., Giampietri, L., Tognoni, G., Siciliano, G., Migliore, L., & Coppedè, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105393 · Cited by 30 · see citing works
Alzheimer’s Disease-Related Epigenetic Changes: Novel Therapeutic Targets
Paniri, A., Hosseini, M. M., & Akhavan‐Niaki, H. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03626-y · Cited by 32 · see citing works
Yamazoe, M., Sasano, T., Ihara, K., Takahashi, K., Nakamura, W., Takahashi, N., Komuro, H., Hamada, S., & Furukawa, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-85204-7 · Cited by 29 · see citing works
Rajendran, R., Raghavan, R. P., Al-Sehemi, A. G., Uddin, M. S., Aleya, L., & Mathew, B. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-17931-3 · Cited by 29 · see citing works
Targeting mitochondria in the regulation of neurodegenerative diseases: A comprehensive review
Maurya, S. K., Gupta, S., Bakshi, A., Kaur, H., Jain, A., Senapati, S., & Baghel, M. S. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25110 · Cited by 29 · see citing works
Zhang, X., Farrell, J. J., Tong, T., Hu, J., Zhu, C., Alzheimer's Disease Sequencing Project, Wang, L., Mayeux, R. P., Haines, J. L., Pericak‐Vance, M. A., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12396 · Cited by 28 · see citing works
Marmolejo-Garza, A., Medeiros-Furquim, T., Rao, R. G., Eggen, B. J. L., Boddeke, E., & Dolga, A. M. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119326 · Cited by 28 · see citing works
The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice
Langie, S. A. S., Cameron, K., Ficz, G., Oxley, D., Tomaszewski, B., Gorniak, J., Maas, L. M., Godschalk, R., van Schooten, F., Reik, W., et al. (2017) · Genes · doi:10.3390/genes8020075 · Cited by 28 · see citing works
An Overview of Epigenetic Changes in the Parkinson’s Disease Brain
Klokkaris, A., & Migdalska‐Richards, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116168 · Cited by 31 · see citing works
Epigenetic regulation in Alzheimer’s disease: is it a potential therapeutic target?
Coppedè, F. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1916469 · Cited by 27 · see citing works
Balasubramanian, N., Jadhav, G., & Sakharkar, A. J. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.09.001 · Cited by 26 · see citing works
Lüth, T., Wasner, K., Klein, C., Schaake, S., Tse, R., Pereira, S. L., Laß, J., Sinkkonen, L., Grünewald, A., & Trinh, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.713084 · Cited by 25 · see citing works
Mitochondrial quality control: Epigenetic signatures and therapeutic strategies
Ambekar, T., Pawar, J., Rathod, R., Patel, M., Fernandes, V., Kumar, R., Singh, S. B., & Khatri, D. K. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105095 · Cited by 23 · see citing works
Genome-wide characterization of mitochondrial DNA methylation in human brain
Devall, M. A. M., Soanes, D. M., Smith, A. R., Dempster, E. L., Smith, R. G., Burrage, J., Iatrou, A., Hannon, E. J., Troakes, C., Moore, K., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1059120 · Cited by 24 · see citing works
Firdaus, Z., & Li, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111658 · Cited by 23 · see citing works
Ceylan, D., Karaçiçek, B., Tufekci, K., Aksahin, I. C., Şenol, Ş. H., & Genç, Ş. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1304660 · Cited by 24 · see citing works
Singh, S., & Singh, R. K. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10297-6 · Cited by 22 · see citing works
Comparative Analysis of CpG Sites and Islands Distributed in Mitochondrial DNA of Model Organisms
Kowal, K., Tkaczyk‐Wlizło, A., Ząbek, T., Pierzchała, M., & Ślaska, B. (2020) · Animals · doi:10.3390/ani10040665 · Cited by 22 · see citing works
Mitochondrially-Targeted Therapeutic Strategies for Alzheimer’s Disease
Onyango, I. G., Bennett, J. P., & Stokin, G. B. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666211208125855 · Cited by 21 · see citing works
- Authors
- Blanch, M., Mosquera, J. L., Ansoleaga, B., Ferrer, I., & Barrachina, M.
- Affiliations
- Bellvitge University Hospital (ES)
- Corresponding author
- Barrachina, Marta
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 186
- Issue
- 2
- Pages
- 385-397
- ISSN
- 0002-9440 (ISSN-L)
- OpenAlex
- W2225347805
- Cited by
- 192
- References
- 67
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 28 · 2023: 13 · 2022: 24 · 2021: 28 · 2020: 33 · 2019: 16 · 2018: 10 · 2017: 18 · 2016: 7
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal Of Pathology (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- European Commission (278486)
- Instituto de Salud Carlos III (PI14/, PI14/00268)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondrial DNA methylation, 5-methylcytosine, Alzheimer's disease, Parkinson's disease, mitochondrial dysfunction, entorhinal cortex, substantia nigra, D-loop, Braak stages, neurodegeneration, epigenetic regulation
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, DNA, Mitochondrial, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Mitochondria, Parkinson Disease, Amyloid beta-Protein Precursor, DNA Methylation, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review