Proteasome activation delays aging in vitro and in vivo

The Hallmarks of Aging

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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Molecular chaperones in protein folding and proteostasis

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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The genetics of ageing

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Adapting Proteostasis for Disease Intervention

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

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Structure of 20S proteasome from yeast at 2.4Å resolution

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

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daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

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Proteasome inhibitors: a novel class of potent and effective antitumor agents.

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

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The plasticity of aging: insights from long-lived mutants

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Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

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Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

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Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

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Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

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Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses

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Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26 S Proteasome

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Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

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A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3

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Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress

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Genetic Analysis of Tissue Aging in <i>Caenorhabditis elegans</i> : A Role for Heat-Shock Factor and Bacterial Proliferation

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Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

Surh, Y., Kundu, J. K., & Na, H. (2008) · Planta Medica · doi:10.1055/s-0028-1088302 · Cited by 758 · see citing works

BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase

Furukawa, M., & Xiong, Y. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.162-171.2005 · Cited by 746 · see citing works

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.

Ding, W.-X., Ni, H.-M., Gao, W., Yoshimori, T., Stolz, D. B., Ron, D., & Yin, X.-M. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070188 · Cited by 708 · see citing works

Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

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The E3 Ligase MuRF1 Degrades Myosin Heavy Chain Protein in Dexamethasone-Treated Skeletal Muscle

Clarke, B. A., Drujan, D., Willis, M. S., Murphy, L. O., Corpina, R. A., Burova, E., Rakhilin, S. V., Stitt, T. N., Patterson, C., Latres, E., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.009 · Cited by 683 · see citing works

DAF-16 Target Genes That Control <i>C. elegans</i> Life-Span and Metabolism

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Proteasome subunit Rpn13 is a novel ubiquitin receptor

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Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway

Kwak, M.-K., Wakabayashi, N., Itoh, K., Motohashi, H., Yamamoto, M. P., & Kensler, T. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211898200 · Cited by 661 · see citing works

Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and ‘aggresomes’ during oxidative stress, aging, and disease

Grune, T., Jung, T., Merker, K., & Davies, K. J. A. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.04.020 · Cited by 653 · see citing works

Proteasomal function is impaired in substantia nigra in Parkinson’s disease

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Collapse of proteostasis represents an early molecular event in <i>Caenorhabditis elegans</i> aging

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Widespread protein aggregation as an inherent part of aging in C. elegans

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Regulation of CD8 + T Cell Development by Thymus-Specific Proteasomes

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During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

Cohen, S., Brault, J. J., Gygi, S. P., Glass, D. J., Valenzuela, D. M., Gartner, C. A., Latres, E., & Goldberg, A. L. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200901052 · Cited by 584 · see citing works

Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

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Mechanisms of cross‐talk between the ubiquitin‐proteasome and autophagy‐lysosome systems

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Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

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Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

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Docking of the Proteasomal ATPases' Carboxyl Termini in the 20S Proteasome's α Ring Opens the Gate for Substrate Entry

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A systematic RNAi screen for longevity genes in C. elegansPreprint

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Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway

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Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

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Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin

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Protein Homeostasis and Aging: the importance of exquisite quality control

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Proteasome subunit Rpn1 binds ubiquitin-like protein domains

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The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

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Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin–proteasome system and onto human diseases and drug targeting

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The Naked Mole-Rat: A New Long-Living Model for Human Aging Research

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Multiubiquitin Chain Receptors Define a Layer of Substrate Selectivity in the Ubiquitin-Proteasome System

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A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal

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RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit

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Genetic links between diet and lifespan: shared mechanisms from yeast to humans

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Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

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RPN-6 determines C. elegans longevity under proteotoxic stress conditions

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The Axial Channel of the Proteasome Core Particle Is Gated by the Rpt2 ATPase and Controls Both Substrate Entry and Product Release

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The proteasomal system

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Sir2 Blocks Extreme Life-Span Extension

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Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

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Mechanism of Gate Opening in the 20S Proteasome by the Proteasomal ATPases

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Development of the Proteasome Inhibitor PS-341

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Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors

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Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

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Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

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Condition‐adapted stress and longevity gene regulation by Caenorhabditis elegans SKN‐1/Nrf

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Oxidative Modification and Inactivation of the Proteasome during Coronary Occlusion/Reperfusion

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Hybrid Proteasomes

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Proteasomes in immune cells: more than peptide producers?

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Protein degradation and the generation of MHC class I-presented peptides

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Multiple Stressors in Caenorhabditis elegans Induce Stress Hormesis and Extended Longevity

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Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

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Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.

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Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

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PA200, a nuclear proteasome activator involved in DNA repair

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Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast

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Higher Respiratory Activity Decreases Mitochondrial Reactive Oxygen Release and Increases Life Span in Saccharomyces cerevisiae

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The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes

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Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7

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Ubiquitin Chains Are Remodeled at the Proteasome by Opposing Ubiquitin Ligase and Deubiquitinating Activities

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Subcellular localization of proteasomes and their regulatory complexes in mammalian cells

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Integration of Clearance Mechanisms: The Proteasome and AutophagyPreprint

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Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

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Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress

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Proteasome Activators

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The testis-specific proteasome subunit Prosα6T of D. melanogaster is required for individualization and nuclear maturation during spermatogenesis

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Age-Associated Decrease in Proteasome Content and Activities in Human Dermal Fibroblasts: Restoration of Normal Level of Proteasome Subunits Reduces Aging Markers in Fibroblasts From Elderly Persons

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A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative-stress adaptation in mammals, C. elegans and D. melanogaster

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The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes

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The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

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Regulation of proteasome assembly and activity in health and disease

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The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks

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Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

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Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders

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Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging

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A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity

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Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases

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18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures

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Impact of Reactive Species on Amino Acids—Biological Relevance in Proteins and Induced Pathologies

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Establishment of a suite of assays that support the discovery of proteasome stimulators

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The burden of trisomy 21 disrupts the proteostasis network in Down syndrome

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Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster

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Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway

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Protein modification and maintenance systems as biomarkers of ageing

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Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions

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Development and Application of a Sensitive Peptide Reporter to Discover 20S Proteasome Stimulators

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Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2

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Proteasome Activation to Combat Proteotoxicity

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GHK and DNA: Resetting the human genome to health

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The Proteasome System in Health and Disease

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From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers

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Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes

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Higher expression of somatic repair genes in long-lived ant queens than workers

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Essential role of proteasomes in maintaining self-renewal in neural progenitor cells

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Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration

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LRRK2 at the Crossroad of Aging and Parkinson’s Disease

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Pharmacological intervention in a transgenic mouse model improves Alzheimer's-associated pathological phenotype: Involvement of proteasome activation

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Modulation of the ubiquitin-proteasome system by marine natural products

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The role of cycloastragenol at the intersection of NRF2/ARE, telomerase, and proteasome activity

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A Genetic Screen for Saccharomyces cerevisiae Mutants That Fail to Enter Quiescence

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A porcine gluteus medius muscle genome-wide transcriptome analysis: dietary effects of omega-6 and omega-3 fatty acids on biological mechanisms

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Decreased lipid absorption due to reduced pancreatic lipase activity in aging male mice

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UPS Activation in the Battle Against Aging and Aggregation-Related Diseases: An Extended Review

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Response Mechanisms to Oxidative Stress in Yeast and Filamentous Fungi

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Approaches for extending human healthspan: from antioxidants to healthspan pharmacology

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FAIM Is a Non-redundant Defender of Cellular Viability in the Face of Heat and Oxidative Stress and Interferes With Accumulation of Stress-Induced Protein Aggregates

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Proteasome function is not impaired in healthy aging of the lung

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The Drosophila TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle

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Protein kinase C activator bryostatin‐1 modulates proteasome function

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Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome

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Pan-cancer analysis of genomic and transcriptomic data reveals the prognostic relevance of human proteasome genes in different cancer types

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Highly purified calf hemodialysate (Actovegin®) may improve endothelial function by activation of proteasomes: A hypothesis explaining the possible mechanisms of action

Stelmakh, A., Abrahamovych, O., & Cherkas, A. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.09.008 · Cited by 14 · see citing works

Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator

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Delivering miR-23b-3p by small extracellular vesicles to promote cell senescence and aberrant lipid metabolism

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Toxicant-mediated redox control of proteostasis in neurodegeneration

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Peptidomimetics Based on C-Terminus of Blm10 Stimulate Human 20S Proteasome Activity and Promote Degradation of Proteins

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Juniper berry extract containing Anthricin and Yatein suppresses lipofuscin accumulation in human epidermal keratinocytes through proteasome activation, increases brightness and decreases spots in human skin

Sakamoto, K., Fujimoto, R., Nakagawa, S., Kamiyama, E., Kanai, K., Kawai, Y., Kojima, H., Hirasawa, A., Wakamatsu, K., & Masutani, T. (2023) · International Journal of Cosmetic Science · doi:10.1111/ics.12876 · Cited by 11 · see citing works

Enhanced Cellular Uptake and Sustained Transdermal Delivery of Collagen for Skin Regeneration

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Evaluation of quantitative biomarkers of aging in human PBMCs

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Role of the Ubiquitin C-Terminal Hydrolase L1-Modulated Ubiquitin Proteasome System in Auditory Cortex Senescence

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Ubiquitin and SUMO Modifications in Caenorhabditis elegans Stress Response

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Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases

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Proteasome inhibitors induce apoptosis by superoxide anion generation via NADPH oxidase 5 in human neuroblastoma SH-SY5Y cells

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Caloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo

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Activation of the 26S Proteasome to Reduce Proteotoxic Stress and Improve the Efficacy of PROTACs

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Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery

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The Effects of Two Different Multivitamins on Aging Mice

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Evaluation of the Immune Response of Patulin by Proteomics

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Protein synthesis inhibition induces proteasome assembly and function

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EFFECTS AND MECHANISMS OF A NEW MULTIVITAMIN ON CHRONIC METABOLIC SYNDROMES AND AGING

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