Mulberry anthocyanin extracts inhibit LDL oxidation and macrophage-derived foam cell formation induced by oxidative LDL
Abstract
Low-density lipoprotein (LDL) oxidation plays a role in atherosclerosis; therefore the lower the formation of oxidative LDL (oxLDL), the lower the occurrence of coronary heart diseases (CHD). Mulberry, the fruit of Morus alba L., is used effectively in Chinese medicines for prevention of CHD. However, the mechanism of this action is unclear. Two extracts, MWEs (mulberry water extracts) and MACs (mulberry anthocyanin-rich extracts), which exhibit antioxidative and anti-atherosclerogensis abilities in vitro. Data showed that MWEs and MACs were able to inhibit (P<0.05) the relative electrophoretic mobility (REM), ApoB fragmentation, and thiobarbituric acid reaction substances (TBARS) formation in Cu2+ -mediated oxidation LDL. MWEs and MACs also had the ability of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging for reducing the formation of free radicals mediated by copper ions. Furthermore, we observed that MWEs and MACs could decrease (P<0.05) macrophage death induced by oxLDL. In addition, the MWEs and MACs also could inhibit (P<0.05) the formation of foam cells. Both MWEs and MACs showed a great ability of scavenging radicals, inhibition of LDL oxidation, and decrease in atherogenic stimuli in macrophages, while the efficacy of MACs is 10-fold greater than that of MWEs. It also demonstrated that anthocyanin components in mulberry extracts were regarded as the prevention of atherosclerosis.
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Several lines of evidence indicate a role for berry anthocyanins in significantly decreasing oxidative damage and inflammation in cellular and animal models of CVD.
“Several lines of evidence indicate a role for berry anthocyanins in significantly decreasing oxidative damage and inflammation in cellular and animal models of CVD.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [62]
Mulberry anthocyanins inhibit oxidation of LDL and formation of foam cells in an in vitro model of atherosclerosis.
“Mulberry anthocyanins have also exhibited antioxidative and antiatherogenic affects, by inhibiting oxidation of LDL and formation of foamcells, respectively, in an in vitro model of atherosclerosis.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [62]
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- Authors
- Liu, L. ‐., Lee, H. ‐., Shih, Y. ‐., Chyau, C. ‐., & Wang, C. ‐.
- Affiliations
- Chung Shan Medical University (TW)
- Corresponding author
- Liu, L.‐K.
- Lee, H.‐J.
- Shih, Y.‐W.
- Chyau, C.‐C.
- Wang, C.‐J.
- Venue
- Journal of Food Science
- Publisher
- Wiley
- Published
- 2008-08
- Volume
- 73
- Issue
- 6
- Pages
- H113-21
- ISSN
- 0022-1147 (ISSN-L)
- 1750-3841
- OpenAlex
- W1980012630
- Cited by
- 115
- References
- 65
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 11 · 2018: 5 · 2017: 5 · 2016: 10 · 2015: 8 · 2014: 6 · 2013: 11 · 2012: 8
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Food Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- mulberry, Morus alba, anthocyanins, LDL oxidation, oxidized LDL, foam cell formation, macrophages, atherosclerosis, coronary artery disease, copper-induced oxidation, antioxidant activity, free radical scavenging, lipoprotein electrophoretic mobility
- MeSH terms
- Anthocyanins, Biphenyl Compounds, Copper, Foam Cells, Fruit, Humans, Lipoproteins, LDL, Macrophages, Oxidation-Reduction, Picrates, Plant Extracts, Free Radical Scavengers, Thiobarbituric Acid Reactive Substances, Morus, Atherosclerosis
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