The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Evaluation of Combined Antibacterial Effects of Eugenol, Cinnamaldehyde, Thymol, and Carvacrol against E. coli with an Improved Method
Abstract
ABSTRACT: In this study, the antibacterial activities of eugenol, cinnamaldehyde, thymol, carvacrol, and their combinations against E. coli were investigated separately. First, broth macro‐dilution assay was adopted to determine the minimal inhibitory concentration (MIC) of the 4 components. Second, the combination testing was performed using chequerboard method. Finally, the combined effects were evaluated with an improved method, which was based on the indices of fractional inhibitory concentration (FIC) and Effect of the Combination (EC) jointly. The results indicated that MICs of the 4 components were 1600, 400, 400, and 400 mg/L, respectively; treatments with cinnamaldehyde/eugenol, thymol/eugenol, carvacrol/eugenol, and thymol/carvacrol revealed synergistic effects according to the 2 indices. By means of combination, MICs of eugenol, cinnamaldehyde, thymol, and carvacrol decreased to 400, 100, 100, and 100 mg/L, respectively. Consequently, the negative impacts of unpleasant smell of these 4 components could be minimized, making it possible to add them to foods as preservatives. In addition, this improved evaluation method provided a more accurate and comprehensive way to evaluate combined effects.
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Cites
Essential oils: Their antibacterial properties and potential applications in foods—A review
Burt, S. (2004) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2004.03.022 · Cited by 10,488
Lambert, R. J. W., Skandamis, P. N., Coote, P. J., & Nychas, G.-J. E. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2001.01428.x · Cited by 2,449
Characterization of the action of selected essential oil components on Gram-negative bacteria
Helander, I. M., Alakomi, H.-L., Latva-Kala, K., Mattila-Sandholm, T., Pol, I., Smid, E. J., Gorris, L. G. M., & von Wright, A. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980154m · Cited by 1,664
Olasupo, N. A., Fitzgerald, D. J., Gasson, M. J., & Narbad, A. (2003) · Letters in Applied Microbiology · doi:10.1046/j.1472-765x.2003.01427.x · Cited by 218
Bacteriocidal effects and inhibition of cell separation of cinnamic aldehyde on Bacillus cereus
Kwon, J. A., Yu, C. B., & Park, H. D. (2003) · Letters in Applied Microbiology · doi:10.1046/j.1472-765x.2003.01350.x · Cited by 118
Cited by
Hyldgaard, M., Mygind, T., & Meyer, R. L. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00012 · Cited by 2,191
El-Saber Batiha, G., Alkazmi, L. M., Wasef, L. G., Beshbishy, A. M., Nadwa, E. H., & Rashwan, E. K. (2020) · Biomolecules · doi:10.3390/biom10020202 · Cited by 643
Zengin, H., & Baysal, A. (2014) · Molecules · doi:10.3390/molecules191117773 · Cited by 519
Use of natural antimicrobials to increase antibiotic susceptibility of drug resistant bacteria
Palaniappan, K., & Holley, R. A. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.04.001 · Cited by 353
Baptista, R. C., Horita, C. N., & Sant'Ana, A. S. (2020) · Food Research International · doi:10.1016/j.foodres.2019.108762 · Cited by 268
Metadata
- Authors
- Pei, R., Zhou, F., Ji, B., & Xu, J.
- Venue
- Journal of Food Science
- Publisher
- Wiley
- Published
- 2009-09
- Volume
- 74
- Issue
- 7
- Pages
- M379-83
- ISSN
- 0022-1147 (ISSN-L)
- 1750-3841
- OpenAlex
- W2030315035
- Cited by
- 413
- References
- 5
- FWCI
- 18.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pei, R., Zhou, F., Ji, B., & Xu, J. (2009). Evaluation of Combined Antibacterial Effects of Eugenol, Cinnamaldehyde, Thymol, and Carvacrol against E. coli with an Improved Method. Journal of Food Science. https://doi.org/10.1111/j.1750-3841.2009.01287.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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