Antibacterial and antioxidant activity of essential oil terpenes against pathogenic and spoilage-forming bacteria and cell structure-activity relationships evaluated by SEM microscopy
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The antibacterial activity and antioxidant effect of the compounds α-terpineol, linalool, eucalyptol and α-pinene obtained from essential oils (EOs), against pathogenic and spoilage forming bacteria were determined. The antibacterial activities of these compounds were observed in vitro on four Gram-negative and three Gram-positive strains. S. putrefaciens was the most resistant bacteria to all tested components, with MIC values of 2% or higher, whereas E. coli O157:H7 was the most sensitive strain among the tested bacteria. Eucalyptol extended the lag phase of S. Typhimurium, E. coli O157:H7 and S. aureus at the concentrations of 0.7%, 0.6% and 1%, respectively. In vitro cell growth experiments showed the tested compounds had toxic effects on all bacterial species with different level of potency. Synergistic and additive effects were observed at least one dose pair of combination against S. Typhimurium, E. coli O157:H7 and S. aureus, however antagonistic effects were not found in these combinations. The results of this first study are encouraging for further investigations on mechanisms of antimicrobial activity of these EO components.
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The potential effect of essential oils on rumen fermentation and methanogenesis is mainly mediated by their antimicrobial activities owing to their interaction with cell membranes of microbes by disrupting membrane stability of the lipid bilayer.
“The potential effect of EO on rumen fermentation and methanogenesis is mainly mediated by their antimicrobial activities owing to their interaction with cell membranes of microbes (by disrupting membrane stability of lipid bilayer).”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [232]
Section 2.2 describes monoterpenes entering bacterial membranes and increasing membrane fluidity and permeability; section 2.5 reports membrane damage after terpene treatment. These passages support the proposed antimicrobial mechanism, but the paper studies pathogenic and spoilage bacteria, not rumen fermentation or methanogenesis. It does not establish that this mechanism mainly mediates effects on those rumen processes. (LLM, conf=0.87)
Experimental — accuracy not yet measuredEssential oils are most effective against gram-positive bacteria and possess almost no activity against gram-negative bacteria because of their hydrophilic bilayer, except thymol and carvacrol.
“They are most effective against gram +ve bacteria and possess almost no activity against gram –ve (because of their hydrophilic bilayer) except thymol and carvacrol (232).”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [232]
Section 2.5 says Gram-positive bacteria are generally more sensitive to terpenes and explains how the hydrophilic surface of some Gram-negative bacteria can impede entry. But Section 2.2 reports that Gram-negative E. coli and Salmonella were inhibited by α-terpineol, linalool, and eucalyptol. The claim that Gram-negative bacteria have almost no susceptibility except to thymol and carvacrol overstates the source. (LLM, conf=0.90)
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Cites
Essential oils: Their antibacterial properties and potential applications in foods—A review
Burt, S. (2004) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2004.03.022 · Cited by 10,488 · see citing works
Thaipong, K., Boonprakob, U., Crosby, K. M., Cisneros‐Zevallos, L., & Byrne, D. (2006) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2006.01.003 · Cited by 3,649 · see citing works
Mechanisms of membrane toxicity of hydrocarbons
Sikkema, J., de Bont, J. A., & Poolman, B. (1995) · Microbiological Reviews · doi:10.1128/mr.59.2.201-222.1995 · Cited by 2,685 · see citing works
Lambert, R. J. W., Skandamis, P. N., Coote, P. J., & Nychas, G.-J. E. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2001.01428.x · Cited by 2,449 · see citing works
Hyldgaard, M., Mygind, T., & Meyer, R. L. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00012 · Cited by 2,191 · see citing works
Characterization of the action of selected essential oil components on Gram-negative bacteria
Helander, I. M., Alakomi, H.-L., Latva-Kala, K., Mattila-Sandholm, T., Pol, I., Smid, E. J., Gorris, L. G. M., & von Wright, A. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980154m · Cited by 1,664 · see citing works
Ultee, A., Bennik, M. H. J., & Moezelaar, R. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.4.1561-1568.2002 · Cited by 1,602 · see citing works
Antioxidant Capacity of 26 Spice Extracts and Characterization of Their Phenolic Constituents
Shan, B., Cai, Y., Sun, M., & Corke, H. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051513y · Cited by 1,520 · see citing works
Essential Oils in Combination and Their Antimicrobial Properties
Bassolé, I. H. N., & Juliani, H. R. (2012) · Molecules · doi:10.3390/molecules17043989 · Cited by 1,366 · see citing works
Mechanisms of antibacterial action of three monoterpenes
Trombetta, D., Castelli, F., Sarpietro, M. G., Venuti, V., Cristani, M., Daniele, C., Saija, A., Mazzanti, G., & Bisignano, G. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.6.2474-2478.2005 · Cited by 1,359 · see citing works
Interactions of cyclic hydrocarbons with biological membranes.
Sikkema, J., de Bont, J. A., & Poolman, B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37154-5 · Cited by 1,203 · see citing works
Antioxidant activity of selected essential oil components in two lipid model systems
Ruberto, G., & Baratta, M. T. (2000) · Food Chemistry · doi:10.1016/s0308-8146(99)00247-2 · Cited by 1,193 · see citing works
Friedman, M., Henika, P. R., & Mandrell, R. E. (2002) · Journal of Food Protection · doi:10.4315/0362-028x-65.10.1545 · Cited by 1,128 · see citing works
DELAQUIS, P. J. (2002) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(01)00734-6 · Cited by 1,057 · see citing works
Devi, K. P., Nisha, S. A., Sakthivel, R., & Pandian, S. K. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.04.025 · Cited by 908 · see citing works
Antibacterial activity of some essential oil components against five foodborne pathogens
Kim, J., Marshall, M. R., & Wei, C.-I. (1995) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00059a013 · Cited by 892 · cited 1× · see citing works
“Uncoupling of oxidative phosphorylation, inhibition of active transport, loss of pool metabolites, and disruption of synthesis of DNA, RNA, protein, lipid, and polysaccharides might follow [8,10].”
BackgroundAntibacterial activity of selected plant essential oils against Escherichia coli O157:H7
Burt, S. A., & Reinders, R. D. (2003) · Letters in Applied Microbiology · doi:10.1046/j.1472-765x.2003.01285.x · Cited by 799 · see citing works
Klančnik, A., Piskernik, S., Jeršek, B., & Možina, S. S. (2010) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2010.02.004 · Cited by 676 · see citing works
Membrane toxicity of antimicrobial compounds from essential oils
Di Pasqua, R., Betts, G., Hoskins, N., Edwards, M., Ercolini, D., & Mauriello, G. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0636465 · Cited by 648 · see citing works
Antimicrobial activity of carvacrol related to its chemical structure
Ben Arfa, A., Combes, S., Preziosi-Belloy, L., Gontard, N., & Chalier, P. (2006) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2006.01938.x · Cited by 647 · see citing works
Candan, F., Unlu, M., Tepe, B., Daferera, D. J., Polissiou, M. G., Sökmen, A., & AKPULAT, H. A. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(03)00149-1 · Cited by 629 · see citing works
Lv, F., Liang, H., Yuan, Q., & Li, C. (2011) · Food Research International · doi:10.1016/j.foodres.2011.07.030 · Cited by 609 · see citing works
Antimicrobial Activity of Some Egyptian Spice Essential Oils
Farag, R. S., Daw, Z. Y., Hewedi, F. M., & El‐Baroty, G. S. (1989) · Journal of Food Protection · doi:10.4315/0362-028x-52.9.665 · Cited by 575 · see citing works
Antimicrobial activity in the vapour phase of a combination of cinnamon and clove essential oils
Goñi, P., Lopez, P., Sánchez, C., Gómez-Lus, R., Becerril, R., & Nerı́n, C. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.03.058 · Cited by 574 · see citing works
Antibacterial and antifungal activity of aromatic constituents of essential oils.
Pattnaik, S., Subramanyam, V. R., Bapaji, M., & Kole, C. R. (1997) · PubMed · Cited by 541 · see citing works
Gutierrez‐Merino, J., Barry‐Ryan, C., & Bourke, P. (2008) · Food Microbiology · doi:10.1016/j.fm.2008.10.008 · Cited by 533 · see citing works
Bioactivity of selected plant essential oils against listeria monocytogenes
Lis‐Balchin, M., & Deans, S. G. (1997) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.1997.00153.x · Cited by 529 · see citing works
Pei, R., Zhou, F. L., Ji, B., & Xu, J. (2009) · Journal of Food Science · doi:10.1111/j.1750-3841.2009.01287.x · Cited by 418 · see citing works
Dadalioǧlu, I., & Evrendilek, G. A. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049033e · Cited by 400 · see citing works
Mulyaningsih, S., Sporer, F., Zimmermann, S., Reichling, J., & Wink, M. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.06.018 · Cited by 396 · see citing works
Shan, B., Cai, Y., Brooks, J. D., & Corke, H. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf070424d · Cited by 364 · see citing works
Antimicrobial Activity of Carvacrol toward Bacillus cereus on Rice
Ultee, A., Slump, R. A., Steging, G., & Smid, E. J. (2000) · Journal of Food Protection · doi:10.4315/0362-028x-63.5.620 · Cited by 350 · see citing works
Ojeda-Sana, A. M., van Baren, C. M., Elechosa, M. A., Juárez, M. A., & Moreno, S. (2012) · Food Control · doi:10.1016/j.foodcont.2012.09.022 · Cited by 333 · see citing works
Schwarz, K., Bertelsen, G., Nissen, L. R., Gardner, P. T., Heinonen, M. I., Hopia, A., Tuong, H. B., Lambelet, P., McPhail, D. B., Skibsted, L. H., et al. (2001) · European Food Research and Technology · doi:10.1007/s002170000256 · Cited by 297 · see citing works
Bassolé, I. H. N., Lamien‐Meda, A., Bayala, B., Tirogo, S., Franz, C., Novak, J., Nébié, R. C. H., & Dicko, M. H. (2010) · Molecules · doi:10.3390/molecules15117825 · Cited by 275 · see citing works
Antimicrobial effect of linalool and α-terpineol against periodontopathic and cariogenic bacteria
Park, S., Lim, Y. K., Freire, M. O., Cho, E., Jin, D.-C., & Kook, J. (2012) · Anaerobe · doi:10.1016/j.anaerobe.2012.04.001 · Cited by 272 · see citing works
Antibacterial and antifungal activity of juniper berry oil and its selected components
Filipowicz, N. H., Kamiński, M. M., Kurlenda, J., Asztemborska, M., & Ochocka, J. R. (2003) · Phytotherapy Research · doi:10.1002/ptr.1110 · Cited by 261 · see citing works
Gallucci, M. N., Oliva, M., Casero, C. N., Dambolena, J. S., Luna, A., Zygadlo, J. A., & Demo, M. S. (2009) · Flavour and Fragrance Journal · doi:10.1002/ffj.1948 · Cited by 240 · see citing works
Wan, Wilcock, & Coventry (1998) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.1998.00338.x · Cited by 232 · see citing works
Ouazzou, A. A., Cherrat, L., Espina, L., Lorán, S., Rota, C., & Pagán, R. (2011) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2011.04.004 · Cited by 224 · see citing works
Antibacterial activity of essential oil components
Moleyar, V., & Narasimham, P. (1992) · International Journal of Food Microbiology · doi:10.1016/0168-1605(92)90035-2 · Cited by 224 · see citing works
de Billerbeck, V. G., Roques, C. G., Bessière, J., Fonvieille, J.-L., & Dargent, R. (2001) · Canadian Journal of Microbiology · doi:10.1139/w00-117 · Cited by 221 · see citing works
Lipids and Essential Oils as Antimicrobial Agents
(2010) · Wiley eBooks · doi:10.1002/9780470976623 · Cited by 204 · see citing works
Role of Fiber in Cardiovascular Diseases: A Review
Viuda‐Martos, M., López-Marcos, M. C., Fernández‐López, J., Sendra, E., Vargas, J. H. L., & Pérez‐Álvarez, J. Á. (2010) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2009.00102.x · Cited by 196 · see citing works
de Azerêdo, G. A., Stamford, T. L. M., Nunes, P. C., Neto, N. J. G., de Oliveira, M. E. G., & de Souza, E. L. (2011) · Food Research International · doi:10.1016/j.foodres.2011.04.012 · Cited by 194 · see citing works
Tepe, B., Sökmen, M., AKPULAT, H. A., Daferera, D. J., Polissiou, M. G., & Sökmen, A. (2004) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2004.04.015 · Cited by 189 · see citing works
Turgis, M., Vu, K. D., Dupont, C., & Lacroix, M. (2012) · Food Research International · doi:10.1016/j.foodres.2012.06.016 · Cited by 188 · see citing works
Chemistry and Bioactivity of Essential Oils
Carson, C. F., & Hammer, K. A. (2010) · Wiley eBooks · doi:10.1002/9780470976623.ch9 · Cited by 161 · see citing works
Gutierrez‐Merino, J., Rodriguez, G., Barry‐Ryan, C., & Bourke, P. (2008) · Journal of Food Protection · doi:10.4315/0362-028x-71.9.1846 · Cited by 152 · see citing works
Moosavy, M., Basti, A. A., Misaghi, A., Salehı, T. Z., Abbasifar, R., Mousavi, H. A. E., Alipour, M., Razavi, À. E., Gandomi, H., & Noori, N. (2008) · Food Research International · doi:10.1016/j.foodres.2008.07.018 · Cited by 150 · see citing works
Tsao, R., & Zhou, T. (2000) · Journal of Essential Oil Research · doi:10.1080/10412905.2000.9712057 · Cited by 139 · see citing works
The combined action of carvacrol and high hydrostatic pressure on Listeria monocytogenes Scott A
Karatzas, K. A. G., Kets, E. P. W., Smid, E. J., & Bennik, M. H. J. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2001.01266.x · Cited by 136 · see citing works
Antioxidant activities and chemical composition of essential oil of Pistacia atlantica from Algeria
Gourine, N., Yousfi, M., Bombarda, I., Nadjemi, B., Stocker, P., & Gaydou, E. M. (2010) · Industrial Crops and Products · doi:10.1016/j.indcrop.2009.10.003 · Cited by 126 · see citing works
Comparison of methods for assessing synergic antibiotic interactions
Mackay, M., Milne, K., & Gould, I. M. (2000) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(00)00149-7 · Cited by 123 · see citing works
Mechanisms of action of biocides
Denyer, S. P. (1990) · International Biodeterioration · doi:10.1016/0265-3036(90)90050-h · Cited by 117 · see citing works
Ramos, C., Teixeira, B., Batista, I., Matos, O., Serrano, C., Neng, N. R., Nogueira, J. M. F., Nunes, M. L., & Marques, A. (2011) · Natural Product Research · doi:10.1080/14786419.2010.531478 · Cited by 112 · see citing works
de Oliveira, C. E. V., Stamford, T. L. M., Neto, N. J. G., & de Souza, E. L. (2009) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2009.11.019 · Cited by 102 · see citing works
Antioxidant activities of volatile components isolated from Eucalyptus species
Lee, K., & Shibamoto, T. (2001) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.980 · Cited by 99 · see citing works
de Sousa, J. P., de Azerêdo, G. A., Torres, R. D. A., Vasconcelos, M. A. D. S., da Conceição, M. L., & de Souza, E. L. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.12.026 · Cited by 82 · see citing works
Selection of Yeasts as Starter Cultures for Table Olives: A Step-by-Step Procedure
Bevilacqua, A., Corbo, M. R., & Sinigaglia, M. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00194 · Cited by 66 · see citing works
Antimicrobial properties of some herb essential oils
Packiyasothy, E. V., & Kyle, S. (2002) · Food Australia · Cited by 58 · see citing works
de Sousa, J. P., Torres, R. D. A., de Azerêdo, G. A., Figueiredo, R. C. B. Q., Vasconcelos, M. A. D. S., & de Souza, E. L. (2012) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2012.06.008 · Cited by 55 · see citing works
Antimicrobial evaluation and chromatographic analysis of some essential and fixed oils.
Aboul-Ela, M., El-Shaer, N., & Ghanem, N. B. E. D. (1996) · PubMed · Cited by 54 · see citing works
POLITEO, O., JUKIC, M., & MILOS, M. (2010) · Journal of Food Biochemistry · doi:10.1111/j.1745-4514.2009.00269.x · Cited by 42 · see citing works
Neto, N. J. G., Luz, I. D. S., Honório, V. G., da Conceição, M. L., & de Souza, E. L. (2012) · Food Research International · doi:10.1016/j.foodres.2012.07.049 · Cited by 15 · see citing works
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Angane, M., Swift, S., Huang, K., Butts, C. A., & Quek, S. Y. (2022) · Foods · doi:10.3390/foods11030464 · Cited by 512 · see citing works
Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (AMR) Pathogens
Mahizan, N. A., Yang, S.-K., Moo, C.-L., Song, A. A., Chong, C. M., Chong, C. W., Abushelaibi, A. A., Lim, S. E., & Lai, K. (2019) · Molecules · doi:10.3390/molecules24142631 · Cited by 491 · see citing works
Pabast, M., Shariatifar, N., Beikzadeh, S., & Khaniki, G. J. (2018) · Food Control · doi:10.1016/j.foodcont.2018.03.047 · Cited by 347 · see citing works
Antioxidant and antibacterial activity of seven predominant terpenoids
Wang, C., Chen, Y., & Hou, C. (2019) · International Journal of Food Properties · doi:10.1080/10942912.2019.1582541 · Cited by 259 · see citing works
Amalraj, A., Haponiuk, J. T., Thomas, S., & Gopi, S. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.02.176 · Cited by 259 · see citing works
Baron, E. P. (2018) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13345 · Cited by 256 · see citing works
Tsuchiya, H. (2015) · Molecules · doi:10.3390/molecules201018923 · Cited by 237 · see citing works
Mori, H.-M., Kawanami, H., Kawahata, H., & Aoki, M. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1128-7 · Cited by 221 · see citing works
Zhang, J., Ye, K.-P., Zhang, X., Pan, D., Sun, Y., & Cao, J. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02094 · Cited by 185 · see citing works
Rakmai, J., Cheirsilp, B., Mejuto, J. C., Torrado, A., & Simal‐Gándara, J. (2016) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2016.11.014 · Cited by 183 · see citing works
Rakmai, J., Cheirsilp, B., Mejuto, J. C., Simal‐Gándara, J., & Torrado, A. (2017) · Industrial Crops and Products · doi:10.1016/j.indcrop.2017.10.027 · Cited by 181 · see citing works
Antibacterial Activity and Mode of Action of β-caryophyllene on Bacillus cereus
Moo, C.-L., Yang, S.-K., Osman, M. A., Yuswan, M. H., Loh, J., Lim, W., Lim, S. E., & Lai, K. (2020) · Polish Journal of Microbiology · doi:10.33073/pjm-2020-007 · Cited by 161 · see citing works
Hassan, F.-U., Arshad, M. A., Ebeid, H. M., Rehman, M. S.-U., Khan, M. S., Shahid, S., & Yang, C. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.575801 · Cited by 160 · see citing works
Commiphora myrrh: a phytochemical and pharmacological update
Batiha, G. E., Wasef, L., Teibo, J. O., Shaheen, H. M., Zakariya, A. M., Akinfe, O. A., Teibo, T. K. A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alexiou, A. T., et al. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-022-02325-0 · Cited by 159 · see citing works
Plant-Derivatives Small Molecules with Antibacterial Activity
Alibí, S., Crespo, D., & Navas, J. (2021) · Antibiotics · doi:10.3390/antibiotics10030231 · Cited by 134 · see citing works
Scherer, M. M. D. C., Marques, F. M., Figueira, M. M., Peisino, M. C. O., Schmitt, E. F. P., Kondratyuk, T. P., Endringer, D. C., Scherer, R., & Fronza, M. (2019) · Journal of Tissue Viability · doi:10.1016/j.jtv.2019.02.003 · Cited by 129 · see citing works
Effect of black pepper essential oil on the quality of fresh pork during storage
Zhang, J., Wang, Y., Pan, D., Cao, J., Shao, X., Chen, Y., Sun, Y., & Ou, C. (2016) · Meat Science · doi:10.1016/j.meatsci.2016.03.002 · Cited by 127 · see citing works
Badawy, M. E. I., Marei, G. I. K., Rabea, E. I., & Taktak, N. E. M. (2019) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2019.05.008 · Cited by 126 · see citing works
Rossi, B., Toschi, A., Piva, A., & Grilli, E. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422420000013 · Cited by 125 · see citing works
Antibacterial and antibiofilm activities of linalool nanoemulsions against Salmonella Typhimurium
Prakash, A., Vadivel, V., Rubini, D., & Nithyanand, P. (2019) · Food Bioscience · doi:10.1016/j.fbio.2019.01.018 · Cited by 120 · see citing works
Natural Compounds in the Battle against Microorganisms—Linalool
Mączka, W. K., Duda-Madej, A., Grabarczyk, M., & Wińska, K. (2022) · Molecules · doi:10.3390/molecules27206928 · Cited by 119 · see citing works
Youssef, F. S., Eid, S. Y., Alshammari, E., Ashour, M. L., Wink, M., & El-Readi, M. Z. (2020) · Foods · doi:10.3390/foods9101460 · Cited by 112 · see citing works
Strategic approach of multifaceted antibacterial mechanism of limonene traced in Escherichia coli
Gupta, A., Jeyakumar, E., & Lawrence, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-92843-3 · Cited by 104 · see citing works
Aelenei, P., Rimbu, C. M., Guguianu, E., Dimitriu, G., Aprotosoaie, A. C., Brebu, M. A., Horhogea, C. E., & Miron, A. (2018) · Letters in Applied Microbiology · doi:10.1111/lam.13100 · Cited by 102 · see citing works
Micic, D. M., Đurović, S. D., Riabov, P., Tomić, A., Šovljanski, O., Filip, S., Tosti, T. B., Dojčinović, B., Božović, R. B., Jovanović, D., et al. (2021) · Foods · doi:10.3390/foods10112734 · Cited by 100 · see citing works
Chrysargyris, A., Mikallou, M., Petropoulos, S. A., & Tzortzakis, N. (2020) · Agronomy · doi:10.3390/agronomy10050727 · Cited by 99 · see citing works
Role of bZIP transcription factors in the regulation of plant secondary metabolism
Han, H., Wang, C., Yang, X., Wang, L., Ye, J., Xu, F., Liao, Y., & Zhang, W. (2023) · Planta · doi:10.1007/s00425-023-04174-4 · Cited by 97 · see citing works
Moo, C.-L., Osman, M. A., Yang, S.-K., Yap, W.-S., Ismail, S., Lim, S. E., Chong, C. M., & Lai, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-00249-y · Cited by 94 · see citing works
Chemical composition of stinging nettle leaves obtained by different analytical approaches
Đurović, S. D., Pavlić, B., Šorgić, S., Popov, S., Savic, S. R., Petronijević, M., Radojković, M., Cvetanović, A. D., & Zeković, Z. P. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.02.019 · Cited by 92 · see citing works
Daula, A. F. M. S. U., Demi̇rci̇, F., Salim, K. A., Demırcı, B., Lim, L. B. L., Başer, K. H. C., & Ahmad, N. (2016) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.12.034 · Cited by 90 · see citing works
Use of essential oils in broiler chicken production – a review
Adaszyńska-Skwirzyńska, M., & Szczerbińska, D. (2016) · Annals of Animal Science · doi:10.1515/aoas-2016-0046 · Cited by 88 · see citing works
Amalraj, A., Raj, K. K. J., Haponiuk, J. T., Thomas, S., & Gopi, S. (2020) · Advanced Composites and Hybrid Materials · doi:10.1007/s42114-020-00178-w · Cited by 85 · see citing works
Utegenova, G. A., Pallister, K. B., Kushnarenko, S. V., Özek, G., Özek, T., Abidkulova, K. T., Kirpotina, L. N., Schepetkin, I. A., Quinn, M. T., & Voyich, J. M. (2018) · Molecules · doi:10.3390/molecules23071679 · Cited by 84 · see citing works
Zhou, C., Li, C., Siva, S., Cui, H., & Lin, L. (2021) · Industrial Crops and Products · doi:10.1016/j.indcrop.2021.113441 · Cited by 84 · see citing works
Lyu, X., Lee, J. J. L., & Chen, W. N. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b07141 · Cited by 82 · see citing works
Merghni, A., Belmamoun, A. R., Urcan, A. C., Bobiş, O., & Lassoued, M. A. (2023) · Antioxidants · doi:10.3390/antiox12071388 · Cited by 80 · see citing works
Mouafo, H. T., Mbawala, A., Hervé, T. M., Ndjouenkeu, R., & Devappa, S. (2018) · Bioresources and Bioprocessing · doi:10.1186/s40643-018-0234-4 · Cited by 78 · see citing works
Rakmai, J., Cheirsilp, B., Torrado, A., Simal‐Gándara, J., & Mejuto, J. C. (2017) · CyTA - Journal of Food · doi:10.1080/19476337.2017.1286523 · Cited by 78 · see citing works
Ashrafudoulla, M., Mizan, M. F. R., Park, S. H., & Ha, S.-D. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1767031 · Cited by 77 · see citing works
What Do We Know about Antimicrobial Activity of Astaxanthin and Fucoxanthin?
Karpiński, T. M. M., Ożarowski, M., Alam, R., Łochyńska, M., & Stasiewicz, M. (2021) · Marine Drugs · doi:10.3390/md20010036 · Cited by 76 · see citing works
Agrimonti, C., White, J. C., Tonetti, S., & Marmiroli, N. (2019) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2019.108246 · Cited by 75 · see citing works
Smaoui, S., Hlima, H. B., Braïek, O. B., Ennouri, K., Mellouli, L., & Khaneghah, A. M. (2021) · Meat Science · doi:10.1016/j.meatsci.2021.108585 · Cited by 75 · see citing works
Monoterpenes: Essential Oil Components with Valuable Features
Dehsheikh, A. B., Sourestani, M. M., Dehsheikh, P. B., Mottaghipisheh, J., Vitalini, S., & Iriti, M. (2020) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557520666200122144703 · Cited by 74 · see citing works
Xiong, K., Li, M., Chen, Y., Hu, Y., & Wen, J. (2024) · Journal of Food Protection · doi:10.1016/j.jfp.2024.100338 · Cited by 74 · see citing works
Hąc-Wydro, K., Flasiński, M., & Romańczuk, K. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.05.051 · Cited by 71 · see citing works
Van, H. T., Thang, T. D., Luu, T. N., & Doan, V. (2021) · RSC Advances · doi:10.1039/d1ra07370b · Cited by 70 · see citing works
Khalil, N. A., Fikry, S., & Salama, O. (2020) · AMB Express · doi:10.1186/s13568-020-0958-3 · Cited by 66 · see citing works
Shahina, Z., Ndlovu, E., Persaud, O., Sultana, T., & Dahms, T. E. S. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.03183-22 · Cited by 66 · see citing works
Najafgholi, H. M., Tarighi, S., Golmohammadi, M., & Taheri, P. (2017) · Molecules · doi:10.3390/molecules22040591 · Cited by 66 · see citing works
Chraibi, M., Farah, A., Lebrazi, S., Amine, O. E., Houssaïni, M. I., & Fikri-Benbrahim, K. (2016) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2016.08.002 · Cited by 64 · see citing works
Khan, M. S. A., Khundmiri, S. U. K., Khundmiri, S. U. K., Al-Sanea, M. M., & Mok, P. L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00569 · Cited by 64 · see citing works
Ferrocenyl chalcone derivatives as possible antimicrobial agents
Henry, E. J., Bird, S. J., Gowland, P., Collins, M., & Cassella, J. P. (2020) · The Journal of Antibiotics · doi:10.1038/s41429-020-0280-y · Cited by 64 · see citing works
Farhanghi, A., Aliakbarlu, J., Tajik, H., Mortazavi, N., Manafi, L., & Jalilzadeh‐Amin, G. (2022) · Food Science & Nutrition · doi:10.1002/fsn3.2870 · Cited by 62 · see citing works
Javaherzadeh, R., Bafroee, A. S. T., & Kanjari, A. (2019) · LWT · doi:10.1016/j.lwt.2019.108783 · Cited by 61 · see citing works
Chaturvedi, T., Kumar, A., Kumar, A., Verma, R. S., Padalia, R. C., Sundaresan, V., Chauhan, A., Saikia, D., Singh, V. R., & Venkatesha, K. T. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.03.050 · Cited by 61 · see citing works
Laptev, G. Y., Филиппова, В., Kochish, I. I., Yildirim, E. A., Il'ina, L. A., Dubrovin, A. V., Brazhnik, E. A., Novikova, N. I., Новикова, О. Б., Dmitrieva, M. E., et al. (2019) · Animals · doi:10.3390/ani9090615 · Cited by 61 · see citing works
Τέρπου, Α., Gialleli, A.-I., Bosnea, L. A., Kanellaki, M., Κουτίνας, Α. Α., & Castro, G. R. (2016) · LWT · doi:10.1016/j.lwt.2016.11.021 · Cited by 60 · see citing works
Abootalebi, S. N., Mousavi, S. M., Hashemi, S. A., Shorafa, E., Omidifar, N., & Gholami, A. (2021) · Journal of Nanomaterials · doi:10.1155/2021/6676555 · Cited by 59 · see citing works
Vlachojannis, C., Chrubasik‐Hausmann, S., Hellwig, E., & Al‐Ahmad, A. (2015) · Phytotherapy Research · doi:10.1002/ptr.5399 · Cited by 59 · see citing works
Chemical Composition and Biological Activities of Lemon (Citrus limon) Leaf Essential Oil
Hojjati, M., & Barzegar, H. (2017) · Nutrition and Food Sciences Research · doi:10.29252/nfsr.4.4.3 · Cited by 59 · see citing works
Pinna, R., Filigheddu, E., Juliano, C., Palmieri, A., Manconi, M., D'Hallewin, G., Petretto, G. L., Maioli, M., Caddeo, C., Manca, M. L., et al. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11050234 · Cited by 58 · see citing works
Electrospun asymmetric membranes for wound dressing applications
Aragón, J., Costa, C., Coelhoso, I. M., Mendoza, G., Aguiar‐Ricardo, A., & Irusta, S. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.109822 · Cited by 57 · see citing works
Using oxidized amylose as carrier of linalool for the development of antibacterial wound dressing
Lyu, Y., Ren, H., Yu, M., Li, X., Li, D., & Mu, C. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.07.033 · Cited by 56 · see citing works
Rivera-Yañez, C. R., Terrazas, L. I., Jiménez‐Estrada, M., Campos, J. E., Flores-Ortíz, C. M., Hernandez, L., Sánchez, T. A. C., Fariña, G. I. G., Rodríguez-Monroy, M. A., & Canales-Martinez, M. M. (2017) · Molecules · doi:10.3390/molecules22122095 · Cited by 56 · see citing works
Elshamy, A. I., Abd‐ElGawad, A. M., Gendy, A. E. G. E., & Assaeed, A. M. (2019) · Chemistry & Biodiversity · doi:10.1002/cbdv.201900051 · Cited by 56 · see citing works
Swathy, J. S., Mishra, P., Thomas, J., Mukherjee, A., & Chandrasekaran, N. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2018.03.045 · Cited by 55 · see citing works
Azizan, N., Mohd-Said, S., Abidin, Z. Z., & Jantan, I. (2017) · Molecules · doi:10.3390/molecules22122135 · Cited by 54 · see citing works
Next generation edible nanoformulations for improving post-harvest shelf-life of citrus fruits
Kumar, N., Upadhyay, A., Shukla, S., Bajpai, V. K., Kieliszek, M., Yadav, A. K., & Kumaravel, V. (2023) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-023-02287-8 · Cited by 53 · see citing works
de Souza, R. C., da Costa, M. M., Baldisserotto, B., Heinzmann, B. M., Schmidt, D., Caron, B. O., & Copatti, C. E. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.10.013 · Cited by 53 · see citing works
Sieniawska, E., Sawicki, R., Swatko‐Ossor, M., Napiórkowska, A., Przekora, A., Ginalska, G., Swatko‐Ossor, M., & AUGUSTYNOWICZ-KOPEĆ, E. M. (2018) · Molecules · doi:10.3390/molecules23010176 · Cited by 53 · see citing works
Ujilestari, T., Martien, R., Ariyadi, B., & Dono, N. D. (2018) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2018.8603 · Cited by 52 · see citing works
Schoina, V., Τέρπου, Α., Bosnea, L. A., Kanellaki, M., & Nigam, P. S. N. (2017) · LWT · doi:10.1016/j.lwt.2017.11.015 · Cited by 52 · see citing works
Antioxidant and Antimicrobial Properties of Cactus Pear ( Opuntia ) Seed Oils
Ramírez‐Moreno, E., Cariño‐Cortés, R., Cruz‐Cansino, N. D. S., Delgado‐Olivares, L., Ariza‐Ortega, J. A., Montañez-Izquierdo, V. Y., Hernández-Herrero, M. M., & Filardo-Kerstupp, T. (2017) · Journal of Food Quality · doi:10.1155/2017/3075907 · Cited by 51 · see citing works
Antioxidant and antifungal activities of a new chemovar of cumin (Cuminum cyminum L.)
Ghasemi, G., Fattahi, M., Alirezalu, A., & Ghosta, Y. (2018) · Food Science and Biotechnology · doi:10.1007/s10068-018-0506-y · Cited by 51 · see citing works
Lorenzo‐Leal, A. C., Palou, E., & López‐Malo, A. (2019) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2019.02.008 · Cited by 51 · see citing works
Semwal, P., & Painuli, S. (2019) · Clinical Phytoscience · doi:10.1186/s40816-019-0105-3 · Cited by 51 · see citing works
Atiphasaworn, P., Monggoot, S., Gentekaki, E., Brooks, S., & Pripdeevech, P. (2017) · Current Microbiology · doi:10.1007/s00284-017-1303-1 · Cited by 51 · see citing works
Antibacterial activity and mechanisms of α-terpineol against foodborne pathogenic bacteria
Yang, X., Zhao, S., Deng, Y., Xu, W., Wang, Z., Wang, W., Lv, R., & Liu, D. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12737-4 · Cited by 50 · see citing works
Mahendran, G., & Vimolmangkang, S. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04214-2 · Cited by 50 · see citing works
Natural Terpenes Used as Plasticizers for Poly(3-hydroxybutyrate)
Mangeon, C., Michely, L., de Anda, A. R., Thévenieau, F., Renard, E., & Langlois, V. (2018) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.8b02896 · Cited by 50 · see citing works
Cid-Pérez, S., Hernández‐Carranza, P., Ochoa‐Velasco, C. E., Ruiz-López, I. I., GuadalupeVirginia, N.-M., & Ávila-Sosa, R. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.02.087 · Cited by 50 · see citing works
González-González, C. R., Ajigbewu, O. H., Delgado‐Pando, G., Theodoridou, K., Doran, O., & Stratakos, A. C. (2021) · LWT · doi:10.1016/j.lwt.2021.111898 · Cited by 50 · see citing works
MAPLE Coatings Embedded with Essential Oil-Conjugated Magnetite for Anti-Biofilm Applications
Gherasim, O., Popescu, R. C., Grumezescu, V., Mogoşanu, G. D., Mogoantă, L., Iordache, F., Holban, A. M., Vasile, B. Ş., Bîrcă, A. C., Oprea, O., et al. (2021) · Materials · doi:10.3390/ma14071612 · Cited by 49 · see citing works
Owen, L., White, A. W., & Laird, K. (2018) · Phytochemical Analysis · doi:10.1002/pca.2797 · Cited by 48 · see citing works
Nguyen, H. V., Meile, J., Lebrun, M., Caruso, D., Chu‐Ky, S., & Sarter, S. (2017) · Letters in Applied Microbiology · doi:10.1111/lam.12837 · Cited by 47 · see citing works
Benyoucef, F., Dib, M. E. A., Arrar, Z., Costa, J., & Muselli, A. (2018) · Journal of Applied Biotechnology Reports · doi:10.29252/jabr.05.04.03 · Cited by 47 · see citing works
Akacha, B. B., Michalak, M., Mekinić, I. G., Kačániová, M., Chaari, M., Brini, F., Saad, R. B., Mnif, W., Garzoli, S., & Hsouna, A. B. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3780 · Cited by 46 · see citing works
Oyekanmi, A. A., Kumar, U. S. U., H. P. S., A. K., Olaiya, N. G., Amirul, A. A., Rahman, A. A., Nuryawan, A., Abdullah, C. K., & Rizal, S. (2021) · Polymers · doi:10.3390/polym13101664 · Cited by 45 · see citing works
Hilgers, F., Habash, S. S., Loeschcke, A., Ackermann, Y. S., Neumann, S., Heck, A., Klaus, O., Hage‐Hülsmann, J., Grundler, F. M. W., Jaeger, K., et al. (2021) · Microorganisms · doi:10.3390/microorganisms9010168 · Cited by 45 · see citing works
Johansen, B., Duval, R. E., & Sergère, J. (2022) · Molecules · doi:10.3390/molecules27217472 · Cited by 45 · see citing works
Tourabi, M., Nouioura, G., Touijer, H., Baghouz, A., Ghouizi, A. E., Chebaibi, M., Bakour, M., Ousaaid, D., Almaary, K. S., Nafidi, H., et al. (2023) · Plants · doi:10.3390/plants12213783 · Cited by 45 · see citing works
Riabov, P., Micic, D. M., Božović, R. B., Jovanović, D. V., Tomić, A., Šovljanski, O., Filip, S., Tosti, T. B., Ostojić, S., Blagojević, S. N., et al. (2020) · Industrial Crops and Products · doi:10.1016/j.indcrop.2020.112498 · Cited by 45 · see citing works
Linalool inhibits 22Rv1 prostate cancer cell proliferation and induces apoptosis
Zhao, Y., Cheng, X., Wang, G., Liao, Y., & Qing, C. (2020) · Oncology Letters · doi:10.3892/ol.2020.12152 · Cited by 45 · see citing works
Fajdek-Bieda, A., Pawlińska, J., Wróblewska, A., & Łuś, A. (2024) · Molecules · doi:10.3390/molecules29050950 · Cited by 44 · see citing works
Polymer–antibiotic conjugates as antibacterial additives in dental resins
Zhang, R., Jones, M. M., Moussa, H., Keskar, M., Huo, N., Zhang, Z., Visser, M. B., Sabatini, C., Swihart, M. T., & Cheng, C. (2018) · Biomaterials Science · doi:10.1039/c8bm01228h · Cited by 44 · see citing works
Mousavi, S. M., Hashemi, S. A., Ramakrishna, S., Esmaeili, H., Bahrani, S., Koosha, M., & Babapoor, A. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101352 · Cited by 44 · see citing works
Fahimirad, S., Abtahi, H., Razavi, S., Alizadeh, H., & Ghorbanpour, M. (2017) · Molecules · doi:10.3390/molecules22060822 · Cited by 43 · see citing works
Aminophenyl chalcones potentiating antibiotic activity and inhibiting bacterial efflux pump
Siqueira, M. M. R., Freire, P., Cruz, B. G., de Freitas, T. S., Bandeira, P. N., dos Santos, H. S., Nogueira, C. E. S., Teixeira, A. M. R., Pereira, R. L. S., Xavier, J. D. C., et al. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105695 · Cited by 43 · see citing works
Tundis, R., Xiao, J., Sanches-Silva, A. T., Carreiró, F., & Loizzo, M. R. (2023) · Plants · doi:10.3390/plants12050991 · Cited by 41 · see citing works
Diverse Bacteriocins Produced by Strains From the Human Milk Microbiota
Angelopoulou, A., Warda, A. K., O’Connor, P. M., Stockdale, S. R., Shkoporov, A. N., Field, D., Draper, L. A., Stanton, C., Hill, C., & Ross, R. P. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00788 · Cited by 41 · see citing works
- Authors
- Zengin, H., & Baysal, A.
- Affiliations
- Izmir Institute of Technology (TR)
- Department of Food Engineering, Izmir Institute of Technology, Urla, Izmir 35437, Turkey
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2014-11-03
- Volume
- 19
- Issue
- 11
- Pages
- 17773-17798
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6272013
- OpenAlex
- W1966480046
- Cited by
- 519
- References
- 65
- Citations by year
- 2026: 31 · 2025: 54 · 2024: 56 · 2023: 59 · 2022: 50 · 2021: 43 · 2020: 72 · 2019: 55 · 2018: 42 · 2017: 30 · 2016: 19 · 2015: 8
- FWCI
- 27.24
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- IYTE GCRIS Database (Izmir Institute of Technology) (submittedVersion, other-oa)
- İYTE (İZMİR YÜKSEK TEKNOLOJİ ENSTİTÜSÜ) (submittedVersion, other-oa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- antibacterial activity, antioxidant activity, α-terpineol, linalool, 1,8-cineole, α-pinene, pathogenic bacteria, synergistic and additive effects, Salmonella typhimurium, Escherichia coli O157:H7, Staphylococcus aureus, minimum inhibitory concentration, bacterial growth inhibition
- MeSH terms
- Eucalyptol, Acyclic Monoterpenes, Cyclohexane Monoterpenes, Bicyclic Monoterpenes, Anti-Bacterial Agents, Antioxidants, Bacteria, Cyclohexanols, Microscopy, Electron, Scanning, Oils, Volatile, Structure-Activity Relationship, Terpenes, Monoterpenes, Cyclohexenes
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