Cited by 96Pomegranate: compositions and health benefitsSkin Protection and AgingPhytochemicals and Antioxidant Activities

Pomegranate Fruit Extract Inhibits UVB‐induced Inflammation and Proliferation by Modulating NF‐κB and MAPK Signaling Pathways in Mouse Skin†

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Khan, Naghma, Syed, Deeba N., Pal, Harish Chandra, Mukhtar, Hasan, Afaq, Farrukh·2012·Photochemistry and Photobiology

Abstract

There is considerable interest in the identification of natural agents capable of affording protection to skin from the adverse effects of solar ultraviolet B (UVB) radiation. Pomegranate (Punica granatum L.) fruit possesses as strong antioxidant, anti-inflammatory and antiproliferative properties. Recently, we have shown that oral feeding of pomegranate fruit extract (PFE) to mice afforded substantial protection from the adverse effects of single UVB radiation via modulation in early biomarkers of photocarcinogenesis. This study was designed to investigate the photochemopreventive effects of PFE (0.2%, wt/vol) after multiple UVB irradiations (180 mJ cm(-2), on alternative day, for a total of seven treatments) to the skin of SKH-1 hairless mice. Oral feeding of PFE to SKH-1 mice inhibited UVB-induced epidermal hyperplasia, infiltration of leukocytes, protein oxidation and lipid peroxidation. Immunoblot analysis demonstrated that oral feeding of PFE to mice inhibited UVB-induced (1) nuclear translocation and phosphorylation of nuclear factor kappa B/p65, (2) phosphorylation and degradation of IκBα, (3) activation of IKKα/ΙΚΚβ and (4) phosphorylation of mitogen-activated protein kinase proteins and c-Jun. PFE consumption also inhibited UVB-induced protein expression of (1) COX-2 and iNOS, (2) PCNA and cyclin D1 and (3) matrix metalloproteinases-2,-3 and -9 in mouse skin. Taken together, these data show that PFE consumption afforded protection to mouse skin against the adverse effects of UVB radiation by modulating UVB-induced signaling pathways.

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Crossref · 10.1111/j.1751-1097.2011.01063.x

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  • Pomegranate fruit extract has been shown to reduce UVB-induced oxidative stress and the oxidation of skin proteins.

    “Pomegranate fruit extract has been shown to reduce UVB-induced oxidative stress and the oxidation of skin proteins [209]”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [209]

  • Pomegranate extract has photochemoprotective, antioxidant, anti-inflammatory and antiproliferative properties.

    “Research has confirmed the photochemoprotective, antioxidant, anti-inflammatory and antiproliferative properties of pomegranate extract.”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [209]

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Authors
Khan, N., Syed, D. N., Pal, H. C., Mukhtar, H., & Afaq, F.
Affiliations
  • University of Wisconsin–Madison (US)
  • University of Alabama at Birmingham (US)
Corresponding author
Afaq, Farrukh
Venue
Photochemistry and Photobiology
Publisher
Wiley
Published
2012-01-13
Volume
88
Issue
5
Pages
1126-1134
ISSN
  • 0031-8655 (ISSN-L)
  • 1751-1097
OpenAlex
W2020211926
Cited by
96
References
51
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 5 · 2019: 14 · 2018: 10 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 7 · 2013: 9 · 2012: 2
FWCI
5.32
Type
journal article
Language
en
Open access
Locations
  • Photochemistry and Photobiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Cancer Institute (P30CA014520)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR050948)
  • National Center for Complementary and Integrative Health (R21AT002429)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
pomegranate fruit extract, Punica granatum, UV-B radiation, skin inflammation, epidermal hyperplasia, NF-κB signaling, MAPK signaling, IκBα degradation, IKK phosphorylation, c-Jun phosphorylation, cyclooxygenase-2, inducible nitric oxide synthase, PCNA, cyclin D1, matrix metalloproteinases, oxidative stress, leukocyte infiltration, SKH-1 mice
MeSH terms
Administration, Oral, Animals, Epidermis, Fruit, Gene Expression Regulation, Hyperplasia, Mice, Hairless, Phosphorylation, Plant Extracts, Ultraviolet Rays, Lipid Peroxidation, Signal Transduction, Biomarkers, Matrix Metalloproteinases, Mitogen-Activated Protein Kinase Kinases, Lythraceae, Mice, Cyclooxygenase 2, I-kappa B Kinase, Transcription Factor RelA

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