Early detection and intervention evaluation for people at high-risk of psychosis-2 (EDIE-2): trial rationale, design and baseline characteristics: Early detection and intervention trial
Abstract
AIMS: Much research has begun to focus on the identification of people who are at high risk of developing psychosis, and clinical services have been initiated for this population. However, only a small number of studies have reported on the efficacy of interventions for preventing or delaying the onset of psychosis. The results of prior work suggest that cognitive therapy (CT) may be an effective, well-tolerated treatment. We report on the rationale and design for a large-scale, multi-site randomized, controlled trial of CT for people who are assessed to be at high risk of psychosis because of either state or state-plus-trait risk factors. METHODS: The study employs a single-blind design in which all participants receive frequent mental-state monitoring, which will efficiently detect transition to psychosis, and half are randomized to weekly sessions of CT for up to 6 months. Participants will be followed-up for a minimum of 12 months and to a maximum of 2 years. RESULTS: We report the characteristics of the final sample at baseline (n=288). CONCLUSIONS: Our study aimed to expand the currently limited evidence base for best practice in interventions for individuals at high risk of psychosis.
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EDIE-2 was a multi-site randomised controlled trial of a psychological intervention aiming to reduce transition to psychosis.
“EDIE-2 was a multi-site randomised controlled trial of a psychological intervention aiming to reduce transition to psychosis (Morrison et al., 2011, Morrison et al., 2012).”
From Sleep duration and psychotic experiences in patients at risk of psychosis: a secondary analysis of the EDIE-2 trial (2019) · cites this paper as Morrison et al., 2011
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Indicated prevention in psychosis risk—psychological approaches
Addington, J., Piškulić, D., Devoe, D. J. A., Santesteban‐Echarri, O., & Stowkowy, J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813201-2.00018-1 · Cited by 1 · see citing works
Johnson, C. (2013) · Research Explorer (The University of Manchester) · Cited by 1 · see citing works
CBT for Individuals at High Risk of Developing Psychosis
Smethurst, N., French, P., & Morrison, A. P. (2012) · doi:10.1002/9781118330029.ch4
Dael, F. W. J. J. V. (2014) · doi:10.26481/dis.20141204fv
Zhang, T., Shapiro, D. I., & Wang, J. (2019) · Springer eBooks · doi:10.1007/978-3-030-17336-4_16
Learning more from complex psychological and social interventions in mental health
Flach, C. (2014) · Research Explorer (The University of Manchester)
Sevi, O. M., Gülen, M., Zeybek, Z., & Zülfikar, N. (2025) · Psychosis · doi:10.1080/17522439.2025.2484520
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- Authors
- Morrison, A. P., Stewart, S. L. K., French, P., Bentall, R. P., Birchwood, M., Byrne, R., Davies, L. M., Fowler, D., Gumley, A. I., Jones, P. B., Lewis, S. W., Murray, G. K., Patterson, P., & Dunn, G.
- Affiliations
- Greater Manchester Mental Health NHS Foundation Trust (GB)
- Bangor University (GB)
- University of Birmingham (GB)
- University of East Anglia (GB)
- University of Glasgow (GB)
- University of Cambridge (GB)
- University of Manchester (GB)
- Birmingham and Solihull Mental Health NHS Foundation Trust (GB)
- Corresponding author
- Morrison, Anthony P.
- ORCID
- Venue
- Early Intervention in Psychiatry
- Publisher
- Wiley
- Published
- 2011-01-27
- Volume
- 5
- Issue
- 1
- Pages
- 24-32
- ISSN
- 1751-7885 (ISSN-L)
- OpenAlex
- W2124230444
- Cited by
- 72
- References
- 36
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 7 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 8 · 2014: 6 · 2013: 13 · 2012: 6
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Early Intervention in Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- National Institute for Health and Care Research
- Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- psychosis prevention, cognitive therapy, early intervention, transition to psychosis, mental state monitoring
- MeSH terms
- Adolescent, Adult, Data Collection, Humans, Male, Psychotic Disorders, Cognitive Behavioral Therapy, Early Diagnosis
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