Cognitive behavioural therapy for psychosis prevention: a systematic review and meta-analysis
Open accessAbstract
Background: Clinical equipoise regarding preventative treatments for psychosis has encouraged the development and evaluation of psychosocial treatments, such as cognitive behavioural therapy (CBT). Method: A systematic review and meta-analysis was conducted, examining the evidence for the effectiveness of CBT-informed treatment for preventing psychosis in people who are not taking antipsychotic medication, when compared to usual or non-specific control treatment. Included studies had to meet basic quality criteria, such as concealed and random allocation to treatment groups. Results: Our search produced 1940 titles, out of which we found seven completed trials (six published). The relative risk (RR) of developing psychosis was reduced by more than 50% for those receiving CBT at every time point [RR at 6 months 0.47, 95% confidence interval (CI) 0.27–0.82, p = 0.008 (fixed-effects only: six randomized controlled trials (RCTs), n = 800); RR at 12 months 0.45, 95% CI 0.28–0.73, p = 0.001 (six RCTs, n = 800); RR at 18–24 months 0.41, 95% CI 0.23–0.72, p = 0.002 (four RCTs, n = 452)]. Heterogeneity was low in every analysis and the results were largely robust to the risk of an unpublished 12-month study having unfavourable results. CBT was also associated with reduced subthreshold symptoms at 12 months, but not at 6 or 18–24 months. No effects on functioning, symptom-related distress or quality of life were observed. CBT was not associated with increased rates of clinical depression or social anxiety (two studies). Conclusions: CBT-informed treatment is associated with a reduced risk of transition to psychosis at 6, 12 and 18–24 months, and reduced symptoms at 12 months. Methodological limitations and recommendations for trial reporting are discussed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048 · see citing works
Schulz (1995) · doi:10.1001/jama.1995.03520290060030 · Cited by 5,634 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1. The Cochrane Collaboration
Higgins, J., Green, S. R., & Higgins, J. (2008) · Cited by 5,544 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions
Tarsilla, M. (2010) · Journal of MultiDisciplinary Evaluation · doi:10.56645/jmde.v6i14.284 · Cited by 5,228 · see citing works
Mapping the Onset of Psychosis: The Comprehensive Assessment of At-Risk Mental States
Yung, A. R., Yung, A. R., Yuen, H. P., McGorry, P. D., Phillips, L., Kelly, D., Dell’Olio, M., Francey, S. M., Cosgrave, E., Killackey, E. J., et al. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2005.01714.x · Cited by 2,195 · see citing works
Miller, T. J., McGlashan, T. H., Rosen, J. L., Cadenhead, K. S., Ventura, J., McFarlane, W. R., Perkins, D. O., Pearlson, G. D., & Woods, S. W. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007040 · Cited by 1,800 · see citing works
Lingjærde, O., Ahlfors, U. G., Bech, P., Dencker, S. J., & Elgen, K. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb10566.x · Cited by 1,705 · see citing works
Better Reporting of Harms in Randomized Trials: An Extension of the CONSORT Statement
Ioannidis, J. P. A., Evans, S. J. W., Gøtzsche, P. C., O'Neill, R. T., Altman, D. G., Schulz, K., Moher, D., & for the CONSORT Group* (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-10-200411160-00009 · Cited by 1,593 · see citing works
Predicting Psychosis: Meta-analysis of Transition Outcomes in Individuals at High Clinical Risk
Fusar-Poli, P. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1472 · Cited by 1,361 · see citing works
How Many Studies Do You Need?: A Primer on Statistical Power for Meta-Analysis
Valentine, J. C., Pigott, T. D., & Rothstein, H. R. (2010) · Journal of Educational and Behavioral Statistics · doi:10.3102/1076998609346961 · Cited by 1,294 · see citing works
McGorry, P. D., Yung, A. R., Phillips, L. J., Yuen, H. P., Francey, S., Cosgrave, E. M., Germano, D., Bravin, J., McDonald, T., Blair, A., et al. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.10.921 · Cited by 1,056 · see citing works
The appropriateness of asymmetry tests for publication bias in meta-analyses: A large survey
Ioannidis, J. P. A., & Trikalinos, T. A. (2007) · Canadian Medical Association Journal · doi:10.1503/cmaj.060410 · Cited by 1,052 · see citing works
Long-term Antipsychotic Treatment and Brain Volumes
Ho, B., Andreasen, N. C., Ziebell, S., Pierson, R. K., & Magnotta, V. A. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.199 · Cited by 975 · see citing works
McGorry, P. D., Hickie, I. B., Yung, A. R., Pantelis, C., & Jackson, H. J. (2006) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2006.01860.x · Cited by 919 · see citing works
Amminger, G. P., Schäfer, M. R., Papageorgiou, K., Klier, C. M., Cotton, S. M., Harrigan, S. M., Mackinnon, A., McGorry, P. D., & Berger, G. E. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.192 · Cited by 896 · see citing works
Monitoring and Care of Young People at Incipient Risk of Psychosis
Yung, A. R., McGorry, P. D., McFarlane, C. A., Jackson, H. J., Patton, G. C., & Rakkar, A. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.2.283 · Cited by 773 · see citing works
Morrison, A. P., French, P., Walford, L., Lewis, S. W., Kilcommons, A., Green, J., Parker, S., & Bentall, R. P. (2004) · British Journal of Psychiatry · doi:10.1192/bjp.185.4.291 · Cited by 740 · see citing works
Sample size slippages in randomised trials: exclusions and the lost and wayward.
Schulz, K. F., & Grimes, D. A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07882-0 · Cited by 642 · see citing works
McGlashan, T. H., Zipursky, R. B., Perkins, D., Addington, J., Miller, T., Woods, S. W., A. Hawkins, K., E. Hoffman, R., Preda, A., Epstein, I., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.5.790 · Cited by 556 · see citing works
Early intervention for psychosis
Marshall, M., & Rathbone, J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004718.pub3 · Cited by 531 · see citing works
Leucht, S., Arbter, D., Engel, R. R., Kissling, W., & Davis, J. M. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002136 · Cited by 489 · see citing works
Leucht, S., Hierl, S., Kissling, W., Dold, M., & Davis, J. M. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.096594 · Cited by 451 · cited 1× · see citing works
“According to a recent comparison of psychiatric and general medical treatments, around 27 (25, 33) patients with heart disease need to take statins to prevent one major cardiac event, while around 16 (13, 25) need to take ACE-inhibitors for one to avoid death from chronic heart failure (Leucht et al., 2012).”
BackgroundGrant, P. M., & Beck, A. T. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn008 · Cited by 419 · see citing works
Xia (2009) · doi:10.1192/pb.bp.108.021949 · Cited by 381 · see citing works
Content and quality of 2000 controlled trials in schizophrenia over 50 years
Thornley, B., & Adams, C. E. (1998) · BMJ · doi:10.1136/bmj.317.7167.1181 · Cited by 362 · see citing works
Grant, P. M. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.129 · Cited by 349 · see citing works
Raduà, J., Borgwardt, S., Crescini, A., Mataix‐Cols, D., Meyer‐Lindenberg, A., McGuire, P. K., & Fusar‐Poli, P. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.012 · Cited by 333 · see citing works
Morrison, A. P., French, P., Stewart, S. L. K., Birchwood, M., Fowler, D., Gumley, A. I., Jones, P. B., Bentall, R. P., Lewis, S. W., Murray, G. K., et al. (2012) · BMJ · doi:10.1136/bmj.e2233 · Cited by 332 · see citing works
Mitchell, A. J., Vancampfort, D., Herdt, A. D., Yu, W., & Hert, M. D. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs082 · Cited by 331 · see citing works
A systematic review of the effects of antipsychotic drugs on brain volume
Moncrieff, J., & Leo, J. (2010) · Psychological Medicine · doi:10.1017/s0033291709992297 · Cited by 309 · see citing works
Chlorpromazine versus placebo for schizophrenia
Adams, C. E., Awad, G. A., Rathbone, J., & Thornley, B. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000284.pub2 · Cited by 241 · see citing works
Last observation carried forward versus mixed models in the analysis of psychiatric clinical trials.
Hamer, R. M., & Simpson, P. M. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09040458 · Cited by 233 · see citing works
Morrison, A. P., French, P., Parker, S., Roberts, M., Stevens, H., Bentall, R. P., & Lewis, S. W. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl042 · Cited by 228 · see citing works
Addington, J., Epstein, I., Liu, L., French, P., Boydell, K. M., & Zipursky, R. B. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2010.10.015 · Cited by 226 · see citing works
Preventing progression to first-episode psychosis in early initial prodromal states
Bechdolf, A., Wagner, M., Ruhrmann, S., Harrigan, S., Putzfeld, V., Pukrop, R., Brockhaus-Dumke, A., Berning, J., Janssen, B., Decker, P., et al. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.066357 · Cited by 224 · see citing works
McGlashan, T. H., Zipursky, R. B., Perkins, D. O., Addington, D. E., Miller, T. J., Woods, S. W., Hawkins, K. A., Hoffman, R., Lindborg, S. R., Tohen, M. F., et al. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00439-5 · Cited by 213 · see citing works
What Are the Components of CBT for Psychosis? A Delphi Study
Morrison, A. P., & Barratt, S. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp118 · Cited by 212 · see citing works
van der Gaag, M., Nieman, D. H., Rietdijk, J., Dragt, S., Ising, H. K., Klaassen, R. M. C., Koeter, M., Cuijpers, P., Wunderink, L., & Linszen, D. H. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs105 · Cited by 209 · see citing works
Fusar‐Poli, P., Byrne, M., Badger, S., Valmaggia, L., & McGuire, P. K. (2012) · European Psychiatry · doi:10.1016/j.eurpsy.2012.08.002 · Cited by 197 · see citing works
Broome, M. R., Woolley, J. B., Johns, L., Valmaggia, L., Tabraham, P., Gafoor, R., Bramon, E., & McGuire, P. K. (2005) · European Psychiatry · doi:10.1016/j.eurpsy.2005.03.001 · Cited by 189 · see citing works
Chlorpromazine versus placebo for schizophrenia
Adams, C. E., Awad, G. A., Rathbone, J., Thornley, B., & Soares‐Weiser, K. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000284.pub3 · Cited by 167 · see citing works
Preti, A., & Cella, M. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.07.026 · Cited by 167 · see citing works
Haloperidol versus placebo for schizophrenia
Adams, C. E., Bergman, H., Irving, C. B., & Lawrie, S. M. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003082.pub3 · Cited by 157 · see citing works
Miller, T. J., Zipursky, R. B., Perkins, D., Addington, J., Woods, S. W., Hawkins, K. A., Hoffman, R., Preda, A., Epstein, I., Addington, D., et al. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00440-1 · Cited by 150 · see citing works
Randomized Controlled Trial of Interventions for Young People at Ultra High Risk for Psychosis
Yung, A. R., Phillips, L., Nelson, B., Francey, S. M., PanYuen, H., Simmons, M. B., Ross, M., Kelly, D., Baker, K., Amminger, G. P., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04979ora · Cited by 146 · see citing works
Randomized Controlled Trial of Interventions for Young People at Ultra-High Risk of Psychosis
McGorry, P. D., Nelson, B., Phillips, L., Yuen, H. P., Francey, S. M., Thampi, A., Berger, G. E., Amminger, G. P., Simmons, M. B., Kelly, D., et al. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m07785 · Cited by 142 · see citing works
Klosterkötter, J., Ruhrmann, S., Schultze‐Lutter, F., Salokangas, R. K. R., LINSZEN, D. H., Birchwood, M. J., Juckel, G., Morrison, A. P., Vázquez‐Barquero, J. L., Hambrecht, M., et al. (2005) · PubMed Central · Cited by 142 · see citing works
Treating Schizophrenia in the Prodromal Phase
Yung, A. R., Phillips, L. A. W., & McGorry, P. D. (2004) · CRC Press eBooks · doi:10.3109/9780203501771 · Cited by 137 · see citing works
The case for including Attenuated Psychotic Symptoms Syndrome in DSM-5 as a psychosis risk syndrome
Woods, S. W., Walsh, B. C., Saksa, J. R., & McGlashan, T. H. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.08.012 · Cited by 130 · see citing works
The psychosis risk syndrome and its proposed inclusion in the DSM-V: A risk–benefit analysis
Corcoran, C. M., First, M. B., & Cornblatt, B. A. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.03.018 · Cited by 129 · see citing works
Acute D2 receptor blockade induces rapid, reversible remodeling in human cortical-striatal circuits
Tost, H., Braus, D. F., Hakimi, S., Ruf, M., Vollmert, C., Höhn, F., & Meyer‐Lindenberg, A. (2010) · Nature Neuroscience · doi:10.1038/nn.2572 · Cited by 127 · see citing works
Antipsychotics: is it time to introduce patient choice?
Morrison, A. P., Hutton, P., Shiers, D., & Turkington, D. (2012) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.112.112110 · Cited by 126 · see citing works
Self-citationMorrison, A., Bentall, R., French, P., Walford, L., Kilcommons, A., Knight, A., Kreutz, M., & Lewis, S. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.181.43.s78 · Cited by 126 · see citing works
Anticipating DSM-V: Should Psychosis Risk Become a Diagnostic Class?
Carpenter, W. T. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp071 · Cited by 112 · see citing works
Should Attenuated Psychosis Syndrome Be a DSM-5 Diagnosis?
Carpenter, W. T., & van Os, J. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10121816 · Cited by 99 · see citing works
More harm than good: The case against using antipsychotic drugs to prevent severe mental illness
Bentall, R. P., & Morrison, A. P. (2002) · Journal of Mental Health · doi:10.1080/09638230020023723 · Cited by 97 · see citing works
French, P., & Morrison, A. P. (2004) · Thammasat University Digital Collections · doi:10.1002/9780470713259 · Cited by 97 · see citing works
Methodological Issues in Current Antipsychotic Drug Trials
Leucht, S., Heres, S., Hamann, J., & Kane, J. M. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm159 · Cited by 96 · see citing works
Should a “Risk Syndrome for Psychosis” be included in the DSMV?
Yung, A. R., Nelson, B., Thompson, A. D., & Wood, S. J. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.03.017 · Cited by 85 · see citing works
Dysfunctional Attitudes and Expectancies in Deficit Syndrome Schizophrenia
Beck, A. T., Grant, P. M., Huh, G. A., Perivoliotis, D., & Chang, N. A. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr040 · Cited by 83 · see citing works
Phillips, L., Nelson, B., Yuen, H. P., Francey, S. M., Simmons, M. B., Stanford, C., Ross, M., Kelly, D., Baker, K., Conus, P., et al. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670903107625 · Cited by 78 · see citing works
Morrison, A. P., Stewart, S. L. K., French, P., Bentall, R. P., Birchwood, M., Byrne, R., Davies, L. M., Fowler, D., Gumley, A. I., Jones, P. B., et al. (2011) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2010.00254.x · Cited by 72 · see citing works
Rietdijk, J., Dragt, S., Klaassen, R. M. C., Ising, H. K., Nieman, D. H., Wunderink, L., Delespaul, P., Cuijpers, P. J., LINSZEN, D. H., & van der Gaag, M. (2010) · Trials · doi:10.1186/1745-6215-11-30 · Cited by 68 · see citing works
Bechdolf, A., Müller, H., Stützer, H., Wagner, M., Maier, W., Lautenschlager, M., Heinz, A., de Millas, W., Janssen, B., Gäebel, W., et al. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr083 · Cited by 66 · see citing works
Hutton, P., Bowe, S. E., Parker, S., & Ford, S. (2011) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2011.00302.x · Cited by 65 · see citing works
Self-citationShould attenuated psychosis syndrome be included in DSM-5?
Fusar‐Poli, P., & Yung, A. R. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61507-9 · Cited by 62 · see citing works
Bechdolf, A., Wagner, M., Veith, V., Ruhrmann, S., Pukrop, R., Brockhaus‐Dumke, A., Berning, J., Stamm, E., Janssen, B., Decker, P., et al. (2007) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2007.00013.x · Cited by 61 · see citing works
Mallett, S. V., & Clarke, M. J. (2002) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462302000624 · Cited by 55 · see citing works
O’Brien, M. P., Zinberg, J. L., Bearden, C. E., Daley, M. L., Niendam, T. A., Kopelowicz, A. J., & Cannon, T. D. (2007) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2007.00046.x · Cited by 51 · see citing works
Assuring That Double-Blind Is Blind
Perlis, R. H., Ostacher, M. J., D, M. F. M., Nierenberg, A. A., Sachs, G. S., & Rosenbaum, J. F. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09060820 · Cited by 50 · see citing works
The effects of guided discontinuation of antipsychotics on neurocognition in first onset psychosis
Faber, G., Smid, H. G. O. M., Gool, A. R. V., Wiersma, D., & van den Bosch, R. J. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2011.02.003 · Cited by 50 · see citing works
Adverse Effects of Cognitive Behavioral Therapy and Cognitive Remediation in Schizophrenia
Klingberg, S., Herrlich, J., Wiedemann, G., Wölwer, W., Meisner, C., Engel, C., Jakobi, U. E., Buchkremer, G., & Wittorf, A. (2012) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e31825bfa1d · Cited by 48 · see citing works
Content and Quality of 10 000 Controlled Trials in Schizophrenia Over 60 Years
Miyar, J., & Adams, C. E. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr140 · Cited by 47 · see citing works
Klingberg, S., Wittorf, A., Meisner, C., Wölwer, W., Wiedemann, G., Herrlich, J., Bechdolf, A., Müller, B. W., Sartory, G., Wagner, M., et al. (2010) · Trials · doi:10.1186/1745-6215-11-123 · Cited by 34 · see citing works
Schlosser, D. A., Miklowitz, D. J., O’Brien, M. P., Silva, S. D. D., Zinberg, J. L., & Cannon, T. D. (2011) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2011.00317.x · Cited by 33 · see citing works
Niemeyer, H., Musch, J., & Pietrowsky, R. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.03.023 · Cited by 31 · see citing works
Chuma, J., & Mahadun, P. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.086868 · Cited by 31 · see citing works
Bowie, C. R., McLaughlin, D., Carrión, R. E., Auther, A. M., & Cornblatt, B. A. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.02.008 · Cited by 30 · see citing works
Zimbron, J., de Azúa, S. R., Khandaker, G. M., Gandamaneni, P. K., Crane, C. M., González-Pinto, A. M., Štochl, J., Jones, P. B., & Pérez, J. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12000 · Cited by 27 · see citing works
Prescription of antipsychotic medication to patients at ultra high risk of developing psychosis
Nieman, D. H., Rike, W. H., Becker, H. E., Dingemans, P. M. A. J., van Amelsvoort, T., de Haan, L., van der Gaag, M., Denys, D. A. J. P., & LINSZEN, D. H. (2009) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e32832e0a76 · Cited by 24 · see citing works
COGNITIVE THERAPY FOR PREVENTING TRANSITION TO PSYCHOSIS IN HIGH RISK INDIVIDUALS: A CASE SERIES
French, P., Morrison, A. P., Walford, L., Knight, A., & Bentall, R. P. (2003) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s1352465803001061 · Cited by 21 · see citing works
Early Detection and Intervention in Psychosis
Riecher‐Rössler, A., & McGorry, P. D. (2016) · Key issues in mental health (Online)/Key issues in mental health (Print) · doi:10.1159/000440924 · Cited by 14 · see citing works
DSM‐5 and the ‘Psychosis Risk Syndrome’: Whose best interests would it serve?
Morrison, A. P., Byrne, R. E., & Bentall, R. P. (2010) · Psychosis · doi:10.1080/17522431003759982 · Cited by 11 · see citing works
Systematic reviews - A perspective on benefits and concerns in 2011. Safe, sound and sorted?
Bushe, C. (2011) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2011.02737.x · Cited by 5 · see citing works
van der Gaag, M., Nieman, D. H., Wunderink, L., et al. (2012) · Schizophrenia Research · doi:10.1016/s0920-9964(12)70058-0 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mental Health Smartphone Apps: Review and Evidence-Based Recommendations for Future Developments
Bakker, D., Kazantzis, N., Rickwood, D., & Rickard, N. (2016) · JMIR Mental Health · doi:10.2196/mental.4984 · Cited by 886 · see citing works
EPA guidance on the early intervention in clinical high risk states of psychoses
Schmidt, S. J., Schultze-Lutter, F., Schimmelmann, B. G., Maric, N. P., Salokangas, R. K. R., Riecher-Rössler, A., van der Gaag, M., Meneghelli, A., Nordentoft, M., Marshall, M., et al. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.01.013 · Cited by 585 · see citing works
Prevention of Psychosis: Advances in Detection, Prognosis, and Intervention
Fusar-Poli, P., Salazar de Pablo, G., Correll, C. U., Meyer-Lindenberg, A., Millan, M. J., Borgwardt, S., Galderisi, S., Bechdolf, A., Pfennig, A., Kessing, L. V., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.4779 · Cited by 476 · see citing works
Ebert, D. D., Cuijpers, P., Muñoz, R. F., & Baumeister, H. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00116 · Cited by 244 · see citing works
Lack of evidence to favor specific preventive interventions in psychosis: a network meta‐analysis
Davies, C., Cipriani, A., Ioannidis, J. P. A., Radua, J., Stahl, D., Provenzani, U., McGuire, P., & Fusar‐Poli, P. (2018) · World Psychiatry · doi:10.1002/wps.20526 · Cited by 229 · see citing works
Mei, C., van der Gaag, M., Nelson, B., Smit, F., Yuen, H. P., Berger, M., Krcmar, M., French, P., Amminger, G. P., Bechdolf, A., et al. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102005 · Cited by 143 · see citing works
Alvarez-Jimenez, M., Gleeson, J. F., Bendall, S., Penn, D. L., Yung, A. R., Ryan, R. M., Eleftheriadis, D., D'Alfonso, S., Rice, S., Miles, C., et al. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.07.022 · Cited by 118 · see citing works
Preventive Treatments for Psychosis: Umbrella Review (Just the Evidence)
Fusar-Poli, P., Davies, C., Solmi, M., Brondino, N., De Micheli, A., Kotlicka-Antczak, M., Shin, J. I., & Radua, J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00764 · Cited by 108 · see citing works
Davies, C., Radua, J., Cipriani, A., Stahl, D., Provenzani, U., McGuire, P., & Fusar-Poli, P. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00187 · Cited by 107 · see citing works
Metacognitive and cognitive-behavioral interventions for psychosis: new developments.
Moritz, S., Klein, J. P., Lysaker, P. H., & Mehl, S. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.3/smoritz · Cited by 101 · see citing works
Wood, L., Byrne, R., Varese, F., & Morrison, A. P. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.05.001 · Cited by 93 · see citing works
Murray, G., Leitan, N. D., Thomas, N., Michalak, E. E., Johnson, S. L., Jones, S., Perich, T., Berk, L., & Berk, M. (2017) · Clinical Psychology Review · doi:10.1016/j.cpr.2017.01.002 · Cited by 87 · see citing works
Fusar-Poli, P., Frascarelli, M., Valmaggia, L., Byrne, M., Stahl, D., Rocchetti, M., Codjoe, L., Weinberg, L., Tognin, S., Xenaki, L., et al. (2015) · Psychological Medicine · doi:10.1017/s003329171400244x · Cited by 73 · see citing works
Psychosis Risk and Development: What Do We Know From Population-Based Studies?
Mennigen, E., & Bearden, C. E. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.12.014 · Cited by 40 · see citing works
The critical need for help-seeking controls in clinical high-risk research
Millman, Z. B., Gold, J. M., Mittal, V. A., & Schiffman, J. (2019) · Clinical Psychological Science · doi:10.1177/2167702619855660 · Cited by 33 · see citing works
Self-Help Interventions for Psychosis: A Meta-Analysis
Scott, A. J., Webb, T. L., & Rowse, G. (2015) · Clinical Psychology Review · doi:10.1016/j.cpr.2015.05.002 · Cited by 33 · see citing works
Interpretation Biases in Clinical Paranoia
Savulich, G., Shergill, S. S., & Yiend, J. (2017) · Clinical Psychological Science · doi:10.1177/2167702617718180 · Cited by 26 · see citing works
The rise of artificial intelligence for cognitive behavioral therapy: A bibliometric overview
Vanhée, L., Andersson, G., Garcia, D., & Sikström, S. (2025) · Applied Psychology Health and Well-Being · doi:10.1111/aphw.70033 · Cited by 14 · see citing works
- Authors
- Hutton, P., & Taylor, P. J.
- Affiliations
- Greater Manchester Mental Health NHS Foundation Trust (GB)
- University of Manchester (GB)
- Corresponding author
- Hutton, P.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013-03-22
- Volume
- 44
- Issue
- 3
- Pages
- 449-468
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2101845848
- Cited by
- 184
- References
- 86
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 9 · 2023: 13 · 2022: 7 · 2021: 11 · 2020: 16 · 2019: 21 · 2018: 18 · 2017: 16 · 2016: 20 · 2015: 20 · 2014: 16 · 2013: 1
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Edinburgh Napier Research Repository (Edinburgh Napier University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Assessments
- Keywords
- cognitive behavioral therapy, psychosis prevention, transition to psychosis, high-risk individuals, subthreshold symptoms, psychosocial interventions, clinical equipoise, depression, social anxiety, quality of life
- MeSH terms
- Anxiety Disorders, Depressive Disorder, Humans, Psychotic Disorders, Quality of Life, Risk, Social Adjustment, Time Factors, Cognitive Behavioral Therapy, Bias, Randomized Controlled Trials as Topic, Treatment Outcome, Disease Progression, Therapeutic Equipoise, Numbers Needed To Treat, Prodromal Symptoms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
