Cited by 196Birth, Development, and HealthChild Nutrition and Water AccessInfant Nutrition and Health

Early childhood growth failure and the developmental origins of adult disease: do enteric infections and malnutrition increase risk for the metabolic syndrome?

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DeBoer, Mark D, Lima, Aldo AM, Oría, Reinaldo B, Scharf, Rebecca J, Moore, Sean R, Luna, Max A, Guerrant, Richard L·2012·Nutrition Reviews

Abstract

Hypotheses regarding the developmental origins of health and disease postulate that developing fetuses - and potentially young children - undergo adaptive epigenetic changes that have longstanding effects on metabolism and other processes. Ongoing research explores whether these adaptations occur during early life following early childhood malnutrition. In the developing world, there remains a high degree of nutritional stunting, defined as linear growth failure caused by inadequate caloric intake, which may be exacerbated by inflammation from ongoing infections. In areas with poor sanitation, children experience vicious cycles of enteric infections and malnutrition, resulting in poor nutrient absorption as a result of changes in the intestinal mucosa, now termed "environmental enteropathy." Emerging evidence links early childhood diarrhea and/or growth failure with an increased occurrence of risk factors for cardiovascular disease in later life, including dyslipidemia, hypertension, and glucose intolerance. The mechanisms for these associations remain poorly understood and may relate to epigenetic responses to poor nutrition, increased inflammation, or both. Given the increased incidence of cardiovascular disease in developing areas of the world, associations between childhood malnutrition, early-life infections, and the increased occurrence of risk factors for cardiovascular disease underscore further reasons to improve nutrition and infection-related outcomes for young children worldwide.

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Crossref · 10.1111/j.1753-4887.2012.00543.x

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  1. [47]Mitchell J The long term association of early childhood diarrhea with school success: A case study from Pakistan Journal of Education for International Development 2006 2 2 1 11

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Authors
DeBoer, M. D., Lima, A. A., Oría, R. B., Scharf, R. J., Moore, S. R., Luna, M. A., & Guerrant, R. L.
Affiliations
  • University of Virginia (US)
  • Cincinnati Children's Hospital Medical Center (US)
Venue
Nutrition Reviews
Published
2012-10-30
Volume
70
Issue
11
Pages
642-653
ISSN
0029-6643 (ISSN-L)
OpenAlex
W2158886196
Cited by
196
References
93
Citations by year
2026: 5 · 2025: 8 · 2024: 11 · 2023: 11 · 2022: 9 · 2021: 15 · 2020: 13 · 2019: 15 · 2018: 39 · 2017: 20 · 2016: 17 · 2015: 7 · 2014: 16 · 2013: 9 · 2012: 1
FWCI
1.65
Type
journal article
Language
en
Open access
Locations
  • Nutrition Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • Fogarty International Center (K02TW008767)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (K08HD060739)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Child Nutrition and Water Access
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords
developmental origins of health and disease, metabolic syndrome, child malnutrition, gastrointestinal infections, environmental enteropathy, epigenetic adaptation, inflammation, cardiovascular risk factors, dyslipidemia, hypertension, impaired glucose tolerance, intestinal mucosa
MeSH terms
Adult, Child, Child, Preschool, Diarrhea, Failure to Thrive, Humans, Infant, Infant, Newborn, Intestinal Absorption, Nutritional Physiological Phenomena, Child Nutrition Disorders, Metabolic Syndrome, Epigenesis, Genetic

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