The DOI matches its Crossref record.
Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent
Abstract
Some pharmacological actions of curcumin (diferuloyl methane) have been examined in rats, mice and cats. The compound possesses significant anti-inflammatory activity in acute as well as in chronic models of inflammation. It is as potent as phenylbutazone in the carrageenan oedema test but only half as potent in chronic tests. Curcumin possesses a much lower ulcerogenic index than phenylbutazone. It prevents the inflammation induced increase in SGOT and SGPT levels. It lacks analgesic and antipyretic activity. It has no other significant pharmacological effects. The oral LD50 in mice is more than 2ṁ0 g kg−1.
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Cited by
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543
Multiple biological activities of curcumin: A short review
Maheshwari, R. K., Singh, A. K., Gaddipati, J., & Srimal, R. C. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.12.007 · Cited by 1,674
Self-citationLim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530
Safety and Anti-Inflammatory Activity of Curcumin: A Component of Tumeric ( Curcuma longa )
Chainani-Wu, N. (2003) · The Journal of Alternative and Complementary Medicine · doi:10.1089/107555303321223035 · Cited by 1,106
Biological activities of Curcuma longa L.
Araújo, C., & Leon, L. (2001) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762001000500026 · Cited by 766
Surh, Y.-J. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s1383-5742(99)00057-5 · Cited by 633
Awasthi, H., Tota, S., Hanif, K., Nath, C., & Shukla, R. (2010) · Life Sciences · doi:10.1016/j.lfs.2009.11.007 · Cited by 86
Metadata
- Authors
- Srimal, R. C., & Dhawan, B. N.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 1973-06-01
- Volume
- 25
- Issue
- 6
- Pages
- 447-452
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W2104989681
- Cited by
- 674
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
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