Independent and Combined Effects of Physical Activity and Weight Loss on Inflammatory Biomarkers in Overweight and Obese Older Adults
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Objectives: To determine the independent effect of long‐term physical activity ( PA ) and the combined effects of long‐term PA and weight loss ( WL ) on inflammation in overweight and obese older adults. Design: Eighteen‐month randomized, controlled trial. Setting: The community infrastructure of cooperative extension centers. Participants: Overweight and obese (body mass index >28.0 kg/m 2 ) community‐dwelling men and women aged 60 to 79 at risk for cardiovascular disease ( CVD ). Intervention: Physical activity + weight loss (PA + WL) (n = 98), PA only (n = 97), or successful aging ( SA ) health education (n = 93) intervention. Measurements: Biomarkers of inflammation (adiponectin, leptin, high‐sensitivity interleukin (hs IL )‐6, IL ‐6s R , IL ‐8, and soluble tumor necrosis factor receptor 1) were measured at baseline and 6 and 18 months. Results: After adjustment for baseline biomarker, wave, sex, and visit, leptin and hsIL‐6 showed a significant intervention effect. Specifically, leptin was significantly lower in the PA + WL group (21.3 ng/mL, 95% confidence interval ( CI ) = 19.7–22.9 ng/mL) than in the PA (29.3 ng/mL, 95% CI = 26.9–31.8 ng/mL) or SA (30.3 ng/mL, 95% CI = 27.9–32.8 ng/mL) group (both P < .001), and hs IL ‐6 was significantly lower in the PA + WL group (2.1 pg/mL, 95% CI = 1.9–2.3 pg/mL) than in the PA (2.5 pg/mL, 95% CI = 2.3–2.7 pg/mL) or SA (2.4 pg/mL, 95% CI = 2.2–2.6 pg/mL) group ( P = .02). Conclusion: Addition of dietary‐induced WL to PA reduced leptin and hs IL ‐6 more than PA alone and more than a SA intervention in older adults at risk for CVD . Results suggest that WL , rather than increased PA , is the lifestyle factor primarily responsible for improvement in the inflammatory profile.
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The addition of weight loss of 0.3 kg per week for 6 months to physical activity in older community-dwelling adults with obesity or overweight results in a greater reduction in serum levels of leptin and IL-6 than either physical activity alone or a successful ageing health education intervention.
“The addition of weight loss of 0.3 kg per week for 6 months to physical activity in older community-dwelling adults with obesity or overweight results in a greater reduction in serum levels of leptin and IL-6 than either physical activity alone or a successful ageing health education intervention308.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [308]
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- Authors
- Beavers, K. M., Ambrosius, W. T., Nicklas, B. J., & Rejeski, W. J.
- Affiliations
- Wake Forest University Health Sciences (US)
- Wake Forest University (US)
- Corresponding author
- Beavers, Kristen M.
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2013-06-17
- Volume
- 61
- Issue
- 7
- Pages
- 1089-1094
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- PMC
- PMC3714323
- OpenAlex
- W1987834895
- Cited by
- 70
- References
- 32
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 8 · 2021: 10 · 2020: 2 · 2019: 11 · 2018: 6 · 2017: 8 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 1
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wake Forest School of Medicine
- National Institute on Aging (F32AG039186, P30AG021332)
- National Heart, Lung, and Blood Institute (HL076441-01A1, R18HL076441, R01HL076441)
- National Center for Research Resources (M01RR007122)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- weight loss, inflammation, inflammatory markers, leptin, interleukin-6, older adults, obesity, overweight, successful aging, cardiovascular risk, dietary intervention, adiponectin, soluble tumor necrosis factor receptor 1
- MeSH terms
- Aged, Analysis of Variance, Community Health Centers, Diet, Reducing, Female, Humans, Inflammation, Male, Middle Aged, North Carolina, Obesity, Biomarkers, Weight Loss, Exercise, Interleukin-6, Interleukin-8, Treatment Outcome, Leptin, Receptors, Tumor Necrosis Factor, Type I, Overweight, Adiponectin
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