Impact of Apolipoprotein E4 Polymorphism on the Gray Matter Volume and the White Matter Integrity in Subjective Memory Impairment without White Matter Hyperintensities: Voxel‐Based Morphometry and Tract‐Based Spatial Statistics Study under 3‐Tesla MRI
Abstract
OBJECTIVE: The aim of this study is to compare gray matter (GM) volume and white matter (WM) integrity in Apolipoprotein E4 (ApoE ε4) carriers with that of ApoE ε4 noncarriers using the voxel‐based morphometry and diffusion tensor imaging (DTI) to investigate the effect of the ApoE ε4 on brain structures in subjective memory impairment (SMI) without white matter hyperintensities (WMH). METHODS: Altogether, 26 participants with SMI without WMH were finally recruited from the Memory impairment clinics of Pusan National University Hospital in Korea. All participants were ApoE genotyped (ApoE ε4 carriers: n = 13, matched ApoE ε4 noncarriers: n = 13) and underwent 3‐tesla magnetic resonance imaging (MRI) including 3‐dimensional volumetric images for GM volume and DTI for WM integrity. RESULTS: ApoE ε4 carriers compared with noncarriers in SMI without WMH showed the atrophy of GM in inferior temporal gyrus, inferior parietal lobule, anterior cingulum, middle frontal gyrus, and precentral gyrus and significantly lower fractional anisotropy WM values in the splenium of corpus callosum and anterior corona radiate. CONCLUSION: Our findings suggest that the ApoE ε4 is associated with both atrophy of GM volume and disruption of WM integrity in SMI without WMH.
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ApoE ɛ4 carriers in SCD populations showed lower FA in the splenium of the corpus callosum and the anterior corona radiata than noncarriers.
“For instance, compared with noncarriers, ApoE ɛ4 carriers in SCD populations showed lower FA in the splenium of the corpus callosum and the anterior corona radiata [117].”
From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [117]
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- Authors
- Lee, Y., Ha, J., Park, J., Lee, B., Moon, E., Chung, Y., Kim, J., Kim, H., Mun, C., Kim, T., & Kim, Y.
- Affiliations
- Pusan National University Hospital (KR)
- Pusan National University (KR)
- Inje University (KR)
- Inje University Haeundae Paik Hospital (KR)
- Corresponding author
- Park, Je‐Min
- ORCID
- Venue
- Journal of Neuroimaging
- Publisher
- Wiley
- Published
- 2015-02-11
- Volume
- 26
- Issue
- 1
- Pages
- 144-149
- ISSN
- 1051-2284 (ISSN-L)
- 1552-6569
- OpenAlex
- W2042426531
- Cited by
- 26
- References
- 36
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Biomedical Research Institute (2014-16)
- Pusan National University Hospital
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- APOE ε4, APOE ε4 carriers, subjective memory impairment, gray matter volume, white matter integrity, white matter hyperintensities, fractional anisotropy, brain atrophy, corpus callosum, corona radiata, inferior temporal gyrus, inferior parietal lobule, anterior cingulate cortex, diffusion tensor imaging
- MeSH terms
- Aged, Brain, Female, Genotype, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Middle Aged, Organ Size, Imaging, Three-Dimensional, Apolipoprotein E4, Diffusion Tensor Imaging, White Matter, Gray Matter
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