The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Essential oils and their constituents as skin penetration enhancer for transdermal drug delivery: a review
Abstract
Objectives: In this paper, we focused on essential oils and their constituents as skin penetration enhancers for transdermal drug delivery, mechanism of their action as well as their possible toxicity. Key findings: Essential oils and their volatile constituents can penetrate through the skin as well as enhance penetration of different drug from topical formulation into the lower skin layers using different mechanisms of action based on (1) disintegration of the highly ordered intercellular lipid structure between corneocytes in stratum corneum, (2) interaction with intercellular domain of protein, which induces their conformational modification, (3) increase the partitioning of a drug. After application to the skin, essential oils and their components are rapidly metabolized, not accumulated in the organism and fast excreted what strongly suggest that they can be successfully use as safe penetration enhancers. Summary: Essential oils and their constituents may be preferred over the traditionally used synthetics materials as safe and suitable permeation enhancers to promote the percutaneous absorption of hydrophilic and lipophilic drugs from topical formulation into the lower skin layers.
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Cites
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Repellent activity of essential oils: A review
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Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
Miguel, M. G. (2010) · Molecules · doi:10.3390/molecules15129252 · Cited by 933 · cited 1×
“They possess antioxidant and antiinflammatory activity,([2]) anticancer activity,([3]) promote wound healing,([4]) can replace conventionally used preservatives,([5]) pesticide([6]) and play many others biological roles.”
BackgroundHerbal Medicines: A Guide for Healthcare Professionals
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Transdermal skin delivery: Predictions for humans from in vivo, ex vivo and animal models☆
GODIN, B., & TOUITOU, E. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.07.004 · Cited by 675
Antimicrobial and Cytotoxic Activities of Origanum Essential Oils
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Terpenes and the Lipid–Protein–Partitioning Theory of Skin Penetration Enhancement
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Cited by
Overcoming skin barriers through advanced transdermal drug delivery approaches
Phatale, V., Vaiphei, K. K., Jha, S., Patil, D., Agrawal, M., & Alexander, A. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.025 · Cited by 482
α-Terpineol, a natural monoterpene: A review of its biological properties
Khaleel, C., Tabanca, N., & Buchbauer, G. (2018) · Open Chemistry · doi:10.1515/chem-2018-0040 · Cited by 325
Nanoemulsions of essential oils to improve solubility, stability and permeability: a review
Barradas, T. N., & de Holanda e Silva, K. G. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-020-01142-2 · Cited by 308
Linalool bioactive properties and potential applicability in drug delivery systems
Pereira, I., Severino, P., Santos, A. C., Silva, A. M., & Souto, E. B. (2018) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2018.08.001 · Cited by 267
Strat-M® synthetic membrane: Permeability comparison to human cadaver skin
Haq, A., Goodyear, B., Ameen, D., Joshi, V., & Michniak-Kohn, B. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.06.012 · Cited by 231
Metadata
- Authors
- Herman, A., & Herman, A. P.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-04-01
- Volume
- 67
- Issue
- 4
- Pages
- 473-485
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W1596484490
- Cited by
- 338
- References
- 52
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Herman, A., & Herman, A. P. (2015). Essential oils and their constituents as skin penetration enhancer for transdermal drug delivery: a review. Journal of Pharmacy and Pharmacology. https://doi.org/10.1111/jphp.12334
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
