The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Essential oils and their constituents as skin penetration enhancer for transdermal drug delivery: a review
Abstract
Objectives: In this paper, we focused on essential oils and their constituents as skin penetration enhancers for transdermal drug delivery, mechanism of their action as well as their possible toxicity. Key findings: Essential oils and their volatile constituents can penetrate through the skin as well as enhance penetration of different drug from topical formulation into the lower skin layers using different mechanisms of action based on (1) disintegration of the highly ordered intercellular lipid structure between corneocytes in stratum corneum, (2) interaction with intercellular domain of protein, which induces their conformational modification, (3) increase the partitioning of a drug. After application to the skin, essential oils and their components are rapidly metabolized, not accumulated in the organism and fast excreted what strongly suggest that they can be successfully use as safe penetration enhancers. Summary: Essential oils and their constituents may be preferred over the traditionally used synthetics materials as safe and suitable permeation enhancers to promote the percutaneous absorption of hydrophilic and lipophilic drugs from topical formulation into the lower skin layers.
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Cites
Williams, A. C., & Barry, B. W. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.025 · Cited by 1,746
Lane, M. E. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.02.040 · Cited by 1,486
Repellent activity of essential oils: A review
Nerio, L. S., Olivero-Verbel, J., & Stashenko, E. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2009.07.048 · Cited by 1,303
Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
Miguel, M. G. (2010) · Molecules · doi:10.3390/molecules15129252 · Cited by 933 · cited 1×
“They possess antioxidant and antiinflammatory activity,([2]) anticancer activity,([3]) promote wound healing,([4]) can replace conventionally used preservatives,([5]) pesticide([6]) and play many others biological roles.”
BackgroundHerbal Medicines: A Guide for Healthcare Professionals
Newall, C. A., Anderson, L. A., & Phillipson, J. D. (1996) · Medical Entomology and Zoology · Cited by 842
Williams, A. C., & Barry, B. W. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.032 · Cited by 715
Transdermal skin delivery: Predictions for humans from in vivo, ex vivo and animal models☆
GODIN, B., & TOUITOU, E. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.07.004 · Cited by 675
Antimicrobial and Cytotoxic Activities of Origanum Essential Oils
Sivropoulou, A., Papanikolaou, E., Nikolaou, C., Kokkini, S., Lanaras, T., & Arsenakis, M. (1996) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf950540t · Cited by 666
Terpenes and the Lipid–Protein–Partitioning Theory of Skin Penetration Enhancement
Williams, A. C., & Barry, B. W. (1991) · Pharmaceutical Research · doi:10.1023/a:1015813803205 · Cited by 550
Reichling, J., Schnitzler, P., Suschke, U., & Saller, R. (2009) · Complementary Medicine Research · doi:10.1159/000207196 · Cited by 482
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Overcoming skin barriers through advanced transdermal drug delivery approaches
Phatale, V., Vaiphei, K. K., Jha, S., Patil, D., Agrawal, M., & Alexander, A. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.025 · Cited by 482
α-Terpineol, a natural monoterpene: A review of its biological properties
Khaleel, C., Tabanca, N., & Buchbauer, G. (2018) · Open Chemistry · doi:10.1515/chem-2018-0040 · Cited by 325
Nanoemulsions of essential oils to improve solubility, stability and permeability: a review
Barradas, T. N., & de Holanda e Silva, K. G. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-020-01142-2 · Cited by 308
Linalool bioactive properties and potential applicability in drug delivery systems
Pereira, I., Severino, P., Santos, A. C., Silva, A. M., & Souto, E. B. (2018) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2018.08.001 · Cited by 267
Strat-M® synthetic membrane: Permeability comparison to human cadaver skin
Haq, A., Goodyear, B., Ameen, D., Joshi, V., & Michniak-Kohn, B. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.06.012 · Cited by 231
Essential oils as multicomponent mixtures and their potential for human health and well-being
Bunse, M., Daniels, R., Gründemann, C., Heilmann, J., Kammerer, D. R., Keusgen, M., Lindequist, U., Melzig, M. F., Morlock, G. E., Schulz, H., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.956541 · Cited by 210
“Apart from the chemical EO composition, the absorption of EOs through the skin is dependent on several further factors, such as temperature, hydration, pressure, specific skin condition, skin microbiome, and age (Buck, 2004; Schmitt et al., 2009; Schommer and Gallo, 2013; Herman and Herman, 2015).”
BackgroundQindeel, M., Khan, D., Ahmed, N., Khan, S., & Asim.ur.Rehman (2020) · ACS Nano · doi:10.1021/acsnano.0c00364 · Cited by 155
Nanostructuring Lipid Carriers Using Ridolfia segetum (L.) Moris Essential Oil
Miranda, M., Cruz, M. T., Vitorino, C., & Cabral, C. (2019) · Materials Science and Engineering: C · doi:10.1016/j.msec.2019.109804 · Cited by 45
Augmenting the Activity of Chlorhexidine for Decolonization of Candida auris from Porcine skin
Johnson, C. J., Eix, E. F., Lam, B. C., Wartman, K. M., Meudt, J. J., Shanmuganayagam, D., & Nett, J. E. (2021) · Journal of Fungi · doi:10.3390/jof7100804 · Cited by 45
Anti-Inflammatory Effect of Chamaecyparis obtusa (Siebold & Zucc.) Endl. Leaf Essential Oil
Kim, S.-H., Jang, Y.-A., & Kwon, Y.-J. (2024) · Molecules · doi:10.3390/molecules29051117 · Cited by 10
Metadata
- Authors
- Herman, A., & Herman, A. P.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-04-01
- Volume
- 67
- Issue
- 4
- Pages
- 473-485
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W1596484490
- Cited by
- 338
- References
- 52
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- closed
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