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Essential oils and their constituents as skin penetration enhancer for transdermal drug delivery: a review
Abstract
Objectives: In this paper, we focused on essential oils and their constituents as skin penetration enhancers for transdermal drug delivery, mechanism of their action as well as their possible toxicity. Key findings: Essential oils and their volatile constituents can penetrate through the skin as well as enhance penetration of different drug from topical formulation into the lower skin layers using different mechanisms of action based on (1) disintegration of the highly ordered intercellular lipid structure between corneocytes in stratum corneum, (2) interaction with intercellular domain of protein, which induces their conformational modification, (3) increase the partitioning of a drug. After application to the skin, essential oils and their components are rapidly metabolized, not accumulated in the organism and fast excreted what strongly suggest that they can be successfully use as safe penetration enhancers. Summary: Essential oils and their constituents may be preferred over the traditionally used synthetics materials as safe and suitable permeation enhancers to promote the percutaneous absorption of hydrophilic and lipophilic drugs from topical formulation into the lower skin layers.
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Cites
Williams, A. C., & Barry, B. W. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.025 · Cited by 1,746
Lane, M. E. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.02.040 · Cited by 1,486
Repellent activity of essential oils: A review
Nerio, L. S., Olivero-Verbel, J., & Stashenko, E. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2009.07.048 · Cited by 1,303
Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
Miguel, M. G. (2010) · Molecules · doi:10.3390/molecules15129252 · Cited by 933 · cited 1×
“They possess antioxidant and antiinflammatory activity,([2]) anticancer activity,([3]) promote wound healing,([4]) can replace conventionally used preservatives,([5]) pesticide([6]) and play many others biological roles.”
BackgroundHerbal Medicines: A Guide for Healthcare Professionals
Newall, C. A., Anderson, L. A., & Phillipson, J. D. (1996) · Medical Entomology and Zoology · Cited by 842
Williams, A. C., & Barry, B. W. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.032 · Cited by 715
Transdermal skin delivery: Predictions for humans from in vivo, ex vivo and animal models☆
GODIN, B., & TOUITOU, E. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.07.004 · Cited by 675
Antimicrobial and Cytotoxic Activities of Origanum Essential Oils
Sivropoulou, A., Papanikolaou, E., Nikolaou, C., Kokkini, S., Lanaras, T., & Arsenakis, M. (1996) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf950540t · Cited by 666
Terpenes and the Lipid–Protein–Partitioning Theory of Skin Penetration Enhancement
Williams, A. C., & Barry, B. W. (1991) · Pharmaceutical Research · doi:10.1023/a:1015813803205 · Cited by 550
Reichling, J., Schnitzler, P., Suschke, U., & Saller, R. (2009) · Complementary Medicine Research · doi:10.1159/000207196 · Cited by 482
Biological properties of essential oils: an updated review
Adorjan, B., & Buchbauer, G. (2010) · Flavour and Fragrance Journal · doi:10.1002/ffj.2024 · Cited by 477
Design principles of chemical penetration enhancers for transdermal drug delivery
Karande, P., Jain, A., Ergun, K., Kispersky, V., & Mitragotri, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501176102 · Cited by 399
Enhancement of transdermal drug delivery via synergistic action of chemicals
Karande, P., & Mitragotri, S. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.08.015 · Cited by 399
Ka, H., Park, H.-J., Jung, H.-J., Choi, J.-W., Cho, K.-S., Ha, J., & Lee, K.-T. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00238-6 · Cited by 360
Chemical Penetration Enhancers for Transdermal Drug Delivery Systems
Pathan, I., & Setty, C. (2009) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v8i2.44527 · Cited by 270
Cytotoxicity of clove (Syzygium aromaticum) oil and its major components to human skin cells
Prashar, A., Locke, I. C., & Evans, C. S. (2006) · Cell Proliferation · doi:10.1111/j.1365-2184.2006.00384.x · Cited by 260
Cytotoxicity of lavender oil and its major components to human skin cells
Prashar, A., Locke, I. C., & Evans, C. S. (2004) · Cell Proliferation · doi:10.1111/j.1365-2184.2004.00307.x · Cited by 242
Temoporfin-loaded invasomes: Development, characterization and in vitro skin penetration studies
Dragicevic-Curic, N., Scheglmann, D., Albrecht, V., & Fahr, A. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.013 · Cited by 231
Transdermal drug delivery of imipramine hydrochloride. I. Effect of terpenes
Jain, A. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00524-7 · Cited by 224
Melissa officinalis L. essential oil: antitumoral and antioxidant activities
de Sousa, A. C., Alviano, D. S., Blank, A. F., Alves, P. B., Alviano, C. S., & Gattass, C. R. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357023321 · Cited by 216
Percutaneous Penetration Enhancers: Overview
Zhai, H., Maibach, H., & Thong, H.-Y. (2007) · Dermatotoxicology, Seventh Edition · doi:10.1201/9781420009774.ch5 · Cited by 216
Loizzo, M. R., Tundis, R., Menichini, F., Saab, A. M., Statti, G. A., & Menichini, F. (2007) · PubMed · Cited by 205
Hayes, A. J., & Markovic, B. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(01)00103-x · Cited by 202
Species Differences in Percutaneous Absorption of Nicorandil
Sato, K., Sugibayashi, K., & Morimoto, Y. (1991) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600800203 · Cited by 188
Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use
Amnuaikit, C., Ikeuchi, I., Ogawara, K.-I., Higaki, K., & Kimura, T. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.11.007 · Cited by 161
In vitro percutaneous absorption enhancement of a lipophilic drug tamoxifen by terpenes
Gao, S., & Singh, J. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00168-5 · Cited by 155
Percutaneous absorption of lavender oil from a massage oil
Jäger, W. R., Buchbauer, G., Jirovetz, L., & Fritzer, M. (1992) · Journal of the Society of Cosmetic Chemists · Cited by 151
Terpene microemulsions for transdermal curcumin delivery: Effects of terpenes and cosurfactants
Liu, C., Chang, F.-Y., & Hung, D.-K. (2010) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2010.08.018 · Cited by 150
Essential Oils and Herbal Extracts as Antimicrobial Agents in Cosmetic Emulsion
Herman, A., Herman, A. P., Domagalska, B. W., & Młynarczyk, A. (2013) · Indian Journal of Microbiology · doi:10.1007/s12088-012-0329-0 · Cited by 146
Self-citationMelaleuca oil (tea tree oil) dermatitis
Knight, T. E., & Hausen, B. M. (1994) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(94)70050-8 · Cited by 144
Slameňová, D., Horváthová, E., Wsólová, L., Šrámková, M., & Navarová, J. (2009) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2009.05.016 · Cited by 141
Influence of Drug Lipophilicity on Terpenes as Transdermal Penetration Enhancers
Godwin, D., & Michniak, B. B. (1999) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-100102251 · Cited by 138
FARTASCH, M., Bassukas, I. D., & DIEPGKN, T. L. (1993) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1993.tb00138.x · Cited by 122
In vitro Cytotoxicity of Australian Tea Tree Oil using Human Cell Lines
Hayes, A. J., Leach, D. N., Markham, J. L., & Markovic, B. (1997) · Journal of Essential Oil Research · doi:10.1080/10412905.1997.9700780 · Cited by 88
Monti, D., Chetoni, P., Burgalassi, S., Najarro, M., Saettone, M. F., & Boldrini, E. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00032-7 · Cited by 77
Modulating Effects of Thyme and Its Major Ingredients on Oxidative DNA Damage in Human Lymphocytes
DİLSİZ, S. A., Başaran, A., & Başaran, N. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0402375 · Cited by 76
The influence of essential oils on the process of wound healing: a review of the current evidence
Woollard, A., Tatham, K. C., & Barker, S. (2007) · Journal of Wound Care · doi:10.12968/jowc.2007.16.6.27064 · Cited by 71
Charoo, N. A., Shamsher, A. A. A., Kohli, K., et al. (2008) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2008.05.001 · Cited by 65
Clarys, P., Alewaeters, K., Jadoul, A., Barel, A., Manadas, R., & Véronique Préat, A. (1998) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(98)00044-7 · Cited by 64
Mechanism of transdermal transport of 5-fluorouracil by terpenes: carvone, 1,8-cineole and thymol
Gao, S., & Singh, J. (1997) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(97)00123-3 · Cited by 61
Horváthová, E., Šrámková, M., Lábaj, J., & Slameňová, D. (2006) · PubMed · Cited by 59
Skin Delivery of Ferulic Acid from Different Vesicular Systems
Chen, M., Liu, X., & Fahr, A. (2010) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2010.1154 · Cited by 57
Sœur, J., Marrot, L., Perez, P., Iraqui, I., Kienda, G., Dardalhon, M., Meunier, J., Averbeck, D., & Huang, M. (2010) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.10.009 · Cited by 52
Fang, J., Leu, Y., Hwang, T., & Cheng, H.-C. (2004) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.27.1819 · Cited by 52
Comparisons of different animal skins with human skin in drug percutaneous penetration studies.
Lin, S., Hou, S., Hsu, T. H., et al. (1992) · PubMed · Cited by 49
Ossmann, A., Kranz, S., Guellmar, A., Völpel, A., Albrecht, V., Fahr, A., & Sigusch, B. W. (2014) · Clinical Oral Investigations · doi:10.1007/s00784-014-1271-9 · Cited by 48
ヒト由来のHepG2,Caco-2およびVH10細胞株における植物の揮発性物質オイゲノールおよびボルネオールの抗酸化作用,細胞障害作用,DNA損傷作用およびDNA防御作用の検討
Slameňová, D., Horváthová, E., Ladislava, W., Monika, S., & Navarová, J. (2009) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · Cited by 47
α-Bisabolol, a possible safe penetration enhancer for dermal and transdermal therapeutics
Kadir, R., & Barry, B. W. (1991) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(91)90167-m · Cited by 46
Das, M. K., Bhattacharya, A., & Ghosal, S. K. (2006) · Drug Delivery · doi:10.1080/10717540500395064 · Cited by 41
Mittal, A., Sara, U. V. S., Ali, A., & Aqil, M. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1766 · Cited by 39
Inoue, S., Ishihara, H., Uchida, K., & Yamaguchi, H. (2000) · Aroma research · Cited by 14
Wang, L.-H., & Chen, J. (2009) · Microchimica Acta · doi:10.1007/s00604-009-0255-y · Cited by 9
Cited by
Overcoming skin barriers through advanced transdermal drug delivery approaches
Phatale, V., Vaiphei, K. K., Jha, S., Patil, D., Agrawal, M., & Alexander, A. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.025 · Cited by 482
α-Terpineol, a natural monoterpene: A review of its biological properties
Khaleel, C., Tabanca, N., & Buchbauer, G. (2018) · Open Chemistry · doi:10.1515/chem-2018-0040 · Cited by 325
Nanoemulsions of essential oils to improve solubility, stability and permeability: a review
Barradas, T. N., & de Holanda e Silva, K. G. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-020-01142-2 · Cited by 308
Linalool bioactive properties and potential applicability in drug delivery systems
Pereira, I., Severino, P., Santos, A. C., Silva, A. M., & Souto, E. B. (2018) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2018.08.001 · Cited by 267
Strat-M® synthetic membrane: Permeability comparison to human cadaver skin
Haq, A., Goodyear, B., Ameen, D., Joshi, V., & Michniak-Kohn, B. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.06.012 · Cited by 231
Metadata
- Authors
- Herman, A., & Herman, A. P.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-04-01
- Volume
- 67
- Issue
- 4
- Pages
- 473-485
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W1596484490
- Cited by
- 338
- References
- 52
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- closed
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