Modest sleep restriction does not influence steps, physical activity intensity or glucose tolerance in obese adults
Open accessAbstract
Sleep restriction (SR) (<6 h) and physical activity (PA) are risk factors for obesity, but little work has examined the inter‐related influences of both risk factors. In a free‐living environment, 13 overweight/obese adults were sleep restricted for five nights to 6 h time‐in‐bed each night, with and without regular exercise (45 min/65% VO 2 max; counterbalanced design). Two days of recovery sleep followed SR. Subjects were measured during a mixed meal tolerance test (MMT), resting metabolic rate, cognitive testing and fat biopsy (n=8). SR increased peak glucose response (+7.3 mg/dl, p = .04), elevated fasting non‐esterified fatty acid (NEFA) concentrations (+0.1 mmol/L, p = .001) and enhanced fat oxidation (p < .001) without modifying step counts or PA intensity. Inclusion of daily exercise increased step count (+4,700 steps/day, p < .001) and decreased the insulin response to a meal (p = .01) but did not prevent the increased peak glucose response or elevated NEFA levels. The weekend recovery period improved fasting glucose (p = .02), insulin (p = .02), NEFA concentrations (p = .001) and HOMA‐IR (p < .01) despite reduced steps (p < .01) and increased sedentary time (p < .01). Abdominal adipose tissue (AT) samples, obtained after baseline, SR and exercise, did not differ in lipolytic capacity following SR. Fatty acid synthase protein content tended to increase following SR (p = .07), but not following exercise. In a free‐living setting, SR adversely affected circulating NEFAs, fuel oxidation and peak glucose response but did not directly affect glucose tolerance or AT lipolysis. SR‐associated metabolic impairments were not mitigated by exercise, yet recovery sleep completely rescued its adverse effects on glucose metabolism.
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Porter et al. concluded that exercise is not an optimal strategy for ameliorating the negative effects of sleep restriction in individuals with obesity.
“Thus, Porter et al. concluded that exercise is not an optimal strategy for ameliorating the negative effects of sleep restriction in individuals with obesity.”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [157]
In individuals with obesity, sleep restriction increased peak glucose response but not 3-h glucose AUC during a meal tolerance test, elevated fasting NEFA, and increased fat oxidation and perceived stress; exercise did not normalise any of these outcomes.
“Sleep restriction increased the peak glucose response but not 3-h glucose AUC during a meal tolerance test, elevated fasting NEFA, and increased fat oxidation and perceived stress.However, exercise did not normalise any of these outcomes.”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [157]
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- Authors
- Porter, J. W., Pettit‐Mee, R. J., Emerson, T. S., McCrae, C. S., Lastra, G., Vieira‐Potter, V. J., Parks, E. J., & Kanaley, J. A.
- Affiliations
- University of Missouri (US)
- Corresponding author
- Kanaley, Jill A.
- ORCID
- Venue
- Journal of Sleep Research
- Publisher
- Wiley
- Published
- 2021-05-05
- Volume
- 30
- Issue
- 6
- Pages
- e13381-e13381
- ISSN
- 0962-1105 (ISSN-L)
- 1365-2869
- PMC
- PMC10315064
- OpenAlex
- W3158796827
- Cited by
- 10
- References
- 44
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Sleep Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (RO1 DK101513)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep restriction, obesity, physical activity, glucose tolerance, insulin resistance, free fatty acids, fat oxidation, step count, sedentary behavior, abdominal fat, lipolysis, fatty acid synthase, recovery sleep, mixed meal tolerance test, resting metabolic rate
- MeSH terms
- Adult, Blood Glucose, Glucose, Humans, Insulin, Obesity, Sleep, Exercise
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