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Review: The role of vitamin D in nervous system health and disease
Abstract
Vitamin D and its metabolites have pleomorphic roles in both nervous system health and disease. Animal models have been paramount in contributing to our knowledge and understanding of the consequences of vitamin D deficiency on brain development and its implications for adult psychiatric and neurological diseases. The conflation of in vitro, ex vivo, and animal model data provide compelling evidence that vitamin D has a crucial role in proliferation, differentiation, neurotrophism, neuroprotection, neurotransmission, and neuroplasticity. Vitamin D exerts its biological function not only by influencing cellular processes directly, but also by influencing gene expression through vitamin D response elements. This review highlights the epidemiological, neuropathological, experimental and molecular genetic evidence implicating vitamin D as a candidate in influencing susceptibility to a number of psychiatric and neurological diseases. The strength of evidence varies for schizophrenia, autism, P arkinson's disease, amyotrophic lateral sclerosis, A lzheimer's disease, and is especially strong for multiple sclerosis.
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Autism Spectrum Disorder and low vitamin D at birth: A sibling control study
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Vitamin D status and Parkinson's disease: a systematic review and meta-analysis
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Vitamin D and Neurotrophin Levels and Their Impact on the Symptoms of Schizophrenia
Peitl, V., Silić, A., Orlović, I., Vidrih, B., Crnković, D., & Karlović, D. (2020) · Neuropsychobiology · doi:10.1159/000504577 · Cited by 22
Metadata
- Authors
- DeLuca, G. C., Kimball, S. M., Kolasinski, J., Ramagopalan, S. V., & Ebers, G. C.
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 2013-07-09
- Volume
- 39
- Issue
- 5
- Pages
- 458-484
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W2150135472
- Cited by
- 326
- References
- 25
- FWCI
- 17.79
- Type
- journal article
- Language
- en
- Open access
- closed
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