Cited by 400Schizophrenia research and treatmentFunctional Brain Connectivity StudiesGenetic Associations and Epidemiology

Neural Mechanisms of a Genome-Wide Supported Psychosis Variant

Esslinger, Christine, Walter, Henrik, Kirsch, Peter, Erk, Susanne, Schnell, Knut, Arnold, Claudia, Haddad, Leila, Mier, Daniela +6 more·2009·Science

Abstract

A genetic polymorphism associated with schizophrenia conveys a risk for abnormal connectivity between brain regions.

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Crossref · 10.1126/science.1167768

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6 of 6 references verified0 citation errors · 0 not checkable

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  • The connectivity matrices are not dominated by simple coactivation during task blocks.

    “To ensure that the connectivity matrices are not dominated by simple coactivation during the task blocks, we have regressed out the task activation using a general linear model (GLM), consistent with our prior work (23, 35, 47, 52).”

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Authors
Esslinger, C., Walter, H., Kirsch, P., Erk, S., Schnell, K., Arnold, C., Haddad, L., Mier, D., Opitz von Boberfeld, C., Raab, K., Witt, S. H., Rietschel, M., Cichon, S., & Meyer-Lindenberg, A.
Affiliations
  • Heidelberg University (DE)
  • University of Bonn (DE)
  • Department of Psychiatry and Psychotherapy, University of Bonn, 53105 Bonn, Germany.
  • Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany.
Corresponding author
  • Esslinger, Christine
  • Walter, Henrik
  • Kirsch, Peter
Venue
Science
Published
2009-05
Volume
324
Issue
5927
Pages
605-605
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1990436516
Cited by
400
References
6
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 10 · 2020: 12 · 2019: 12 · 2018: 16 · 2017: 19 · 2016: 19 · 2015: 34 · 2014: 46 · 2013: 42 · 2012: 51
FWCI
35.68
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
schizophrenia, ZNF804A, rs1344706, genetic risk variants, imaging genetics, gene dosage, functional connectivity, dorsolateral prefrontal cortex, hippocampus, amygdala, linkage disequilibrium, endophenotypes, psychosis
MeSH terms
Adult, Affective Symptoms, Bipolar Disorder, Brain Mapping, Female, Genotype, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Mental Processes, Phenotype, Schizophrenia, Prefrontal Cortex, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Kruppel-Like Transcription Factors, Genome-Wide Association Study

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