Neural Mechanisms of a Genome-Wide Supported Psychosis Variant
Abstract
A genetic polymorphism associated with schizophrenia conveys a risk for abnormal connectivity between brain regions.
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The connectivity matrices are not dominated by simple coactivation during task blocks.
“To ensure that the connectivity matrices are not dominated by simple coactivation during the task blocks, we have regressed out the task activation using a general linear model (GLM), consistent with our prior work (23, 35, 47, 52).”
From Dynamic reconfiguration of frontal brain networks during executive cognition in humans (2015) · cites this paper as [35]
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Neural correlates of disgust- and fear-conditioned responses
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- Authors
- Esslinger, C., Walter, H., Kirsch, P., Erk, S., Schnell, K., Arnold, C., Haddad, L., Mier, D., Opitz von Boberfeld, C., Raab, K., Witt, S. H., Rietschel, M., Cichon, S., & Meyer-Lindenberg, A.
- Affiliations
- Heidelberg University (DE)
- University of Bonn (DE)
- Department of Psychiatry and Psychotherapy, University of Bonn, 53105 Bonn, Germany.
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany.
- Corresponding author
- Esslinger, Christine
- Walter, Henrik
- Kirsch, Peter
- ORCID
- Venue
- Science
- Published
- 2009-05
- Volume
- 324
- Issue
- 5927
- Pages
- 605-605
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990436516
- Cited by
- 400
- References
- 6
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 10 · 2020: 12 · 2019: 12 · 2018: 16 · 2017: 19 · 2016: 19 · 2015: 34 · 2014: 46 · 2013: 42 · 2012: 51
- FWCI
- 35.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- schizophrenia, ZNF804A, rs1344706, genetic risk variants, imaging genetics, gene dosage, functional connectivity, dorsolateral prefrontal cortex, hippocampus, amygdala, linkage disequilibrium, endophenotypes, psychosis
- MeSH terms
- Adult, Affective Symptoms, Bipolar Disorder, Brain Mapping, Female, Genotype, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Mental Processes, Phenotype, Schizophrenia, Prefrontal Cortex, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Kruppel-Like Transcription Factors, Genome-Wide Association Study
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