Reactive glial cells: increased stiffness correlates with increased intermediate filament expression
Abstract
Increased stiffness of reactive glial cells may impede neurite growth and contribute to the poor regenerative capabilities of the mammalian central nervous system. We induced reactive gliosis in rodent retina by ischemia-reperfusion and assessed intermediate filament (IF) expression and the viscoelastic properties of dissociated single glial cells in wild-type mice, mice lacking glial fibrillary acidic protein and vimentin (GFAP(-/-)Vim(-/-)) in which glial cells are consequently devoid of IFs, and normal Long-Evans rats. In response to ischemia-reperfusion, glial cells stiffened significantly in wild-type mice and rats but were unchanged in GFAP(-/-)Vim(-/-) mice. Cell stiffness (elastic modulus) correlated with the density of IFs. These results support the hypothesis that rigid glial scars impair nerve regeneration and that IFs are important determinants of cellular viscoelasticity in reactive glia. Thus, therapeutic suppression of IF up-regulation in reactive glial cells may facilitate neuroregeneration.
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In several models of acute central nervous system injury, deletion of the genes encoding GFAP and Vim suppresses morphological changes associated with astrocyte activation.
“In several models of acute central nervous system injury, deletion of the genes encoding these proteins suppresses morphological changes associated with astrocyte activation (22, 23, 26, 30, 32, 36).”
From Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice (2013) · cites this paper as [26]
Cites
Müller cells in the healthy and diseased retina
Bringmann, A., Pannicke, T., Grosche, J., Francke, M., Wiedemann, P., Skatchkov, S. N., Osborne, N. N., & Reichenbach, A. (2006) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.05.003 · Cited by 1,905 · see citing works
Self-citationTripartite synapses: astrocytes process and control synaptic information
Perea, G., Navarrete, M., & Araque, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.001 · Cited by 1,820 · see citing works
Astrocyte activation and reactive gliosis
Pekny, M., & Nilsson, M. (2005) · Glia · doi:10.1002/glia.20207 · Cited by 1,611 · see citing works
Self-citationNeurite branching on deformable substrates
Flanagan, L. A., Ju, Y. S., Marg, B., Osterfield, M., & Janmey, P. A. (2002) · Neuroreport · doi:10.1097/00001756-200212200-00007 · Cited by 759 · see citing works
Wilhelmsson, U., Bushong, E. A., Price, D. L., Smarr, B. L., Phung, V., Terada, M., Ellisman, M. H., & Pekny, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602841103 · Cited by 643 · cited 1× · see citing works
“IFs and IF proteins are commonly used as markers of normal and reactive glial cells (9, 24, 27), but their physiological and pathophysiological functions are poorly understood (10).”
BackgroundSelf-citationViscoelastic properties of individual glial cells and neurons in the CNS
Lu, Y., Franze, K., Seifert, G., Steinhäuser, C., Kirchhoff, F., Wolburg, H., Guck, J. R., Janmey, P. A., Wei, E.-Q., Käs, J. A., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606150103 · Cited by 580 · see citing works
Self-citationScanning Probe-Based Frequency-Dependent Microrheology of Polymer Gels and Biological Cells
Mahaffy, R. E., Shih, C.-K. K., MacKintosh, F. C., & Käs, J. A. (2000) · Physical Review Letters · doi:10.1103/physrevlett.85.880 · Cited by 509 · see citing works
Self-citationMahaffy, R. E., Park, S., Gerde, E., Käs, J. A., & Shih, C.-K. K. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74245-9 · Cited by 460 · see citing works
Self-citationWilhelmsson, U., Li, L., Pekna, M., Berthold, C.-H., Blom, S., Eliasson, C., Renner, O., Bushong, E., Ellisman, M., Morgan, T. E., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0820-04.2004 · Cited by 455 · see citing works
Self-citationAstrocytes and the regulation of cerebral blood flow
Koehler, R. C., Roman, R. J., & Harder, D. R. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.11.005 · Cited by 439 · see citing works
Müller cells are living optical fibers in the vertebrate retina
Franze, K., Grosche, J., Skatchkov, S. N., Schinkinger, S., Foja, C., Schild, D., Uckermann, O., Travis, K., Reichenbach, A., & Guck, J. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611180104 · Cited by 426 · see citing works
Self-citationAstrocyte intermediate filaments in CNS pathologies and regeneration
Pekny, M., & Pekna, M. (2004) · The Journal of Pathology · doi:10.1002/path.1645 · Cited by 420 · see citing works
Self-citationPekny, M., Johansson, C. B., Eliasson, C., Stakeberg, J., Wallén, Å., Perlmann, T., Lendahl, U., Betsholtz, C., Berthold, C.-H., & Frisén, J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.3.503 · Cited by 405 · see citing works
Self-citationDahl, D. R. (1979) · Experimental Eye Research · doi:10.1016/0014-4835(79)90106-4 · Cited by 358 · see citing works
Intermediate Filament Protein Partnership in Astrocytes
Eliasson, C., Sahlgren, C., Berthold, C.-H., Stakeberg, J., Celis, J. E., Betsholtz, C., Eriksson, J. E., & Pekny, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23996 · Cited by 357 · see citing works
Self-citationDeposition of Scar Tissue in the Central Nervous System
Berry, M., Maxwell, W. L., Logan, A., Mathewson, A. J., Mcconnell, P., Ashhurst, D. E., & Thomas, G. H. (1983) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-7091-4147-2_3 · Cited by 280 · see citing works
Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin
Kinouchi, R., Takeda, M., Yang, L., Wilhelmsson, U., Lundkvist, A., Pekny, M., & Chen, D. F. (2003) · Nature Neuroscience · doi:10.1038/nn1088 · Cited by 229 · see citing works
Self-citationMaterial characterization of the brainstem from oscillatory shear tests
Arbogast, K. B., & Margulies, S. S. (1998) · Journal of Biomechanics · doi:10.1016/s0021-9290(98)00068-2 · Cited by 225 · see citing works
A potassium channel-linked mechanism of glial cell swelling in the postischemic retina
Pannicke, T., Iandiev, I., Uckermann, O., Biedermann, B., Kutzera, F., Wiedemann, P., Wolburg, H., Reichenbach, A., & Bringmann, A. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.04.005 · Cited by 214 · see citing works
Self-citationThe promotion of neuronal maturation on soft substrates
Teixeira, A. I., Ilkhanizadeh, S., Wigenius, J. A., Duckworth, J. K., Inganäs, O., & Hermanson, O. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.05.013 · Cited by 187 · see citing works
Re-establishing the regenerative potential of central nervous system axons in postnatal mice
Cho, K.-S., Yang, L., Lu, B., Feng Ma, H., Huang, X., Pekny, M., & Chen, D. F. (2005) · Journal of Cell Science · doi:10.1242/jcs.01658 · Cited by 164 · see citing works
Self-citationNeurite Branch Retraction Is Caused by a Threshold-Dependent Mechanical Impact
Franze, K., Gerdelmann, J. C., Weick, M., Betz, T., Pawlizak, S., Lakadamyali, M., Bayer, J., Rillich, K., Goegler, M., Lu, Y., et al. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.07.033 · Cited by 162 · see citing works
Self-citationMiller, G. (2005) · Science · doi:10.1126/science.308.5723.778 · Cited by 153 · see citing works
Lundkvist, A., Reichenbach, A., Betsholtz, C., Carmeliet, P., Wolburg, H., & Pekny, M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01221 · Cited by 147 · see citing works
Self-citationExperimental ischemia induces cell mitosis in the adult rat retina.
Stefánsson, E., Wilson, C. A., Schoen, T. J., & Kuwabara, T. (1988) · PubMed · Cited by 114 · see citing works
Widestrand, Å., Faijerson, J., Wilhelmsson, U., Smith, P. L. P., Li, L., Sihlbom, C., Eriksson, P. S., & Pekny, M. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0122 · Cited by 100 · see citing works
Self-citationBrain energetics (thought needs food)
Pellerin, L. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328312c368 · Cited by 79 · see citing works
Mitz, S. A., Reuss, S., Folkow, L. P., Blix, A. S., Ramirez, J., Hankeln, T., & Burmester, T. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.06.058 · Cited by 78 · see citing works
Mechanically Induced Reactive Gliosis Causes ATP-Mediated Alterations in Astrocyte Stiffness
Miller, W. J., Leventhal, I., Scarsella, D., Haydon, P. G., Janmey, P. A., & Meaney, D. F. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0727 · Cited by 56 · see citing works
MECHANICALLY INDUCED REACTIVE GLIOSIS CAUSES ATP-MEDIATED ALTERATIONS IN ASTROCYTE STIFFNESS
Miller, W. J., Levental, I., Scarsella, D., Haydon, P. G., Janmey, P. A., & Meaney, D. F. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008-0727 · Cited by 55 · see citing works
Quantitative electron microscopy of rabbit Müller (glial) cells in dependence on retinal topography.
Reichenbach, A., Hagen, E., Schippel, K., & Eberhardt, W. (1988) · PubMed · Cited by 49 · see citing works
Self-citationSchiwy, N., Brazda, N., & Müller, H. W. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06929.x · Cited by 47 · see citing works
Reichenbach, A., & Pannicke, T. (2008) · Science · doi:10.1126/science.1166197 · Cited by 32 · see citing works
Self-citationResponse to Quinlan and Nilsson: Astroglia sitting at the controls?
Pekny, M., Pekna, M., Wilhelmsson, U., & Chen, D. F. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.01.012 · Cited by 15 · see citing works
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Lacour, S. P., Courtine, G., & Guck, J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.63 · Cited by 738 · see citing works
Reichenbach, A., & Bringmann, A. (2013) · Glia · doi:10.1002/glia.22477 · Cited by 720 · see citing works
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Liu, Z., & Chopp, M. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.008 · Cited by 596 · see citing works
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Bringmann, A., & Wiedemann, P. (2012) · Ophthalmologica · doi:10.1159/000328979 · Cited by 436 · see citing works
Self-citationCuenca, N., Fernández-Sánchez, L., Campello, L., Maneu, V., De la Villa, P., Lax, P., & Pinilla, I. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.07.001 · Cited by 401 · see citing works
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Bringmann, A., Syrbe, S., Görner, K., Kacza, J., Francke, M., Wiedemann, P., & Reichenbach, A. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.03.006 · Cited by 355 · see citing works
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Mota, C., Camarero‐Espinosa, S., Baker, M., Wieringa, P., & Moroni, L. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00789 · Cited by 308 · see citing works
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Kraft, A. W., Hu, X., Yoon, H., Yan, P., Xiao, Q., Wang, Y., Gil, S. C., Brown, J., Wilhelmsson, U., Restivo, J. L., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-208660 · Cited by 324 · see citing works
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Self-citationKamphuis, W., Middeldorp, J., Kooijman, L., Sluijs, J. A., Kooi, E., Moeton, M., Freriks, M., Mizee, M. R., & Hol, E. M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.035 · Cited by 244 · see citing works
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Franze, K. (2013) · Development · doi:10.1242/dev.079145 · Cited by 225 · see citing works
Liu, Z., Li, Y., Cui, Y., Roberts, C. J., Lü, M., Wilhelmsson, U., Pekny, M., & Chopp, M. (2014) · Glia · doi:10.1002/glia.22723 · Cited by 200 · see citing works
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Kamphuis, W., Kooijman, L., Orre, M., Stassen, O., Pekny, M., & Hol, E. M. (2015) · Glia · doi:10.1002/glia.22800 · Cited by 155 · see citing works
Self-citationKöster, S., Weitz, D. A., Goldman, R. D., Aebi, U., & Herrmann, H. O. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.01.001 · Cited by 155 · see citing works
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Eide, P. K., & Hansson, H. ‐. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12420 · Cited by 119 · see citing works
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Using extracellular matrix for regenerative medicine in the spinal cord
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Schürmann, M., Cojoc, G., Girardo, S., Ulbricht, E., Guck, J. R., & Müller, P. F. (2017) · Journal of Biophotonics · doi:10.1002/jbio.201700145 · Cited by 91 · see citing works
Self-citationMüller cells as a target for retinal therapy
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Reactive gliosis in the adult zebrafish retina
Thomas, J. L., Ranski, A. H., Morgan, G. W., & Thummel, R. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.09.017 · Cited by 85 · see citing works
Müller cells and astrocytes in tractional macular disorders
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Munder, T., Pfeffer, A., Schreyer, S., Guo, J., Braun, J., Sack, I., Steiner, B., & Klein, C. (2017) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25741 · Cited by 69 · see citing works
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Klein, C., Hain, E. G., Braun, J., Riek, K., Mueller, S. G., Steiner, B., & Sack, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092582 · Cited by 67 · see citing works
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Self-citationGovetto, A., Hubschman, J., Sarraf, D., Figueroa, M. S., Bottoni, F. G., dell’Omo, R., Curcio, C. A., Seidenari, P., Delledonne, G., Gunzenhauser, R. C., et al. (2019) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2019-314245 · Cited by 65 · see citing works
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Bonney, P. A., Briggs, R. G., Wu, K., Choi, W., Khahera, A. S., Ojogho, B., Shao, X., Zhao, Z., Borzage, M., Wang, D. J. J., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.866313 · Cited by 52 · see citing works
GLIAL CELLS AND COLLAGENS IN EPIRETINAL MEMBRANES ASSOCIATED WITH IDIOPATHIC MACULAR HOLES
Bu, S., Kuijer, R., van der Worp, R. J., Huiskamp, E. A., de Lavalette, V. W. R., Li, X., Hooymans, J. M. M., & Los, L. I. (2013) · Retina · doi:10.1097/iae.0000000000000013 · Cited by 52 · see citing works
Cortical astrogliosis and increased perivascular aquaporin-4 in idiopathic intracranial hypertension
Eide, P. K., Eidsvaag, V. A., Nagelhus, E. A., & Hansson, H. (2016) · Brain Research · doi:10.1016/j.brainres.2016.05.024 · Cited by 52 · see citing works
Young, C. C., van der Harg, J. M., Lewis, N. J., Brooks, K. J., Buchan, A. M., & Szele, F. G. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs049 · Cited by 52 · see citing works
Langlois, B., Belozertseva, E., Parlakian, A., Bourhim, M., Gao-Li, J., Blanc, J., Tian, L., Coletti, D., Labat, C., Ramdame-Cherif, Z., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12024-z · Cited by 51 · see citing works
Blood-brain barrier leakage of blood proteins in idiopathic normal pressure hydrocephalus
Eide, P. K., & Hansson, H. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146547 · Cited by 51 · see citing works
Astrogliosis in a dish: substrate stiffness induces astrogliosis in primary rat astrocytes
Wilson, C. L., Hayward, S. L., & Kidambi, S. (2016) · RSC Advances · doi:10.1039/c5ra25916a · Cited by 49 · see citing works
Berg, A., Zelano, J., Pekna, M., Wilhelmsson, U., Pekny, M., & Cullheim, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079395 · Cited by 46 · see citing works
Self-citationBringmann, A., Unterlauft, J. D., Wiedemann, R., Barth, T., Rehák, M., & Wiedemann, P. (2020) · International Ophthalmology · doi:10.1007/s10792-020-01477-3 · Cited by 46 · see citing works
Self-citationCorneal Antifibrotic Switch Identified in Genetic and Pharmacological Deficiency of Vimentin
Bargagna‐Mohan, P., Paranthan, R. R., Hamza, A., Zhan, C., Lee, D.-M., Kim, K. B., Lau, D. L., Srinivasan, C., Nakayama, K., Nakayama, K., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.297150 · Cited by 45 · see citing works
Mechanotransduction assays for neural regeneration strategies: A focus on glial cells
Marinval, N., & Chew, S. Y. (2021) · APL Bioengineering · doi:10.1063/5.0037814 · Cited by 40 · see citing works
Harnessing the Neuroprotective Behaviors of Müller Glia for Retinal Repair
Peña, J. S., & Vázquez, M. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2706169 · Cited by 38 · see citing works
Hain, E. G., Klein, C., Munder, T., Braun, J., Riek, K., Mueller, S. G., Sack, I., & Steiner, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161179 · Cited by 39 · see citing works
Xu, X., Wang, S., Jin, Y., Hu, Y., Feng, K., & Ma, Z. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12428 · Cited by 38 · see citing works
Cao, K., Ishida, T., Fang, Y., Shinohara, K., Li, X., Nagaoka, N., Ohno‐Matsui, K., & Yoshida, T. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.3.13 · Cited by 38 · see citing works
Simon, M. G., Dokukin, M., Kalaparthi, V., Spedden, E., Sokolov, I. Y., & Staii, C. (2016) · Langmuir · doi:10.1021/acs.langmuir.5b04317 · Cited by 37 · see citing works
Pourabdolhossein, F., Gil‐Perotín, S., García‐Belda, P., Dauphin, A., Mozafari, S., Tepavčević, V., García‐Verdugo, J. M., & Evercooren, A. B. (2017) · Glia · doi:10.1002/glia.23124 · Cited by 36 · see citing works
Taylor, L., Arnér, K. M., Holmgren-Taylor, I., & Ghosh, F. K. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13535 · Cited by 32 · see citing works
RetractedEarly remodeling of müller cells in the rd/rd mouse model of retinal dystrophy
Chua, J., Nivison‐Smith, L., Fletcher, E. L., Trenholm, S., Awatramani, G. B., & Kalloniatis, M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23307 · Cited by 32 · see citing works
Wang, Y., Eshwaran, R., Beck, S. C., Hammes, H., Wieland, T., & Feng, Y. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101736 · Cited by 31 · see citing works
Different modes of full-thickness macular hole formation
Bringmann, A., Unterlauft, J. D., Barth, T., Wiedemann, R., Rehák, M., & Wiedemann, P. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108393 · Cited by 31 · see citing works
Self-citationTaylor, L., Moran, D., Arnér, K. M., Warrant, E. J., & Ghosh, F. K. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-11420 · Cited by 31 · see citing works
Hippert, C., Graca, A. B., Basche, M., Kalargyrou, A. A., Georgiadis, A., Ribeiro, J., Matsuyama, A., Aghaizu, N. D., Bainbridge, J. W., Smith, A. J., et al. (2021) · Glia · doi:10.1002/glia.24034 · Cited by 29 · see citing works
Wunderlich, K. A., Tanimoto, N., Grosche, A., Zrenner, E., Pekny, M., Reichenbach, A., Seeliger, M. W., Pannicke, T., & Perez, M.-T. (2015) · The FASEB Journal · doi:10.1096/fj.15-272963 · Cited by 29 · see citing works
Self-citationAndersson, D., Wilhelmsson, U., Nilsson, M., Kubista, M., Ståhlberg, A., Pekna, M., & Pekny, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070699 · Cited by 29 · see citing works
Self-citationIntraretinal changes in the presence of epiretinal traction
Romano, M. R., Cennamo, G., Amoroso, F., Montorio, D., Castellani, C., Reibaldi, M., & Cennamo, G. (2016) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-016-3413-z · Cited by 28 · see citing works
Pressure-Induced Changes in Astrocyte GFAP, Actin, and Nuclear Morphology in Mouse Optic Nerve
Ling, Y. T. T., Pease, M. E., Jefferys, J. L., Kimball, E., Quigley, H. A., & Nguyen, T. D. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.11.14 · Cited by 28 · see citing works
Huesmann, G., Schwarb, H. D., Smith, D. R., Pohlig, R. T., Anderson, A. T., McGarry, M., Paulsen, K. D., Wszalek, T., Sutton, B. P., & Johnson, C. L. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102313 · Cited by 26 · see citing works
Yan, L., Dwiggins, C. W., Moriarty, R. A., Jung, J. W., Gupta, U., Brandon, K. D., & Stroka, K. M. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.06.003 · Cited by 26 · see citing works
Biomechanical properties of retinal glial cells: Comparative and developmental data
Lu, Y., Pannicke, T., Wei, E.-Q., Bringmann, A., Wiedemann, P., Habermann, G., Buse, E., Käs, J. A., & Reichenbach, A. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.05.012 · Cited by 26 · see citing works
Self-citationIntracranial Biomechanics of Acute Experimental Hydrocephalus in Live Rats
Shulyakov, A. V., Buist, R. J., & Bigio, M. R. D. (2012) · Neurosurgery · doi:10.1227/neu.0b013e3182690a0c · Cited by 25 · see citing works
Müller cells trophism and pathology as the next therapeutic targets for retinal diseases
Arrigo, A., Cremona, O., Aragona, E., Casoni, F., Consalez, G., Dogru, R. M., Hauck, S. M., Antropoli, A., Bianco, L., Parodi, M. B., et al. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101357 · Cited by 25 · see citing works
Characterization of retinal biomechanical properties using Brillouin microscopy
Ambekar, Y. S., Singh, M., Scarcelli, G., Rueda, E. M., Hall, B. M., Poché, R. A., & Larin, K. V. (2020) · Journal of Biomedical Optics · doi:10.1117/1.jbo.25.9.090502 · Cited by 24 · see citing works
Decorin—An Antagonist of TGF-β in Astrocytes of the Optic Nerve
Schneider, M., Dillinger, A. E., Ohlmann, A., Iozzo, R. V., & Fuchshofer, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147660 · Cited by 24 · see citing works
Luna, R. I. M., Ku, R. Y., Aruck, A. M., Santiago, F. N., Viczian, A. S., Mauro, D. S., & Zuber, M. E. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.03.005 · Cited by 24 · see citing works
Cerebral microvascular abnormalities in patients with idiopathic intracranial hypertension
Eidsvaag, V. A., Hansson, H., Heuser, K., Nagelhus, E. A., & Eide, P. K. (2018) · Brain Research · doi:10.1016/j.brainres.2018.02.017 · Cited by 23 · see citing works
Makhija, E., Jagielska, A., Zhu, L., Bost, A. C., Ong, W., Chew, S. Y., Shivashankar, G. V., & Vliet, K. J. V. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00059 · Cited by 24 · see citing works
Zhao, Z., He, J., Chen, Y., Wang, Y.-C., Wang, C., Tan, C., Liao, J., & Xiao, G. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.952036 · Cited by 23 · see citing works
Host reaction to poly(2-hydroxyethyl methacrylate) scaffolds in a small spinal cord injury model
Li, H. Y., Führmann, T., Zhou, Y., & Dalton, P. D. (2013) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-013-4956-8 · Cited by 22 · see citing works
Brain cells and neuronal networks: Encounters with controlled microenvironments
Tomba, C., & Villard, C. (2014) · Microelectronic Engineering · doi:10.1016/j.mee.2014.10.007 · Cited by 22 · see citing works
Chen, L., Li, W., Maybeck, V., Offenhäusser, A., & Krause, H. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.08.029 · Cited by 21 · see citing works
- Authors
- Lu, Y., Iandiev, I., Hollborn, M., Körber, N., Ulbricht, E., Hirrlinger, P. G., Pannicke, T., Wei, E., Bringmann, A., Wolburg, H., Wilhelmsson, U., Pekny, M., Wiedemann, P., Reichenbach, A., & Käs, J. A.
- Affiliations
- Zhejiang University (CN)
- Leipzig University (DE)
- University of Tübingen (DE)
- University of Gothenburg (SE)
- Corresponding author
- Reichenbach, Andreas
- ORCID
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2010-10-25
- Volume
- 25
- Issue
- 2
- Pages
- 624-631
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1977341002
- Cited by
- 172
- References
- 34
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 15 · 2020: 15 · 2019: 14 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 17 · 2014: 10 · 2013: 19 · 2012: 12
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SPP1172)
- National Natural Science Foundation of China (30700150)
- Deutscher Akademischer Austauschdienst (Y2080105)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- reactive glial cells, cell stiffness, intermediate filaments, glial fibrillary acidic protein, vimentin, reactive gliosis, retinal ischemia-reperfusion, viscoelasticity, glial scar, nerve regeneration
- MeSH terms
- Animals, Biomechanical Phenomena, Gene Expression Regulation, Glial Fibrillary Acidic Protein, Gliosis, Intermediate Filaments, Nerve Tissue Proteins, Neuroglia, Vimentin, Reperfusion Injury, Mice, Knockout, Rats, Long-Evans, Mice, Rats
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