Colonic immune cells in irritable bowel syndrome: A systematic review and meta‐analysis
Abstract
Background & aims Increases in mucosal immune cells have frequently been observed in irritable bowel syndrome (IBS) patients. However, this finding is not completely consistent between studies, possibly due to a combination of methodological variability, population differences and small sample sizes. We performed a meta-analysis of case-control studies that compared immune cell counts in colonic biopsies of IBS patients and controls. Methods PubMed and Embase were searched in February 2017. Results were pooled using standardized mean difference (SMD) and were considered significant when zero was not within the 95% confidence interval (CI). Heterogeneity was assessed based on I 2 statistics where I 2 ≤ 50% and I 2 > 50% indicated fixed and random effect models, respectively. Key results Twenty-two studies on 706 IBS patients and 401 controls were included. Mast cells were increased in the rectosigmoid (SMD: 0.38 [95% CI: 0.06-0.71]; P = .02) and descending colon (SMD: 1.69 [95% CI: 0.65-2.73]; P = .001) of IBS patients. Increased mast cells were observed in both constipation (IBS-C) and diarrhea predominant IBS (IBS-D). CD3 + T cells were increased in the rectosigmoid (SMD: 0.53 [95% CI: 0.21-0.85]; P = .001) and the descending colon of the IBS patients (SMD: 0.79, 95% CI [0.28-1.30]; P = .002). This was possibly in relation to higher CD4 + T cells in IBS (SMD: 0.33 [95% CI: 0.01-0.65]; P = .04) as there were no differences in CD8 + T cells. Conclusions & inferences Mast cells…
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In twin studies, concordance of a diagnosis of IBS is commoner in monozygotic, compared with dizygotic twins.
“In twin studies, concordance of a diagnosis of IBS is commoner in monozygotic, compared with dizygotic twins; however, having a parent with IBS is a stronger predictor, suggesting that environmental factors such as learned illness behaviour are more important. 58”
From Irritable bowel syndrome (2020) · cites this paper as [58]
Having a parent with IBS is a stronger predictor than twin concordance, suggesting that environmental factors such as learned illness behaviour are more important.
“In twin studies, concordance of a diagnosis of IBS is commoner in monozygotic, compared with dizygotic twins; however, having a parent with IBS is a stronger predictor, suggesting that environmental factors such as learned illness behaviour are more important. 58”
From Irritable bowel syndrome (2020) · cites this paper as [58]
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Self-citation
- Authors
- Bashashati, M., Moossavi, S., Cremon, C., Barbaro, M. R., Moraveji, S., Talmon, G., Rezaei, N., Hughes, P. A., Bian, Z. X., Choi, C. H., Lee, O. Y., Coëffier, M., Chang, L., Ohman, L., Schmulson, M. J., McCallum, R. W., Simren, M., Sharkey, K. A., & Barbara, G.
- Affiliations
- Texas Tech University Health Sciences Center (US)
- Digestive Disease Research Institute (IR)
- University of Bologna (IT)
- Fred and Pamela Buffett Cancer Center (US)
- Children's Medical Center (IR)
- South Australian Health and Medical Research Institute (AU)
- Hong Kong Baptist University (HK)
- Chung-Ang University (KR)
- Hanyang University (KR)
- Inserm (FR)
- University of California, Los Angeles (US)
- Departments of Internal Medicine and Clinical Nutrition and Microbiology and Immunology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden
- Hospital General de México (MX)
- Department of Internal Medicine & Clinical Nutrition Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden
- University of Calgary (CA)
- Corresponding author
- Bashashati, M.
- ORCID
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2017-08-29
- Volume
- 30
- Issue
- 1
- Pages
- e13192
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2751288039
- Cited by
- 175
- References
- 19
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 16 · 2023: 27 · 2022: 22 · 2021: 25 · 2020: 22 · 2019: 14 · 2018: 13 · 2017: 4
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Crohn's and Colitis Canada
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- irritable bowel syndrome, colonic mucosa, mucosal immune cells, mast cells, CD3+ T cells, CD4+ T cells, CD8+ T cells, colonic biopsy, irritable bowel syndrome with constipation, diarrhea-predominant irritable bowel syndrome, colonic inflammation
- MeSH terms
- Colon, Humans, Mast Cells, CD4-Positive T-Lymphocytes, CD3 Complex, CD8-Positive T-Lymphocytes, Irritable Bowel Syndrome
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