Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice

Guida, F.; Turco, F.; Iannotta, M.; De Gregorio, D.; Palumbo, I.; Sarnelli, G.; Furiano, A.; Napolitano, F.; Boccella, S.; Luongo, L.; Mazzitelli, M.; Usiello, A.; De Filippis, F.; Iannotti, F.A.; Piscitelli, F.; Ercolini, D.; de Novellis, V.; Di Marzo, V.; Cuomo, R.; Maione, S.

doi:10.1016/j.bbi.2017.09.001

Cited by 383Gut microbiota and healthTryptophan and brain disordersGastrointestinal motility and disorders

Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice

Guida, F., Turco, F., Iannotta, M., De Gregorio, D., Palumbo, I., Sarnelli, G., Furiano, A., Napolitano, F. +12 more·2018·Brain Behavior and Immunity

DOI 10.1016/j.bbi.2017.09.001

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Abstract

The microbiota-gut-brain axis (MGBA) regulates the reciprocal interaction between chronic inflammatory bowel and psychiatric disorders. This interaction involves multiple pathways that are highly debated. We examined the behavioural, biochemical and electrophysiological alterations, as well as gut microbiota composition in a model of antibiotic-induced experimental dysbiosis. Inflammation of the small intestine was also assessed. Mice were exposed to a mixture of antimicrobials for 2weeks. Afterwards, they received Lactobacillus casei DG (LCDG) or a vehicle for up to 7days via oral gavage. Perturbation of microbiota was accompanied by a general inflammatory state and alteration of some endocannabinoidome members in the gut. Behavioural changes, including increased immobility in the tail suspension test and reduced social recognition were observed, and were associated with altered BDNF/TrkB signalling, TRPV1 phosphorylation and neuronal firing in the hippocampus. Moreover, morphological rearrangements of non-neuronal cells in brain areas controlling emotional behaviour were detected. Subsequent probiotic administration, compared with vehicle, counteracted most of these gut inflammatory, behavioural, biochemical and functional alterations. Interestingly, levels of Lachnospiraceae were found to significantly correlate with the behavioural changes observed in dysbiotic mice. Our findings clarify some of the biomolecular and functional modifications leading to the development of affective disorders associated with gut microbiota alterations.

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Antibiotic administration to laboratory animals has been shown to influence behaviors such as sociability and anxiety.
“antibiotic administration to laboratory animals has been shown to influence behaviors such as sociability and anxiety (Degroote et al., 2016;Frohlich et al., 2016;Guida et al., 2018).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Guida et al., 2018
This was somewhat ameliorated by treatment with the probiotic L. casei DG probably via a gut anti-inflammatory mechanism.
“This was somewhat ameliorated by treatment with the probiotic L. casei DG probably via a gut anti-inflammatory mechanism (Guida et al., 2018).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Guida et al., 2018
Two weeks of antibiotic cocktail administration resulted in marked changes in hippocampal BDNF TrkB signaling, TRPV1 phosphorylation and heavily reduced hippocampal CA3-CA1 synaptic activity.
“two weeks of antibiotic cocktail administration resulted in marked changes in hippocampal BDNF tropomyosin receptor kinase B (TrkB) signaling, transient receptor potential vanilloid 1 (TRPV1) phosphorylation and overall heavily reduced hippocampal CA3-CA1 synaptic activity.”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Guida et al., 2018
Prior work has associated the relative abundance of ASVs from Muribaculaceae to various measures of mouse cognition.
“While the linkage between Muribaculaceae and neurophysiology has been less well documented relative to other mouse microbiome taxa, prior work has associated the relative abundance of ASVs from this group to various measures of mouse cognition48,56.”
From Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice (2021) · cites this paper as [56]
Antibiotics may be related to depression.
“the findings showing that antibiotics may be related to depression [159,168].”
From Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature (2021) · cites this paper as [159]

QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
FLASH: fast length adjustment of short reads to improve genome assemblies
Magoč, T., & Salzberg, S. L. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr507 · Cited by 15,366 · see citing works
An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea
McDonald, D. T., Price, M. N., Goodrich, J. K., Nawrocki, E. P., DeSantis, T. Z., Probst, A. J., Andersen, G. L., Knight, R. D., & Hugenholtz, P. (2011) · The ISME Journal · doi:10.1038/ismej.2011.139 · Cited by 5,010 · see citing works
Quality control and preprocessing of metagenomic datasets
Schmieder, R., & Edwards, R. A. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr026 · Cited by 4,989 · see citing works
Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460 · see citing works
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works
The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748 · see citing works
So depression is an inflammatory disease, but where does the inflammation come from?
Berk, M., Williams, L. J., Jacka, F. N., O’Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-200 · Cited by 1,423 · see citing works
Assessment of psychotropic-like properties of a probiotic formulation ( Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects
Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324 · see citing works
Brain-gut-microbe communication in health and disease
Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952 · see citing works
Cognitive impairment by antibiotic-induced gut dysbiosis: analysis of gut microbiota-brain communication
Fröhlich, E. E., Farzi, A., Mayerhofer, R., Reichmann, F., Jačan, A., Wagner, B., Zinser, E., Bordag, N., Magnes, C., Fröhlich, E., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.02.020 · Cited by 720 · see citing works
ELECTROPHYSIOLOGY OF HIPPOCAMPAL NEURONS: II. AFTER-POTENTIALS AND REPETITIVE FIRING
Kandel, E. R., & Spencer, W. A. (1961) · Journal of Neurophysiology · doi:10.1152/jn.1961.24.3.243 · Cited by 694 · see citing works
Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice
Bercik, P., Verdu, E. F., Foster, J. A., Macri, J., Potter, M., Huang, X., Malinowski, P., Jackson, W., Blennerhassett, P., Neufeld, K. A., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.063 · Cited by 674 · see citing works
Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury
Hains, B. C., & Waxman, S. G. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0003-06.2006 · Cited by 641 · see citing works
The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease
Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612 · see citing works
The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.
Maes, M. H. J., Kubera, M., & Leunis, J. (2008) · PubMed · Cited by 607 · see citing works
Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation
Petra, A. I., Panagiotidou, S., Hatziagelaki, E., Stewart, J. M., Conti, P., & Theoharides, T. C. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.04.002 · Cited by 592 · see citing works
Beneficial psychological effects of a probiotic formulation ( Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers
Messaoudi, M., Violle, N., Bisson, J.-F., Desor, D., Javelot, H., & Rougeot, C. (2011) · Gut Microbes · doi:10.4161/gmic.2.4.16108 · Cited by 574 · see citing works
BDNF in schizophrenia, depression and corresponding animal models
Angelucci, F., Brené, S., & Mathé, A. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001637 · Cited by 548 · see citing works
Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism
Gupta, S., Ellis, S. E., Ashar, F. N., Moes, A., Bader, J. S., Zhan, J., West, A. B., & Arking, D. E. (2014) · Nature Communications · doi:10.1038/ncomms6748 · Cited by 504 · see citing works
Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms
Alcock, J., Maley, C. C., & Aktipis, C. A. (2014) · BioEssays · doi:10.1002/bies.201400071 · Cited by 454 · see citing works
Microbes and the gut‐brain axis
Bercik, P., Collins, S. M., & Verdu, E. F. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01906.x · Cited by 417 · see citing works
TRPV1 Channels Mediate Long-Term Depression at Synapses on Hippocampal Interneurons
Gibson, H. E., Edwards, J. G., Page, R. S., Van Hook, M. J., & Kauer, J. A. (2008) · Neuron · doi:10.1016/j.neuron.2007.12.027 · Cited by 388 · see citing works
Endocannabinoids–at the crossroads between the gut microbiota and host metabolism
Cani, P. D., Plovier, H., Van Hul, M., Geurts, L., Delzenne, N. M., Druart, C., & Everard, A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.211 · Cited by 367 · see citing works
TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus
Chávez, A. E., Chiu, C. Q., & Castillo, P. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2684 · Cited by 351 · see citing works
New insights into the role of brain-derived neurotrophic factor in synaptic plasticity
Waterhouse, E. G., & Xu, B. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.06.009 · Cited by 341 · see citing works
Communication between gastrointestinal bacteria and the nervous system
Bravo, J. A., Julio-Pieper, M., Forsythe, P., Kunze, W., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.09.010 · Cited by 261 · see citing works
Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity
Sen, T., Cawthon, C. R., Ihde, B. T., Hajnal, A., DiLorenzo, P. M., de La Serre, C. B., & Czaja, K. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.02.027 · Cited by 239 · see citing works
Antibiotic Treatment Affects Intestinal Permeability and Gut Microbial Composition in Wistar Rats Dependent on Antibiotic Class
Tulstrup, M. V.-L., Christensen, E. G., Carvalho, V., Linninge, C., Ahrné, S., Højberg, O., Licht, T. R., & Bahl, M. I. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144854 · Cited by 227 · see citing works
Up‐regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation
D’Argenio, G., Valenti, M., Scaglione, G., Cosenza, V., Sorrentini, I., & Marzo, V. D. (2006) · The FASEB Journal · doi:10.1096/fj.05-4943fje · Cited by 223 · see citing works
The “psychomicrobiotic”: targeting microbiota in major psychiatric disorders: a systematic review
Fond, G., Boukouaci, W., Chevalier, G., Regnault, A., Eberl, G., Hamdani, N., Dickerson, F., Macgregor, A., Boyer, L., Dargel, A., et al. (2015) · Pathologie Biologie · doi:10.1016/j.patbio.2014.10.003 · Cited by 219 · see citing works
Gut-brain Axis: Role of Lipids in the Regulation of Inflammation, Pain and CNS Diseases
Russo, R., Cristiano, C., Avagliano, C., Caro, C. D., Rana, G. L., Raso, G. M., Canani, R. B., Meli, R., & Calignano, A. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170216113756 · Cited by 213 · see citing works
Dopaminergic Regulation of Inhibitory and Excitatory Transmission in the Basolateral Amygdala–Prefrontal Cortical Pathway
Floresco, S. B., & Tse, M. T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5474-06.2007 · Cited by 204 · see citing works
Analgesic actions of N ‐arachidonoyl‐serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors
Maione, S., PETROCELLIS, L. D., de Novellis, V., Moriello, A. S., Petrosino, S., Palazzo, E., Rossi, F., Woodward, D. F., & Marzo, V. D. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707145 · Cited by 195 · see citing works
Enteroglial-derived S100B protein integrates bacteria-induced Toll-like receptor signalling in human enteric glial cells
Turco, F., Sarnelli, G., Cirillo, C., Palumbo, I., Giorgi, F. D., D’Alessandro, A., Cammarota, M., Giuliano, M., & Cuomo, R. (2013) · Gut · doi:10.1136/gutjnl-2012-302090 · Cited by 187 · see citing works
Convergence and Interaction of Hippocampal and Amygdalar Projections within the Prefrontal Cortex in the Rat
Ishikawa, A., & Nakamura, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-31-09987.2003 · Cited by 185 · see citing works
Depression as a Glial-Based Synaptic Dysfunction
Rial, D., Lemos, C., Pinheiro, H., Duarte, J. M., Gonçalves, F. Q., Real, J. I., Prediger, R. D., Gonçalves, N., Gomes, C. A., Canas, P. M., et al. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00521 · Cited by 182 · see citing works
Colonic immune cells in irritable bowel syndrome: A systematic review and meta‐analysis
Bashashati, M., Moossavi, S., Cremon, C., Barbaro, M. R., Moraveji, S., Talmon, G., Rezaei, N., Hughes, P. A., Bian, Z. X., Choi, C. H., et al. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13192 · Cited by 175 · see citing works
Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota
Geurts, L., Everard, A., Hul, M. V., Essaghir, A., Duparc, T., Matamoros, S., Plovier, H., Castel, J., Denis, R., Bergiers, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7495 · Cited by 171 · see citing works
Probiotics Improve Inflammation-Associated Sickness Behavior by Altering Communication between the Peripheral Immune System and the Brain
D'Mello, C., Ronaghan, N., Zaheer, R., Dicay, M., Le, T., MacNaughton, W. K., Surrette, M. G., & Swain, M. G. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0575-15.2015 · Cited by 169 · see citing works
Enteric Glial Cells
Ochoa‐Cortés, F., Turco, F., Liñán-Rico, A., Soghomonyan, S., Whitaker, E. E., Wehner, S., Cuomo, R., & Christofi, F. L. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000667 · Cited by 162 · see citing works
The Same Microbiota and a Potentially Discriminant Metabolome in the Saliva of Omnivore, Ovo-Lacto-Vegetarian and Vegan Individuals
De Filippis, F., Vannini, L., La Storia, A., Laghi, L., Piombino, P., Stellato, G., Serrazanetti, D. I., Gozzi, G., Turroni, S., Ferrocino, I., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112373 · Cited by 146 · see citing works
Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice
Piscitelli, F., Carta, G., Bisogno, T., Murru, E., Cordeddu, L., Berge, K., Tandy, S., Cohn, J. S., Griinari, M., Banni, S., et al. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-51 · Cited by 141 · see citing works
Endocannabinoid system: Role in depression, reward and pain control (Review)
Huang, W., Chen, W., & Zhang, X. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5585 · Cited by 135 · see citing works
Amygdala input monosynaptically innervates parvalbumin immunoreactive local circuit neurons in rat medial prefrontal cortex
Gabbott, P. L. A., Warner, T., & Busby, S. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.026 · Cited by 133 · see citing works
Lactobacillus casei DG and its postbiotic reduce the inflammatory mucosal response: an ex-vivo organ culture model of post-infectious irritable bowel syndrome
Compare, D., Rocco, A., Coccoli, P., Angrisani, D., Sgamato, C., Iovine, B., Salvatore, U., & Nardone, G. (2017) · BMC Gastroenterology · doi:10.1186/s12876-017-0605-x · Cited by 133 · see citing works
Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice
Guida, F., Luongo, L., Marmo, F., Romano, R., Iannotta, M., Napolitano, F., Belardo, C., Marabese, I., D’Aniello, A., Gregorio, D. D., et al. (2015) · Molecular Brain · doi:10.1186/s13041-015-0139-5 · Cited by 128 · see citing works
Proinflammatory stimuli activates human‐derived enteroglial cells and induces autocrine nitric oxide production
Cirillo, C., Sarnelli, G., Turco, F., Mango, A., Grosso, M., Aprea, G., Masone, S., & Cuomo, R. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01748.x · Cited by 119 · see citing works
The Intestinal Flora Is Required to Support Antibody Responses to Systemic Immunization in Infant and Germ Free Mice
Lamousé-Smith, E. S. N., Tzeng, A., & Starnbach, M. N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027662 · Cited by 107 · see citing works
Progressive alterations of hippocampal CA3-CA1 synapses in an animal model of depression
Qiao, H., An, S.-C., Ren, W., & Ma, X. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.040 · Cited by 105 · see citing works
Rectal Administration of Lactobacillus casei DG Modifies Flora Composition and Toll-Like Receptor Expression in Colonic Mucosa of Patients with Mild Ulcerative Colitis
Renata D'Incà, Barollo, M., Scarpa, M., Grillo, A. R., Brun, P., Vettorato, M. G., Castagliuolo, I., & Sturniolo, G. C. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1384-1 · Cited by 99 · see citing works
Role of acylethanolamides in the gastrointestinal tract with special reference to food intake and energy balance
Borrelli, F., & Izzo, A. A. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.10.003 · Cited by 96 · see citing works
Glucocorticoid Receptors, Brain-Derived Neurotrophic Factor, Serotonin and Dopamine Neurotransmission are Associated with Interferon-Induced Depression
Udina, M., Navinés, R., Egmond, E., Oriolo, G., Langohr, K., Giménez, D., Valdés, M., Gómez‐Gil, E., Grande, I., Gratacòs, M., et al. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv135 · Cited by 88 · see citing works
Palmitoylethanolamide normalizes intestinal motility in a model of post‐inflammatory accelerated transit: involvement of CB 1 receptors and TRPV 1 channels
Capasso, R., Orlando, P., Pagano, E., Aveta, T., Buono, L., Borrelli, F., Marzo, V. D., & Izzo, A. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12759 · Cited by 85 · see citing works
Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels
de Lago, E., Petrosino, S., Valenti, M., Morera, E., Ortega‐Gutiérrez, S., Fernández‐Ruíz, J., & Marzo, V. D. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.05.011 · Cited by 85 · see citing works
Probiotics and irritable bowel syndrome
Dai, C. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i36.5973 · Cited by 84 · see citing works
The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis
Navarria, A., Tamburella, A., Iannotti, F. A., Micale, V., Camillieri, G., Gozzo, L., Verde, R., Imperatore, R., Leggio, G. M., Drago, F., et al. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.04.014 · Cited by 82 · see citing works
Probiotic Lactobacillus rhamnosus GG therapy and microbiological programming in infantile colic: a randomized, controlled trial
Pärtty, A., Lehtonen, L., Kalliomäki, M., Salminen, S., & Isolauri, E. (2015) · Pediatric Research · doi:10.1038/pr.2015.127 · Cited by 80 · see citing works
Effect of vanilloid drugs on gastrointestinal transit in mice
Izzo, A. A., Capasso, R., Pinto, L., Carlo, G. D., Mascolo, N., & Capasso, F. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703975 · Cited by 79 · see citing works
Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators, in the intestinal tract
Verhoeckx, K. C. M., Voortman, T., Balvers, M. G. J., Hendriks, H., Wortelboer, H. M., & Witkamp, R. F. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.07.008 · Cited by 77 · see citing works
Fatty acids, endocannabinoids and inflammation
Witkamp, R. F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.08.051 · Cited by 76 · see citing works
Approaches to studying and manipulating the enteric microbiome to improve autism symptoms
Frye, R. E., Slattery, J. M., MacFabe, D. F., Allen‐Vercoe, E., Parker, W., Rodakis, J., Adams, J. B., Krajmalnik‐Brown, R., Bolte, E. R., Kahler, S. G., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26878 · Cited by 75 · see citing works
Endocannabinoids and Mental Disorders
Rubino, T., Zamberletti, E., & Parolaro, D. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_9 · Cited by 71 · see citing works
Altered endocannabinoid signalling after a high-fat diet in Apoe −/− mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance
Bartelt, A., Orlando, P., Mele, C., Ligresti, A., Toedter, K., Scheja, L., Heeren, J., & Marzo, V. D. (2011) · Diabetologia · doi:10.1007/s00125-011-2274-6 · Cited by 71 · see citing works
Gut Emotions - Mechanisms of Action of Probiotics as Novel Therapeutic Targets for Depression and Anxiety Disorders
Slyepchenko, A., Carvalho, A. F., Cha, D. S., Kasper, S. F., & McIntyre, R. S. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130205242 · Cited by 71 · see citing works
NewN-Arachidonoylserotonin Analogues with Potential “Dual” Mechanism of Action against Pain
Ortar, G., Cascio, M. G., PETROCELLIS, L. D., Morera, E., Rossi, F., Moriello, A. S., Nalli, M., de Novellis, V., Woodward, D. F., Maione, S., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070678q · Cited by 67 · see citing works
Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression?
Boorman, E., Zajkowska, Z., Ahmed, R., Pariante, C. M., & Zunszain, P. A. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4105-9 · Cited by 66 · see citing works
A Lognormal Recurrent Network Model for Burst Generation during Hippocampal Sharp Waves
Omura, Y., Carvalho, M. M., Inokuchi, K., & Fukai, T. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4944-14.2015 · Cited by 66 · see citing works
Effect of delta-9-tetrahydrocannabinol on behavioral despair and on pre- and postsynaptic serotonergic transmission
Bambico, F. R., Hattan, P. R., Garant, J.-P., & Gobbi, G. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.006 · Cited by 61 · see citing works
The genetic ablation or pharmacological inhibition of TRPV1 signalling is beneficial for the restoration of quiescent osteoclast activity in ovariectomized mice
Rossi, F., Bellini, G., Torella, M., Tortora, C., Manzo, I., Giordano, C. S. D. S., Guida, F., Luongo, L., Papale, F., Rosso, F., et al. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12542 · Cited by 60 · see citing works
TRPV1 Regulates Stress Responses through HDAC2
Wang, S. E., Ko, S. Y., Jo, S., Choi, M., Lee, S. H., Jo, H.-R., Seo, J. Y., Lee, S. H., Kim, Y.-S., Jung, S. J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.050 · Cited by 57 · see citing works
Transient receptor potential vanilloid 1 agonists modulate hippocampal CA1 LTP via the GABAergic system
Bennion, D. M., Jensen, T., Walther, C., Hamblin, J., Wallmann, A., Couch, J., Blickenstaff, J., Castle, M., Dean, L., Beckstead, S., et al. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.018 · Cited by 52 · see citing works
Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice
Brown, T. E., Chirila, A. M., Schrank, B. R., & Kauer, J. A. (2013) · Hippocampus · doi:10.1002/hipo.22125 · Cited by 52 · see citing works
Lactobacillus casei CRL 431 administration decreases inflammatory cytokines in a diet-induced obese mouse model
Núñez, I. N., Galdeano, C. M., de LeBlanc, A. D. M., & Perdigón, G. (2015) · Nutrition · doi:10.1016/j.nut.2015.02.006 · Cited by 51 · see citing works
Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signaling Deficiency
Cristino, L., Luongo, L., Imperatore, R., Boccella, S., Becker, T., Morello, G., Piscitelli, F., Busetto, G., Maione, S., & Marzo, V. D. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.173 · Cited by 45 · see citing works
The endocannabinoidome : the world of endocannabinoids and related mediators
Marzo, V. D., & Wang, J. Y. (2015) · Cited by 38 · see citing works
Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1
Henry, R. J., Kerr, D. M., Flannery, L. E., Killilea, M., Hughes, E. M., Corcoran, L., Finn, D. P., & Roche, M. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.02.016 · Cited by 37 · see citing works
Identification of an arylalkylamine N‐acyltransferase from Drosophila melanogaster that catalyzes the formation of long‐chain N‐acylserotonins
Dempsey, D. R., Jeffries, K. A., Anderson, R. L., Carpenter, A., Opsina, S. R., & Merkler, D. J. (2014) · FEBS Letters · doi:10.1016/j.febslet.2013.12.027 · Cited by 36 · see citing works
A dual inhibitor of FAAH and TRPV1 channels shows dose-dependent effect on depression-like behaviour in rats
Kirkedal, C., Wegener, G., Moreira, F. A., Joca, S. R. L., & Liebenberg, N. (2016) · Acta Neuropsychiatrica · doi:10.1017/neu.2016.68 · Cited by 32 · see citing works
Sinularioside, a triacetylated glycolipid from the Indonesian soft coral Sinularia sp., is an inhibitor of NO release
Putra, M. Y., Ianaro, A., Panza, E., Bavestrello, G., Cerrano, C., Fattorusso, E., & Taglialatela‐Scafati, O. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.02.102 · Cited by 25 · see citing works
The Role of Leukotriene B4 in Clostridium difficile Toxin A--Induced Ileitis in Rats
McVey, D. C., & Vigna, S. R. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.017 · Cited by 22 · see citing works
Enhanced expression of codon optimized Mycobacterium avium subsp. paratuberculosis antigens in Lactobacillus salivarius
Johnston, C. D. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00120 · Cited by 21 · see citing works
Sex-dependent effects of neonatal maternal deprivation on endocannabinoid levels in the adipose tissue: influence of diet
Mela, V., Piscitelli, F., Llorente‐Berzal, A., Chowen, J. A., Silvestri, C., Viveros, M., & Marzo, V. D. (2016) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-017-0558-0 · Cited by 5 · see citing works

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The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Cannabinoids and the expanded endocannabinoid system in neurological disorders
Cristino, L., Bisogno, T., & Di Marzo, V. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-019-0284-z · Cited by 970 · see citing works
Gut microbiota and its metabolites in depression: from pathogenesis to treatment
Liu, L., Wang, H., Chen, X., Zhang, Y., Zhang, H., & Xie, P. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104527 · Cited by 713 · see citing works
Systematic Review of Gut Microbiota and Major Depression
Cheung, S. G., Goldenthal, A. R., Uhlemann, A.-C., Mann, J. J., Miller, J. M., & Sublette, M. E. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00034 · Cited by 597 · see citing works
New approaches and challenges to targeting the endocannabinoid system
Marzo, V. D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.115 · Cited by 480 · see citing works
Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature
Remes, O., Mendes, J. F., & Templeton, P. (2021) · Brain Sciences · doi:10.3390/brainsci11121633 · Cited by 482 · see citing works
Microbiota and the social brain
Sherwin, E., Bordenstein, S. R., Quinn, J. L., Dinan, T. G., & Cryan, J. F. (2019) · Science · doi:10.1126/science.aar2016 · Cited by 462 · see citing works
Recognizing Depression from the Microbiota–Gut–Brain Axis
Liang, S., Wu, X., Hu, X., Wang, T., & Jin, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061592 · Cited by 387 · see citing works
The Role of Microbiome in Insomnia, Circadian Disturbance and Depression
Li, Y., Hao, Y., Fan, F., & Zhang, B. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00669 · Cited by 294 · see citing works
Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis
Tian, P., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.01.007 · Cited by 257 · see citing works
The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases
Hosseinkhani, F., Heinken, A., Thiele, I., Lindenburg, P. W., Harms, A. C., & Hankemeier, T. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1882927 · Cited by 244 · see citing works
You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan
Jaggar, M., Rea, K., Spichak, S., Dinan, T. G., & Cryan, J. F. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100815 · Cited by 200 · see citing works
The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies
Alli, S. R., Gorbovskaya, I., Liu, J. C. W., Kolla, N. J., Brown, L., & Müller, D. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094494 · Cited by 202 · see citing works
Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years
Maccarrone, M., Di Marzo, V., Gertsch, J., Grether, U., Howlett, A. C., Hua, T., Makriyannis, A., Piomelli, D., Ueda, N., & van der Stelt, M. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000600 · Cited by 183 · see citing works
Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption
Schepper, J. D., Collins, F. L., Rios-Arce, N. D., Raehtz, S., Schaefer, L., Gardinier, J. D., Britton, R. A., Parameswaran, N., & McCabe, L. R. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3635 · Cited by 182 · see citing works
Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases
Opazo, M. C., Ortega-Rocha, E. M., Coronado-Arrázola, I., Bonifaz, L. C., Boudin, H., Neunlist, M., Bueno, S. M., Kalergis, A. M., & Riedel, C. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00432 · Cited by 179 · see citing works
Microbiota influence the development of the brain and behaviors in C57BL/6J mice
Lu, J., Synowiec, S., Lu, L., Yu, Y., Bretherick, T., Takada, S., Yarnykh, V., Caplan, J., Caplan, M., Claud, E. C., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201829 · Cited by 159 · see citing works
Mechanistic Insights into the Link between Gut Dysbiosis and Major Depression: An Extensive Review
Sonali, S., Ray, B., Hediyal, T. A., Rathipriya, A. G., Sunanda, T., Mahalakshmi, A. M., Rungratanawanich, W., Essa, M. M., Qoronfleh, M. W., Chidambaram, S. B., et al. (2022) · Cells · doi:10.3390/cells11081362 · Cited by 159 · see citing works
Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options
Kumar, A., Pramanik, J., Goyal, N., Chauhan, D., Sivamaruthi, B. S., Prajapati, B. G., & Chaiyasut, C. (2023) · Pharmaceuticals · doi:10.3390/ph16040565 · Cited by 164 · see citing works
Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling
Manca, C., Boubertakh, B., Leblanc, N., Deschênes, T., Lacroix, S., Martin, C., Houde, A., Veilleux, A., Flamand, N., Muccioli, G. G., et al. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000424 · Cited by 152 · see citing works
Gut-Brain-Microbiota Axis: Antibiotics and Functional Gastrointestinal Disorders
Karakan, T., Özkul, C., Akkol, E. K., Bilici, S., Sobarzo‐Sánchez, E., & Capasso, R. (2021) · Nutrients · doi:10.3390/nu13020389 · Cited by 155 · see citing works
Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3
Hao, W., Ma, Q., Wang, L., Yuan, N., Gan, H. T., He, L., Li, X., Huang, J., & Chen, J. (2024) · Microbiome · doi:10.1186/s40168-024-01756-6 · Cited by 149 · see citing works
A review of antibiotics, depression, and the gut microbiome
Hao, W., Li, X., Zhang, P.-W., & Chen, J. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.112691 · Cited by 144 · see citing works
Updated review of research on the gut microbiota and their relation to depression in animals and human beings
Yang, Z., Li, J., Gui, X., Shi, X., Bao, Z., Han, H., & Li, M. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0729-1 · Cited by 139 · see citing works
The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases
Zhou, Y., Chen, Y., He, H., Peng, M., Zeng, M., & Sun, H. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109690 · Cited by 141 · see citing works
The role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135 · see citing works
Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner
Rincel, M., Aubert, P., Chevalier, J., Grohard, P. ‐., Basso, L., de Oliveira, C. M., Helbling, J., Lévy, É., Chevalier, G., Leboyer, M., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.03.006 · Cited by 132 · see citing works
High-Dietary Fiber Intake Alleviates Antenatal Obesity-Induced Postpartum Depression: Roles of Gut Microbiota and Microbial Metabolite Short-chain Fatty Acid Involved
Liu, Z., Li, L., Ma, S., Jin, Y., Zhang, H., Li, Y., Sair, A. T., Pan, J., Liu, X., Li, X., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04290 · Cited by 128 · see citing works
Inflammatory Bowel Disease: A Stressed “Gut/Feeling”
Oligschlaeger, Y., Yadati, T., Houben, T., Oliván, C. M. C., & Shiri‐Sverdlov, R. (2019) · Cells · doi:10.3390/cells8070659 · Cited by 116 · see citing works
Tryptophan-rich diet ameliorates chronic unpredictable mild stress induced depression- and anxiety-like behavior in mice: The potential involvement of gut-brain axis
Wang, D., Wu, J., Zhu, P., Xie, H., Lu, L., Bai, W., Pan, W., Shi, R., Ye, J., Xia, B., et al. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111289 · Cited by 112 · see citing works
Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain
Guida, F., Boccella, S., Belardo, C., Iannotta, M., Piscitelli, F., Filippis, F. D., Paino, S., Ricciardi, F., Siniscalco, D., Marabese, I., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.006 · Cited by 111 · see citing works
Microbiota-brain interactions: Moving toward mechanisms in model organisms
Nagpal, J. K., & Cryan, J. F. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.036 · Cited by 107 · see citing works
Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice
Bistoletti, M., Caputi, V., Baranzini, N., Marchesi, N., Filpa, V., Marsilio, I., Cerantola, S., Terova, G., Baj, A., Grimaldi, A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212856 · Cited by 108 · see citing works
Early exposure to antibiotic drugs and risk for psychiatric disorders: a population-based study
Lavebratt, C., Yang, L. L., Giacobini, M., Forsell, Y., Schalling, M., Partonen, T., & Gissler, M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0653-9 · Cited by 104 · see citing works
The cancer-immune dialogue in the context of stress
Ma, Y., & Kroemer, G. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00949-8 · Cited by 110 · see citing works
Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders
Shahbazi, R., Yasavoli‐Sharahi, H., Alsadi, N., Ismail, N., & Matar, C. (2020) · Molecules · doi:10.3390/molecules25214891 · Cited by 101 · see citing works
Links Between Gut Dysbiosis and Neurotransmitter Disturbance in Chronic Restraint Stress-Induced Depressive Behaviours: the Role of Inflammation
Yang, H., Li, M., Zhou, M., Xu, H., Huan, F., Liu, N., Gao, R., Wang, J., Zhang, N., & Jiang, L. (2021) · Inflammation · doi:10.1007/s10753-021-01514-y · Cited by 101 · see citing works
Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat
Castonguay-Paradis, S., Lacroix, S., Rochefort, G., Parent, L., Perron, J., Martin, C., Lamarche, B., Raymond, F., Flamand, N., Marzo, V. D., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72861-3 · Cited by 97 · see citing works
Antibiotic effects on gut microbiota, metabolism, and beyond
Mu, C., & Zhu, W. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10165-x · Cited by 97 · see citing works
Antibiotic-Induced Microbiome Depletion Is Associated with Resilience in Mice after Chronic Social Defeat Stress
Wang, S., Qu, Y., Chang, L., Pu, Y., Zhang, K., & Hashimoto, K. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.09.064 · Cited by 94 · see citing works
The Role of Bacteria and Its Derived Metabolites in Chronic Pain and Depression: Recent Findings and Research Progress
Li, S., Hua, D., Wang, Q., Yang, L., Wang, X., Luo, A., & Yang, C. (2019) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyz061 · Cited by 91 · see citing works
The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders
Marzo, V. D. (2020) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2020.22.3/vdimarzo · Cited by 91 · see citing works
Ovarian progesterone suppresses depression and anxiety-like behaviors by increasing the Lactobacillus population of gut microbiota in ovariectomized mice
Watcharin, S., Sovijit, W., Pu, S., Usuda, K., Inoüe, R., Watanabe, G., Yamaguchi, H., & Nagaoka, K. (2019) · Neuroscience Research · doi:10.1016/j.neures.2019.04.005 · Cited by 89 · see citing works
A review of the antimicrobial side of antidepressants and its putative implications on the gut microbiome
McGovern, A. S., Hamlin, A. S., & Winter, G. (2019) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867419877954 · Cited by 89 · see citing works
The gut microbiome, endocannabinoids and metabolic disorders
Iannotti, F. A., & Marzo, V. D. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0444 · Cited by 89 · see citing works
Next‐Generation Probiotics: Microflora Intervention to Human Diseases
Zhang, H., Duan, Y., Cai, F., Cao, D., Wang, L., Qiao, Z., Hong, Q., Li, N., Zheng, Y., Su, M., et al. (2022) · BioMed Research International · doi:10.1155/2022/5633403 · Cited by 91 · see citing works
Dietary Interventions to Modulate the Gut Microbiome—How Far Away Are We From Precision Medicine
Filippis, F. D., Vitaglione, P., Cuomo, R., Canani, R. B., & Ercolini, D. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy080 · Cited by 87 · see citing works
The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice
Xu, L., Surathu, A., Raplee, I., Chockalingam, A., Stewart, S. R., Walker, L., Sacks, L. V., Patel, V. P., Li, Z., & Rouse, R. L. (2020) · BMC Genomics · doi:10.1186/s12864-020-6665-2 · Cited by 87 · see citing works
Reciprocal Interactions Between Gut Microbiota and Host Social Behavior
Münger, E., Montiel-Castro, A. J., Langhans, W., & Pacheco‐López, G. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00021 · Cited by 84 · see citing works
Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to Diet-Induced Obesity in Mice
Lacroix, S., Pechereau, F., Leblanc, N., Boubertakh, B., Houde, A., Martin, C., Flamand, N., Silvestri, C., Raymond, F., Marzo, V. D., et al. (2019) · mSystems · doi:10.1128/msystems.00407-19 · Cited by 84 · see citing works
Endocannabinoid System: Chemical Characteristics and Biological Activity
Rezende, B., Alencar, A. K. N., de Bem, G. F., Fontes-Dantas, F. L., & Montes, G. C. (2023) · Pharmaceuticals · doi:10.3390/ph16020148 · Cited by 90 · see citing works
Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats
Lv, W., Liu, C., Yu, L., Zhou, J., Li, Y., Xiong, Y., Guo, A., Chao, L., Qu, Q., Guang-wei, W., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1241894 · Cited by 85 · see citing works
The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
Sarubbo, F., Cavallucci, V., & Pani, G. (2022) · Cells · doi:10.3390/cells11030382 · Cited by 82 · see citing works
Role of the endocannabinoid system in the regulation of intestinal homeostasis
Cuddihey, H., MacNaughton, W. K., & Sharkey, K. A. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.05.015 · Cited by 79 · see citing works
Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice
Kundu, P., Torres, E. R. S., Stagaman, K., Kasschau, K., Okhovat, M., Holden, S., Ward, S., Nevonen, K. A., Davis, B. A., Saito, T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-83851-4 · Cited by 75 · see citing works
Gut microbiome-linked metabolites in the pathobiology of major depression with or without anxiety-a role for bile acids
MahmoudianDehkordi, S., Bhattacharyya, S., Brydges, C. R., Jia, W., Fiehn, O., Rush, A. J., Dunlop, B. W., & Kaddurah-Daouk, R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.937906 · Cited by 75 · see citing works
Anesthesia and surgery induce cognitive dysfunction in elderly male mice: the role of gut microbiota
Zhan, G., Hua, D., Huang, N., Wang, Y., Li, S., Zhou, Z., Yang, N., Jiang, R., Zhu, B., Yang, L., et al. (2019) · Aging · doi:10.18632/aging.101871 · Cited by 71 · see citing works
Antibiotics and the nervous system: More than just the microbes?
Champagne-Jorgensen, K., Kunze, W. A., Forsythe, P., Bienenstock, J., & McVey Neufeld, K.-A. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.12.014 · Cited by 92 · see citing works
Early-Life Stress Modulates Gut Microbiota and Peripheral and Central Inflammation in a Sex-Dependent Manner
Park, H. J., Kim, S. A., Kang, W. S., & Kim, J. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041899 · Cited by 59 · see citing works
Naturally occurring TPE-CA maintains gut microbiota and bile acids homeostasis via FXR signaling modulation of the liver-gut axis
Liu, L., Liu, Z., Li, H., Cao, Z., Li, W., Song, Z., Li, X., Lu, A., Lu, C., & Liu, Y. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00012 · Cited by 68 · see citing works
Long-term probiotic intervention mitigates memory dysfunction through a novel H3K27me3-based mechanism in lead-exposed rats
Xiao, J., Wang, T., Xu, Y., Gu, X., Li, D., Niu, K., Wang, T., Zhao, J., Zhou, R., & Wang, H.-L. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0719-8 · Cited by 70 · see citing works
Bipolar disorder and the gut microbiome: A systematic review
Sublette, M. E., Cheung, S. G., Lieberman, E. E., Hu, S., Mann, J. J., Uhlemann, A., & Miller, J. M. (2021) · Bipolar Disorders · doi:10.1111/bdi.13049 · Cited by 68 · see citing works
Nutritional Neuroscience as Mainstream of Psychiatry: The Evidence- Based Treatment Guidelines for Using Omega-3 Fatty Acids as a New Treatment for Psychiatric Disorders in Children and Adolescents
Chang, J. P., & Su, K. (2020) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2020.18.4.469 · Cited by 65 · see citing works
Finding intestinal fortitude: Integrating the microbiome into a holistic view of depression mechanisms, treatment, and resilience
Flux, M. C., & Lowry, C. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104578 · Cited by 68 · see citing works
Colitis-Induced Microbial Perturbation Promotes Postinflammatory Visceral Hypersensitivity
Esquerre, N., Basso, L., Defaye, M., Vicentini, F., Cluny, N. L., Bihan, D. G., Hirota, S. A., Schick, A., Jijon, H. B., Lewis, I. A., et al. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.04.003 · Cited by 65 · see citing works
Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Chen, M., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01506-0 · Cited by 63 · see citing works
The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats
Lv, W.-J., Wu, X.-L., Chen, W.-Q., Li, Y.-F., Zhang, G.-F., Chao, L.-M., Zhou, J.-H., Guo, A., Liu, C., & Guo, S.-N. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7902874 · Cited by 61 · see citing works
Gut microbiota and neuropsychiatric disorders: Implications for neuroendocrine-immune regulation
Ge, T., Yao, X., Zhao, H., Yang, W., Zou, X., Peng, F., Li, B., & Cui, R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105909 · Cited by 62 · see citing works
MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microglia
Infantino, R., Schiano, C., Luongo, L., Paino, S., Mansueto, G., Boccella, S., Guida, F., Ricciardi, F., Iannotta, M., Belardo, C., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105611 · Cited by 61 · see citing works
Antibiotics-induced intestinal dysbacteriosis caused behavioral alternations and neuronal activation in different brain regions in mice
Wang, P., Tu, K., Cao, P., Yang, Y., Zhang, H., Qiu, X.-T., Zhang, M., Wu, X., Yang, H., & Chen, T. (2021) · Molecular Brain · doi:10.1186/s13041-021-00759-w · Cited by 60 · see citing works
Exploring the microbiota-gut-brain axis: impact on brain structure and function
Yassin, L. K., Nakhal, M. M., Alderei, A., Almehairbi, A., Mydeen, A. B., Akour, A. A., & Hamad, M. I. K. (2025) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2025.1504065 · Cited by 60 · see citing works
Remodeling of microbiota gut-brain axis using psychobiotics in depression
Palepu, M. S. K., & Dandekar, M. P. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175171 · Cited by 59 · see citing works
Endocannabinoids Inhibit the Induction of Virulence in Enteric Pathogens
Ellermann, M., Pacheco, A. R., Jimenez, A. G., Russell, R. M., Cuesta, S., Kumar, A., Zhu, W., do Vale, G. D., Martin, S. A., Raj, P., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.022 · Cited by 60 · see citing works
The microbiome and gut endocannabinoid system in the regulation of stress responses and metabolism
Srivastava, R. K., Lutz, B., & Ruiz de Azua, I. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.867267 · Cited by 56 · see citing works
Interactions Between Antidepressants and Intestinal Microbiota
Xu, F., Xie, Q., Kuang, W., & Dong, Z. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01362-8 · Cited by 58 · see citing works
Enduring neurobehavioral effects induced by microbiota depletion during the adolescent period
Lach, G., Fülling, C., Bastiaanssen, T. F. S., Fouhy, F., Donovan, A. N. O., Ventura‐Silva, A. P., Stanton, C., Dinan, T. G., & Cryan, J. F. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01073-0 · Cited by 55 · see citing works
Beyond the lesion site: minocycline augments inflammation and anxiety-like behavior following SCI in rats through action on the gut microbiota
Schmidt, E. K. A., Raposo, P. J. F., Espin, A. T., Fenrich, K. K., & Fouad, K. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02123-0 · Cited by 53 · see citing works
Melatonin Ameliorates Depressive‐Like Behaviors in Ovariectomized Mice by Improving Tryptophan Metabolism via Inhibition of Gut Microbe Alistipes Inops
Zheng, K., Gao, B., Wang, H., He, J., Chen, H., Hu, Z., Long, L., Chen, J., & Wang, F. (2024) · Advanced Science · doi:10.1002/advs.202309473 · Cited by 55 · see citing works
Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota
Dione, N., Lacroix, S., Taschler, U., Deschênes, T., Abolghasemi, A., Leblanc, N., Marzo, V. D., & Silvestri, C. (2020) · Cells · doi:10.3390/cells9122705 · Cited by 55 · see citing works
Role of gut microbiota in neuropathy and neuropathic pain states: A systematic preclinical review
Pane, K., Boccella, S., Guida, F., Franzese, M., Maione, S., & Salvatore, M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105773 · Cited by 52 · see citing works
The microbiota promotes social behavior by modulating microglial remodeling of forebrain neurons
Bruckner, J. J., Stednitz, S. J., Grice, M. Z., Zaidan, D., Massaquoi, M. S., Larsch, J., Tallafuß, A., Guillemin, K. J., Washbourne, P., & Eisen, J. S. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001838 · Cited by 52 · see citing works
Visceral sensitivity modulation by faecal microbiota transplantation: the active role of gut bacteria in pain persistence
Lucarini, E., Pilato, V. D., Parisio, C., Micheli, L., Toti, A., Pacini, A., Bartolucci, G., Baldi, S., Niccolai, E., Amedei, A., et al. (2021) · Pain · doi:10.1097/j.pain.0000000000002438 · Cited by 50 · see citing works
Multimodal neuroimaging fusion biomarkers mediate the association between gut microbiota and cognition
Zhu, J., Wang, C., Qian, Y., Cai, H., Zhang, S., Zhang, C., Zhao, W., Zhang, T., Zhang, B., Chen, J., et al. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110468 · Cited by 50 · see citing works
Manual acupuncture benignly regulates blood-brain barrier disruption and reduces lipopolysaccharide loading and systemic inflammation, possibly by adjusting the gut microbiota
Zhang, Y., Ding, N., Hao, X., Zhao, J., Zhao, Y., Li, Y., & Li, Z. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1018371 · Cited by 52 · see citing works
Enrofloxacin Exposure Induces Anxiety-Like Behavioral Responses in Zebrafish by Affecting the Microbiota-Gut-Brain Axis
Tian, D., Shi, W. M., Yu, Y., Zhou, W., Tang, Y., Zhang, W., Huang, L., Han, Y., & Liu, G. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.160094 · Cited by 49 · see citing works
Advances in the mechanisms of polysaccharides in alleviating depression and its complications
Guo, Y., Chen, X., Gong, P., Li, Z., Wu, Y., Zhang, J., Wang, J., Yao, W., Yang, W., & Chen, F. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154566 · Cited by 53 · see citing works
Maternal antibiotic administration during a critical developmental window has enduring neurobehavioural effects in offspring mice
O’Connor, R., Moloney, G. M., Fülling, C., O’Riordan, K. J., Fitzgerald, P., Bastiaanssen, T. F. S., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113156 · Cited by 50 · see citing works
Gut microbiome partially mediates and coordinates the effects of genetics on anxiety-like behavior in Collaborative Cross mice
Jin, X., Zhang, Y., Celniker, S., Xia, Y., Mao, J., Snijders, A. M., & Chang, H. (2021) · Scientific Reports · doi:10.1038/s41598-020-79538-x · Cited by 49 · see citing works
Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats
Khambadkone, S. G., Cordner, Z. A., Dickerson, F., Severance, E. G., Prandovszky, E., Pletnikov, M. V., Xiao, J., Li, Y., Boersma, G. J., Talbot, C. C., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0105-6 · Cited by 48 · see citing works
O Uter Membrane Protein Amuc_1100 of Akkermansia Muciniphila Alleviates Antibiotic-Induced Anxiety and Depression-Like Behavior in Mice
Yan, S., Zhu, H., Cheng, R., Tang, Z., & Zhang, M. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.114023 · Cited by 47 · see citing works
Involvement of Intestinal Microbiota in Adult Neurogenesis and the Expression of Brain-Derived Neurotrophic Factor
Agnihotri, N., & Mohajeri, M. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415934 · Cited by 46 · see citing works
Early paracetamol exposure decreases brain-derived neurotrophic factor (BDNF) in striatum and affects social behaviour and exploration in rats
Blecharz‐Klin, K., Wawer, A., Jawna, K., Pyrzanowska, J., Piechal, A., Mirowska-Guzel, D. M., & Widy‐Tyszkiewicz, E. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.03.004 · Cited by 46 · see citing works
Impact of gut microbiota on neurogenesis and neurological diseases during infancy
Cerdó, T., Diéguez, E., & Campoy, C. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.11.006 · Cited by 45 · see citing works
Implications of neurogenesis in depression through BDNF: rodent models, regulatory pathways, gut microbiota, and potential therapy
Han, H., Yao, J., Wu, J., Mao, S., Pan, H., Qv, L., Zhu, G., Ren, J., Yu, Y., Xuan, F., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03044-7 · Cited by 46 · see citing works
The Antidepressant-like Effect of Flavonoids from Trigonella Foenum-Graecum Seeds in Chronic Restraint Stress Mice via Modulation of Monoamine Regulatory Pathways
Wang, J., Cheng, C., Xin, C., & Wang, Z. (2019) · Molecules · doi:10.3390/molecules24061105 · Cited by 44 · see citing works
Pulmonary hypertension: Pathophysiology beyond the lung
Oliveira, A. C. D. S., Richards, E. M., & Raizada, M. K. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104518 · Cited by 43 · see citing works
Effects of early-life penicillin exposure on the gut microbiome and frontal cortex and amygdala gene expression
Volkova, A., Ruggles, K. V., Schulfer, A. F., Gao, Z., Ginsberg, S. D., & Blaser, M. J. (2021) · iScience · doi:10.1016/j.isci.2021.102797 · Cited by 43 · see citing works
Antibiotics-induced depression in mice via the microbiota-gut-brain axis
Fan, X., Deng, H., Qiu, J., Ji, H., & Shen, X. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.08.059 · Cited by 44 · see citing works
Antibiotic-induced dysbiosis effects on the murine gastrointestinal tract and their systemic repercussions
Rosa, C. P., Brancaglion, G. A., Miyauchi-Tavares, T. M., Corsetti, P. P., & de Almeida, L. A. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.06.030 · Cited by 41 · see citing works
Targeting the endocannabinoid system with microbial interventions to improve gut integrity
Jansma, J., Brinkman, F. N., van Hemert, S., & Aidy, S. E. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110169 · Cited by 45 · see citing works

Antibiotic-induced diarrhea
Vogel, L. C. (1995) · International Journal of Trauma Nursing · doi:10.1016/s1075-4210(05)80009-4 · Cited by 1 · see citing works
Antibiotic-induced gut microbe dysbiosis alters neurobehavior in mice through modulation of BDNF and gut integrity
Thabet, E. H., Dief, A. E., Arafa, S., Yakout, D., & Ali, M. A. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114621 · Cited by 20 · see citing works
Antibiotics-induced intestinal dysbacteriosis caused behavioral alternations and neuronal activation in different brain regions in mice
Wang, P., Tu, K., Cao, P., Yang, Y., Zhang, H., Qiu, X.-T., Zhang, M., Wu, X., Yang, H., & Chen, T. (2021) · Molecular Brain · doi:10.1186/s13041-021-00759-w · Cited by 60 · see citing works
The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748 · see citing works
Antibiotic-induced gut dysbiosis leads to activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus
Çalışkan, G., French, T., Lacalle, S. E., del Ángel, M., Steffen, J., Heimesaat, M. M., Dunay, I. R., & Stork, O. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.10.007 · Cited by 55 · see citing works

Authors: Guida, F., Turco, F., Iannotta, M., De Gregorio, D., Palumbo, I., Sarnelli, G., Furiano, A., Napolitano, F., Boccella, S., Luongo, L., Mazzitelli, M., Usiello, A., De Filippis, F., Iannotti, F. A., Piscitelli, F., Ercolini, D., de Novellis, V., Di Marzo, V., Cuomo, R., & Maione, S.
Affiliations: University of Campania "Luigi Vanvitelli" (IT)
Federico II University Hospital (IT)
CEINGE Biotecnologie Avanzate Franco Salvatore (Italy) (IT)
Istituto di Chimica Biomolecolare (IT)
University of Naples Federico II (IT)
Corresponding author: Guida, F.
Maione, S.
ORCID: Guida, F.
Turco, F.
Iannotta, M.
Palumbo, I.
Sarnelli, G.
Napolitano, F.
Boccella, S.
Luongo, L.
Mazzitelli, M.
Usiello, A.
Iannotti, F.A.
Piscitelli, F.
Ercolini, D.
Cuomo, R.
Maione, S.
Venue: Brain Behavior and Immunity
Publisher: Elsevier BV
Published: 2018-01
Volume: 67
Pages: 230-245
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2017.09.001
OpenAlex: W2753690838
Cited by: 367
References: 87
Citations by year: 2026: 20 · 2025: 45 · 2024: 52 · 2023: 58 · 2022: 49 · 2021: 48 · 2020: 38 · 2019: 37 · 2018: 18 · 2017: 2
FWCI: 11.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: microbiota-gut-brain axis, antibiotic-induced dysbiosis, depression, probiotics, Lactobacillus casei, BDNF/TrkB signaling, TRPV1, Lachnospiraceae, intestinal inflammation, social recognition, anxiety-like behavior, mood disorders
MeSH terms: Gastrointestinal Microbiome, Animals, Anti-Bacterial Agents, Behavior, Animal, Depression, Hippocampus, Inflammation, Intestinal Mucosa, Intestines, Male, Mice, Inbred C57BL, Neuroglia, Neurons, Brain-Derived Neurotrophic Factor, Probiotics, Endocannabinoids, Dysbiosis

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Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice

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