The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Towards CRISPR/Cas crops – bringing together genomics and genome editing
Open accessAbstract
Summary: With the rapid increase in the global population and the impact of climate change on agriculture, there is a need for crops with higher yields and greater tolerance to abiotic stress. However, traditional crop improvement via genetic recombination or random mutagenesis is a laborious process and cannot keep pace with increasing crop demand. Genome editing technologies such as clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‐associated protein (CRISPR/Cas) allow targeted modification of almost any crop genome sequence to generate novel variation and accelerate breeding efforts. We expect a gradual shift in crop improvement away from traditional breeding towards cycles of targeted genome editing. Crop improvement using genome editing is not constrained by limited existing variation or the requirement to select alleles over multiple breeding generations. However, current applications of crop genome editing are limited by the lack of complete reference genomes, the sparse knowledge of potential modification targets, and the unclear legal status of edited crops. We argue that overcoming technical and social barriers to the application of genome editing will allow this technology to produce a new generation of high‐yielding, climate ready crops. Contents Summary 682 I. Introduction 682 II. Genomic‐based crop improvement before CRISPR/Cas 683 III. Genome assembly as the starting point for genome editing 684 IV. Identifying targets for genome editing using functional genomics 685 V. Using CRISPR/Cas to improve crops 685 VI. Improving the efficiency of the CRISPR/Cas system 688 VII. An emerging new breeding process 690 VIII. Conclusion 694 Acknowledgements 694 References 694
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Cites
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Cited by
CRISPR/Cas system: recent advances and future prospects for genome editing
Manghwar, H., Lindsey, K., Zhang, X., & Jin, S. (2019) · Trends in Plant Science · doi:10.1016/j.tplants.2019.09.006 · Cited by 529
“As described above, the CRISPR/Cas system can induce sequence-specific mutagenesis to interrupt genes to evaluate their functions and be used for trait improvement in crops [77].”
BackgroundRapid improvement of domestication traits in an orphan crop by genome editing
Lemmon, Z. H., Reem, N. T., Dalrymple, J., Soyk, S., Swartwood, K. E., Rodriguez-Leal, D., Van Eck, J., & Lippman, Z. B. (2018) · Nature Plants · doi:10.1038/s41477-018-0259-x · Cited by 518
De Novo Domestication: An Alternative Route toward New Crops for the Future
Fernie, A. R., & Yan, J. (2019) · Molecular Plant · doi:10.1016/j.molp.2019.03.016 · Cited by 398
Salt stress under the scalpel – dissecting the genetics of salt tolerance
Morton, M. J. L., Awlia, M., Al‐Tamimi, N., Saade, S., Pailles, Y., Negrão, S., & Tester, M. (2019) · The Plant Journal · doi:10.1111/tpj.14189 · Cited by 373
González, M. N., Massa, G. A., Andersson, M., Turesson, H., Olsson, N., Fält, A.-S., Storani, L., Décima Oneto, C. A., Hofvander, P., & Feingold, S. E. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01649 · Cited by 285
Metadata
- Authors
- Scheben, A., Wolter, F., Batley, J., Puchta, H., & Edwards, D.
- Venue
- New Phytologist
- Publisher
- Wiley
- Published
- 2017-08
- Volume
- 216
- Issue
- 3
- Pages
- 682-698
- ISSN
- 0028-646X (ISSN-L)
- 1469-8137
- OpenAlex
- W2741617948
- Cited by
- 313
- References
- 145
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- green
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