Angiopoietin‐2: a multifaceted cytokine that functions in both angiogenesis and inflammation

Cancer-related inflammation

Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570

Modes of resistance to anti-angiogenic therapy

Bergers, G., & Hanahan, D. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2442 · Cited by 2,953

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,872

Distinct role of macrophages in different tumor microenvironments

Lewis, C. E., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4005 · Cited by 2,225

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

Holash, J. A., Maisonpierre, P. C., Compton, D. L., Boland, P., Alexander, C., Zagzag, D., Yancopoulos, G. D., & Wiegand, S. J. (1999) · Science · doi:10.1126/science.284.5422.1994 · Cited by 2,222

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

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Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

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Angiopoietin-1 protects the adult vasculature against plasma leakage

Thurston, G., Rudge, J. S., Ioffe, E., Zhou, H., Ross, L. H., Croll, S. D., Glazer, N. L., Holash, J. A., McDonald, D. M., & Yancopoulos, G. D. (2000) · Nature Medicine · doi:10.1038/74725 · Cited by 1,314

Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1

Gale, N. W., Thurston, G., Hackett, S. F., Renard, R. A., Wang, Q., McClain, J., Martin, C., Witte, C. L., Witte, M. H., Jackson, D. G., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00217-4 · Cited by 1,017

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.

Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

Schmittnaegel, M., Rigamonti, N., Kadioglu, E., Cassará, A., Wyser Rmili, C., Kiialainen, A., Kienast, Y., Mueller, H.-J., Ooi, C.-H., Laoui, D., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aak9670 · Cited by 582

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Paskeh, M. D. A., Entezari, M., Mirzaei, S., Zabolian, A., Saleki, H., Naghdi, M. J., Sabet, S., Khoshbakht, M. A., Hashemi, M., Hushmandi, K., et al. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01305-4 · Cited by 591

Next generation of immune checkpoint inhibitors and beyond

Marin-Acevedo, J. A., Kimbrough, E. O., & Lou, Y. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01056-8 · Cited by 574

Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology

Akwii, R. G., Sajib, M. S., Zahra, F. T., & Mikelis, C. M. (2019) · Cells · doi:10.3390/cells8050471 · Cited by 566

Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches

Jin, Y., Ji, W., Yang, H., Chen, S., Zhang, W., & Duan, G. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00454-7 · Cited by 407

Simultaneous Inhibition of Angiopoietin-2 and Vascular Endothelial Growth Factor-A with Faricimab in Diabetic Macular Edema

Sahni, J., Patel, S. S., Dugel, P. U., Khanani, A. M., Jhaveri, C. D., Wykoff, C. C., Hershberger, V. S., Pauly-Evers, M., Sadikhov, S., Szczesny, P. J., et al. (2019) · Ophthalmology · doi:10.1016/j.ophtha.2019.03.023 · Cited by 286

Tie1 controls angiopoietin function in vascular remodeling and inflammation

Korhonen, E. A., Lampinen, A., Giri, H., Anisimov, A., Kim, M., Allen, B., Fang, S., D’Amico, G., Sipilä, T. J., Lohela, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84923 · Cited by 283

Endothelial cell‐derived angiopoietin‐2 is a therapeutic target in treatment‐naive and bevacizumab‐resistant glioblastoma

Scholz, A., Harter, P. N., Cremer, S., Yalcin, B. H., Gurnik, S., Yamaji, M., Tacchio, M. D., Sommer, K., Baumgarten, P., Bähr, O., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201505505 · Cited by 171

Angiopoietin-2 as a Biomarker and Target for Immune Checkpoint Therapy

Wu, X., Giobbie-Hurder, A., Liao, X., Connelly, C., Connolly, E. M., Li, J., Manos, M. P., Lawrence, D., McDermott, D., Severgnini, M., et al. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0206 · Cited by 164

The role of inflammation in diabetic eye disease

Mesquida, M., Drawnel, F., & Fauser, S. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00750-7 · Cited by 159

Biomarkers for Sepsis: What is and What Might Be?

Girard, B., Ayala, A., & Lomas‐Neira, J. (2015) · Biomarker Insights · doi:10.4137/bmi.s29519 · Cited by 149

Treatment of Diabetic Macular Edema

Kim, E. J., Lin, W. V., Rodriguez, S. M., Chen, A., Loya, A., & Weng, C. Y. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1188-4 · Cited by 141

Targeting Angiopoietin in Retinal Vascular Diseases: A Literature Review and Summary of Clinical Trials Involving Faricimab

Khan, M., Aziz, A. A., Shafi, N., Abbas, T., & Khanani, A. M. (2020) · Cells · doi:10.3390/cells9081869 · Cited by 132

Safety and Efficacy of Different Doses and Regimens of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration: The AVENUE Phase 2 Randomized Clinical Trial

Sahni, J., Dugel, P. U., Patel, S. S., Chittum, M. E., Berger, B., del Valle Rubido, M., Sadikhov, S., Szczesny, P., Schwab, D., Nogoceke, E., et al. (2020) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2020.2685 · Cited by 129

Biomarkers for the acute respiratory distress syndrome: how to make the diagnosis more precise

García-Laorden, M. I., Lorente, J. A., Flores, C., Slutsky, A. S., & Villar, J. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.06.49 · Cited by 118

Deregulated TGF-β/BMP Signaling in Vascular Malformations

Cunha, S. I., Magnusson, P. U., Dejana, E., & Lampugnani, M. G. (2017) · Circulation Research · doi:10.1161/circresaha.117.309930 · Cited by 123

Sticking for a Cause: The Falciparum Malaria Parasites Cytoadherence Paradigm

Lee, W.-C., Russell, B., & Rénia, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01444 · Cited by 119

Tumor Vessel Normalization, Immunostimulatory Reprogramming, and Improved Survival in Glioblastoma with Combined Inhibition of PD-1, Angiopoietin-2, and VEGF

Tacchio, M. D., Macas, J., Weissenberger, J., Sommer, K., Bähr, O., Steinbach, J., Senft, C., Seifert, V., Glas, M., Herrlinger, U., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0865 · Cited by 108

Central Role of Metabolism in Endothelial Cell Function and Vascular Disease

Bierhansl, L., Conradi, L., Treps, L., Dewerchin, M. A., & Carmeliet, P. (2017) · Physiology · doi:10.1152/physiol.00031.2016 · Cited by 107

Angiopoietin-2 induces angiogenesis via exosomes in human hepatocellular carcinoma

Xie, J., Wei, J., Lv, L., Han, Q., Yang, W., Li, G., Wang, P., Wu, S., Duan, J., Zhuo, W., et al. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00535-8 · Cited by 96

Recent Advances in Age-Related Macular Degeneration Therapies

Fabre, M., Mateo, L., Lamaa, D., Baillif, S., Pagès, G., Demange, L., Ronco, C., & Benhida, R. (2022) · Molecules · doi:10.3390/molecules27165089 · Cited by 98

Befriending the Hostile Tumor Microenvironment in CAR T-Cell Therapy

Lindo, L., Wilkinson, L., & Hay, K. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.618387 · Cited by 92

Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development

Yao, Y., Li, F., Huang, J., Jin, J., & Wang, H. (2021) · Experimental Hematology and Oncology · doi:10.1186/s40164-021-00233-2 · Cited by 93

Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis

An, Y., Sun, K., Joffin, N., Zhang, F., Deng, Y., Donzé, O., Kusminski, C. M., & Scherer, P. E. (2017) · eLife · doi:10.7554/elife.24071 · Cited by 77

FGF21 protects myocardial ischemia-reperfusion injury through reduction of miR-145-mediated autophagy.

Hu, S., Cao, S., Tong, Z., & Liu, J. (2018) · Europe PMC (PubMed Central) · Cited by 77

The Tie2 signaling pathway in retinal vascular diseases: a novel therapeutic target in the eye

Nguyen, Q. D., Heier, J. S., Diana, V., Mirando, A. C., Pandey, N. B., Sheng, H., & Heah, T. (2020) · International Journal of Retina and Vitreous · doi:10.1186/s40942-020-00250-z · Cited by 76

IDH mutation status is associated with distinct vascular gene expression signatures in lower-grade gliomas

Zhang, L., He, L., Lugano, R., Roodakker, K. R., Bergqvist, M., Smits, A., & Dimberg, A. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy088 · Cited by 74

Elevated Plasma Angiopoietin-2 Levels Are Associated With Fluid Overload, Organ Dysfunction, and Mortality in Human Septic Shock

Fisher, J., Douglas, J. J., Linder, A., Boyd, J. H., Walley, K. R., & Russell, J. A. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001853 · Cited by 77

Neurovascular unit, neuroinflammation and neurodegeneration markers in brain disorders

Kempuraj, D., Dourvetakis, K. D., Cohen, J., Valladares, D. S., Joshi, R. S., Kothuru, S. P., Anderson, T., Chinnappan, B., Cheema, A. K., Klimas, N. G., et al. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1491952 · Cited by 78

Role of Endothelial Cells in Acute and Chronic Thrombosis

Bochenek, M. L., & Schäfer, K. (2019) · Hämostaseologie · doi:10.1055/s-0038-1675614 · Cited by 72

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression

Bi, Y., Shirure, V. S., Liu, R., Cunningham, C., Ding, L., Meacham, J. M., Goedegebuure, S. P., George, S. C., & Fields, R. C. (2020) · Integrative Biology · doi:10.1093/intbio/zyaa017 · Cited by 75

A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10

Ruiz, S., Zhao, H., Chandakkar, P., Chatterjee, P. K., Papoin, J., Blanc, L., Metz, C. N., Campagne, F., & Marambaud, P. (2016) · Scientific Reports · doi:10.1038/srep37366 · Cited by 75

Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels

Huang, L., Bichsel, C. A., Norris, A. L., Thorpe, J., Pevsner, J., Alexandrescu, S., Pinto, A., Zurakowski, D., Kleiman, R. J., Sahin, M., et al. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316651 · Cited by 69

Faricimab for the Treatment of Diabetic Macular Edema and Neovascular Age-Related Macular Degeneration

Desideri, L. F., Traverso, C. E., Nicolò, M., & Munk, M. R. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051413 · Cited by 67

Uremic Toxins and Cardiovascular Risk in Chronic Kidney Disease: What Have We Learned Recently beyond the Past Findings?

Chamieh, C. E., Liabeuf, S., & Massy, Z. A. (2022) · Toxins · doi:10.3390/toxins14040280 · Cited by 69

Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness*

Binnie, A., Walsh, C. J., Hu, P., Dwivedi, D. J., Fox‐Robichaud, A., Liaw, P. C., Tsang, J. L. Y., Batt, J. A. E., Carrasqueiro, G., Gupta, S., et al. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000004097 · Cited by 65

Angiopoietins as Potential Targets in Management of Retinal Disease

Khanani, A. M., Russell, M. W., Aziz, A. A., Danzig, C. J., Weng, C. Y., Eichenbaum, D. A., & Singh, R. P. (2021) · Clinical ophthalmology · doi:10.2147/opth.s231801 · Cited by 65

Immunometabolism: Another Road to Sepsis and Its Therapeutic Targeting

Kumar, V. (2018) · Inflammation · doi:10.1007/s10753-018-0939-8 · Cited by 66

MYBL1 induces transcriptional activation of ANGPT2 to promote tumor angiogenesis and confer sorafenib resistance in human hepatocellular carcinoma

Zhu, J., Wu, Y., Yu, Y., Li, Y., Shen, J., & Zhang, R. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05180-2 · Cited by 62

Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways

Liang, N. N., Li, Y.-L., & Chung, H. Y. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4004 · Cited by 54

Extreme prematurity: Risk and resiliency

Taylor, G., & O’Shea, T. M. (2022) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2022.101132 · Cited by 55

Levetiracetam treatment influences blood-brain barrier failure associated with angiogenesis and inflammatory responses in the acute phase of epileptogenesis in post-status epilepticus mice

Itoh, K., Ishihara, Y., Komori, R., Nochi, H., Taniguchi, R., Chiba, Y., Ueno, M., Takata-Tsuji, F., Dohgu, S., & Kataoka, Y. (2016) · Brain Research · doi:10.1016/j.brainres.2016.09.038 · Cited by 50

Remote Ischemic Postconditioning vs. Physical Exercise After Stroke: an Alternative Rehabilitation Strategy?

Geng, X., Wang, Q., Lee, H., Huber, C., Wills, M. V., Elkin, K. B., Li, F., Ji, X., & Ding, Y. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02329-6 · Cited by 48

Mutually Supportive Mechanisms of Inflammation and Vascular Remodeling

Whiteford, J. R., Rossi, G. D., & Woodfin, A. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.05.001 · Cited by 48

Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of Sepsis-Induced Coagulopathy

Li, Y., Li, H., Wang, Y., Guo, J., & Zhang, D. (2023) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296231195089 · Cited by 46

Controversial roles for dexamethasone in glioblastoma – Opportunities for novel vascular targeting therapies

Dubinski, D., Hattingen, E., Senft, C., Seifert, V., Peters, K. G., Reiss, Y., Devraj, K., & Plate, K. H. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19859847 · Cited by 46

Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential

Whitehead, M., Osborne, A., Widdowson, P. S., Yu‐Wai‐Man, P., & Martin, K. R. G. (2019) · Journal of Diabetes Research · doi:10.1155/2019/5140521 · Cited by 44

Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas

Girolamo, F., de Trizio, I., Errede, M., Longo, G., d’Amati, A., & Virgintino, D. (2021) · Fluids and Barriers of the CNS · doi:10.1186/s12987-021-00242-7 · Cited by 47

Characterization of Biomarker Levels in Crimean–Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome

Korva, M., Rus, K. R., Pavletič, M., Saksida, A., Knap, N., Jelovšek, M., Smrdel, K. S., Jakupi, X., Humolli, I., Dedushaj, J., et al. (2019) · Viruses · doi:10.3390/v11080686 · Cited by 43

Space microgravity improves proliferation of human iPSC-derived cardiomyocytes

Rampoldi, A., Forghani, P., Li, D., Hwang, H., Armand, L. C., Fite, J., Boland, E. D., Maxwell, J. T., Maher, K. O., & Xu, C. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.08.007 · Cited by 40

Angiopoietin-2, Angiopoietin-1 and subclinical cardiovascular disease in Chronic Kidney Disease

Tsai, Y., Lee, C., Chiu, Y., Kuo, H., Lee, S., Hwang, S., Kuo, M., & Chen, H. (2016) · Scientific Reports · doi:10.1038/srep39400 · Cited by 40

Pathophysiological Association of Endothelial Dysfunction with Fatal Outcome in COVID-19

Maruhashi, T., & Higashi, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105131 · Cited by 40

Soluble Tie2 overrides the heightened invasion induced by anti-angiogenesis therapies in gliomas

Cortes‐Santiago, N., Hossain, M. B., Gabrusiewicz, K. R., Fan, X., Gumin, J., Marini, F. C., Alonso, M. M., Lang, F. F., Yung, W. K. A., Fueyo-Margareto, J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7550 · Cited by 40

Tie2 as a novel key factor of microangiopathy in systemic sclerosis

Moritz, F., Gote-Schniering, J., Distler, J. H. W., Gay, R. E., Gay, S., Distler, O., & Maurer, B. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1304-2 · Cited by 36

Characterisation of the inflammatory cytokine and growth factor profile in a rabbit model of proliferative vitreoretinopathy

Wong, C. W., Cheung, N., Ho, C. E. H., Barathi, V. A., Storm, G., & Wong, T. T. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-51633-8 · Cited by 35

Ang-2 promotes lung cancer metastasis by increasing epithelial-mesenchymal transition

Dong, Z., Chen, J., Yang, X., Zheng, W., Wang, L., Fang, M., Wu, M., Yao, M., & Yao, D. (2018) · Oncotarget · doi:10.18632/oncotarget.24061 · Cited by 36

Prognostic value of angiopoietin-2 in patients with chronic heart failure

Eleuteri, E., Stefano, A. D., Giordano, A., Corrà, U., Genta, F. T., Gnemmi, I., & Giannuzzi, P. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.03.005 · Cited by 34

CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology

Jiang, S., Fu, R., Shi, J., Wu, H., Mai, J., Hua, X., Huan, C., Liu, J., Lu, M.-Q., & Li, N. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.553706 · Cited by 34

Chemically defined human vascular laminins for biologically relevant culture of hiPSC-derived brain microvascular endothelial cells

Motallebnejad, P., & Azarin, S. M. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00215-2 · Cited by 32

Vascular normalization: reshaping the tumor microenvironment and augmenting antitumor immunity for ovarian cancer

Yu, P., Wang, Y., Yuan, D., Sun, Y., Qin, S., & Li, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1276694 · Cited by 36

Physical activity and progenitor cell-mediated endothelial repair in chronic heart failure: Is there a role for epigenetics?

Recchioni, R., Marcheselli, F., Antonicelli, R., Lazzarini, R., Mensa’, E., Testa, R., Procopio, A. D., & Olivieri, F. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.03.008 · Cited by 33

Role of angiopoietin-2 in the cardioprotective effect of fibroblast growth factor 21 on ischemia/reperfusion-induced injury in H9c2 cardiomyocytes

Hu, S., Cao, S., & Liu, J. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4564 · Cited by 31

Rac1 Regulates Endometrial Secretory Function to Control Placental Development

Dávila, J., Laws, M. J., Kannan, A., Li, Q., Taylor, R. N., Bagchi, M. K., & Bagchi, I. C. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005458 · Cited by 30

Clinical value of selected markers of angiogenesis, inflammation, insulin resistance and obesity in type 1 endometrial cancer

Terlikowska, K. M., Dobrzycka, B., Terlikowski, R., Sienkiewicz, A., Kinalski, M., & Terlikowski, S. J. (2020) · BMC Cancer · doi:10.1186/s12885-020-07415-x · Cited by 32

Total NT-proBNP, a novel biomarker related to recurrent atrial fibrillation

Staszewsky, L. I., Meessen, J. M. T. A., Novelli, D., Wienhues‐Thelen, U., Disertori, M., Maggioni, A. P., Masson, S., Tognoni, G., Franzosi, M. G., Lucci, D., et al. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-02358-y · Cited by 30

Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis

Akwii, R. G., Sajib, M. S., Zahra, F. T., Tullar, P., Zabet‐Moghaddam, M., Zheng, Y., Gutkind, J. S., Doçi, C. L., & Mikelis, C. M. (2022) · Angiogenesis · doi:10.1007/s10456-022-09831-y · Cited by 30

The natural compound atraric acid suppresses androgen-regulated neo-angiogenesis of castration-resistant prostate cancer through angiopoietin 2

Ehsani, M., Bartsch, S., Rasa, S. M. M., Dittmann, J., Pungsrinont, T., Neubert, L., Huettner, S. S., Kotolloshi, R., Schindler, K., Ahmad, A., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02333-7 · Cited by 30

Plasma PTX3, MCP1 and Ang2 are early biomarkers to evaluate the severity of sepsis and septic shock

Tian, R., Wang, X., Pan, T., Li, R., Wang, J., Liu, Z., Chen, E., Mao, E., Tan, R., Yang, C., et al. (2019) · Scandinavian Journal of Immunology · doi:10.1111/sji.12823 · Cited by 30

Increased Lymphangiogenesis and Lymphangiogenic Growth Factor Expression in Perivascular Adipose Tissue of Patients with Coronary Artery Disease

Drosos, I., Pavlaki, M., Carrillo, M. O., Kourkouli, A., Buschmann, K., Konstantinou, F., Gogiraju, R., Bochenek, M. L., Chalikias, G. K., Tortopidis, C., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8071000 · Cited by 28

Activated mesangial cells induce glomerular endothelial cells proliferation in rat anti‐Thy‐1 nephritis through VEGFA/VEGFR2 and Angpt2/Tie2 pathway

Zhao, Y., Fu, B., Chen, P., Li, Q., Ouyang, Q., Zhang, C., Cai, G., Wu, L., & Chen, X. (2021) · Cell Proliferation · doi:10.1111/cpr.13055 · Cited by 28

Statins Restore Endothelial Protection against Complement Activity in Obstructive Sleep Apnea: A Randomized Clinical Trial

Shah, R., Patel, N., Emin, M. T., Çelik, Y., Jimenez, A., Gao, S., Garfinkel, J., Wei, Y., & Jelić, S. (2023) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202209-761oc · Cited by 29

Angiopoietin 2 Levels in the Risk Stratification and Mortality Outcome Prediction of Sepsis-Associated Coagulopathy

Statz, S., Sabal, G., Walborn, A., Williams, M. D., Hoppensteadt, D., Mosier, M. M., Rondina, M. T., & Fareed, J. (2018) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029618786029 · Cited by 29

Complement promotes endothelial von Willebrand factor and angiopoietin-2 release in obstructive sleep apnea

Gao, S., Emin, M. T., Thoma, T., Pastellas, K., Castagna, F., Shah, R., Jimenez, A., Patel, N., Wei, Y., & Jelić, S. (2020) · SLEEP · doi:10.1093/sleep/zsaa286 · Cited by 28

Angiopoietin1 Deficiency in Hepatocytes Affects the Growth of Colorectal Cancer Liver Metastases (CRCLM)

Ibrahim, N. S., Lazaris, A., Rada, M., Petrillo, S. K., Huck, L., Hussain, S. N. A., Ouladan, S., Gao, Z., Gregorieff, A., Essalmani, R., et al. (2019) · Cancers · doi:10.3390/cancers12010035 · Cited by 26

Novel plasma protein biomarkers from critically ill sepsis patients

Nynatten, L. R. V., Slessarev, M., Martin, C. M., Leligdowicz, A., Miller, M. R., Patel, M. A., Daley, M., Patterson, E. K., Cepinskas, G., & Fraser, D. D. (2022) · Clinical Proteomics · doi:10.1186/s12014-022-09389-3 · Cited by 29

Therapeutic angiogenesis based on injectable hydrogel for protein delivery in ischemic heart disease

Wang, J., Song, Y., Xie, W., Zhao, J., Wang, Y., & Yu, W. (2023) · iScience · doi:10.1016/j.isci.2023.106577 · Cited by 26

Expression of Angiopoietins and Angiogenic Signaling Pathway Molecules in Chronic Subdural Hematomas

Isaji, T., Osuka, K., Ohmichi, Y., Ohmichi, M., Naito, M., Nakano, T., Iwami, K., & Miyachi, S. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7042 · Cited by 25

Valproic acid mitigates the inflammatory response and prevents acute respiratory distress syndrome in a murine model of Escherichia coli pneumonia at the expense of bacterial clearance

Kasotakis, G., Galvan, M. D., King, E. G., Sarkar, B., Stucchi, A. F., Mizgerd, J. P., Burke, P., & Remick, D. G. (2017) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000001389 · Cited by 25

Circulating angiopoietin-2 and its soluble receptor Tie-2 concentrations are related to inflammatory markers in the general population

Schuldt, E., Lieb, W., Dörr, M., Lerch, M. M., Völzke, H., Nauck, M. A., & Friedrich, N. (2018) · Cytokine · doi:10.1016/j.cyto.2018.02.003 · Cited by 25

Anti‐VEGF‐A/ANG2 combotherapy limits pathological angiogenesis in the eye: a replication study

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Insights into Sorafenib resistance in hepatocellular carcinoma: Mechanisms and therapeutic aspects

Yousef, E. H., Gayar, A. M. E., & El‐Magd, N. F. A. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104765 · Cited by 27

Maternal omega-3 PUFA supplementation prevents hyperoxia-induced pulmonary hypertension in the offspring

Zhong, Y., Catheline, D., Houeijeh, A., Sharma, D., Du, L., Besengez, C., Deruelle, P., Legrand, P., & Storme, L. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00527.2017 · Cited by 23

Effects of High Glucose Concentration on Pericyte-Like Differentiated Human Adipose-Derived Mesenchymal Stem Cells

Mannino, G., Longo, A., Gennuso, F., Anfuso, C. D., Lupo, G., Giurdanella, G., Giuffrida, R., & Furno, D. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094604 · Cited by 30

Inhibition of ANGPT2 activates autophagy during hypertrophic scar formation via PI3K/AKT/mTOR pathway

Chen, H., Xu, K., Sun, C., Gui, S., Wu, J., & Wang, S. (2022) · Anais Brasileiros de Dermatologia · doi:10.1016/j.abd.2021.12.005 · Cited by 22

New prognostic biomarkers of mortality in patients undergoing liver transplantation for hepatocellular carcinoma

Lorente, L. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i37.4230 · Cited by 22

Dissecting gastric cancer heterogeneity and exploring therapeutic strategies using bulk and single-cell transcriptomic analysis and experimental validation of tumor microenvironment and metabolic interplay

Lin, X., Yang, P., Wang, M., Huang, X., Wang, B., Chen, C., Xu, A., Cai, J., Khan, M. B., Liu, S., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1355269 · Cited by 23

Navigating the Modern Landscape of Sepsis: Advances in Diagnosis and Treatment

Jang, J. H., Choi, E., Kim, T., Yeo, H. J., Jeon, D., Kim, Y. S., & Cho, W. H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137396 · Cited by 21

Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis

Cheng, H., Chen, N., Chen, W.-F., Wu, Z., Sun, Y., Teng, W.-N., Su, F.-W., Sung, C., & Wen, Z. (2024) · The Journal of Headache and Pain · doi:10.1186/s10194-024-01916-x · Cited by 22

UC-MSCs promote frozen-thawed ovaries angiogenesis via activation of the Wnt/β-catenin pathway in vitro ovarian culture system

Xu, W., Wu, C., Zhu, X., Wu, J., Zhang, Z., Wei, Z., Cao, Y., Zhou, P. H., & Wang, J. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02989-8 · Cited by 21

P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation

Liu, M., Lu, B., Li, Y., Yuan, S., Zhuang, Z., Li, G., Wang, D., Ma, L., Zhu, J., Zhao, J., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01631-0 · Cited by 21

Angiopoietin-2 as a prognostic biomarker in septic adult patients: a systemic review and meta-analysis

Zhuo, M., Fu, S., Chi, Y., Li, X., Li, S., Li, X., & Li, X. (2024) · Annals of Intensive Care · doi:10.1186/s13613-024-01393-0 · Cited by 25

Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling

Mirando, A. C., Silva, R. L. E., Chu, Z., Campochiaro, P. A., Pandey, N. B., & Popel, A. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145142 · Cited by 20

Role of Angiopoietin/Tie2 System in Sepsis: A Potential Therapeutic Target

Chi, Y., Yu, S., Jia, Y., Liu, D., Zhuo, M., & Li, X. (2024) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296241238010 · Cited by 24

Suppression of KSHV-induced angiopoietin-2 inhibits angiogenesis, infiltration of inflammatory cells, and tumor growth

Yu, X., Sha, J., Shao, X., Qin, S., Conrad, P., Ghosh, S. K., Weinberg, A., & Ye, F. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1196303 · Cited by 20

Polymorphisms of genes involved in inflammation and blood vessel development influence the risk of varicose veins

Shadrina, A. S., Tsepilov, Y. A., Smetanina, M. A., Voronina, E. N., Seliverstov, E. I., Ilyukhin, Е. А., Кириенко, А. И., Zolotukhin, I. A., & Филипенко, М. Л. (2018) · Clinical Genetics · doi:10.1111/cge.13362 · Cited by 19

ISL2 modulates angiogenesis through transcriptional regulation of ANGPT2 to promote cell proliferation and malignant transformation in oligodendroglioma

Qi, L., Wang, Z.-Y., Shao, X., Li, M., Chen, S., Liu, X., Yan, S., Zhang, B., Zhang, X.-D., Li, X., et al. (2020) · Oncogene · doi:10.1038/s41388-020-01411-y · Cited by 19

Efficacy and Safety of Intravitreal Faricimab in Neovascular Age-Related Macular Degeneration, Diabetic Macular Edema, and Retinal Vein Occlusion: A Meta-Analysis

Nichani, P. A. H., Popovic, M. M., Mihalache, A., Pathak, A., Muni, R. H., Wong, D. T. W., & Kertes, P. J. (2024) · Ophthalmologica · doi:10.1159/000541662 · Cited by 18

Factors Associated with Success of Switching to Faricimab for Neovascular Age-Related Macular Degeneration Refractory to Intravitreal Aflibercept

Machida, A., Oishi, A., Ikeda, J., Kurihara, J., Yoneda, A., Tsuiki, E., Hirata, Y., Murakami, R., & Kitaoka, T. (2024) · Life · doi:10.3390/life14040476 · Cited by 18

Angiopoietin-2 as a Marker of Retinopathy in Children and Adolescents With Sickle Cell Disease: Relation to Subclinical Atherosclerosis

Andrawes, N. G., Ismail, E. A. R., Roshdy, M. M. S., Ebeid, F. S. E., Eissa, D. S., & Ibrahim, A. (2019) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000001486 · Cited by 18

Role of angiopoietin-2 in inflammatory autoimmune diseases: A comprehensive review

Wu, Q., Xu, W., & Huang, A. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106223 · Cited by 30

Angiogenesis and inflammation face off

Imhof, B. A., & Aurrand‐Lions, M. (2006) · Nature Medicine · doi:10.1038/nm0206-171 · Cited by 181

Angiopoietin/Tie2 signaling, tumor angiogenesis and inflammatory diseases

Kobayashi, H. (2005) · Frontiers in bioscience · doi:10.2741/1561 · Cited by 35

Angiopoietin-2 promotes inflammatory lymphangiogenesis and its effect can be blocked by the specific inhibitor L1-10

Yan, Z., Jiang, Z., & Liu, N.-F. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00895.2011 · Cited by 35

Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

Fiedler, U., Reiss, Y., Scharpfenecker, M., Grunow, V., Koidl, S., Thurston, G., Gale, N. W., Witzenrath, M., Rosseau, S., Suttorp, N., et al. (2006) · Nature Medicine · doi:10.1038/nm1351 · Cited by 933