The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Angiopoietin‐2: a multifaceted cytokine that functions in both angiogenesis and inflammation
Abstract
Angiogenesis and inflammation are two highly linked processes. In the last decade, several factors with dual function in both of these major pathways have been identified. This review focuses on angiopoietin‐2 (Ang‐2), an important proangiogenic factor that has more recently been implicated in mediating inflammatory processes as well. Ang‐2 is upregulated in multiple inflammatory diseases and has been implicated in the direct control of inflammation‐related signaling pathways. As a consequence of its multiple roles, designs for therapeutic targeting of Ang‐2 should consider the dual function of this factor in regulating angiogenesis and inflammation.
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“Interestingly, both ANG-2 and VEGF-A promote an antiinflammatory macrophage polarization (60,61).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [61]
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Cites
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Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning
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Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
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Angiopoietin-1 protects the adult vasculature against plasma leakage
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Cited by
Sorted by citations
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.
Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732
Schmittnaegel, M., Rigamonti, N., Kadioglu, E., Cassará, A., Wyser Rmili, C., Kiialainen, A., Kienast, Y., Mueller, H.-J., Ooi, C.-H., Laoui, D., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aak9670 · Cited by 582
Emerging role of exosomes in cancer progression and tumor microenvironment remodeling
Paskeh, M. D. A., Entezari, M., Mirzaei, S., Zabolian, A., Saleki, H., Naghdi, M. J., Sabet, S., Khoshbakht, M. A., Hashemi, M., Hushmandi, K., et al. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01305-4 · Cited by 591
Next generation of immune checkpoint inhibitors and beyond
Marin-Acevedo, J. A., Kimbrough, E. O., & Lou, Y. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01056-8 · Cited by 574
Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology
Akwii, R. G., Sajib, M. S., Zahra, F. T., & Mikelis, C. M. (2019) · Cells · doi:10.3390/cells8050471 · Cited by 566
Metadata
- Authors
- Scholz, A., Plate, K. H., & Reiss, Y.
- Affiliations
- Stanford Medicine (US)
- Goethe University Frankfurt (DE)
- Corresponding author
- Scholz, Alexander
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2015-03-13
- Volume
- 1347
- Issue
- 1
- Pages
- 45-51
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1758592134
- Cited by
- 248
- References
- 72
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 23 · 2023: 18 · 2022: 28 · 2021: 38 · 2020: 25 · 2019: 24 · 2018: 17 · 2017: 16 · 2016: 17 · 2015: 6
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SCHO 1551/1-1)
- Cluster of Excellence 147 Cardiopulmonary System (Start-Up Grant)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
- Keywords
- angiopoietin-2, angiogenesis, inflammation, angiogenic factors, inflammatory signaling, inflammatory diseases, therapeutic targeting
- MeSH terms
- Autoimmune Diseases, Endothelium, Vascular, Humans, Inflammation, Leukocytes, Neoplasms, Signal Transduction, Sepsis, Neovascularization, Physiologic, Vascular Endothelial Growth Factor A, Angiopoietin-2, Endothelial Cells
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