Angiopoietin‐2: a multifaceted cytokine that functions in both angiogenesis and inflammation

Cancer-related inflammation

Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570

Modes of resistance to anti-angiogenic therapy

Bergers, G., & Hanahan, D. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2442 · Cited by 2,953

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,872

Distinct role of macrophages in different tumor microenvironments

Lewis, C. E., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4005 · Cited by 2,225

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

Holash, J. A., Maisonpierre, P. C., Compton, D. L., Boland, P., Alexander, C., Zagzag, D., Yancopoulos, G. D., & Wiegand, S. J. (1999) · Science · doi:10.1126/science.284.5422.1994 · Cited by 2,222

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

Davis, S., Aldrich, T. H., Jones, P. F., Acheson, A., Compton, D. L., Jain, V., Ryan, T. E., Bruno, J., Radziejewski, C., Maisonpierre, P. C., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81812-7 · Cited by 1,989

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

Augustin, H. G., Koh, G. Y., Thurston, G., & Alitalo, K. K. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2639 · Cited by 1,512

Angiopoietin-1 protects the adult vasculature against plasma leakage

Thurston, G., Rudge, J. S., Ioffe, E., Zhou, H., Ross, L. H., Croll, S. D., Glazer, N. L., Holash, J. A., McDonald, D. M., & Yancopoulos, G. D. (2000) · Nature Medicine · doi:10.1038/74725 · Cited by 1,314

Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1

Gale, N. W., Thurston, G., Hackett, S. F., Renard, R. A., Wang, Q., McClain, J., Martin, C., Witte, C. L., Witte, M. H., Jackson, D. G., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00217-4 · Cited by 1,017

Reduced Angiopoietin-2 as a Predictive Biomarker for Clomiphene Citrate Resistance in Polycystic Ovary Syndrome

Rajendiran, L., Nandeesha, H., & Thyagaraju, C. (2021) · Journal of Human Reproductive Sciences · doi:10.4103/jhrs.jhrs_179_20 · Cited by 2

Assessment of Angiopoietin-2 Single Nucleotide Polymorphism in Patients with Rheumatoid Arthritis

Nasef, S. I., Ellawindy, A., Askar, A. M., Hashem, A. A., & Omar, H. H. (2022) · Inflammation · doi:10.1007/s10753-022-01773-3 · Cited by 2

The Effects of SARS-CoV-2 on the Angiopoietin/Tie Axis and the Vascular Endothelium

Janchivlamdan, D., Shivkumar, M., & Singh, H. (2024) · Encyclopedia · doi:10.3390/encyclopedia4010035 · Cited by 2

Pericyte loss leads to microvessel remodeling and nasal polyp formation

Cui, N., Zhu, X., Zhao, C., Meng, C., Sha, J., & Zhu, D. (2023) · Acta Oto-Laryngologica · doi:10.1080/00016489.2023.2276345 · Cited by 1

Angiogenesis: Biological Mechanisms and In Vitro Models

Brunmaier, L. A. E., Özdemir, T., & Walker, T. W. (2025) · Annals of Biomedical Engineering · doi:10.1007/s10439-025-03721-2 · Cited by 1

Faricimab bei vorbehandelter neovaskulärer altersabhängiger Makuladegeneration (nAMD)

Heimes, B., Bellenbaum, R., Njoo, C., Liakopoulos, S., Schmitz-Valckenberg, S., Zortel, M., Rothaus, K., Leemhuis, J., Mussinghoff, P., & Lommatzsch, A. P. (2025) · Die Ophthalmologie · doi:10.1007/s00347-025-02258-y · Cited by 1

The role of lncRNA NEAT1-miR-542-3p-ANG2 regulatory network on choroidal neovascularization in tree shrew

Liu, X., Yang, W., Zhao, H., Feng, X., & Wu, M. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110528 · Cited by 1

Proteomic predictors of mortality among people with Coronary Artery Disease

Liu, C., Hui, Q., Quyyumi, A. A., Vaccarino, V., & Sun, Y. V. (2025) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2025.101347 · Cited by 1

Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss

Yoon, S.-H., Fei, Y., Zhu, X., Tang, H., Abdurakhimova, D. A., Krier, J. D., Eirin, A., Lerman, A., Cohen, P., & Lerman, L. O. (2025) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2025.100429 · Cited by 1

Combined Therapy Versus Fortified Anti-VEGF Monotherapy in Type C Polypoidal Choroidal Vasculopathy: Long-Term Outcomes and Exploratory Biomarker Insights

Chao, W. W., Chao, H. W., & Chao, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031224 · Cited by 1

CSF and plasma neuro-biomarker dynamics after gene therapy for cerebral adrenoleukodystrophy

Lund, T. C., Gupta, A. O., Kemp, S., Loes, D. J., Nascene, D. R., & Orchard, P. J. (2026) · Molecular Therapy Advances · doi:10.1016/j.omta.2026.201702 · Cited by 1

Aqueous Humor Biomarkers, Efficacy, and Safety in Patients with Naïve Diabetic Macular Edema Treated with Faricimab: The ALTIMETER Study

Schlottmann, P. G., Fawzi, A. A., Amador, M. J., Dieckmann, A., Gibson, K., Glittenberg, C. G., Jhaveri, C. D., Kotak, A., Mar, F. A., Neubert, A., et al. (2026) · Ophthalmology Science · doi:10.1016/j.xops.2026.101129 · Cited by 1

Angiogenesis, Inflammation, and Oxidative Stress: Interrelationships in Autoimmune Thyroid Diseases

Milanovic, J. D., Ignjatović, V., Nedic, K. V., Ilić, N., Pirkovic, M. S., Terzić, J. N., Živančević-Simonović, S., Zdravkovic, N., Vukomanović, V., Urakovic, N., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062568 · Cited by 1

Circulating and Respiratory Biomarkers in Sepsis-Induced ARDS: Diagnostic and Prognostic Insights – A Narrative Review

Muhoza, B.-G., liu, S., Niyonkuru, E., & Sun, T. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s571504 · Cited by 1

Ulinastatin attenuates capillary leakage and suppresses FoxO1-dependent angiopoietin-2 in sepsis-associated acute lung injury via PI3K pathway

Lv, Y., Meng, Y., Rui, H., Li, T. Z., Zhang, J., Liu, J., Ma, X., Wang, J., Yuan, Y., Jiang, Y., et al. (2026) · PLoS ONE · doi:10.1371/journal.pone.0348261 · Cited by 1

Diabetic retinopathy, a disease with low-grade inflammation

Li, W., & Zhang, J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-93064-2.00001-9 · Cited by 1

Cytokine Response of CD4+ T-Lymphocytes with Red Rose (Rosa Rosaceae – Pierre de Ronsard) Extracts by in Vitro Evaluation

Arokiaraj, M. C., & Menesson, E. (2022) · Galician Medical Journal · doi:10.21802/gmj.2022.1.5 · Cited by 1

Rose Extract Treatment on the CD4+ T lymphocytesPreprint

Arokiaraj, M. C., & Menesson, E. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.06.438604 · Cited by 1

The Effects of SARS-CoV-2 on Angiopoietin/Tie Axis and Vascular EndotheliumPreprint

Janchivlamdan, D., Shivkumar, M., & Singh, H. (2024) · Preprints.org · doi:10.20944/preprints202402.0212.v1 · Cited by 1

Von Willebrand Factor Deficiency Impairs Vascular Morphogenesis via Angiopoietin-2: Relevance for Gut AngiodysplasiaPreprint

Constantinescu‐Bercu, A., Smith, K. E., Wong, S. Y., Ballerini, M., Nastro, A., Wiggins, B. G., Pirri, D., Li, A. K. C., Evers, J., Tsiamita, O., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.09.675051 · Cited by 1

Supplementary Issue: Gene and Protein Expression Profiling in Disease

Lomas, J. L. (2015)

EPAS1 Promotes Endothelial Cell Migration in an IRX3-Dependent Manner

Woodruff, R. W., & Barnett, P. (2016)

Angiopoietin-2 and VEGF in non-small cell lung cancer prognosis: can vessel co-option have a role here?

Coelho, A. (2016) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/bcms-4m26

[Research Advances of Ang-2 in Non-small Cell Lung Cancer].

Hua, X., & Zhu, X. (2018) · Europe PMC (PubMed Central) · doi:10.3779/j.issn.1009-3419.2018.11.09

Evaluation of Angiopoietin 2 Serum Level in Lichen Planus and Psoriasis Patients

Teama, M. A., Bessar, H. A., El-Sayed, N. M., & Mahmoud, T. M. I. (2021) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2021.146632

RE: Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via enhancing angiogenesis

Savira, F., Kompa, A. R., Edgley, A. J., Jucker, B. M., Willette, R. N., Kelly, D. J., & Wang, B. H. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.10.035

Liposomes for anti-inflammatory drug delivery in ocular diseases: From in vivo models to clinical application

Wong, C. W. (2021) · doi:10.33540/526

Angiopoietin-1 attenuates lipopolysaccharide-induced endotoxemia in a Hirschsprung’s disease murine model by improving intestinal vascular integrity: implications for treating postoperative Hirschsprung-associated enterocolitis

Ishiyama, A., Suda, K., Rao, X., Sun, M., Lane, G. J., Yamataka, A., & Koga, H. (2024) · Pediatric Surgery International · doi:10.1007/s00383-024-05867-x

ANGIOPOETIN-2 LEVELS IN PATIENTS WITH COMORBIDITY OF CORONARY ARTERY DISEASE AND TYPE 2 DIABETES MELLITUS

Lytvynova, O. M., Yeromenko, R. F., Lytvynenko, G. L., & Lytvynov, V. (2025) · Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії · doi:10.31718/2077-1096.25.1.50

Effects of Dual Inhibition of VEGF ‐A and Angpt‐2 on Angiogenesis and Lymphangiogenesis in an Alkali‐Induced Corneal Injury Model

Kuribayashi, H., Iwagawa, T., Kadohara, S., Ohashi, H., Kawaji, C., Iida, T., Suzuki, T., Inokuchi, Y., Soeda, T., Saita, K., et al. (2025) · Genes to Cells · doi:10.1111/gtc.70035

Effects of one-week intake of different edible oils on the urinary proteome of rats

Su, Y., & Gao, Y. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1571846

Retrospective study on the value of serum angiopoietin 2 and cystatin C levels in the early diagnosis of acute coronary syndrome

Zou, Q., Huang, Y., Peng, Y., Lu, X., Ye, F., Xu, J., & Fang, L. (2025) · Medicine · doi:10.1097/md.0000000000043650

Exploring some pro-inflammatory cytokines and adipokines as novel biomarkers in polycystic ovary syndrome

Mustafa, D. A., & Ismail, P. A. (2025) · Italian Journal of Medicine · doi:10.4081/itjm.2025.2023

Additional file of Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas

Girolamo, F., de Trizio, I., Errede, M., Longo, G., d’Amati, A., & Virgintino, D. (2021) · Figshare · doi:10.6084/m9.figshare.14431841

Additional file 1 of Total NT-proBNP, a novel biomarker related to recurrent atrial fibrillation

Staszewsky, L. I., Meessen, J. M. T. A., Novelli, D., Wienhues-Thelen, U.-H., Disertori, M., Maggioni, A. P., Masson, S., Tognoni, G., Franzosi, M. G., Lucci, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17054718

Additional file 1 of UC-MSCs promote frozen-thawed ovaries angiogenesis via activation of the Wnt/β-catenin pathway in vitro ovarian culture system

Xu, W., Wu, C., Zhu, X., Wu, J., Zhang, Z., Wei, Z., Cao, Y., Zhou, P., & Wang, J. (2022) · Figshare · doi:10.6084/m9.figshare.20326421

Additional file 1 of FOXC2 is a prognostic biomarker and contributes to the growth and invasion of human hepatocellular carcinoma

Chen, J., Rong, X., Liu, X., Zheng, D., Rong, X., Chen, F., Zhao, P., Liu, F., & Ruan, J. (2020) · Figshare · doi:10.6084/m9.figshare.12375599

Additional file 1 of Angiopoietin-2 induces angiogenesis via exosomes in human hepatocellular carcinoma

Xie, J.-Y., Wei, J.-X., Lv, L.-H., Han, Q.-F., Yang, W., Li, G.-L., Wang, P.-X., Wu, S.-B., Duan, J.-X., Zhuo, W.-F., et al. (2020) · Figshare · doi:10.6084/m9.figshare.11998479

Angiopoietins: A potential therapeutic target in the treatment of diabetic nephropathy

Thapa, K., Kanojia, N., Khan, H., Kaur, A., & Singh, T. G. (2025) · Obesity Medicine · doi:10.1016/j.obmed.2025.100659

Striatal Dysregulation of Angpt2 and Circadian Gene Expression in a Rotenone Rat Model of Parkinson’s Disease

Saeedy, D. A., Hawkins, E., Dozmorov, M. G., Tripathi, O. S., Mahdiani, S., Jahr, F. M., AlAzzeh, O., Deshpande, L. S., & McClay, J. L. (2026) · Journal of Molecular Neuroscience · doi:10.1007/s12031-026-02506-z

Teriparatide as a Candidate Therapy in Incomplete Spinal Cord Injury: Improving Both Bone and Neurological Function

Papanastasiou, C., Zafeiris, Ε. P., Vasilakou, A., Visvardis, I. P., Petropoulou, D., Zafeiris, C., & Chronopoulos, E. (2026) · Spine Open · doi:10.1097/bn9.0000000000000075

Identification of new biomarkers for colorectal cancers

Hasanova, R. (2019) · theses.fr (ABES) · doi:10.70675/38dbe0adza892z41d3za889zbee31c0eb152

Évaluation préclinique de l'effet de l'Angiopoïétine-2, un facteur angiogénique immunomodulateur, sur la progession du glioblastome et sa réponse à la radiochimiothérapie

Hélaine, C. (2020) · theses.fr (ABES) · doi:10.70675/5bf11265z378bz402az828dz5f799de58167

Impact de stratégies nanoparticulaires de réoxygénation sur les macrophages associés aux glioblastomes

Ferré, A. E. (2021) · theses.fr (ABES) · doi:10.70675/bd3a46adzb3cfz4dfaza13dz05e92e57bbf8

Influence des toxines urémiques sur la morbi-mortalité cardiovasculaire des patients en Maladie Rénale Chronique dans la cohorte CKD-REIN

Chamieh, C. E. (2024) · doi:10.70675/560e6547z0ad3z4f54zaebfz75c173de646d

Air leak syndrome in patients with a new Coronavirus infection. Pathogenetic, clinical, laboratory, and instrumental features

Bortа, K. E., Medvedev, K. V., Kokhanenko, N. Y., Glushkov, N. I., Zinserling, V. A., & Semenova, N. Y. (2026) · HERALD of North-Western State Medical University named after I I Mechnikov · doi:10.17816/mechnikov677806

A Potential Link Between Dyslipidemia and Inflammation in Patients with Schizophrenia: Insights from Sterols and HDL Profile Analysis

Bagnasco, S., Simone, G. D., Cernera, G., Usiello, A., Iasevoli, F., Castaldo, G., Gelzo, M., & de Bartolomeis, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167219

Single-cell transcriptomics identifies a putative perivascular macrophage–endothelial MIF–ACKR3 axis associated with endothelial activation in acute traumatic brain injury

林艳雅, Lin, C., Chen, J., Chen, S., Huang, J., & Hu, J. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1863509

Role of angiopoietin-2 in inflammatory autoimmune diseases: A comprehensive review

Wu, Q., Xu, W., & Huang, A. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106223 · Cited by 30

Angiogenesis and inflammation face off

Imhof, B. A., & Aurrand‐Lions, M. (2006) · Nature Medicine · doi:10.1038/nm0206-171 · Cited by 181

Angiopoietin/Tie2 signaling, tumor angiogenesis and inflammatory diseases

Kobayashi, H. (2005) · Frontiers in bioscience · doi:10.2741/1561 · Cited by 35

Angiopoietin-2 promotes inflammatory lymphangiogenesis and its effect can be blocked by the specific inhibitor L1-10

Yan, Z., Jiang, Z., & Liu, N.-F. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00895.2011 · Cited by 35

Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

Fiedler, U., Reiss, Y., Scharpfenecker, M., Grunow, V., Koidl, S., Thurston, G., Gale, N. W., Witzenrath, M., Rosseau, S., Suttorp, N., et al. (2006) · Nature Medicine · doi:10.1038/nm1351 · Cited by 933