Angiopoietin‐2: a multifaceted cytokine that functions in both angiogenesis and inflammation

Cancer-related inflammation

Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570

Modes of resistance to anti-angiogenic therapy

Bergers, G., & Hanahan, D. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2442 · Cited by 2,953

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,872

Distinct role of macrophages in different tumor microenvironments

Lewis, C. E., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4005 · Cited by 2,225

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

Holash, J. A., Maisonpierre, P. C., Compton, D. L., Boland, P., Alexander, C., Zagzag, D., Yancopoulos, G. D., & Wiegand, S. J. (1999) · Science · doi:10.1126/science.284.5422.1994 · Cited by 2,222

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

Davis, S., Aldrich, T. H., Jones, P. F., Acheson, A., Compton, D. L., Jain, V., Ryan, T. E., Bruno, J., Radziejewski, C., Maisonpierre, P. C., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81812-7 · Cited by 1,989

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

Augustin, H. G., Koh, G. Y., Thurston, G., & Alitalo, K. K. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2639 · Cited by 1,512

Angiopoietin-1 protects the adult vasculature against plasma leakage

Thurston, G., Rudge, J. S., Ioffe, E., Zhou, H., Ross, L. H., Croll, S. D., Glazer, N. L., Holash, J. A., McDonald, D. M., & Yancopoulos, G. D. (2000) · Nature Medicine · doi:10.1038/74725 · Cited by 1,314

Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1

Gale, N. W., Thurston, G., Hackett, S. F., Renard, R. A., Wang, Q., McClain, J., Martin, C., Witte, C. L., Witte, M. H., Jackson, D. G., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00217-4 · Cited by 1,017

Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

Fiedler, U., Reiss, Y., Scharpfenecker, M., Grunow, V., Koidl, S., Thurston, G., Gale, N. W., Witzenrath, M., Rosseau, S., Suttorp, N., et al. (2006) · Nature Medicine · doi:10.1038/nm1351 · Cited by 933

The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

Fiedler, U., Scharpfenecker, M., Koidl, S., Hegen, A., Grunow, V., Schmidt, J. M., Kriz, W., Thurston, G., & Augustin, H. G. (2004) · Blood · doi:10.1182/blood-2003-10-3685 · Cited by 742

Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

Mazzieri, R., Pucci, F., Moi, D., Zonari, E., Ranghetti, A., Berti, A., Politi, L. S., Gentner, B., Brown, J. L., Naldini, L., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.005 · Cited by 639

Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer

Venneri, M. A., Palma, M. D., Ponzoni, M., Pucci, F., Scielzo, C., Zonari, E., Mazzieri, R., Doglioni, C., & Naldini, L. (2007) · Blood · doi:10.1182/blood-2006-10-053504 · Cited by 519

Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis

Stratmann, A., Risau, W., & Plate, K. H. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65733-1 · Cited by 485

Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans

Valenzuela, D. M., Griffiths, J. A., Rojas, J., Aldrich, T. H., Jones, P. F., Zhou, H., McClain, J., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.1904 · Cited by 477

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

Sato, T. N., Qin, Y., Kozak, C. A., & Audus, K. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9355 · Cited by 462

Tumor associated macrophages and neutrophils in tumor progression

Galdiero, M. R., Garlanda, C., Jaillon, S., Marone, G., & Mantovani, A. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24260 · Cited by 457

Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

Wong, A. L., Haroon, Z. A., Werner, S., Dewhirst, M. W., Greenberg, C. S., & Peters, K. G. (1997) · Circulation Research · doi:10.1161/01.res.81.4.567 · Cited by 417

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

Dumont, D., Yamaguchi, T. P., Conlon, R. A., Rossant, J., & Breitman, M. L. (1992) · PubMed · Cited by 410

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

Gavard, J., Patel, V., & Gutkind, J. S. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.10.019 · Cited by 409

The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism

Scharpfenecker, M., Fiedler, U., Reiss, Y., & Augustin, H. G. (2005) · Journal of Cell Science · doi:10.1242/jcs.01653 · Cited by 382

Angiopoietin-2 Regulates Gene Expression in TIE2-Expressing Monocytes and Augments Their Inherent Proangiogenic Functions

Coffelt, S. B., Tal, A. O., Scholz, A., Palma, M. D., Patel, S. S., Urbich, C., Biswas, S. K., Murdoch, C., Plate, K. H., Reiss, Y., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0012 · Cited by 355

Angiopoietin-2 Causes Pericyte Dropout in the Normal Retina

Hammes, H., Lin, J., Wagner, P., Feng, Y., Hagen, F. V., Krzizok, T. H., Renner, O., Breier, G., Brownlee, M., & Deutsch, U. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1104 · Cited by 347

Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death

Bhandari, V., Choo-Wing, R., Lee, C. G., Zhu, Z., Nedrelow, J. H., Chupp, G. L., Zhang, X., Matthay, M. A., Ware, L. B., Homer, R., et al. (2006) · Nature Medicine · doi:10.1038/nm1494 · Cited by 339

Expression of Tie-2 by Human Monocytes and Their Responses to Angiopoietin-2

Murdoch, C., Tazzyman, S., Webster, S., & Lewis, C. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.7405 · Cited by 318

Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer.

Zhang, L., Yang, N., Park, J.-W., Katsaros, D., Fracchioli, S., Cao, G., O’Brien-Jenkins, A., Randall, T. C., Rubin, S. C., & Coukos, G. (2003) · PubMed · Cited by 263

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited

Plate, K. H., Scholz, A., & Dumont, D. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1066-5 · Cited by 257

Angiopoietin signaling in the vasculature

Eklund, L., & Saharinen, P. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.03.011 · Cited by 253

Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade

Rigamonti, N., Kadioglu, E., Keklikoglou, I., Wyser Rmili, C., Leow, C. C., & De Palma, M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.059 · Cited by 247

Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering

Davis, S., Papadopoulos, N., Aldrich, T. H., Maisonpierre, P. C., Huang, T., Kovac, L., Xu, A., Leidich, R., Radziejewska, E., Rafique, A., et al. (2003) · Nature Structural Biology · doi:10.1038/nsb880 · Cited by 234

Angiopoietin 2 Stimulates TIE2-Expressing Monocytes To Suppress T Cell Activation and To Promote Regulatory T Cell Expansion

Coffelt, S. B., Chen, Y.-Y., Muthana, M., Welford, A. F., Tal, A. O., Scholz, A., Plate, K. H., Reiss, Y., Murdoch, C., De Palma, M., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002802 · Cited by 220

Angiopoietins, growth factors, and vascular morphology in early arthritis.

Fearon, U., Griosios, K., Fraser, A. D., Reece, R., Emery, P., Jones, P. F., & Veale, D. J. (2003) · PubMed · Cited by 208

Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*

David, S., Mukherjee, A., Ghosh, C. C., Yano, M., Khankin, E. V., Wenger, J., Karumanchi, S. A., Shapiro, N. I., & Parikh, S. M. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e31825fdc31 · Cited by 199

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis

Ziegler, T., Horstkotte, J., Schwab, C., Pfetsch, V., Weinmann, K., Dietzel, S., Rohwedder, I., Hinkel, R., Groß, L., Lee, S.-M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66549 · Cited by 195

Angiopoietin-1 and Angiopoietin-2 Share the Same Binding Domains in the Tie-2 Receptor Involving the First Ig-like Loop and the Epidermal Growth Factor-like Repeats

Fiedler, U., Krissl, T., Koidl, S., Weiss, C., Koblizek, T. I., Deutsch, U., Martiny‐Baron, G., Marmé, D., & Augustin, H. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208550200 · Cited by 195

Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses

Lemieux, C., Maliba, R., Favier, J., Théorêt, J., Merhi, Y., & Sirois, M. G. (2004) · Blood · doi:10.1182/blood-2004-09-3531 · Cited by 178

Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients

Kümpers, P., Lukasz, A. H., David, S., Horn, R., Hafer, C., Faulhaber‐Walter, R., Fliser, D., Haller, H. G., & Kielstein, J. T. (2008) · Critical Care · doi:10.1186/cc7130 · Cited by 163

Elusive Identities and Overlapping Phenotypes of Proangiogenic Myeloid Cells in Tumors

Coffelt, S. B., Lewis, C. E., Naldini, L., Brown, J. M., Ferrara, N., & Palma, M. D. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090786 · Cited by 162

The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis

Kümpers, P., Gueler, F., David, S., Slyke, P. V., Dumont, D., Park, J.-K., Bockmeyer, C. L., Parikh, S. M., Pavenstädt, H. J., Haller, H. G., et al. (2011) · Critical Care · doi:10.1186/cc10523 · Cited by 142

Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth

Huang, H., Lai, J.-Y., Do, J., Liu, D., Li, L., Rosario, J. D., Doppalapudi, V. R., Pirie-Shepherd, S. R., Levin, N., Bradshaw, C. W., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2317 · Cited by 142

Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules

Baffert, F., Le, T., Thurston, G., & McDonald, D. M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00542.2005 · Cited by 139

Altered Expression of Angiopoietins and Tie2 Endothelium Receptor in Psoriasis

Kuroda, K., Sapadin, A. N., Shoji, T., Fleischmajer, R., & Lebwohl, M. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01316.x · Cited by 128

Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells

Huang, Y.-Q., Li, J., Hu, L., Lee, M., & Karpatkin, S. (2002) · Blood · doi:10.1182/blood.v99.5.1646 · Cited by 125

Angiopoietin-2 Impairs Revascularization After Limb Ischemia

Reiss, Y., Droste, J., Heil, M., Tribulova, S., Schmidt, M. H. H., Schaper, W. K. A., Dumont, D., & Plate, K. H. (2007) · Circulation Research · doi:10.1161/circresaha.106.143594 · Cited by 111

Angiopoietin-2 promotes myeloid cell infiltration in a β2-integrin–dependent manner

Scholz, A., Lang, V., Henschler, R., Czabanka, M., Vajkoczy, P., Chavakis, E., Drynski, J., Harter, P. N., Mittelbronn, M., Dumont, D. J., et al. (2011) · Blood · doi:10.1182/blood-2011-03-343293 · Cited by 102

Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays

Lukasz, A. H., Hellpap, J., Horn, R., Kielstein, J. T., David, S., Haller, H. G., & Kümpers, P. (2008) · Critical Care · doi:10.1186/cc6966 · Cited by 87

Constitutive expression of angiopoietin-1 and -2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts.

Scott, B. B., Zaratin, P., Colombo, A., Hansbury, M., Winkler, J. D., & Jackson, J. R. (2002) · PubMed · Cited by 85

Angiopoietin-2 in experimental colitis

Ganta, V. C., Cromer, W. E., Mills, G. L., Traylor, J. G., Jennings, M. H., Daley, S. K., Clark, B., Mathis, J. M., Bernas, M. J., Boktor, M., et al. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21150 · Cited by 74

Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis

Alfieri, A., Watson, J. J., Kammerer, R. A., Tasab, M., Progias, P., Reeves, K., Brown, N. J., & Brookes, Z. L. S. (2012) · Critical Care · doi:10.1186/cc11666 · Cited by 66

Angiogenin, angiopoietin-1, angiopoietin-2, and endostatin serum levels in inflammatory bowel disease

Oikonomou, K. A., Kapsoritakis, A. N., Kapsoritaki, A. I., Manolakis, A. C., Tiaka, E. K., Tsiopoulos, F. D., Tsiompanidis, I., & Potamianos, S. P. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21410 · Cited by 62

Regulation of angiopoietin expression by bacterial lipopolysaccharide

Mofarrahi, M., Nouh, T., Qureshi, S., Guillot, L., Mayaki, D., & Hussain, S. N. A. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00449.2007 · Cited by 60

Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis

Anisimov, A., Tvorogov, D., Alitalo, A. K., Leppänen, V., An, Y., Han, E. C., Orsenigo, F., Gaál, E. I., Holopainen, T., Koh, Y. J., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.127472 · Cited by 56

Tie2 Signaling Cooperates with TNF to Promote the Pro-Inflammatory Activation of Human Macrophages Independently of Macrophage Functional Phenotype

García, S., Krausz, S., Ambarus, C. A., Malvar‐Fernández, B., Hartkamp, L. M., van Es, I. E., Hamann, J., Baeten, D., Tak, P. P., & Reedquist, K. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0082088 · Cited by 55

Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis

Kanakaraj, P., Puffer, B. A., Yao, X.-T., Kankanala, S., Boyd, E., Shah, R. R., Wang, G., Patel, D., Krishnamurthy, R., Kaithamana, S., et al. (2012) · mAbs · doi:10.4161/mabs.21227 · Cited by 53

Angiopoietin chemotactic activities on neutrophils are regulated by PI-3K activation

Brkovic, A., Pelletier, M., Girard, D., & Sirois, M. G. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0906580 · Cited by 52

Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis

Krausz, S., García, S., Ambarus, C. A., de Launay, D., Foster, M. L., Naiman, B. M., Iverson, W., Connor, J. R., Sleeman, M. A., Coyle, A. J., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200718 · Cited by 48

Potential role of soluble angiopoietin‐2 and Tie‐2 in patients with inflammatory bowel disease

Κoutroubakis, I. E., Xidakis, C., Κarmiris, K., Sfiridaki, A., Kandidaki, E., & Kouroumalis, E. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01602.x · Cited by 43

Angiopoietin-2 is highly correlated with inflammation and disease activity in recent-onset rheumatoid arthritis and could be predictive for cardiovascular disease

Westra, J. M., de Groot, L., Plaxton, S., Brouwer, E., Posthumus, M. D., Kallenberg, C. G. M., & Bijl, M. (2010) · Lara D. Veeken · doi:10.1093/rheumatology/keq378 · Cited by 41

Role of vascular endothelial growth factor and angiopoietin systems in serum of Crohnʼs disease patients

Pousa, I. D., Maté, J., Salcedo-Mora, X., Abreu, M. T., Moreno‐Otero, R., & Gisbert, J. P. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20269 · Cited by 40

Angiopoietin-1 Elicits Pro-Inflammatory Responses in Monocytes and Differentiating Macrophages

Seok, S. H., Heo, J.-I., Hwang, J., Na, Y.-R., Yun, J.-H., Lee, E. H., Park, J., & Cho, C. (2013) · Molecules and Cells · doi:10.1007/s10059-013-0088-8 · Cited by 38

Angiopoietin-1 ameliorates inflammation-induced vascular leakage and improves functional impairment in a rat model of acute experimental autoimmune encephalomyelitis.

Jiang, H., Zhang, F., Yang, J., & Han, S. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.05.013 · Cited by 38

Angiopoietin-2 serum levels correlate with severity, early onset and cardiovascular disease in patients with rheumatoid arthritis.

López‐Mejías, R., Corrales, A., Genre, F., Hernández, J. L., Ochoa, R., Blanco, R., González‐Juanatey, C., Martin, J. J., Llorca, J., & González-Gay, M. Á. (2013) · PubMed · Cited by 32

VEGF and Angiopoietins Promote Inflammatory Cell Recruitment and Mature Blood Vessel Formation in Murine Sponge/Matrigel Model

Sinnathamby, T., Yun, T. J., Clavet‐Lanthier, M., Cheong, C., & Sirois, M. G. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24941 · Cited by 29

Angiopoietin/Tie2 Signaling Transforms Capillaries into Venules Primed for Leukocyte Trafficking in Airway Inflammation

Fuxe, J., Lashnits, E. W., O’Brien, S., Bałuk, P., Tabruyn, S. P., Kuhnert, F., Kuo, C. J., Thurston, G., & McDonald, D. M. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090976 · Cited by 29

G‐CSF rescues tumor growth and neo‐angiogenesis during liver metastasis under host angiopoietin‐2 deficiency

Im, J. H., Tapmeier, T., Balathasan, L., Gal, A., Yameen, S., Hill, S., Smart, S., Noterdaeme, O., Kelly, M., Brady, M., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.27677 · Cited by 25

Double-antiangiogenic protein DAAP targeting vascular endothelial growth factor A and angiopoietins attenuates collagen-induced arthritis

Hah, Y., Koh, Y. J., Lim, H. S., Kim, H. O., Cheon, Y., Noh, H. S., Jang, K. Y., Lee, S. Y., Lee, G. M., Koh, G. Y., et al. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4265 · Cited by 24

The Role of Angiopoietin 2 in Hyperoxia-Inuduced Acute Lung Injury

Bhandari, V., & Elias, J. A. (2007) · Cell Cycle · doi:10.4161/cc.6.9.4229 · Cited by 21

Angiopoietins

Reiss, Y. (2009) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-540-78281-0_2 · Cited by 21

Angiopoietin-2 Enhances Survival in Experimental Sepsis Induced by Multidrug-Resistant Pseudomonas aeruginosa

Tzepi, I., Giamarellos‐Bourboulis, E. J., Carrer, D.-P., Τσαγανός, Θ., Claus, R. A., Vaki, I., Πελεκάνου, Α., Kotsaki, A., Tziortzioti, V., Topouzis, S., et al. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.195180 · Cited by 20

Pleiotropic effects of angiopoietin-2 deficiency do not protect mice against endotoxin-induced acute kidney injury

Kurniati, N. F., van Meurs, M., Hagen, F. V., Jongman, R. M., Moser, J., Zwiers, P. J., Struys, M. M. R. F., Westra, J., Zijlstra, J. G., Hammes, H., et al. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs336 · Cited by 20

Angiopoietin-1 Upregulates De Novo Expression of Il-1β and Il1-Ra, and the Exclusive Release of Il1-Ra from Human Neutrophils

Haddad, L. E., & Sirois, M. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088980 · Cited by 16

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.

Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

Schmittnaegel, M., Rigamonti, N., Kadioglu, E., Cassará, A., Wyser Rmili, C., Kiialainen, A., Kienast, Y., Mueller, H.-J., Ooi, C.-H., Laoui, D., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aak9670 · Cited by 582

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Paskeh, M. D. A., Entezari, M., Mirzaei, S., Zabolian, A., Saleki, H., Naghdi, M. J., Sabet, S., Khoshbakht, M. A., Hashemi, M., Hushmandi, K., et al. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01305-4 · Cited by 591

Next generation of immune checkpoint inhibitors and beyond

Marin-Acevedo, J. A., Kimbrough, E. O., & Lou, Y. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01056-8 · Cited by 574

Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology

Akwii, R. G., Sajib, M. S., Zahra, F. T., & Mikelis, C. M. (2019) · Cells · doi:10.3390/cells8050471 · Cited by 566

Role of angiopoietin-2 in inflammatory autoimmune diseases: A comprehensive review

Wu, Q., Xu, W., & Huang, A. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106223 · Cited by 30

Angiogenesis and inflammation face off

Imhof, B. A., & Aurrand‐Lions, M. (2006) · Nature Medicine · doi:10.1038/nm0206-171 · Cited by 181

Angiopoietin/Tie2 signaling, tumor angiogenesis and inflammatory diseases

Kobayashi, H. (2005) · Frontiers in bioscience · doi:10.2741/1561 · Cited by 35

Angiopoietin-2 promotes inflammatory lymphangiogenesis and its effect can be blocked by the specific inhibitor L1-10

Yan, Z., Jiang, Z., & Liu, N.-F. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00895.2011 · Cited by 35

Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

Fiedler, U., Reiss, Y., Scharpfenecker, M., Grunow, V., Koidl, S., Thurston, G., Gale, N. W., Witzenrath, M., Rosseau, S., Suttorp, N., et al. (2006) · Nature Medicine · doi:10.1038/nm1351 · Cited by 933