The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases?
Abstract
It is increasingly recognized that there is a connection between diet, intestinal microbiota, intestinal barrier function and the low-grade inflammation that characterizes the progression from obesity to metabolic disturbances, making dietary strategies to modulate the intestinal environment relevant. In this context, the ability of some Gram-positive anaerobic bacteria to produce the short-chain fatty acid butyrate is interesting. A lower abundance of butyrate-producing bacteria has been associated with metabolic risk in humans, and recent studies suggest that butyrate might have an anti-inflammatory potential that can alleviate obesity-related metabolic complications, possibly due to its ability to enhance the intestinal barrier function. Here, we review and discuss the potential of butyrate as an anti-inflammatory mediator in metabolic diseases, and the potential for dietary interventions increasing the intestinal availability of butyrate.
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“SCFAs are estimated to account for ~60–70% of the energy requirements of colon epithelial cells and 5–15% of the total caloric requirements of humans [251].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [251]
In the citing paper
“Studies on the human gut microbiota have shown that fewer butyrate-producing bacteria are found in stool samples from patients with type 2 diabetes than in healthy controls, thus suggesting a possible protective role of butyrate in obesity-related metabolic diseases [251].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [251]
Citations
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Research works printed but not linked: 2
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- 10.1096/fj.10‐164921 · DOI · Paper page
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Metadata
- Authors
- Brahe, L. K., Astrup, A., & Larsen, L. H.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Brahe, L. K.
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2013-08-16
- Volume
- 14
- Issue
- 12
- Pages
- 950-959
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W1866784611
- Cited by
- 264
- References
- 114
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 26 · 2023: 23 · 2022: 26 · 2021: 31 · 2020: 23 · 2019: 20 · 2018: 25 · 2017: 19 · 2016: 13 · 2015: 18 · 2014: 9
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- butyrate, short-chain fatty acids, gut microbiota, obesity, metabolic disorders, low-grade inflammation, intestinal barrier function, anaerobic Gram-positive bacteria, dietary intervention, anti-inflammatory activity
- MeSH terms
- Anti-Inflammatory Agents, Bacteria, Anaerobic, Butyrates, Diet, Humans, Intestines, Metabolic Diseases, Obesity, Microbiota
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