Cited by 264Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesMicrobial Metabolites in Food Biotechnology

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Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases?

Brahe, L. K., Astrup, A., Larsen, L. H.·2013·Obesity Reviews

DOI 10.1111/obr.12068

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Abstract

It is increasingly recognized that there is a connection between diet, intestinal microbiota, intestinal barrier function and the low-grade inflammation that characterizes the progression from obesity to metabolic disturbances, making dietary strategies to modulate the intestinal environment relevant. In this context, the ability of some Gram-positive anaerobic bacteria to produce the short-chain fatty acid butyrate is interesting. A lower abundance of butyrate-producing bacteria has been associated with metabolic risk in humans, and recent studies suggest that butyrate might have an anti-inflammatory potential that can alleviate obesity-related metabolic complications, possibly due to its ability to enhance the intestinal barrier function. Here, we review and discuss the potential of butyrate as an anti-inflammatory mediator in metabolic diseases, and the potential for dietary interventions increasing the intestinal availability of butyrate.

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Authors: Brahe, L. K., Astrup, A., & Larsen, L. H.
Affiliations: University of Copenhagen (DK)
Corresponding author: Brahe, L. K.
ORCID: Brahe, L. K.
Astrup, A.
Larsen, L. H.
Venue: Obesity Reviews
Publisher: Wiley
Published: 2013-08-16
Volume: 14
Issue: 12
Pages: 950-959
ISSN: 1467-7881 (ISSN-L)
1467-789X
DOI: 10.1111/obr.12068
OpenAlex: W1866784611
Cited by: 264
References: 114
Citations by year: 2026: 14 · 2025: 17 · 2024: 26 · 2023: 23 · 2022: 26 · 2021: 31 · 2020: 23 · 2019: 20 · 2018: 25 · 2017: 19 · 2016: 13 · 2015: 18 · 2014: 9
FWCI: 1.25
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Obesity Reviews (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: butyrate, short-chain fatty acids, gut microbiota, obesity, metabolic disorders, low-grade inflammation, intestinal barrier function, anaerobic Gram-positive bacteria, dietary intervention, anti-inflammatory activity
MeSH terms: Anti-Inflammatory Agents, Bacteria, Anaerobic, Butyrates, Diet, Humans, Intestines, Metabolic Diseases, Obesity, Microbiota

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Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases?

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