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Cited by 31Nail Diseases and TreatmentsDermatology and Skin DiseasesAntifungal resistance and susceptibility

New insights into immunity to skin fungi shape our understanding of health and disease

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Ruchti, Fiorella, LeibundGut‐Landmann, Salomé·2023·Parasite Immunology
DOI 10.1111/pim.12948PMC PMC10078452
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Abstract

Fungi represent an integral part of the skin microbiota. Their complex interaction network with the host shapes protective immunity during homeostasis. If host defences are breached, skin‐resident fungi including Malassezia and Candida , and environmental fungi such as dermatophytes can cause cutaneous infections. In addition, fungi are associated with diverse non‐infectious skin disorders. Despite their multiple roles in health and disease, fungi remain elusive and understudied, and the mechanisms underlying the emergence of pathological conditions linked to fungi are largely unclear. The identification of IL‐17 as an important antifungal effector mechanism represents a milestone for understanding homeostatic antifungal immunity. At the same time, host‐adverse, disease‐promoting roles of IL‐17 have been delineated, as in psoriasis. Fungal dysbiosis represents another feature of many pathological skin conditions with an unknown causal link of intra‐ and interkingdom interactions to disease pathogenesis. The emergence of new fungal pathogens such as Candida auris highlights the need for more research into fungal immunology to understand how antifungal responses shape health and diseases. Recent technological advances for genetically manipulating fungi to target immunomodulatory fungal determinants, multi‐omics approaches for studying immune cells in the human skin, and novel experimental models open up a promising future for skin fungal immunity.

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Authors
Ruchti, F., & LeibundGut‐Landmann, S.
Affiliations
University of Zurich (CH)
Corresponding author
LeibundGut‐Landmann, Salomé
ORCID
Venue
Parasite Immunology
Publisher
Wiley
Published
2022-09-20
Volume
45
Issue
2
Pages
e12948-e12948
ISSN
  • 0141-9838 (ISSN-L)
  • 1365-3024
DOI
10.1111/pim.12948
PMC
PMC10078452
OpenAlex
W4294124689
Cited by
31
References
17
Citations by year
2026: 8 · 2025: 11 · 2024: 6 · 2023: 5 · 2022: 1
FWCI
0.91
Type
journal article
Language
en
Open access
Licence
Locations
  • Parasite Immunology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc-nd)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (310030_189255)
Topics
  • Health Sciences › Medicine › Epidemiology › Nail Diseases and Treatments
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords
fungal skin infection, Malassezia, Candida, dermatophytes, IL-17, antifungal immunity, fungal dysbiosis, psoriasis, Candida auris, skin microbiome, host-fungus interactions
MeSH terms
Antifungal Agents, Fungi, Humans, Malassezia, Skin, Interleukin-17, Microbiota

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