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Cited by 30Epigenetics and DNA MethylationChild Abuse and TraumaIntimate Partner and Family Violence

Experiencing community and domestic violence is associated with epigenetic changes in DNA methylation of BDNF and CLPX in adolescents

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Serpeloni, Fernanda, Nätt, Daniel, Assis, Simone Gonçalves de, Wieling, Elizabeth, Elbert, Thomas·2020·Psychophysiology
DOI 10.1111/psyp.13382PMC PMC7003421
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Abstract

Experiencing violence changes behavior, shapes personalities, and poses a risk factor for mental disorders. This association might be mediated through epigenetic modifications that affect gene expression, such as DNA methylation. The present study investigated the impact of community and domestic violence on DNA methylation measured in saliva collected from 375 individuals including three generations: grandmothers (n = 126), mothers (n = 125), and adolescents (n = 124, 53% female). Using the Infinium HumanMethylation450 BeadChip array, in adolescents, we detected two CpG sites that showed an association of DNA methylation and lifetime exposure to community and domestic violence even after FDR correction: BDNF _cg06260077 (logFC −0.454, p = 3.71E‐07), and CLPX _cg01908660 (logFC = −0.372, p = 1.38E‐07). Differential DNA methylation of the CpG BDNF _cg06260077 associated with exposure to violence was also observed in the maternal but not the grandmaternal generation. BDNF (brain‐derived neurotrophic factor) and CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit) genes are involved in neural development. Our results thus reveal altered molecular mechanisms of developmental and intergenerational trajectories in survivors of repeated violent experiences.

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  • Chronic IPV exposure has been associated with epigenetic modification of stress-regulatory and neural plasticity pathways.

    “Chronic IPV exposure has been associated with epigenetic modification of stress-regulatory and neural plasticity pathways.”

    From Epigenetic changes associated with multi-generational trauma: characterization, mechanisms, and therapeutics (2026) · cites this paper as [54]

    The Results report that greater lifetime exposure to community and domestic violence was associated with altered DNA methylation of BDNF and CLPX in adolescents. The Discussion links BDNF to neural plasticity and describes the affected genes as associated with stress regulation. The study did not isolate intimate partner violence (IPV) exposure from other violence or establish modification of the pathways themselves. (LLM, conf=0.85)

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  • Multigenerational findings demonstrate differential DNA methylation in genes involved in synaptic signaling and mitochondrial regulation, including BDNF and CLPX, supporting coordinated involvement of neurodevelopmental and metabolic systems.

    “Multigenerational findings demonstrate differential DNA methylation in genes involved in synaptic signaling and mitochondrial regulation, including BDNF and CLPX, supporting coordinated involvement of neurodevelopmental and metabolic systems (54).”

    From Epigenetic changes associated with multi-generational trauma: characterization, mechanisms, and therapeutics (2026) · cites this paper as [54]

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Authors
Serpeloni, F., Nätt, D., Assis, S. G. D., Wieling, E., & Elbert, T.
Affiliations
  • University of Konstanz (DE)
  • Linköping University (SE)
  • Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (BR)
  • University of Minnesota (US)
Corresponding author
Serpeloni, Fernanda
ORCID
Venue
Psychophysiology
Publisher
Wiley
Published
2019-05-06
Volume
57
Issue
1
Pages
e13382-e13382
ISSN
  • 0048-5772 (ISSN-L)
  • 1469-8986
DOI
10.1111/psyp.13382
PMC
PMC7003421
OpenAlex
W2944095887
Cited by
30
References
23
Citations by year
2026: 5 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 4 · 2019: 1
FWCI
0.99
Type
journal article
Language
en
Open access
Licence
Locations
  • Psychophysiology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • KOPS (University of Konstanz) (submittedVersion, cc-by-nc)
  • DiVA (Linkoping University) (submittedVersion, other-oa)
Funders
H2020 European Research Council (323977)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Health › Intimate Partner and Family Violence
Keywords
community violence, domestic violence, DNA methylation, epigenetics, brain-derived neurotrophic factor, ClpX, adolescents, intergenerational transmission, saliva, CpG sites, neural development, trauma exposure
MeSH terms
Grandparents, Exposure to Violence, Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, Humans, Male, Middle Aged, Mothers, Residence Characteristics, Domestic Violence, Survivors, DNA Methylation, Brain-Derived Neurotrophic Factor, Epigenesis, Genetic, Endopeptidase Clp, Young Adult

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