Neural correlates of suicidality in adolescents with major depression: Resting-state functional connectivity of the precuneus and posterior cingulate cortex
Abstract
OBJECTIVE: Major depressive disorder (MDD) is associated with suicidal thoughts and behaviors ("suicidality"). Of the three components of Joiner's interpersonal theory of suicide, two involve negatively valenced, self-related beliefs: perceived burdensomeness and thwarted belongingness. However, the neurocircuitry underlying self-processing and suicidality has not been fully explored. This study examined the association between suicidality and the neurocircuitry of regions relevant to self-referential processing in adolescents with depression. METHOD: Fifty-eight adolescents underwent assessment and a resting-state fMRI scan. Resting-state functional connectivity (RSFC) analyses included two brain regions implicated in self-referential processing: precuneus and posterior cingulate cortex (PCC). Suicidality was measured using the Index of Depression and Anxiety Symptoms. While controlling for depression severity, we conducted whole-brain correlation analyses between suicidality and left and right precuneus and PCC connectivity maps. RESULTS: Suicidality was positively associated with RSFC between left precuneus and left primary motor and somatosensory cortices, and middle and superior frontal gyri. Suicidality was negatively associated with RSFC between left PCC and left cerebellum, lateral occipital cortex, and temporal-occipital fusiform gyrus. CONCLUSIONS: Findings of hyperconnectivity stemming from the precuneus and hypoconnectivity from the PCC may reflect maladaptive self-reflection and mentalization. However, additional investigation is warranted to further clarify these relationships.
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In an expanded sample of depressed youth, suicide ideation severity associates with greater connectivity between a right precuneus seed and cerebellum and right IFG, and lower connectivity between a left PCC seed and cerebellum and cingulate.
“within-group analyses show that suicide ideation severity associates with greater connectivity between a right precuneus seed and cerebellum and right IFG, as well as lower connectivity between a left PCC seed and cerebellum and cingulate (101).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [101]
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Neural correlates associated with suicide and nonsuicidal self-injury in youth
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- Authors
- Schreiner, M. W., Klimes‐Dougan, B., & Cullen, K. R.
- Affiliations
- Department of Psychology University of Minnesota College of Liberal Arts Minneapolis MN USA
- University of Minnesota (US)
- Venue
- Suicide and Life-Threatening Behavior
- Publisher
- Wiley
- Published
- 2018-05-13
- Volume
- 49
- Issue
- 3
- Pages
- 899-913
- ISSN
- 0363-0234 (ISSN-L)
- 1943-278X
- OpenAlex
- W2804588921
- Cited by
- 69
- References
- 54
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 12 · 2023: 13 · 2022: 14 · 2021: 8 · 2020: 7 · 2019: 1 · 2018: 2
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Suicide and Life-Threatening Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K23MH090421)
- National Alliance for Research on Schizophrenia and Depression
- Graduate School, University of Minnesota
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Psychology › Social Psychology › Mental Health via Writing
- Keywords
- suicidality, adolescent depression, major depressive disorder, resting-state functional connectivity, precuneus, posterior cingulate cortex, self-referential processing, perceived burdensomeness, thwarted belongingness, mentalization, cerebellum, fusiform gyrus
- MeSH terms
- Adolescent, Child, Depression, Major Depressive Disorder, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Parietal Lobe, Rest, Suicide, Suicide, Attempted, Young Adult, Functional Neuroimaging
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