Preserved hippocampal function during learning in the context of risk in adolescent suicide attempt
Open accessAbstract
Impairment in decision-making is frequently observed in suicide attempters. Little is known, however, about neural circuitry underlying decision-making in adolescent attempters. Functional magnetic resonance imaging (fMRI) was used to assess decision-making and learning-related neural activity during Iowa Gambling Task (IGT) performance in adolescents with depression and suicide attempt (ATT, n=15), non-attempters with depression (NAT, n=14), and healthy controls (HC, n=13). ATT performed best on the IGT. A three group by two condition (high-risk versus low-risk) by three IGT block (each of 20 cards) whole-brain analysis (p<0.05, corrected) interaction was found in the left hippocampal, frontal and temporal cortical, striatal and thalamic regions. Post-hoc analyses revealed that during low-risk decisions in blocks 2 and 3, NAT, but not ATT, showed greater left hippocampal activation versus HC (p=0.0004, p=0.003); in block 2, during low-risk decisions NAT showed greater left middle temporal gyral activation versus HC (p=0.003); in block 3, during high-risk decisions ATT showed less activation in the right thalamus versus NAT (p=0.001) and during low risk decisions ATT showed greater activation than HC in the left caudate (p=0.002). NAT, but not ATT are differentiated from HC during performance of the IGT. Functional abnormalities in neural circuitry implicated in learning in the context of risk may underlie risk for MDD, but not risk for suicide attempt, in adolescence.
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Non-attempters show greater left hippocampal activation during low-risk but not high-risk decisions relative to healthy adolescents and suicide attempters during an Iowa Gambling Task, but this does not survive correction.
“Although non-attempters show greater left hippocampal activation during low-risk (but not high-risk) decisions relative to healthy adolescents and suicide attempters during an Iowa Gambling Task (77), it does not survive post-hoc correction for multiple comparisons.”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [77]
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Multimodal neuroimaging and suicidality in a US population-based sample of school-aged childrenPreprint
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Early Childhood Adversity, Stress, and Developmental Pathways of Suicide Risk
Ortin‐Peralta, A., Myruski, S., Rosario‐Williams, B., & Xu, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-82465-5_3 · Cited by 5 · see citing works
A Systematic Review of Behavior-Outcome Psychological Assessments as Correlates of Suicidality
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Stress, Vulnerability, and Suicide
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.003 · Cited by 2 · see citing works
Influences of sleep, cortisol reactivity, and risk/reward-based decision-making on suicide
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Neurobiological understanding of suicide
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Visualizing the Suicidal Brain
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Human Imaging Studies of Suicidal Behavior and its Risk Factors
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Suicide 1 The neurobiology of suicide
van Heeringen, K., & Mann, J. J. (2014)
Research: Mediators and Moderators
Koslow, S. H., Ruiz, P., & Nemeroff, C. B. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139519502.033
Theuse of neuroimaging to investigate the pathophysiology of suicide
Bailey, C. R., Greene, A. M., & Neumeister, A. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139519502.035
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What Is Suicidal Behavior, and Can It Be Prevented?
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.002
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I Predict, Therefore I Cannot Be
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Neuroimaging of suicidal behaviour
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I Think, Therefore I Do Not Want to Be
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Peripheral and Neural Correlates of Self-Harm in Children and Adolescents: A Scoping ReviewPreprint
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Adolescent Homicide and the Brain
Fabian, J. M. (2026) · doi:10.1002/9781118832202.ch10
Differential neural activation during reward processing in preadolescent suicidal ideation.
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- Authors
- Pan, L., Segreti, A., Almeida, J., Jollant, F., Lawrence, N., Brent, D., & Phillips, M.
- Affiliations
- University of Pittsburgh (US)
- McGill University (CA)
- Cardiff University (GB)
- Corresponding author
- Pan, Lisa
- Venue
- Psychiatry Research Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 211
- Issue
- 2
- Pages
- 112-118
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC3570719
- OpenAlex
- W2136103745
- Cited by
- 82
- References
- 47
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 22 · 2017: 9 · 2016: 3 · 2015: 1 · 2014: 9 · 2013: 1
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- Klingenstein Third Generation Foundation
- University of Pittsburgh
- Carnegie Mellon University
- National Institutes of Health (UL1TR000005, 5r01mh076971-05)
- National Institute of Mental Health (R01-MH076971, MH076971, -MH56612, MH-18951, -MH65368, R10MH056612, K23MH082884, R01MH056612, U10MH066775, R01MH065368, MH66775, T32MH018951)
- National Center for Research Resources (UL1RR024153)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- adolescent suicide attempts, decision-making, hippocampal activation, Iowa Gambling Task, depression, middle temporal gyrus, thalamus, caudate nucleus, neural circuits
- MeSH terms
- Adolescent, Adolescent Behavior, Brain, Child, Decision Making, Depression, Female, Hippocampus, Humans, Learning, Male, Suicide, Attempted, Case-Control Studies, Functional Neuroimaging
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