Network basis of suicidal ideation in depressed adolescents

Ordaz, Sarah J.; Goyer, Meghan S.; Ho, Tiffany C.; Singh, Manpreet K.; Gotlib, Ian H.

doi:10.1016/j.jad.2017.09.021

Cited by 111Functional Brain Connectivity StudiesSuicide and Self-Harm StudiesMental Health Research Topics

Network basis of suicidal ideation in depressed adolescents

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Ordaz, Sarah J., Goyer, Meghan S., Ho, Tiffany C., Singh, Manpreet K., Gotlib, Ian H.·2018·Journal of Affective Disorders

DOI 10.1016/j.jad.2017.09.021PMC PMC12758917

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Abstract

Background Suicidal ideation rates rise precipitously in adolescence, contributing to risk for attempts. Although researchers are beginning to explore the brain basis of attempts in depressed adolescents, none have focused on the basis of ideation, which has implications for prevention. This study examined the association between intrinsic neural network coherence and the severity of suicidal ideation in depressed adolescents.Methods Forty adolescents diagnosed with Major Depressive Disorder were administered the Columbia-Suicide Severity Rating Scale and underwent resting-state fMRI. We quantified within-network coherence in the executive control (ECN), default mode (DMN), and salience (SN) networks, and in a non-relevant network consisting of noise signal. We associated coherence in each of these networks with the greatest lifetime severity of suicidal ideation experienced, covarying for motion, age of depression onset, and severity of current depressive and anxious symptoms.Results Lower coherence in the left ECN, anterior DMN, and SN were independently associated with greater lifetime severity of suicidal ideation. When including all three significant networks and covariates in a single model, only the left ECN significantly predicted suicidal ideation.Limitation Studies with a larger sample size are needed to verify our findings.Conclusions Our finding of hypoconnectivity in multiple networks extends emerging evidence for hypoconnectivity in adolescent suicidality and is consistent with theoretical conceptualizations of suicidal ideation as a complex set of cognitions associated with cognitive control, self-referential thinking, and processing salient information. While multiple networks could be targets for effective early interventions, those targeting ECN functionality (cognitive control) may be particularly beneficial.

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Individuals with a history of suicidal ideation show abnormal resting-state connectivity between prefrontal control regions and subcortical brain regions.
“individuals with a history of suicidal ideation appear to show abnormal resting state connectivity between PFC control regions and subcortical brain regions (Chase et al. 2017, Ordaz et al. 2018)”
From Adolescent Suicide as a Failure of Acute Stress-Response Systems. (2019) · cites this paper as Ordaz et al. 2018
The Results (Network Associations with Lifetime Suicidal Ideation; page unavailable) associate greater lifetime ideation severity in depressed adolescents with lower resting-state coherence in the left executive control, anterior default mode, and salience networks. The Methods (Operationalizing Network Coherence; page unavailable) place prefrontal cortex and caudate nucleus within the executive control network, but the study measures coherence within networks, not connectivity specifically between prefrontal control regions and subcortical regions. The claim also generalizes beyond the studied population of depressed adolescents. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Among depressed adolescents, lower average connectivity/coherence in left fronto-parietal executive control network, anterior DMN, and salience network associates with greater lifetime ideation severity.
“Among depressed adolescents, lower average connectivity/coherence in the left fronto-parietal executive control network (ECN), anterior DMN, and SN associates with greater lifetime ideation severity (104).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [104]
Resting-state fMRI indicates lower functional connectivity in adolescent and adult suicide attempters, predominantly in the default mode network.
“Resting-state functional MRI (rs-fMRI) indicates lower functional connectivity in adolescent and adult suicide attempters, predominantly in the default mode network, which is implicated in self-referential processing and social cognition (85-87).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [85]
Other studies have reported lower rs-fMRI activity and functional connectivity, probably due to different outcome measures and heterogeneity of suicidal ideation.
“However, other studies have reported lower rs-fMRI activity and functional connectivity (85, 86, 92, 93), probably due to use of different outcome measures of rs-fMRI activity, for example, regional homogeneity, fractional amplitude of low-frequency fluctuations among studies, and heterogeneity of suicidal ideation.”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [85]

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Longitudinal decreases in suicidal ideation are associated with increases in salience network coherence in depressed adolescents
Schwartz, J., Ordaz, S. J., Ho, T. C., & Gotlib, I. H. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.009 · Cited by 46 · see citing works
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186. Longitudinal Decreases in Suicidal Ideation are Associated With Increases in Salience Network Coherence in Depressed Adolescents
Kirshenbaum, J. S., Ho, T. C., Ordaz, S. J., & Gotlib, I. H. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.03.200
Self-citation
Default mode and salience network alterations in suicidal and non-suicidal self-injurious thoughts and behaviors in adolescents with depression
Ho, T. C., Walker, J. C., Teresi, G. I., Kulla, A., Kirshenbaum, J. S., Gifuni, A. J., Singh, M. K., & Gotlib, I. H. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01103-x · Cited by 121 · see citing works
Self-citation
Parahippocampal network dysfunction distinguishes suicidal ideation from suicide attempts in adolescents with major depressive disorder: a cross-sectional resting-state fMRI study
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6.95 Structural Brain Connectivity Correlates of Suicidal Ideation in Adolescents
Tymofiyeva, O., Sipes, B. S., Jakary, A., Hu, R., Henje, E., & Yang, T. T. (2023) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2023.09.502

Authors: Ordaz, S. J., Goyer, M. S., Ho, T. C., Singh, M. K., & Gotlib, I. H.
Affiliations: Stanford Medicine (US)
Stanford University (US)
Corresponding author: Ordaz, Sarah J.
ORCID: Ordaz, Sarah J.
Goyer, Meghan S.
Ho, Tiffany C.
Singh, Manpreet K.
Gotlib, Ian H.
Venue: Journal of Affective Disorders
Publisher: Elsevier BV
Published: 2018-01
Volume: 226
Pages: 92-99
ISSN: 0165-0327 (ISSN-L)
DOI: 10.1016/j.jad.2017.09.021
PMC: PMC12758917
OpenAlex: W2758974767
Cited by: 111
References: 60
Citations by year: 2026: 10 · 2025: 13 · 2024: 16 · 2023: 10 · 2022: 9 · 2021: 16 · 2020: 18 · 2019: 13 · 2018: 6
FWCI: 5.80
Type: journal article
Language: en
Open access: green
pmc.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Affective Disorders (publishedVersion)
PubMed (publishedVersion)
PubMed Central (publishedVersion)
Funders: American Foundation for Suicide Prevention (PDF-1–064-13)
Brain & Behavior Research Foundation (23582)
National Institutes of Health (R21-MH101545, R01-MH101495)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords: suicidal ideation, adolescent depression, major depressive disorder, resting-state functional connectivity, frontoparietal network, default mode network, salience network, hypoconnectivity, cognitive control, self-referential processing, suicide prevention
MeSH terms: Adolescent, Adolescent Behavior, Depression, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Risk Factors, Suicide, Suicide, Attempted, Thinking, Executive Function, Suicidal Ideation

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