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The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Hidden Behind Autophagy: The Unconventional Roles of ATG Proteins

Bestebroer, Jovanka, V'kovski, Philip, Mauthe, Mario, Reggiori, Fulvio·2013·Traffic
DOI 10.1111/tra.12091
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Abstract

Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved intracellular catabolic transport route that generally allows the lysosomal degradation of cytoplasmic components, including bulk cytosol, protein aggregates, damaged or superfluous organelles and invading microbes. Target structures are sequestered by double‐membrane vesicles called autophagosomes, which are formed through the concerted action of the autophagy (ATG)‐related proteins. Until recently it was assumed that ATG proteins were exclusively involved in autophagy. A growing number of studies, however, have attributed functions to some of them that are distinct from their classical role in autophagosome biogenesis. Autophagy‐independent roles of the ATG proteins include the maintenance of cellular homeostasis and resistance to pathogens. For example, they assist and enhance the turnover of dead cells and microbes upon their phagocytic engulfment, and inhibit murine norovirus replication. Moreover, bone resorption by osteoclasts, innate immune regulation triggered by cytoplasmic DNA and the ER‐associated degradation regulation all have in common the requirement of a subset of ATG proteins. Microorganisms such as coronaviruses, Chlamydia trachomatis or Brucella abortus have even evolved ways to manipulate autophagy‐independent functions of ATG proteins in order to ensure the completion of their intracellular life cycle. Taken together these novel mechanisms add to the repertoire of functions and extend the number of cellular processes involving the ATG proteins.

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Metadata

Authors
Bestebroer, J., V'kovski, P., Mauthe, M., & Reggiori, F.
Affiliations
  • Department of Medical Microbiology University Medical Centre Utrecht Heidelberglaan 100 3584 CX Utrecht The Netherlands
  • Department of Cell Biology and Institute of Biomembranes University Medical Centre Utrecht Heidelberglaan 100 3584 CX Utrecht The Netherlands
Venue
Traffic
Publisher
Wiley
Published
2013-07-30
Volume
14
Issue
10
Pages
1029-1041
ISSN
  • 1398-9219
  • 1600-0854
DOI
10.1111/tra.12091
Cited by
113
References
15
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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