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Rab35 GTPase : A Central Regulator of Phosphoinositides and F‐actin in Endocytic Recycling and Beyond

Klinkert, Kerstin, Echard, Arnaud·2016·Traffic
DOI 10.1111/tra.12422
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Abstract

Rab35 is one of the first discovered members of the large Rab GTPase family, yet it received little attention for 10 years being considered merely as a Rab1‐like GTPase . In 2006, Rab35 was recognized as a unique Rab GTPase localized both at the plasma membrane and on endosomes, playing essential roles in endocytic recycling and cytokinesis. Since then, Rab35 has become one of the most studied Rabs involved in a growing number of cellular functions, including endosomal trafficking, exosome release, phagocytosis, cell migration, immunological synapse formation and neurite outgrowth. Recently, Rab35 has been acknowledged as an oncogenic GTPase with activating mutations being found in cancer patients. In this review, we provide a comprehensive summary of known Rab35‐dependent cellular functions and detail the few Rab35 effectors characterized so far. We also review how the Rab35 GTP / GDP cycle is regulated, and emphasize a newly discovered mechanism that controls its tight activation on newborn endosomes. We propose that the involvement of Rab35 in such diverse and apparently unrelated cellular functions can be explained by the central role of this GTPase in regulating phosphoinositides and F‐actin, both on endosomes and at the plasma membrane.

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Crossref · 10.1111/tra.12422

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  • The study extended the known Retromer regulators to include DENND4A and DENND4C, TBC1D13, and a TBC1D1/TBC1D4 heterodimer, establishing mechanistic links between Retromer and the switching of RAB10 and RAB35.

    “We have now extended these regulators to include DENND4A and DENND4C, TBC1D13, and a TBC1D1/TBC1D4 heterodimer, and in so doing, established mechanistic links between Retromer and the switching of RAB10 and RAB35; two RAB GTPases previously linked to the regulation of endosomal cargo recycling85,88–90,92,96,101,121,122.”

    From Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation (2025) · cites this paper as [122]

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Metadata

Authors
Klinkert, K., & Echard, A.
Affiliations
Membrane Traffic and Cell Division Lab, Cell Biology and Infection Department Institut Pasteur 25‐28 rue du Dr Roux 75724 Paris France
Venue
Traffic
Publisher
Wiley
Published
2016-07-14
Volume
17
Issue
10
Pages
1063-1077
ISSN
  • 1398-9219
  • 1600-0854
DOI
10.1111/tra.12422
Cited by
160
References
2
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
  • Institut Pasteur
  • Fondation pour la Recherche Médicale (FRM DEQ20120323707, FDT20150532389)

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