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Cited by 21Exercise and Physiological ResponsesMuscle metabolism and nutritionCardiovascular and exercise physiology

Glucose ingestion during endurance training in men attenuates expression of myokine receptor

Akerstrom, Thorbjorn C. A., Krogh‐Madsen, Rikke, Petersen, Anne Marie Winther, Pedersen, Bente Klarlund·2009·Experimental Physiology
DOI 10.1113/expphysiol.2009.048983
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Abstract

Glucose ingestion during exercise attenuates the release of the myokine interleukin‐6 (IL‐6) from working skeletal muscle, which results in a diminished increase in plasma IL‐6. Interleukin‐6 receptor α (IL‐6Rα) expression in skeletal muscle is induced by acute exercise, mediated in part by an increased IL‐6 concentration in the bloodstream. We hypothesized that endurance training would increase the density of IL‐6Rα in skeletal muscle and that glucose ingestion would attenuate the effect. Nine subjects performed 10 weeks of one‐legged knee‐extensor training. They trained one leg (Glc‐leg) while ingesting a glucose solution (Glc) and ingested a placebo (Plc) while training the other leg (Plc‐leg). Endurance training increased peak power by ∼14% and reduced the exercise‐induced gene expression of IL‐6 and IL‐6Rα in skeletal muscle and IL‐6 plasma concentration. The IL‐6Rα density increased to a lesser extent in the Glc‐leg, suggesting that glucose ingestion attenuates the effect of training on IL‐6Rα by blunting the IL‐6 response. We conclude that glucose ingestion during endurance training attenuates the increase in IL‐6Rα density.

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Crossref · 10.1113/expphysiol.2009.048983

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  • In a 10-week leg extension training program, glucose ingestion did not alter training adaptations related to substrate metabolism, mitochondrial enzyme activity, glycogen content, or performance.

    “However, in a carefully conducted study by Akerstrom et al. [46] in which a 10-week leg extension training program was followed by the subjects, glucose ingestion did not alter training adaptations related to substrate metabolism, mitochondrial enzyme activity, glycogen content, or performance.”

    From Periodized Nutrition for Athletes (2017) · cites this paper as [46]

  • Significant increases were observed in CS and HAD activities after the 10-week training program but there was no effect of carbohydrate supplementation on these changes.

    “Significant increases were observed in CS and HAD activities after the 10-week training program but there was no effect of carbohydrate supplementation on these changes.”

    From Periodized Nutrition for Athletes (2017) · cites this paper as [46]

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Authors
Akerstrom, T. C. A., Krogh‐Madsen, R., Petersen, A. M. W., & Pedersen, B. K.
Affiliations
University of Copenhagen (DK)
ORCID
Venue
Experimental Physiology
Publisher
Wiley
Published
2009-10-14
Volume
94
Issue
11
Pages
1124-1131
ISSN
  • 0958-0670 (ISSN-L)
  • 1469-445X
DOI
10.1113/expphysiol.2009.048983
OpenAlex
W2157744739
Cited by
21
References
31
Citations by year
2024: 1 · 2020: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 2
FWCI
1.36
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Experimental Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
glucose ingestion, endurance training, interleukin-6, IL-6 receptor alpha, myokines, skeletal muscle gene expression, exercise-induced gene expression, carbohydrate supplementation
MeSH terms
Adaptation, Physiological, Adult, Bicycling, Glucose, Humans, Male, Physical Endurance, Physical Fitness, RNA, Messenger, Blotting, Western, Interleukin-6, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-6 Receptor alpha Subunit, Young Adult

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