Maternal corticosterone regulates nutrient allocation to fetal growth in mice
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Key points: Stress during pregnancy leads to fetal growth restriction. Natural glucocorticoids, such as corticosterone, are elevated by maternal stress and, hence, may mediate the effects of stress on fetal growth. This study shows that increasing corticosterone levels in pregnant mice limits fetal growth by reducing the amino acid supply and density of blood vessels in the placenta. The findings suggest that excess corticosterone may act to defend maternal resources during times of stress by constraining the placental allocation of nutrients to the fetus. The results also provide a potential mechanism by which stresses during pregnancy can program intrauterine growth and development with consequences in later life. Abstract Stresses during pregnancy that increase maternal glucocorticoids reduce birth weight in several species. However, the role of natural glucocorticoids in the mother in fetal acquisition of nutrients for growth remains unknown. This study aimed to determine whether fetal growth was reduced as a consequence of altered amino acid supply when mice were given corticosterone in their drinking water for 5 day periods in mid to late pregnancy (day, D, 11–16 or D14–19). Compared to controls drinking tap water, fetal weight was always reduced by corticosterone. At D16, corticosterone had no effect on materno‐fetal transfer of [ 14 C]methylaminoisobutyric acid (MeAIB), although placental MeAIB accumulation and expression of the Slc38a1 and Slc38a2 transporters were increased. However, at D19, 3 days after treatment ended, materno‐fetal transfer of MeAIB was increased by 37% ( P < 0.04). During treatment at D19, placental accumulation and materno‐fetal transfer of MeAIB were reduced by 40% ( P < 0.01), although expression of Slc38a1 was again elevated. Permanent reductions in placental vascularity occurred during the earlier but not the later period of treatment. Placental Hsd11b2 expression, which regulates feto‐placental glucocorticoid bioavailability, was also affected by treatment at D19 only. Maternal corticosterone concentrations inversely correlated with materno‐fetal MeAIB clearance and fetal weight at D19 but not D16. On D19, weight gain of the maternal carcass was normal during corticosterone treatment but reduced in those mice treated from D11 to D16, in which corticosterone levels were lowest. Maternal corticosterone is, therefore, a physiological regulator of the amino acid supply for fetal growth via actions on placental phenotype.
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The adaptive responses of the placenta to these signals depend on the species, stage of gestation, total uterine mass, evolutionary history and on the specific nature of the environmental cues.
“The adaptive responses of the placenta to these signals depends on the species, stage of gestation, total uterine mass, evolutionary history and on the specific nature of the environmental cues (546).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [546]
Similar changes in placental growth and efficiency are seen in murine and ovine placentas in response to maternal undernutrition.
“Similar changes in placental growth and efficiency are seen in murine and ovine placentas in response to maternal undernutrition (198,546,550).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [546]
The extent to which this strategy is successful in altering maternal-fetal resource allocation in favour of the mouse fetus depends on the actual nutritional and endocrine environment of the mother and on the mass, gestational age and genetic background of her litter.
“However, the extent to which this strategy is successful in altering maternal-fetal resource allocation in favour of the mouse fetus depends on the actual nutritional and endocrine environment of the mother and on the mass, gestational age and genetic background of her litter (74,193,546).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [546]
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- Authors
- Vaughan, O. R., Sferruzzi‐Perri, A. N., & Fowden, A. L.
- Affiliations
- University of Cambridge (GB)
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2012-09-28
- Volume
- 590
- Issue
- 21
- Pages
- 5529-5540
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC3515836
- OpenAlex
- W2160711568
- Cited by
- 75
- References
- 51
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 7 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 7 · 2013: 7
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- fetal growth restriction, maternal stress, amino acid transport, SLC38A1, SLC38A2, placental vascularization, 11β-hydroxysteroid dehydrogenase type 2, birth weight, maternal resource allocation, placenta, pregnancy
- MeSH terms
- Amino Acids, Animals, Corticosterone, Female, Humans, Mice, Inbred C57BL, Placenta, Placentation, Pregnancy, Pregnancy, Animal, RNA, Messenger, Amino Acid Transport System A, 11-beta-Hydroxysteroid Dehydrogenase Type 2, Fetal Development, Mice
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