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Phosphenes produced by electrical stimulation of human occipital cortex, and their application to the development of a prosthesis for the blind
Open accessAbstract
1. To explore the feasibility of a visual prosthesis for the blind, human visual cortex has been stimulated during a series of surgical procedures on conscious volunteers undergoing other occipital lobe surgery. 2. Area no. 17 seems the most effective locus for such stimulation, at least in sighted or recently hemianopic patients. 3. Changes in electrode size and configuration, or in stimulus parameters, have little effect on subjective sensation. 4. Thresholds do vary depending on parameters, but not electrode size, and these effects have been studied. 5. Painful effects are associated with stimulation of the dura, but not of the calcarine artery and associated vessels. 6. Stimulation of a single electrode usually produces one phosphene, whose size ranges from tiny punctate sensations like ‘a star in the sky’ up to a large coin at arm's length. Very large elongated phosphenes, like those seen by Brindley's second patient, have not been reported despite the number of patients, electrodes, and combinations of stimulus parameters tested. These large phosphenes may be an effect of prolonged blindness. 7. Stimulation substantially above threshold may produce a second conjugate phosphene, inverted about the horizontal meridian. 8. Stimulation of a single electrode may also produce multiple phosphenes with no differential threshold. 9. Chromatic effects and/or phosphene flicker may, or may not occur. This can vary from point to point on the same patient. 10. Phosphenes fade after 10–15 sec of continuous stimulation. 11. All phosphenes move proportionately with voluntary eye movements, within the accuracy of our mapping techniques. 12. Brightness modulation can easily be achieved by changing pulse amplitude. 13. The position of phosphenes in the visual field corresponds only roughly with expectations based on classical maps showing the projection of the visual field onto the cortex. 14. Patients can usually discriminate phosphenes produced by 1 mm 2 electrodes on 3 mm centres, although this seems to be close to the limit of resolution. 15. Patterns of up to four phosphenes produced by four electrodes have been recognized. However, a variety of complex interactions have been reported. 16. Multiple phosphenes are co‐planar, although patients are unable to estimate their distance. 17. Phosphenes appear immediately when stimulation is begun, and disappear immediately upon cessation of stimulation. 18. Future work must concentrate on blind volunteers to explore possible differences in subjective sensation produced after prolonged blindness, and to explore more complex pattern presentation which requires substantial periods of time with any given patient.
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“Furthermore, in contrast to the assumptions of our model, interactions between simultaneous stimulation of multiple electrodes can have an effect on the phosphene size and sometimes lead to unexpected percepts (Fernández et al., 2021; Dobelle and Mladejovsky, 1974; Bak et al., 1990).”
From Towards biologically plausible phosphene simulation for the differentiable optimization of visual cortical prostheses (2024) · cites this paper as Dobelle and Mladejovsky, 1974
In the citing paper
“They showed that visual percepts (phosphenes) could be evoked by electrical stimulation of the visual cortex via an array of electrodes implanted on the surface of a subject's visual cortex.”
From Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex (2021) · cites this paper as [4]
In the citing paper
“This 2-point resolution is closer than the 500 μ m resolution reported previously with a single electrode pair of gold wire electrodes (10), and about 5 times closer than has been achieved with surface electrodes (2-5, 7).”
From Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex (2021) · cites this paper as [4]
In the citing paper
“However, there were also some problems, such as the induction of epileptic seizures and the appearance of pain due to meningeal or scalp stimulation.”
From Toward Long-Term Communication With the Brain in the Blind by Intracortical Stimulation: Challenges and Future Prospects (2020) · cites this paper as Dobelle and Mladejovsky, 1974
In the citing paper
“Increasing the electrode density increases the risk of having a stimulation cross-talk and current summation when neighbouring electrodes are activated simultaneously.”
From Three-dimensional multilayer concentric bipolar electrodes restrict spatial activation in optic nerve stimulation (2022) · cites this paper as [7]
Citations
Cites
Wiesel, T. N., & Hubel, D. H. (1965) · Journal of Neurophysiology · doi:10.1152/jn.1965.28.6.1029 · Cited by 1,598
The sensations produced by electrical stimulation of the visual cortex
Brindley, G. S., & Lewin, W. S. (1968) · The Journal of Physiology · doi:10.1113/jphysiol.1968.sp008519 · Cited by 1,170
The topography and variability of the primary visual cortex in man
Stensaas, S. S., Eddington, D. K., & Dobelle, W. H. (1974) · Journal of neurosurgery · doi:10.3171/jns.1974.40.6.0747 · Cited by 420
Self-citationLibet, B., Alberts, W. W., Wright, E. W., Delattre, L. D., Levin, G., & FEINSTEIN, B. (1964) · Journal of Neurophysiology · doi:10.1152/jn.1964.27.4.546 · Cited by 319
Structural changes in the area striata of the mouse after enucleation
Valverde, F. (1968) · Experimental Brain Research · doi:10.1007/bf00235903 · Cited by 286
The decline of potassium permeability during extreme hyperpolarization in frog skeletal muscle
Almers, W. (1972) · The Journal of Physiology · doi:10.1113/jphysiol.1972.sp009929 · Cited by 135
The variability of the human striate cortex.
Gs, B. (1972) · PubMed · Cited by 93
A Prosthesis for the Deaf Based on Cortical Stimulation
Dobelle, W. H., Stensaas, S. S., Mladejovsky, M. G., & Smith, J. B. (1973) · Annals of Otology Rhinology & Laryngology · doi:10.1177/000348947308200404 · Cited by 83
Self-citationExperimental visual prosthesis
Donaldson, P. E. K. (1973) · Proceedings of the Institution of Electrical Engineers · doi:10.1049/piee.1973.0061 · Cited by 58
Brindley, G. S. (1970) · PubMed Central · Cited by 38
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Items 401–470 of 470
Zou, Y., Niu, H., Zhao, B., Yi, G.-L., Yang, M., Ju, J., Yin, J., & Li, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.12.688136 · Cited by 1
Melnyk, A. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511498817.003
Melnyk, A. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511498817.001
Photogenetic Retinal Prosthesis
Grossman, N. (2010) · Spiral (Imperial College London) · doi:10.25560/6155
Onnela, N. (2012) · Tampere University Institutional Repository (Tampere University)
Regele, O. B. (2013) · Purdue e-Pubs (Purdue University System)
An embedded approach to visual prosthesis chip
Sefat, M. S., & Shahjahan, M. (2015) · International Conference on Electrical Engineering and Information Communication Technology · doi:10.1109/iceeict.2015.7307385
Melnyk, A. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511498817.002
Shuranova, Z. P., & Gvozdikova, Z. M. (1981) · Neuroscience and Behavioral Physiology · doi:10.1007/bf01349675
Responses of rabbit visual cortical neurons to intracortical electrical stimulation
Polyanskii, V. B., Латанов, А. В., & Ruderman, G. L. (1984) · Neurophysiology · doi:10.1007/bf01059872
Record, P. M., Williams, E., Hitchcock, E. R., & Ahmon, M. (1989) · Journal of Medical Engineering & Technology · doi:10.3109/03091908909030195
Image processing system dedicated to a visual intra‐cortical stimulator
Ghannoum, A., Ghafar‐Zadeh, E., & Sawan, M. (2014) · IET Image Processing · doi:10.1049/iet-ipr.2013.0838
Nuevos dispositivos electrónicos para interaccionar con el sistema nervioso
Jover, E. F. (2004) · Arbor · doi:10.3989/arbor.2004.i698.610 · Cited by 2
Neurosurgical stimulation, impedance monitoring and data acquisition system
Record, P. M., Williams, E., Ahmon, M., & Hitchcock, E. (1989) · Journal of Biomedical Engineering · doi:10.1016/0141-5425(89)90123-4
Entorno hardware/software para experimentación con neuroprótesis visuales
García, R., & Francisco, S. (2011)
An implantableP-m.o.s. monolithic switch for biphasic stimulation
Donaldson, N. (1980) · Medical & Biological Engineering & Computing · doi:10.1007/bf02441907
Eye Movements by Striate Cortex Phosphene Induction and the Generation of Saccadic
Slocum, W. M., Carvey, C. E., Schiller, P. H., Manzur, H., Alvarez, J., Babul, C., Maldonado, P., Happel, M. F. K., Deliano, M., Handschuh, J., et al. (2015)
Towards closed-loop stimulation for stroke rehabilitation
Walter, A. (2013)
A Novel Approach for Quantitative Analysis of 3D Phosphenes
Soto‐Sánchez, C., Olmedo-Payá, A., de Santos‐Sierra, D., Agullo, C., & Fernández, E. (2013) · Lecture notes in computer science · doi:10.1007/978-3-642-38637-4_35
Moxon, K. A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5227-0_3
Melnyk, A. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511498817.004
Gall, C., & Sabel, B. A. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139136907.011
The Evidence for Realization Physicalism
Melnyk, A. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511498817.008
Realizationism and R*d*ct**n*sm
Melnyk, A. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511498817.005
Causation and Explanation in a Realizationist World
Melnyk, A. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511498817.006
The Evidence against Realization Physicalism
Melnyk, A. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511498817.007
Melnyk, A. (2003) · doi:10.1017/cbo9780511498817.010
Electrocortical (Cerebral) Stimulation
Girvin, J. P. (2014) · Springer eBooks · doi:10.1007/978-3-319-10921-3_4
Surgical Instrumentation and Devices
Ho, J., Nguyen, B. J., & Chao, D. L. (2018) · Current practices in ophthalmology · doi:10.1007/978-981-10-8545-1_9
Tokuda, T., Ohta, J., Tashiro, H., & Terasawa, Y. (2018) · Wiley eBooks · doi:10.1002/047134608x.w8370
Current Advances in the Design of Retinal and Cortical Visual Prostheses
Bareket, L., Barriga‐Rivera, A., Rosenfeld, J. V., Lovell, N. H., & Suaning, G. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812539-7.00005-2
Novel flexible multielectrode arrays for neuronal stimulation and recording
Adams, C. (2007) · Enlighten: Theses (The University of Glasgow) · doi:10.5525/gla.thesis.71782
Современное состояние проблемы «интерфейс мозг—компьютер»
Shurkhay, V. A., Aleksandrova, E. V., Potapov, A. A., & Goryainov, S. A. (2015)
Humayun, M. S., Brant, R., & Weiland, J. D. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-0737-9.00126-0
Diseases and Repair Approaches in Vision
Lamba, D. A., & Reh, T. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.23901-1
Spatial navigation with a simulated prosthetic vision in a virtual environment
Vergnieux, V., Macé, M. J. ‐., & Jouffrais, C. (2012) · HAL
邦彦, 満. (2009) · 認知神経科学 · doi:10.11253/ninchishinkeikagaku.11.10
Human Full Potential Abilities Training: Psi Mechanisms and its Model of Training
Shiah, Y. (2020) · International and cultural psychology/International and cultural psychology series · doi:10.1007/978-3-030-61404-1_6
Gilson, M. (2003) · PolyPublie (École Polytechnique de Montréal)
Melnyk, A. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511498817.009
Borda, E., Gaillet, V., Leccardi, M. J. I. A., Zollinger, E. G., Moreira, R. C., & Ghezzi, D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.21.485100
Robinson, C. J. (2013) · IGI Global eBooks · doi:10.4018/978-1-4666-0122-2.ch016
Kalaska, J. F. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733788778.793560130
Meneï, P., Clavreul, A., Casanova, M., Colle, D., & Colle, H. (2021) · Springer eBooks · doi:10.1007/978-3-030-75071-8_2
Interfacing Microelectronics and the Human Visual System
Lazzi, G., Humayun, M. S., Gosalia, K. C., Weiland, J. D., & Agrawal, R. N. (2005) · CRC Press eBooks · doi:10.1201/9781420037715.ch17
Dagnelie, G., Weiland, J. D., Sadda, S. R., & Eong, K. A. (2002) · Elsevier eBooks · doi:10.1016/b978-012436636-7/50215-9
Ortega, A. M. L. (2022) · Digital Repository (Polytechnic University of Cartagena) · doi:10.31428/10317/11200
Visual Prostheses: Neuroengineering Handbook
Guo, T., Shivdasani, M. N., Tsai, D., Ayton, L. N., Rathbun, D. L., & Lovell, N. H. (2023) · Handbook of Neuroengineering · doi:10.1007/978-981-16-5540-1_31
van Steveninck, J. D. R., Nipshagen, M., van Gerven, M. A. J., Güçlü, U., Güçlütürk, Y., & Wezel, R. J. A. V. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.18.558225
Yang, J., Shen, L., Long, Q., Li, W., Zhang, W., Chen, Q., & Han, B. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad473
Singh, S. L. R. R. (2025) · Lecture notes in computer science · doi:10.1007/978-3-032-00800-8_20
Phosphenes and the effects of charged particles on the visual system
Carozzo, S., & Sannita, W. G. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1621659
Mortimer, J. T. (1981) · Comprehensive physiology · doi:10.1002/j.2040-4603.1981.tb00843.x
Charge Pumps for Implantable Microstimulators in Low and High-Voltage Technologies
Kar, G. C. (2013) · PolyPublie (École Polytechnique de Montréal)
市江, 雅., & 半田, 康. (1999) · BME : bio medical engineering · doi:10.11239/jsmbe1987.13.2_20
市江, 雅., 半田, 康., & 望, 星. (1997) · 人工臓器 · doi:10.11392/jsao1972.26.913
Yuina Terakura, K. Y., Terakura, Y., Fukuda, S., & Hayashida, Y. (2026) · Bioengineering · doi:10.3390/bioengineering13020231
Motion perception with visual prostheses
Renshaw, K. T., & Pezaris, J. S. (2026) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ae46fd · Cited by 1
Poulkouras, R. (2022) · theses.fr (ABES) · doi:10.70675/18e3c078z78a1z4e5czbd7dz301fcc213f06
Singh, S. L. R. R., & Chakrabarty, S. (2026) · Studies in Rhythm Engineering · doi:10.1007/978-3-032-19974-4_10
Scialom, E., Lonnqvist, B., Bornet, A., & Herzog, M. H. (2026) · Journal of Neural Engineering · doi:10.1088/1741-2552/ae9227
Electrical Microstimulation in Macaque Early Visual Cortex Reveals Causal Links to Color Perception
彭建仁, & Gu, Y. (2026) · Neuroscience Bulletin · doi:10.1007/s12264-026-01707-1
Restorative and regenerative therapies for vision loss
Boychev, N., Soucy, J. R., Dang, S. H., Tran, C. T., Malkin, A. G., Yeung, V., Ross, A. E., Hutcheon, A. E. K., & Kanu, L. N. (2026) · Eye · doi:10.1038/s41433-026-04913-3
Renshaw, K. T., & Pezaris, J. S. (2026) · Oxford University Press eBooks · doi:10.1093/9780197851494.003.0595
Findings from Acute Retinal Stimulation in Blind Patients
Walter, P., & Roessler, G. F. (2011) · Springer eBooks · doi:10.1007/978-1-4419-0754-7_13
Metadata
- Authors
- Dobelle, W. H., & Mladejovsky, M. G.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1974-12
- Volume
- 243
- Issue
- 2
- Pages
- 553-576
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC1330721
- OpenAlex
- W2018103408
- Cited by
- 468
- References
- 11
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 7 · 2023: 14 · 2022: 20 · 2021: 16 · 2020: 19 · 2019: 11 · 2018: 17 · 2017: 11 · 2016: 19 · 2015: 17 · 2014: 15 · 2013: 25 · 2012: 22
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- phosphenes, visual prosthesis, visual cortex stimulation, occipital lobe, blind patients, area 17, electrode configuration, stimulation threshold, brightness modulation, electrode spacing, hemianopia
- MeSH terms
- Adult, Aged, Arteriovenous Malformations, Astrocytoma, Blindness, Electric Stimulation, Electrodes, Eye Movements, Female, Humans, Male, Meningioma, Methods, Middle Aged, Occipital Lobe, Pain, Pulse, Vision, Ocular, Visual Cortex, Prostheses and Implants
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