Persistent Firing Supported by an Intrinsic Cellular Mechanism in a Component of the Head Direction System
Open accessAbstract
The rat postsubiculum has head direction cells that fire persistently when the rat's head is oriented in particular directions. This persistent firing is maintained even if the rat is motionless, when spatial cues are removed from the environment and in the dark, but the mechanism that supports persistent firing of the head direction cells is still unclear. Here, using in vitro whole-cell patch recording, we found that a short-triggering stimulus (as few as five induced spikes) can initiate persistent firing in cells of the postsubiculum. Pharmacological results indicated that this persistent firing is driven by a calcium-sensitive nonselective cation current. The distribution of cells with persistent firing in superficial and deep layers in the postsubiculum was similar to that of head direction cells. These results suggest that persistent firing of head direction cells in the postsubiculum could be supported by an intrinsic mechanism.
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The cholinergic enhancement of persistent spiking is reduced by muscarinic antagonists such as scopolamine, indicating a dependence on mechanisms activated by mAChRs.
“The cholinergic enhancement of persistent spiking is reduced by muscarinic antagonists such as scopolamine, indicating a dependence on mechanisms activated by mAChRs (Klink and Alonso 1997; Egorov et al, 2002; Yoshida and Hasselmo, 2009).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Yoshida and Hasselmo, 2009
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Self-citation
- Authors
- Yoshida, M., & Hasselmo, M. E.
- Affiliations
- Boston University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-04-15
- Volume
- 29
- Issue
- 15
- Pages
- 4945-4952
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2704018
- OpenAlex
- W2083922453
- Cited by
- 94
- References
- 42
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 9 · 2013: 9 · 2012: 10
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- National Institute of Mental Health (MH-71702, P50MH060450, MH 60013, MH-60450, MH61492, R01MH060013, R01MH061492, P50MH071702)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- head direction cells, postsubiculum, persistent firing, spatial orientation
- MeSH terms
- Action Potentials, Animals, Neurons, Orientation, Space Perception, Head Movements, Rats, Long-Evans, Rats
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