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GABA and glutamate mediate rapid neurotransmission from suprachiasmatic nucleus to hypothalamic paraventricular nucleus in rat
Open accessAbstract
1. Intracellular sharp electrode and whole-cell patch-clamp recording from characterized paraventricular nucleus (PVN) neurones in rat hypothalamic slices were used to study the synaptic mechanism and associated neurotransmitters that mediate their response to suprachiasmatic nucleus (SCN) stimulation. 2. Electrical stimulation restricted to SCN evoked short-latency inhibitory postsynaptic potentials (IPSPs) or combinations of IPSPs and excitatory postsynaptic potentials (EPSPs) in all (n = 59) PVN neurones tested. Type I neurones (n = 18) were magnocellular and a majority (13/18) demonstrated monosynaptic IPSPs that reversed polarity at the chloride equilibrium potential and were sensitive to bicuculline. 3. Type II (n = 10) and III parvocellular (n = 13), and unclassifiable neurones (n = 18) displayed combinations of IPSPs and EPSPs following similar stimuli applied to SCN. IPSP blockade with bicuculline uncovered SCN-evoked monosynaptic dual-component EPSPs that were sensitive to N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists. In addition, chemical microstimulation within SCN was associated with transient increases in spontaneous EPSPs recorded from these PVN neurones. 4. These data imply that the amino acids GABA and glutamate are important mediators of fast monosynaptic transmission from SCN to defined neurones in PVN, and are candidates for conveying circadian rhythmicity to PVN regulation of neuroendocrine and autonomic processes.
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Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421
“Electrophysiological studies have also shown that glutamate is an SCN transmitter (70) and conveys circadian signals to hypothalamic target structures (71).”
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“…lesions abolish the rhythm of MEL synthesis in the pineal gland (Klein et al., 1983), PVN neurons respond to an electrical stimulation of SCN cells (Hermes et al., 1997), VIP or VP infusion in the PVN elevates pineal melatonin release (Kalsbeek et al., 1993), and retrograde labeling from the…”
BackgroundHypothalamic integration of central and peripheral clocks
Buijs, R. M., & Kalsbeek, A. (2001) · Nature reviews. Neuroscience · doi:10.1038/35081582 · Cited by 601
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“Functional connections between SCN and autonomically projecting neurons of PVN were also recently demonstrated by Hermes & Renaud (1993), and Hermes et al. (1996).”
BackgroundBuijs, R. M., van Eden, C. G., Goncharuk, V. D., & Kalsbeek, A. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1770017 · Cited by 387
“However, the neurotransmitter ( -amino butyric acid; GABA) and glutamate, for which, in contrast to peptides, high-affinity uptake sites are present, also play a role in the synaptic transmission of SCN output (Hermes et al. 1996, Csaki et al. 2000, Cui et al. 2002).”
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Metadata
- Authors
- Hermes, M. L., Coderre, E. M., Buijs, R. M., & Renaud, L. P.
- Affiliations
- University of Ottawa (CA)
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1996-11
- Volume
- 496
- Issue
- 3
- Pages
- 749-757
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC1160861
- OpenAlex
- W2023286290
- Cited by
- 184
- References
- 33
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 7 · 2012: 6
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Heart and Stroke Foundation of Canada
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- suprachiasmatic nucleus, paraventricular nucleus, GABA, glutamate, monosynaptic transmission, inhibitory postsynaptic potentials, excitatory postsynaptic potentials, circadian rhythm, hypothalamus, magnocellular neurons, parvocellular neurons, NMDA receptor, non-NMDA receptors, bicuculline, chloride equilibrium potential, neuroendocrine regulation
- MeSH terms
- Animals, Bicuculline, Electric Stimulation, Evoked Potentials, gamma-Aminobutyric Acid, Male, Synaptic Transmission, Neurons, Paraventricular Hypothalamic Nucleus, Suprachiasmatic Nucleus, Time Factors, Patch-Clamp Techniques, Glutamic Acid, Rats, In Vitro Techniques
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