Balance between cardiac output and sympathetic nerve activity in resting humans: role in arterial pressure regulation
Open accessAbstract
Large, reproducible interindividual differences exist in resting sympathetic nerve activity among normotensive humans with similar arterial pressures, resulting in a lack of correlation between muscle sympathetic nerve activity (MSNA) and arterial pressure among individuals. Although it is known that the arterial pressure is the main short‐term determinant of MSNA in humans via the arterial baroreflex, the lack of correlation among individuals suggests that the level of arterial pressure is not the only important input in regulation of MSNA in humans. We studied the relationship between cardiac output (CO) and baroreflex control of sympathetic activity by measuring MSNA (peroneal microneurography), arterial pressure (arterial catheter), CO (acetylene uptake technique) and heart rate (HR; electrocardiogram) in 17 healthy young men during 20 min of supine rest. Across individuals, MSNA did not correlate with mean or diastolic blood pressure ( r < 0.01 for both), but displayed a significant negative correlation with CO ( r =−0.71, P = 0.001). To assess whether CO is related to arterial baroreflex control of MSNA, we constructed a baroreflex threshold diagram for each individual by plotting the percentage occurrence of a sympathetic burst against diastolic pressure. The mid‐point of the diagram ( T 50 ) at which 50% of cardiac cycles are associated with bursts, was inversely related to CO ( r =−0.75, P < 0.001) and stroke volume (SV) ( r =−0.57, P = 0.015). We conclude that dynamic inputs from CO and SV are important in regulation of baroreflex control of MSNA in healthy, normotensive humans. This results in a balance between CO and sympathetically mediated vasoconstriction that may contribute importantly to normal regulation of arterial pressure in humans.
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Sympathetic bursts in the integrated neurogram were identified by a custom-manufactured analysis program, and burst identification was corrected by visual inspection by a single investigator.
“Sympathetic bursts in the integrated neurogram were identified by a custom-manufactured analysis program (8, 9); burst identification was then corrected by visual inspection by a single investigator.”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [8]
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Self-citation
- Authors
- Charkoudian, N., Joyner, M. J., Johnson, C. P., Eisenach, J. H., Dietz, N. M., & Wallin, B. G.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Charkoudian, N.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2005-09-28
- Volume
- 568
- Issue
- 1
- Pages
- 315-321
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1613720875
- Cited by
- 254
- References
- 31
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 6 · 2021: 11 · 2020: 11 · 2019: 11 · 2018: 13 · 2017: 16 · 2016: 11 · 2015: 10 · 2014: 19 · 2013: 15 · 2012: 14
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01ns032352-003, NS3 2352, RR-00585)
- Medical Research Council
- National Heart, Lung, and Blood Institute (HL-73884, R01HL073884)
- National Institute of Neurological Disorders and Stroke (N01 NS032352)
- National Center for Research Resources (RR-00585, M01RR000585)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- cardiac output, muscle sympathetic nerve activity, arterial baroreflex, blood pressure regulation, stroke volume, sympathetic vasoconstriction, interindividual variability, heart rate
- MeSH terms
- Adult, Arteries, Blood Pressure, Cardiac Output, Heart Rate, Humans, Male, Muscle, Smooth, Vascular, Peroneal Nerve, Stroke Volume, Sympathetic Nervous System, Baroreflex
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