Sympathetic nervous system behavior in human obesity
Open accessAbstract
The sympathetic nervous system (SNS) plays an essential role in the regulation of metabolic and cardiovascular homeostasis. Low SNS activity has been suggested to be a risk factor for weight gain and obesity development. In contrast, SNS activation is characteristic of a number of metabolic and cardiovascular diseases that occur more frequently in obese individuals. Until recently, the relation between obesity and SNS behavior has been controversial because previous approaches for assessing SNS activity in humans have produced inconsistent findings. Beginning in the early 1990s, many studies using state of the art neurochemical and neurophysiological techniques have provided important insight. The purpose of the present review is to provide an overview of our current understanding of the region specific alterations in SNS behavior in human obesity. We will discuss findings from our own laboratory which implicate visceral fat as an important depot linking obesity with skeletal muscle SNS activation. The influence of weight change on SNS behavior and the potential mechanisms and consequences of region specific SNS activation in obesity will also be considered.
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Sex and age-related variations in body fat distribution may contribute to differences in sympathetic nerve activity between women and men, and between younger and older adults.
“Sex and age-related variations in body fat distribution may also contribute to differences in SNA between women and men, and between younger and older adults157.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [157]
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- Authors
- Davy, K. P., & Orr, J. S.
- Affiliations
- Virginia Tech (US)
- Corresponding author
- Davy, Kevin P.
- ORCID
- Davy, Kevin P.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 33
- Issue
- 2
- Pages
- 116-124
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC2630381
- OpenAlex
- W1986885124
- Cited by
- 166
- References
- 85
- Citations by year
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- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (K02HL067227, R01 HL 62283, K02 HL 67227, R01HL062283)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- sympathetic nervous system, obesity, visceral fat, weight change, metabolic homeostasis, cardiovascular homeostasis, sympathetic activation
- MeSH terms
- Energy Metabolism, Humans, Kidney, Obesity, Risk Factors, Sympathetic Nervous System, Weight Gain, Muscle, Skeletal, Intra-Abdominal Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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