Cited by 166Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesNeuroscience of respiration and sleep

Sympathetic nervous system behavior in human obesity

Open access
Davy, Kevin P., Orr, Jeb S.·2009·Neuroscience & Biobehavioral Reviews

Abstract

The sympathetic nervous system (SNS) plays an essential role in the regulation of metabolic and cardiovascular homeostasis. Low SNS activity has been suggested to be a risk factor for weight gain and obesity development. In contrast, SNS activation is characteristic of a number of metabolic and cardiovascular diseases that occur more frequently in obese individuals. Until recently, the relation between obesity and SNS behavior has been controversial because previous approaches for assessing SNS activity in humans have produced inconsistent findings. Beginning in the early 1990s, many studies using state of the art neurochemical and neurophysiological techniques have provided important insight. The purpose of the present review is to provide an overview of our current understanding of the region specific alterations in SNS behavior in human obesity. We will discuss findings from our own laboratory which implicate visceral fat as an important depot linking obesity with skeletal muscle SNS activation. The influence of weight change on SNS behavior and the potential mechanisms and consequences of region specific SNS activation in obesity will also be considered.

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Crossref · 10.1016/j.neubiorev.2008.05.024

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  • Sex and age-related variations in body fat distribution may contribute to differences in sympathetic nerve activity between women and men, and between younger and older adults.

    “Sex and age-related variations in body fat distribution may also contribute to differences in SNA between women and men, and between younger and older adults157.”

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Authors
Davy, K. P., & Orr, J. S.
Affiliations
Virginia Tech (US)
Corresponding author
Davy, Kevin P.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2009-02
Volume
33
Issue
2
Pages
116-124
ISSN
0149-7634 (ISSN-L)
OpenAlex
W1986885124
Cited by
166
References
85
Citations by year
2026: 1 · 2025: 7 · 2024: 10 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 12 · 2019: 12 · 2018: 4 · 2017: 13 · 2016: 15 · 2015: 14 · 2014: 20 · 2013: 10 · 2012: 15
FWCI
0.77
Type
journal article
Language
en
Open access
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Heart Association
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (K02HL067227, R01 HL 62283, K02 HL 67227, R01HL062283)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
sympathetic nervous system, obesity, visceral fat, weight change, metabolic homeostasis, cardiovascular homeostasis, sympathetic activation
MeSH terms
Energy Metabolism, Humans, Kidney, Obesity, Risk Factors, Sympathetic Nervous System, Weight Gain, Muscle, Skeletal, Intra-Abdominal Fat

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